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Impact of low-intensity extracorporeal shockwave therapy on vascular parameters and sexual function in patients with arteriogenic erectile dysfunction

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Asian Journal of Andrology 2024年第4期26卷 344-348页

作者： matteo Rubino Anna Ricapito marco finati Ugo G falagario Pasquale Annese Vito mancini gian maria Busetto Luigi Cormio Giuseppe Carrieri carlo Bettocchi Andrology Unit Department of Urology and Renal TransplantationUniversity of FoggiaFoggia 71122Italy Department of molecular medicine and Surgery Karolinska InstitutetStockholm 17177Sweden Department of Urology Bonomo Teaching HospitalUniversity of FoggiaAndria 76123Italy.

Previous published studies have shown an improvement of penile hemodynamic parameters after low-intensity extracorporeal shockwave therapy(Li-ESWT).However,the clinical significance of these findings remains unclear,and definitive selection criteria for Li-ESWT based on preexisting comorbidities have yet to be *** was an observational study of 113 patients with ED,evaluated between January 2019 and December 2021 in Andrology Unit at the Department of Urology and Renal Transplantation,University of foggia(foggia,Italy).Penile dynamic Doppler was performed to evaluate vascular parameters and 5-item version of the International Index of Erectile Dysfunction(IIEf-5)questionnaire was administered to assess the severity of *** was repeated 1 month after *** with a peak systolic velocity(PSV)m s−1 were considered eligible for *** protocol consisted of 8 weekly sessions with 1500 strokes distributed in 5 different locations along the *** treatment,a significant mean(±standard deviation[s.d.])PSV increase of 5.0(±3.4)cm s−1 was recorded and 52/113(46.0%)patients reached a PSV>30 cm s−1 at posttherapeutic penile dynamic Doppler.A clinically significant IIEf-5 score improvement was observed in 7 patients,21 patients,and 2 patients with mild-to-moderate,moderate,and severe pretreatment ED,*** different outcomes were assessed based on smoking habits,previous pelvic surgery,or use of oral phosphodiesterase-5 inhibitor(PDE5i).On the other side,only 1(6.7%)in 15 patients with diabetes mellitus showed an IIEf-5 score improvement after *** treatment determined a significant increase in PSV and correlated IIEf-5 improvement in ED *** advantage seemed particularly evident for moderate ED and was not affected by smoking habits,previous pelvic surgery,and use of ***,diabetic patients did not benefit from the treatment.

关键词： arteriogenic erectile dysfunction International Index of Erectile function low-intensity extracorporeal shockwave therapy peak systolic velocity

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Antioxidant treatment for oligoasthenoteratozoospermia and varicocele:a DBPC trial to evaluate the impact of age and body mass index

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Asian Journal of Andrology 2024年第3期26卷 239-244页

作者： gian maria Busetto Bernarde f Rodrigues Ashraf Virmani Andrea Checchia Antonella Ninivaggi Anna Ricapito Giovanni Barbieri Piero fischetti Ugo G falagario Pasquale Annese Nicola d’Altilia Vito mancini matteo ferro felice Crocetto Angelo Porreca carlo Bettocchi Luigi Cormio Ashok Agarwal Giuseppe Carrieri University of foggia Foggia 71122Italy Department of Urology and Renal Transplantation Policlinico of FoggiaFoggia 71122Italy Department of Urology Human Reproduction SectionFederal University of Sao PauloSao Paulo 05403-000Brazil Alfasigma Healthscience Utrecht 3528 BGThe Netherlands Urology Unit “G.Tatarella”HospitalCerignola 71042Italy Urology Unit European Institute of Oncology(IEO)IRCCSMilan 20142Italy University of Naples federico II Naples80126Italy Department of Oncological Urology Veneto Institute of Oncology(IOV)IRCCSPadua 35039Italy Urology Unit “L.Bonomo”HospitalAndria 70031Italy Global Andrology forum Moreland HillsOH 44022USA

Oxidative stress is one of the main mechanisms responsible for male *** conditions such as varicocele,obesity,advanced age,and lifestyle can lead to an increase in reactive oxygen species,causing an oxidative imbalance in the *** are sensitive to reactive oxygen species and require energy to carry out their main function of fertilizingthe *** reactive oxygen species can affect sperm metabolism,leading to immobility,impaired acrosome reaction,and celldeath,thereby impairing reproductive *** double-blind randomized study evaluated the effect of supplementation withL-carnitine,acetyl-L-carnitine,vitamins,and other nutrients on semen quality in 104 infertile patients with or without varicocele,while also investigating the impact of factors such as obesity and advanced age on *** concentration significantlyincreased in the supplemented group compared to the placebo group(P=0.0186).Total sperm count also significantly increasedin the supplemented group(P=0.0117),as did sperm motility(P=0.0120).The treatment had a positive effect on patients upto 35 years of age in terms of sperm concentration(P=0.0352),while a body mass index(BmI)above 25 kg m^(−2) had a negativeeffect on sperm concentration(P=0.0110).Results were not showing a net benefit in stratifying patients in accordance withtheir BmI since sperm quality increase was not affected by this *** conclusion,antioxidant supplementation may bebeneficial for infertile patients and has a more positive effect on younger patients with a normal weight.

关键词： aging antioxidants body mass index oligoasthenoteratozoospermia varicocele

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Nutrient restriction-activated fra-2 promotes tumor progression via IGf1R in miR-15a downmodulated pancreatic ductal adenocarcinoma

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1132-1146页

作者： gian Luca Rampioni Vinciguerra marina Capece Luca Reggiani Bonetti Giovanni Nigita federica Calore Sydney Rentsch Paolo magistri Roberto Ballarin fabrizio Di Benedetto Rosario Distefano Roberto Cirombella Andrea Vecchione Barbara Belletti Gustavo Baldassarre francesca Lovat carlo m.Croce Department of Cancer Biology and Genetics and Comprehensive Cancer Center The Ohio State UniversityColumbus 43210 OHUSA Department of Clinical and molecular medicine Faculty of Medicine and PsychologySant’Andrea HospitalUniversity of Rome“Sapienza”Rome 00189Italy Department of Diagnostic Clinic and Public Health MedicineUniversity of Modena and Reggio EmiliaModena 41100Italy Hepato-pancreato-biliary Surgery and Liver Transplantation Unit University of Modena and Reggio EmiliaModena 41100Italy Division of molecular Oncology Centro di Riferimento Oncologico di Aviano(CRO)Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)National Cancer InstituteAviano 33081Italy

Pancreatic ductal adenocarcinoma(PDAC)is a lethal disease,characterized by an intense desmoplastic reaction that compresses blood vessels and limits nutrient *** aggressiveness largely relies on its extraordinary capability to thrive and progress in a challenging tumor *** of the onco-suppressor miR-15a has been extensively documented in ***,we identified the transcription factor fos-related antigen-2(fra-2)as a miR-15a target mediating the adaptive mechanism of PDAC to nutrient *** report that the IGf1 signaling pathway was enhanced in nutrient deprived PDAC cells and that fra-2 and IGf1R were significantly overexpressed in miR-15a downmodulated PDAC ***,we discovered that miR-15a repressed IGf1R expression via fra-2 *** miR-15a-low context,IGf1R hyperactivated mTOR,modulated the autophagic flux and sustained PDAC growth in nutrient *** a genetic mouse model,mir15aKO PDAC showed fra-2 and Igf1r upregulation and mTOR activation in response to diet ***,nutrient restriction improved the efficacy of IGf1R inhibition in a fra-2 dependent ***,our results point to a crucial role of fra-2 in the cellular stress response due to nutrient restriction typical of pancreatic cancer and support IGf1R as a promising and vulnerable target in miR-15a downmodulated PDAC.

关键词： IGf1R fra miR

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Poly(A)-specific RNase(PARN)generates and regulates miR-125a-5p 3’-isoforms,displaying an altered expression in breast cancer

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1805-1807页

作者： Luisa Tomasello Shoshanah m.Holub Giovanni Nigita Rosario Distefano carlo m.Croce Department of Cancer Biology and Genetics The Ohio State UniversityColumbusOHUSA Department of Internal medicine Division of HematologyThe Ohio State UniversityColumbusOHUSA

Dear Editor,microRNAs(miRNAs)are small non-coding RNAs crucial for post-transcriptional gene regulation,processed from primary miRNA transcripts by Drosha and Dicer.1 Latest advancements in Next Generation Sequencing highlighted the existence of miRNA isoforms(isomiRs)resulting from alternative processing,RNA editing,or post-transcriptional modifications.

关键词： breast cancer advancement

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minimally invasive surgical therapies(mISTs)for lower urinary tract symptoms(LUTS):promise or panacea?

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Asian Journal of Andrology 2024年第2期26卷 135-143页

作者： gian maria Busetto Andrea Checchia marco Recchia Edoardo Tocci Ugo G falagario Gennaro Annunziata Pasquale Annese Nicola d'Altilia Vito mancini matteo ferro felice Crocetto Octavian Sabin Tataru Luca Di gianfrancesco Angelo Porreca francesco Del Giudice Ettore De Berardinis carlo Bettocchi Luigi Cormio Giuseppe Carrieri University of foggia Foggia 71122Italy Department of Urology and Renal Transplantation Policlinico of FoggiaFoggia 71122Italy Urology Unit "G.Tatarlla"HospitalCerignola 71042Italy Urology Unit European Institute of Oncology(IE0)IRCcSMilan 20141Italy University of Naples federico Il Naples 80126Italy G.E.Palade University of medicine PharmacyScienceand Technology of Targu MuresTargu Mures 540142Romania Department of Oncological Urology Veneto Institute of Oncology(IOv)IRccSPadua 35128Italy Department of maternal-Infant and Urological Sciences Sapienza Rome UniversityRoma 00161Italy Urology Unit "L.Bonomo"HospitalAndria 76123Italy

The increasing importance of treatment of lower urinary tract symptoms(LUTS),while avoiding side effects and maintaining sexual function,has allowed for the development of minimally invasive surgical therapies(miSTs).Recently,the European Association of Urology guidelines reported a paradigm shift from the management of benign prostatic hyperplasia(BPH)to the management of nonneurogenic male *** aim of the present review was to evaluate the efficacy and safety of the most commonly used misTs:ablative techniques such as aquablation,prostatic artery embolization,water vapor energy,and transperineal prostate laser ablation,and nonablative techniques such as prostatic urethral lift and temporarily implanted nitinol device(iTIND).miSTs are becoming a new promise,even if clinical trials with longer follow-up are still *** of them are still under investigation and,to date,only a few options have been given as a recommendation for *** cannot be considered as standard of care and are not suitable for all *** and disadvantages should be underlined,without forgetting our objective:treatment of LUTS and re-treatment avoidance.

关键词： aquablation iTIND prostatic artery embolization prostatic urethral lift transperineal prostate laser ablation water vapor energy

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metal-Halide Perovskite Submicrometer-Thick films for Ultra-Stable Self-Powered Direct X-Ray Detectors

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Nano-micro Letters 2024年第9期16卷 410-431页

作者： marco Girolami fabio matteocci Sara Pettinato Valerio Serpente Eleonora Bolli Barbara Paci Amanda Generosi Stefano Salvatori Aldo Di carlo Daniele m.Trucchi CNR‑ISm Consiglio Nazionale delle RicercheIstituto di Struttura della MateriaSede Secondaria di MontelibrettiDiaTHEMA LabStrada Provinciale 35D900010 MontelibrettiRomeItaly CHOSE–Centre for Hybrid and Organic Solar Energy Department of Electronic EngineeringUniversity of Rome“Tor Vergata”Via del Politecnico 100133 RomeItaly faculty of Engineering Universita degli Studi Niccolo CusanoVia don Carlo Gnocchi 300166 RomeItaly SpecXLab CNR‑ISMConsiglio Nazionale Delle RicercheIstituto di Struttura Della MateriaArea della Ricerca di Tor VergataVia del Fosso del Cavaliere 10000133 RomeItaly

metal-halide perovskites are revolutionizing the world of X-ray detectors,due to the development of sensitive,fast,and cost-effective ***-powered operation,ensuring portability and low power consumption,has also been recently demonstrated in both bulk materials and thin ***,the signal stability and repeatability under continuous X-ray exposure has only been tested up to a few hours,often reporting degradation of the detection *** it is shown that self-powered direct X-ray detectors,fabricated starting from a fAPbBr_(3)submicrometer-thick film deposition onto a mesoporous TiO_(2)scaffold,can withstand a 26-day uninterrupted X-ray exposure with negligible signal loss,demonstrating ultra-high operational stability and excellent *** structural modification is observed after irradiation with a total ionizing dose of almost 200 Gy,revealing an unexpectedly high radiation hardness for a metal-halide perovskite thin *** addition,trap-assisted photoconductive gain enabled the device to achieve a record bulk sensitivity of 7.28 C Gy^(−1)cm^(−3)at 0 V,an unprecedented value in the field of thin-film-based photoconductors and photodiodes for“hard”***,prototypal validation under the X-ray beam produced by a medical linear accelerator for cancer treatment is also introduced.

关键词： metal-halide perovskite thin films Direct X-ray detectors Self-powered devices Operational stability medical linear accelerator

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Stubborn Hypoxia in Neonates with D-Transposition of the Great Arteries after Arterial Switch Operation: Central Sleep Apnea as the Cause and Potential Indicator of Brain Immaturity

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Congenital Heart Disease 2024年第2期19卷 185-195页

作者： Camden L.Hebson Kyle Bliton Amr Y.Hammouda Kaitlyn Barr W.Hampton Gray mohini Gunnett Waldemar f.carlo Department of Pediatrics Division of Pediatric CardiologyUniversity of Alabama BirminghamBirmingham35233USA Department of Pediatrics Division of Pediatric PulmonologyUniversity of Alabama BirminghamBirmingham35233USA Department of Pediatrics University of Alabama BirminghamBirmingham35233USA Department of Surgery Division of Cardiothoracic SurgeryUniversity of Alabama BirminghamBirmingham35233USA

D-transposition of the great arteries(d-TGA)is surgically repaired with the arterial switch operation(ASO)with excellent results,however short and long-term morbidities still develop including neurocognitive *** significant central sleep apnea is uncommon in non-premature infants,but when present indicates immature autonomic control of respiration likely due to a neurologic *** report the unanticipatedfinding of central sleep apnea in four-term neonates with d-TGA after uncomplicated ASO,with the short-term complication of delayed hospital discharge and long-term concerns regarding this early marker of brain immaturity and its hindrance to normal *** this report,we will review each patient’s clinical course and then examine the literature on pediatric central sleep apnea,neurodevelopmental outcomes after ASO,and the important overlap of these entities in the care of patients going forward.

关键词： Transposition congenital heart disease sleep apnea polysomnography

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Programming nonlinear propagation for efficient optical learning machines

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Advanced Photonics 2024年第1期6卷 73-83页

作者： Ilker Oguz Jih-Liang Hsieh Niyazi Ulas Dinc Ugur Tegin mustafa Yildirim carlo Gigli Christophe moser Demetri Psaltis École Polytechnique fédérale de Lausanne Institute of Electrical and Micro EngineeringEcublensSwitzerland Koc University Department of Electrical and Electronics EngineeringIstanbulTurkey

The ever-increasing demand for training and inferring with larger machine-learning models requires more efficient hardware solutions due to limitations such as power dissipation and *** is a promising contender for providing lower power computation,since light propagation through a nonabsorbing medium is a lossless ***,to carry out useful and efficient computations with light,generating and controlling nonlinearity optically is a necessity that is still *** fibers(mmfs)have been shown that they can provide nonlinear effects with microwatts of average power while maintaining parallelism and low *** propose an optical neural network architecture that performs nonlinear optical computation by controlling the propagation of ultrashort pulses in mmf by wavefront *** a surrogate model,optimal sets of parameters are found to program this optical computer for different tasks with minimal utilization of an electronic *** show a remarkable decrease of 97%in the number of model parameters,which leads to an overall 99%digital operation reduction compared to an equivalently performing digital neural *** further demonstrate that a fully optical implementation can also be performed with competitive accuracies.

关键词： neural networks nonlinear optics fiber optics surrogate optimization neuromorphic computing wavefront shaping

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The Correct Reissner-Nordstrøm, Kerr and Kerr-Newman metrics

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Journal of modern Physics 2024年第10期15卷 1502-1522页

作者： carlo maria Pace ICRANet Pescara Italy

In a very recent article of mine I have corrected the traditional derivation of the Schwarzschild metric thus arriving to formulate a correct Schwarzschild metric different from the traditional Schwarzschild metric. In this article, starting from this correct Schwarzschild metric, I also propose corrections to the other traditional Reissner-Nordstrøm, Kerr and Kerr-Newman metrics on the basis of the fact that these metrics should be equal to the correct Schwarzschild metric in the borderline case in which they reduce to the case described by this metric. In this way, we see that, like the correct Schwarzschild metric, also the correct Reissner-Nordstrøm, Kerr and Kerr-Newman metrics do not present any event horizon (and therefore do not present any black hole) unlike the traditional Reissner-Nordstrøm, Kerr and Kerr-Newman metrics.

关键词： General Theory of Relativity Schwarzschild Reissner-Nordstrøm Kerr Kerr-Newman metric Event Horizon Black Hole

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你的奖励由谁买单:信用卡市场的再分配

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新金融 2024年第1期 59-66页

作者： Sumit Agarwal Andrea Presbitero Andre f.Silva carlo Wix 新加坡国立大学国际货币基金组织经济政策研究中心美国联邦储备委员会

将信用卡奖励作为一个理想的实验进行研究,以量化零售金融市场中消费者之间的再分配。通过对有奖励和无奖励的信用卡进行比较,可以发现:无论收入如何,成熟的消费者都能从有奖励的信用卡中获利,而有的消费者则要付出代价。为了探究其背... 详细信息

将信用卡奖励作为一个理想的实验进行研究,以量化零售金融市场中消费者之间的再分配。通过对有奖励和无奖励的信用卡进行比较,可以发现:无论收入如何,成熟的消费者都能从有奖励的信用卡中获利,而有的消费者则要付出代价。为了探究其背后的机制,本文利用银行在信用卡层面主动提高账户限额的方法进行研究。结果表明:奖励卡会诱发更多的消费,使消费者有更高的未付余额;消费者在偿还信用卡时还会遵循次优平衡匹配启发模式,从而产生更高的成本;银行通过提供比无奖励的同类信用卡更低的利率来激励消费者使用奖励卡;从教育程度较低的地区到较高的地区,从较贫穷的地区到较富裕的地区,信用卡奖励以重新分配的方式扩大了现有的差距。本刊编译此篇美联储的工作论文,以期就信用卡相关问题为读者带来启发。

关键词：消费金融信用卡金融复杂性用卡奖励

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