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Actin(g) toward a revised understanding of the role of cytoskeletal dynamics in neuronal bioenergetics

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Neural Regeneration Research 2024年第10期19卷 2109-2110页

作者： Sabrina m.Holland gianluca Gallo Department of Neural Sciences Shriners Pediatric Research CenterLewis Katz School of Medicine at Temple UniversityPhiladelphiaPAUSA

Neurons are energy-demanding *** in energy metabolism can quickly interrupt neuronal function,leading to cell death and *** instance,ischemia rapidly depletes adenosine triphosphate(ATp)thereby disrupting energy-dependent cellular processes crucial for homeostasis,and axon degeneration is preceded by a collapse of axonal ATp levels.

关键词： metabolism homeostasis degeneration

Biofabrication of nanocomposite-based scaffolds containing human bone extracellularmatrix for the differentiation of skeletal stem and progenitor cells

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Bio-Design and manufacturing 2024年第2期7卷 121-136页

作者： Yang-Hee Kim Janos m.Kanczler Stuart Lanham Andrew Rawlings marta Roldo gianluca Tozzi Jonathan I.Dawson gianluca Cidonio Richard O.C.Oreffo Faculty of medicine Bone and Joint Research GroupCentre for Human DevelopmentStem Cells and RegenerationInstitute of Developmental SciencesUniversity of SouthamptonSouthampton SO166YDUK School of pharmacy and Biomedical Science University of PortsmouthPortsmouth PO12DTUK School of Engineering Faculty of Engineering and ScienceUniversity of GreenwichGreenwich ME44TBUK Center for Life Nano-and Neuro-Science(CLN2S) Italian Institute of Technology00161 RomeItaly

Autograft or metal implants are routinely used in skeletal ***,they fail to provide long-term clinical resolution,necessitating a functional biomimetic tissue engineering *** use of native human bone tissue for synthesizing a biomimeticmaterial inkfor three-dimensional(3D)bioprintingof skeletal tissueis anattractivestrategyfor ***,human bone extracellular matrix(bone-ECm)offers an exciting potential for the development of an appropriate microenvironment for human bone marrow stromal cells(HBmSCs)to proliferate and differentiate along the osteogenic *** this study,we engineered a novel material ink(LAB)by blending human bone-ECm(B)with nanoclay(L,Laponite®)and alginate(A)polymers using extrusion-based *** inclusion of the nanoﬁller and polymeric material increased the rheology,printability,and drug retention properties and,critically,the preservation of HBmSCs viability upon *** composite of human bone-ECm-based 3D constructs containing vascular endothelial growth factor(VEGF)enhanced vascularization after implantation in an ex vivo chick chorioallantoic membrane(CAm)*** inclusion of bone morphogenetic protein-2(Bmp-2)with the HBmSCs further enhanced vascularization and mineralization after only seven *** study demonstrates the synergistic combination of nanoclay with biomimetic materials(alginate and bone-ECm)to support the formation of osteogenic tissue both in vitro and ex vivo and offers a promising novel 3D bioprinting approach to personalized skeletal tissue repair.

关键词： Extracellular matrix Nanoclay Bone 3D bioprinting

Beyond dentistry:could prevention and screening for neurodegenerative diseases start in the dental office?

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Neural Regeneration Research 2024年第1期19卷 156-157页

作者： Francesca R.Buccellato Daniela Galimberti gianluca m.Tartaglia Department of Biomedical Surgical and Dental SciencesUniversity of MilanMilanItalyFondazione IRCCS Ca’GrandaOspedale Maggiore PoliclinicoMilanItaly

The differential diagnosis of neurodegenerative diseases is complex and relies on clinical assessment,biomarker levels in cerebrospinal fluid,neuroimaging and neuropsychological *** efforts of the scientific community are focused on two aspects:a)the discovery of minimally invasive biomarkers;b)the discovery of early biomarkers that can predict the progression to clinical disease in the presymptomatic stage of a *** the impact of the number of patients affected by chronic neurodegenerative diseases on public health expenditures,early diagnosis seems to be a primary need of our society.

关键词： diagnosis diseases prevention

In vivo polydopamine coating of Rhodobacter sphaeroides for enhanced electron transfer

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Nano Research 2024年第2期17卷 875-881页

作者： Rossella Labarile Danilo Vona maria Varsalona matteo Grattieri melania Reggente Roberto Comparelli gianluca m.Farinola Fabian Fischer Ardemis A.Boghossian massimo Trotta Istituto per i processi Chimico Fisici Consiglio Nazionale delle RicercheBari 70126Italy Dipartimento di Chimica Universitàdegli Studi di BariBari 70126Italy Institute of Chemical Sciences and Engineering(ISIC) Ecole Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Institute of Life Technologies HES-SO Valais-Wallis1950 SionSwitzerland Institute for Renewable Energy HES-SO Valais-Wallis1950 SionSwitzerland

Recent advances in coupling light-harvesting microorganisms with electronic components have led to a new generation of biohybrid devices based on microbial *** devices are limited by the poorly conductive interface between phototrophs and synthetic materials that inhibit charge *** study focuses on overcoming this bottleneck through the metabolically-driven encapsulation of photosynthetic cells with a bio-inspired conductive *** of the purple non sulfur bacterium Rhodobacter sphaeroides were coated with a polydopamine(pDA)nanoparticle layer via the self-polymerization of dopamine under anaerobic *** treated cells show preserved light absorption of the photosynthetic pigments in the presence of dopamine concentrations ranging between 0.05–3.5 *** thickness and nanoparticle formation of the membrane-associated pDA matrix were further shown to vary with the dopamine concentrations in this *** to uncoated cells,the encapsulated cells show up to a 20-fold enhancement in transient photocurrent measurements under mediatorless *** biologically synthesized pDA can thus act as a matrix for electronically coupling the light-harvesting metabolisms of cells with conductive surfaces.

关键词： bioelectronics photosynthetic bacteria purple bacteria electron transfer polydopamine biophotovoltaics

Tuning of frictional properties in torsional contact by means of disk grading

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Friction 2022年第5期10卷 787-802页

作者： gianluca COSTAGLIOLA Federico BOSIA Nicola m pUGNO Civil Engineering Institute Ecole Polytechmique Federale de LausamneLausanne 1015Switzerland Department ofApplied Science and Technology Politecnico di TorinoCorso Duca degli Abruzzi 24Torino 10129Italy Laboratory for BioinspiredBionicNanoMeta Materials&MechanicsDepartment of CivilEnvironmental and Mechanical EngineeringUniversity of TrentoTrento 38123Italy School of Engineering and materials Science Queen Mary University of LondonLondon EI 4NSUK

The contact of two surfaces in relative rotating motion occurs in many practical applications,from mechanical devices to human joints,displaying an intriguing interplay of effects at the onset of sliding due to the axisymmetric stress *** and numerical models have been developed for some typical configurations,but work remains to be done to understand how to modify the emergent friction properties in this *** this paper,we extend the two-dimensional(2D)spring-block model to investigate friction between surfaces in torsional *** investigate how the model describes the behavior of an elastic surface slowly rotating over a rigid substrate,comparing results with analytical calculations based on energy *** show that an appropriate grading of the tribological properties of the surface can be used to avoid a non-uniform transition to sliding due to the axisymmetric configuration.

关键词： friction torsion numerical simulations grading

BOUNDARY pROCEDURES FOR THE TImE-DEpENDENT BURGERS' EQUATION UNDER UNCERTAINTY

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Acta mathematica Scientia 2010年第2期30卷 539-550页

作者： per pettersson Jan Nordstrm gianluca Iaccarino mechanical Engineering and Institute for Computational mathematical Engineering Stanford University Division of Scientific Computing Department of Information TechnologyUppsala University School of mechanical Industrial and Aeronautical EngineeringUniversity of the Witvatersrand Department of Aeronautics and Systems Integration FOIThe Swedish Defense Research Agency

The Burgers＇ equation with uncertain initial and boundary conditions is approximated using a polynomial Chaos Expansion （pCE） approach where the solution is represented as a series of stochastic, orthogonal polynomials. The resulting truncated pCE system is solved using a novel numerical discretization method based on spatial derivative operators satisfying the summation by parts property and weak boundary conditions to ensure stability. The resulting pCE solution yields an accurate quantitative description of the stochastic evolution of the system, provided that appropriate boundary conditions are available. The specification of the boundary data is shown to influence the solution; we will discuss the problematic implications of the lack of precisely characterized boundary data and possible ways of imposing stable and accurate boundary conditions.

关键词： stochastic Burgers' equation uncertainty quantification polynomial chaos

Transperineal laser ablation of the prostate as a treatment for benign prostatic hyperplasia and prostate cancer: The results of a Delphi consensus project

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Asian Journal of Urology 2024年第2期11卷 271-279页

作者： Andrea Cocci marta pezzoli Fernando Bianco Franco Blefari pierluigi Bove Francois Cornud Gaetano De Rienzo paolo Destefanis Danilo Di Trapani Alessandro Giacobbe Luca Giovanessi Antonino Laganà Giovanni Lughezzani Guglielmo manenti gianluca muto Gianluigi patelli Novello pinzi Stefano Regusci Giorgio I.Russo Juan I.m.Salamanca matteo Salvi Luigi Silvestri Fabrizio Verweij Eric Walser Riccardo GBertolo Valerio Iacovelli Alessandro Bertaccini Debora marchiori Hugo Davila pasquale Ditonno paolo Gontero Gennaro Iapicca Theo m De Reijke Vito Ricapito pierluca pellegrini Andrea minervini Sergio Serni Francesco Sessa Department of Urology Careggi HospitalUniversity of FlorenceFlorenceItaly Urology Section University of FlorenceFlorenceItaly Urological Research Network MiamiFLUSA Urology Section Prato HospitalPratoItaly Torvergata Oncoscience Research Centre of Excellence TORDepartment of Experimental MedicineUniversity of Rome Tor VergataRomeItaly Department of Urology San Carlo di Nancy HospitalRomeItaly Department of Radiology Hôpital CochinParis Descartes UniversityParisFrance Urology and Andrology Unit II Department of Emergency and Organ TransplantationUniversity of BariBariItaly Unit of Urology Cittàdella Salute e della Scienza HospitalUniversity of TurinTurinItaly Urology Unit Buccheri La Ferla Fatebenefratelli HospitalPalermoItaly Department of Urology Humanitas Gradenigo HospitalTurinItaly Urology Unit Surgical DepartmentFondazione Poliambulanza Istituto OspedalieroBresciaItaly Departement of Urology “S.Giovanni Evangelista”HospitalTivoliItaly Humanitas Clinical and Research CentereIRCCS Department of UrologyRozzanoItaly Department of Biomedical Sciences Humanitas UniversityPieve EmanueleItaly Department of Biomedicine and prevention University of Rome“Tor Vergata”RomeItaly Department of Diagnostic Imaging and Interventional Radiology University of Rome“Tor Vergata”RomeItaly Department of Interventional Radiology Pesenti-Fenaroli Hospital-ASST Bergamo EstAlzano LombardoItaly Department of Urology University of SienaSienaItaly Swiss International prostate Center GenevaSwitzerland Clinique Générale Beaulieu GenevaSwitzerland Department of Urology University of CataniaItaly Department of Urology Puerta de Hierro-Majadahonda University HospitalMadridSpain Lyx Institute of Urology Universidad Francisco de VitoriaMadridSpain Department of medico-Surgical Sciences and Biotechnologies Sapienza University of RomeFaculty of Pharmacy and MedicineUrology Unit ICOTLatinaItaly Department of Urology European Institute of Oncology(IEO)IRCCSMilanItaly Department of Radiology D

Objective: To evaluate transperineal laser ablation (TpLA) with Echolaser® (Echolaser® TpLA, Elesta S.p.A., Calenzano, Italy) as a treatment for benign prostatic hyperplasia (BpH) and prostate cancer (pCa) using the Delphi consensus ***: Italian and international experts on BpH and pCa participated in a collaborative consensus project. During two rounds, they expressed their opinions on Echolaser® TpLA for the treatment of BpH and pCa answering online questionnaires on indications, methodology, and potential complications of this technology. Level of agreement or disagreement to reach consensus was set at 75%. If the consensus was not achieved, questions were modified after each round. A final round was performed during an online meeting, in which results were discussed and ***: Thirty-two out of forty invited experts participated and consensus was reached on all topics. Agreement was achieved on recommending Echolaser® TpLA as a treatment of BpH in patients with ample range of prostate volume, from mL (80%) to >80 mL (80%), comorbidities (100%), antiplatelet or anticoagulant treatment (96%), indwelling catheter (77%), and strong will of preserving ejaculatory function (100%). majority of respondents agreed that Echolaser® TpLA is a potential option for the treatment of localized pCa (78%) and recommended it for low-risk pCa (90%). During the final round, experts concluded that it can be used for intermediate-risk pCa and it should be proposed as an effective alternative to radical prostatectomy for patients with strong will of avoiding urinary incontinence and sexual dysfunction. Almost all participants agreed that the transperineal approach of this organ-sparing technique is safer than transrectal and transurethral approaches typical of other techniques (97% of agreement among experts). pre-procedural assessment, technical aspects, post-procedural catheterization, pharmacological therapy, and expected outcomes were discussed, leading t

关键词： Transperineal laser ablation prostatecancer Benignprostatic hyperplasia Delphi consensus

A Quantitative Comparison of physical Accuracy and Numerical Stability of Lattice Boltzmann Color Gradient and pseudopotential multicomponent models for microfluidic Applications

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Communications in Computational physics 2022年第7期32卷 450-489页

作者： Karun p.N.Datadien gianluca Di Staso Herman m.A.Wijshoff Federico Toschi Department of Applied physics Eindhoven University of Technology5612 AZ EindhovenNetherlands FLOW matters Consultancy B.V. 5612AEEindhovenThe Netherlands Department of mechanical Engineering Eindhoven University of Technology5612 AZ EindhovenNetherlands Canon production printing Netherlands B.V. 5914 HHVenloThe Netherlands Department of mathematics and Computer Science Eindhoven University of Technology5612 AZ EindhovenNetherlands Istituto per le Applicazioni del Calcolo Consiglio Nazionale delle Ricerche00185 RomeItaly

The performances of the Color-Gradient(CG)and the Shan-Chen(SC)multicomponent Lattice Boltzmann models are quantitatively compared side-by-side on multiple physical flow problems where breakup,coalescence and contraction of fluid ligaments are *** flow problems are relevant to microfluidic applications,jetting of microdroplets as seen in inkjet printing,as well as emulsion dynamics.A significantly wider range of parameters is shown to be accessible for CG in terms of density-ratio,viscosity-ratio and surface tension *** stability for a high density ratio O(1000)is required for simulating the drop formation process during inkjet printing which we show here to be achievable using the CG model but not using the SC *** results show that the CG model is a suitable choice for challenging simulations of droplet formation,due to a combination of both numerical stability and physical *** also present a novel approach to incorporate repulsion forces between interfaces for CG,with possible applications to the study of stabilized ***,we show that the CG model can produce similar results to a known multirange potentials extension of the SC model for modelling a disjoining pressure,opening up its use for the study of dense stabilized emulsions.

关键词： Lattice Boltzmann method multiphase flow multicomponent flow inkjet printing turbulent emulsion

Collagen-based biological glue after Appleby operation for advanced gastric cancer

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World Journal of Gastroenterology 2011年第35期17卷 4044-4047页

作者： gianluca Baiocchi Nazario portolani Federico Gheza Stefano m Giulini Department of medical and Surgical Sciences Surgical Clinic Brescia University25127 Brescia Italy

pancreatic fistula is a common complication of distal pancreatectomy; although various surgical procedures have been proposed, no clear advantage is evident for a single technique. We herein report the case of a 38-year-old patient affected by an advanced gastric carcinoma infiltrating the pancreas body, with exten- sive nodal metastases involving the celiac trunk, who underwent total gastrectomy with lymphadenectomy, distal pancreatectomy and resection en bloc of the celiac trunk (Appleby operation). At the end of the demolitive phase, the pancreatic stump and the aorta at the level of the celiac ligature were covered with a layer of Tachosil, a horse collagen sponge made with human coagulation factors (fibrinogen and thrombin). presenting this case, we wish to highlight the possible sealing effect of this product and hypothesize a role in preventing pancreatic fistula and postoperative lymphorrhagia from extensive nodal dissection.

关键词： Gastric cancer pancreatic fistula Vascular infiltration Biologic sealant