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Biomarkers Expression in Cervical Cancer and High Grade Squamous Intraepithelial Lesions

Journal of Cancer Therapy 2012年第6期3卷 1066-1073页

作者： Ostojich Marcela Gimenez Liliana gianni sergio Alvarez Ana Marino Lina De Dios Diana Jasnis Maria Adela Departament of Gynecology Institute of Oncology Angel H Roffo University of Buenos Aires Argentina Department of Clinical Oncology Institute of Oncology Angel H Roffo University of Buenos Aires Argentina Department of Immunobiology Institute of Oncology Angel H Roffo University of Buenos Aires Argentina. Department of Pathology Institute of Oncology Angel H Roffo University of Buenos Aires Argentina

Objectives: The finding of new prognostic factors in human cervix cancer is necessary to improve present conventional treatments. The aim of the present study was to determine the expression and evaluate the prognostic value of hypoxia-inducible factor-1(HIF-1α), vascular endothelial growth factor (VEGF) and eritropoyetin receptor (EpoR) in cervix cancer stages IIA-IIB and in preinvasive high grade squamous intraepithelial lesions (HSIL) Methods: The study included 70 patients with cervix cancer, FIGO stages IIA-IIB, 28 patients with HSIL and normal cervix (n = 28). HIF-1α, VEGF and EpoR expression were analyzed in tissue samples by immunohistochemistry using commercial antibodies. Expression and overexpression of the tumor markers were quantified according to German Immunoreactive Score. Results: HIF-1α, EpoR and VEGF overexpression was detected in 30%, 37% and 51% of cancer patients respectively. Patients with HSIL showed enhanced expression only of EpoR and VEGF (39.2% and 71.4%) while VEGF was overexpressed in 21% of the specimen. No correlation was found between VEGF and EpoR with disease-free overall survival (OS), tumor recurrences or prognostic factors. Only overexpression of HIF-1 was associated with less median survival measured up to 24 months, unless it was not maintained a long time. Conclusion: Although any of the markers could be considered as independent prognostic factor for cervix cancer patients, our data showed a significant increase in their expression from the premalignant lesion up to the invasive stages of tumor progression.

关键词： Prognostic Marker Cervical Cancer Intraepithelial Lesion HIF-1α VEGF EpoR

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Refractive outcome of keratoconus treated by big-bubble deep anterior lamellar keratoplasty in pediatric patients: two-year follow-up comparison between mechanical trephine and femtosecond laser assisted techniques

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Eye and Vision 2019年第1期6卷 1-5页

作者： Luca Buzzonetti gianni Petrocelli Paola Valente sergio Petroni Rosa Parrilla Giancarlo Iarossi Ophthalmology Department Bambino GesùIRCCS Children’s HospitalVia Torre di Palidoro snc-00050 PassoscuroRomeItaly

Background:To evaluate refractive outcome 24 months after Deep Anterior Lamellar Keratoplasty(DALK)in pediatric patients by comparing results achieved using mechanical trephine and femtosecond ***:Twenty eyes of 20 patients affected by keratoconus were *** perform big-bubble DALK,10 eyes(Group 1;mean age 11.2±2.2 years)were subjected to the Hessburg-Barron mechanical trephine and the remaining 10 eyes(Group 2;mean age 11.3±3.1 years)to a 150 kHz femtosecond laser that performed mushroom *** thinnest point in the corneal thickness map and K readings were measured by the Sirius Scheimpflug *** also evaluated corrected distance visual acuity(CDVA)as logMAR value using spectacles,spherical equivalent and refractive ***:Mean preoperative thinnest point and pre-and post-operative K readings did not show significant difference(P>0.05)between the two ***,spherical equivalent and refractive astigmatism were respectively,0.14±0.08 logMAR and 0.13±0.10 logMAR(P=0.8),−4.2±1.1 D and−2.8±1.2 D(P=0.03),4.4±2.0 D and 3.6±1.2 D(P=0.4)in Groups 1 and *** DALK procedures were ***:Our findings suggest that femtosecond laser compared to mechanical trephine could significantly reduce the spherical equivalent amount in pediatric big-bubble DALK.

关键词： Pediatric keratoplasty Deep anterior lamellar keratoplasty Femtosecond laser

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