Biomarkers Expression in Cervical Cancer and High Grade Squamous Intraepithelial Lesions
Biomarkers Expression in Cervical Cancer and High Grade Squamous Intraepithelial Lesions作者机构：Departament of Gynecology Institute of Oncology Angel H Roffo University of Buenos Aires Argentina Department of Clinical Oncology Institute of Oncology Angel H Roffo University of Buenos Aires Argentina Department of Immunobiology Institute of Oncology Angel H Roffo University of Buenos Aires Argentina. Department of Pathology Institute of Oncology Angel H Roffo University of Buenos Aires Argentina
出 版 物：《Journal of Cancer Therapy》 (癌症治疗（英文）)
年 卷 期：2012年第3卷第6期
页 面：1066-1073页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Prognostic Marker Cervical Cancer Intraepithelial Lesion HIF-1α VEGF EpoR
摘 要：Objectives: The finding of new prognostic factors in human cervix cancer is necessary to improve present conventional treatments. The aim of the present study was to determine the expression and evaluate the prognostic value of hypoxia-inducible factor-1(HIF-1α), vascular endothelial growth factor (VEGF) and eritropoyetin receptor (EpoR) in cervix cancer stages IIA-IIB and in preinvasive high grade squamous intraepithelial lesions (HSIL) Methods: The study included 70 patients with cervix cancer, FIGO stages IIA-IIB, 28 patients with HSIL and normal cervix (n = 28). HIF-1α, VEGF and EpoR expression were analyzed in tissue samples by immunohistochemistry using commercial antibodies. Expression and overexpression of the tumor markers were quantified according to German Immunoreactive Score. Results: HIF-1α, EpoR and VEGF overexpression was detected in 30%, 37% and 51% of cancer patients respectively. Patients with HSIL showed enhanced expression only of EpoR and VEGF (39.2% and 71.4%) while VEGF was overexpressed in 21% of the specimen. No correlation was found between VEGF and EpoR with disease-free overall survival (OS), tumor recurrences or prognostic factors. Only overexpression of HIF-1 was associated with less median survival measured up to 24 months, unless it was not maintained a long time. Conclusion: Although any of the markers could be considered as independent prognostic factor for cervix cancer patients, our data showed a significant increase in their expression from the premalignant lesion up to the invasive stages of tumor progression.
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