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Heterotopic gastric mucosa in the anus and rectum:first case report of endoscopic submucosal dissection and systematic review

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Gastroenterology Report 2016年第3期4卷 196-205,I0001页

作者： Federico iacopini Takuji Gotoda Walter Elisei Patrizia Rigato Fabrizio Montagnese Yutaka Saito Guido Costamagna giampaolo iacopini Gastroenterology and Endoscopy Unit Ospedale S.GiuseppeAlbano L.RomeItaly Division of Gastroenterology and Hepatology Nihon University School of MedicineTokyoJapan Pathology Unit Ospedale S.GiuseppeMarinoItaly Endoscopy Division National Cancer Center HospitalTokyoJapan Digestive Endoscopy Unit Policlinico GemelliCatholic UniversityRomeItaly Gastroenterology Clinic RomeItaly

Background:Heterotopic gastric mucosa(HGM)is the most reported epithelial heterotopia,but it is very rare in the rectum and ***:The first case of an asymptomatic adult male with a large nonpolypoid HGM in the low rectum underwent complete resection by endoscopic submucosal dissection(ESD)is *** systematic review was based on a comprehensive search of MEDLINE,EMBASE and Google *** on humans were identified with the term‘heterotopic gastric mucosa in the rectum and/or anus.’Results:The search identified 79 citations,and 72 cases were evaluated comprising the present *** malformations were observed in 17(24%)patients;rectal duplication accounted for most of the *** HGM was located in the anus and perineal rectum in 25 cases(41%)and low,middle and proximal pelvic rectum in 20(33%),five(8%)and 11 cases(18%),*** was nonpolypoid in 37 cases(51%),polypoid in 26 cases(36%)and ulcerated in nine cases(13%).Specific anorectal symptoms were reported by 50(69%)patients of the whole study population,and by 33(97%)of 34 patients≤18 *** were observed in 23 cases(32%).The HGM was excised in 50 cases(83%).Endoscopic resection was performed in 17 cases(34%);resection was piecemeal in five of 12 lesions≥5mm,required argon plasma coagulation in two cases and was associated with residual tissue in two(17%).Intestinal metaplasia and an adenoma with lowgrade dysplasia were described in three adults(4%).Discussion:This systematic review shows that the HGM in the rectum and anus may be associated with specific rectal symptoms and serious complications,mainly in the pediatric population,and a risk of malignancy in *** complete excision should be recommended,and the ESD can overcome the technical limits of conventional endoscopic snare resection and avoid unnecessary surgery.

关键词： heterotopic gastric mucosa endoscopic submucosal dissection review rectum

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A Double Assessment of Privacy Risks Aboard Top‑Selling Cars

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Automotive Innovation 2023年第2期6卷 146-163页

作者： giampaolo Bella Pietro Biondi Giuseppe Tudisco Dipartimento di Matematica e Informatica Universitàdegli Studi di CataniaCataniaItaly Osservatorio Astrofisico di Catania Istituto Nazionale di AstrofisicaCataniaItaly

The advanced and personalised experience that modern cars offer makes them more and more *** example,the cabin preferences of the possible drivers must be recorded and associated to some identity,while such data could be exploited to deduce sensitive information about the driver’s ***,drivers’privacy must be taken seriously,requiring a dedicated risk assessment framework,as presented in this paper through a double assessment combining the asset-oriented ISO approach with the threat-oriented STRIDE *** framework is tailored to the level of specific car brand and demonstrated on the ten top-selling brands as well as,due to its innovative character,*** two approaches yield different,but complementary findings,demonstrating the additional insights gained through their parallel adoption.

关键词： Automotive Cyber physical systems Risk management ISO 27005 STRIDE

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A gate driver for parallel connected MOSFETs with crosstalk suppression

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iEnergy 2023年第3期2卷 240-250页

作者： Yury Mikhaylov giampaolo Buticchi Michael Galea Department of Electrical and Electronic Engineering University of Nottingham Ningbo ChinaNingbo 315100China Department of Electrical Engineering University of MaltaMalta

New semiconductor materials offer several advantages for modern power systems,including low switching and conduction losses,excellent thermal conduction of a die,and high operation *** is one of the main beneficiaries of the progress in power devices,as it enables more compact and lighter converters for future More Electrical ***,these advancements also come with new challenges that must be addressed to avoid potentially dangerous situations and fully utilize the capabilities of fast SiC *** such challenge is the high drain voltage rate during the switching process,which leads to a significant injection of current into the gate circuit(crosstalk effect).This increased current injection increases the risk of shoot-through conduction and thermal *** preventive measures are well-known,they offer limited protection in the case of parallel MOSFET ***,this paper considers crosstalk features for parallel MOSFET connections,such as parasitic inductance of gate driver trace and gate voltage distribution.A special model is proposed to predict the magnitude of induced gate voltage under different conditions considering the nonlinear behavior of the MOSFET reverse capacitance.A new clamp circuit with an individual low-inductance path for each parallel switch is also proposed to suppress the consequences of *** modified circuit operates independently from the main gate driver circuit;therefore,it does not change the switching time and electromagnetic interference pattern of the *** efficiency of the new gate driver is confirmed through simulation and experimental results.

关键词： Power electronics SiC MOSFET parallel connection gate driver parasitic effects

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Morbidity and psychological impact of prostate biopsy： the future calls for a change

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Asian Journal of Andrology 2014年第3期16卷 415-417页

作者： Andrea Minervini Gianni Vittori giampaolo Siena Marco Carini Department of Urology University of FlorenceCareggi Hospital Florence Italy.

Currently transrectal ultrasound-guided prostate biopsy （TRUS-Bx） is one of the most common urological procedures, with more than 1 million performed per year in Europe and the United States. Among patients undergoing TRUS-Bx, approximately one-third will receive a diagnosis of prostate cancer （PCa）, while two-thirds receive a negative result on initial biopsy. Negative biopsy patients maintain an estimated risk of repeated biopsy of 12% at I year and 38% at 5 years. 2 Standard TRUS-Bx is likely to systematically miss significant tumors, particularly in the anterior and apical parts of the gland.3 A crucial aim of urologists in the next decade is to increase the accuracy of the procedure and avoid the use of inappropriate biopsies.

关键词： Morbidity psychological impact prostate biopsy

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Embedded fuzzing:a review of challenges,tools,and solutions

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Cybersecurity 2022年第4期5卷 1-18页

作者： Max Eisele Marcello Maugeri Rachna Shriwas Christopher Huth giampaolo Bella Safety Security and PrivacyRobert Bosch GmbHRenningenGermany Dept.of Math and Computer Science Universita degli Studi di CataniaCataniaItaly RBEl Robert Bosch GmbHBangaloreIndia.

Fuzzing has become one of the best-established methods to uncover software ***,the market of embedded systems,which binds the software execution tightly to the very hardware architecture,has grown at a steady pace,and that pace is anticipated to become yet more sustained in the near *** systems also beneft from fuzzing,but the innumerable existing architectures and hardware peripherals complicate the development of general and usable approaches,hence a plethora of tools have recently *** comes a stringent need for a systematic review in the area of fuzzing approaches for embedded systems,which we term'embedded fuzzing"for *** inclusion criteria chosen in this article are semi-objective in their coverage of the most relevant publication venues as well as of our personal *** review rests on a formal definition we develop to represent the realm of embedded *** continues by discussing the approaches that satisfy the inclusion criteria,then defines the relevant elements of comparison and groups the approaches according to how the execution environment is served to the system under *** resulting review produces a table with 42 entries,which in turn supports discussion suggesting vast room for future research due to the limitations noted.

关键词： Embedded systems Dynamic analysis Vulnerability mining Embedded security Software security

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The “mitochondrial stress responses”: the “Dr. Jekyll and Mr. Hyde” of neuronal disorders

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Neural Regeneration Research 2022年第12期17卷 2563-2575页

作者： Simone Patergnani giampaolo Morciano Marianna Carinci Sara Leo Paolo Pinton Alessandro Rimessi Department of Medical Sciences Section of Experimental MedicineLaboratory for Technologies of Advanced TherapiesUniversity of FerraraFerraraItaly Center of Research for Innovative Therapies in Cystic Fibrosis University of FerraraFerraraItaly

Neuronal disorders are associated with a profound loss of mitochondrial functions caused by various stress conditions,such as oxidative and metabolic stress,protein folding or import defects,and mitochondrial DNA *** engage in different coordinated responses to safeguard mitochondrial *** this review,we will explore the contribution of mitochondrial stress responses that are activated by the organelle to perceive these dangerous conditions,keep them under control and rescue the physiological condition of nervous *** the sections to come,particular attention will be dedicated to analyzing how compensatory mitochondrial hyperfusion,mitophagy,mitochondrial unfolding protein response,and apoptosis impact human neuronal ***,we will discuss the relevance of the new concept:the“mito-inflammation”,a mitochondria-mediated inflammatory response that is recently found to cover a relevant role in the pathogenesis of diverse inflammatory-related diseases,including neuronal disorders.

关键词： Alzheimer’s disease apoptosis mitochondrial dynamics mito-inflammation mitophagy multiple sclerosis neurodegeneration Parkinson’s disease UPRmt

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Personalized surgical management of colorectal cancer in elderly population

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World Journal of Gastroenterology 2014年第14期20卷 3762-3777页

作者： giampaolo Ugolini Federico Ghignone Davide Zattoni Giacomo Veronese Isacco Montroni Department of Medical and Surgical Sciences University of BolognaPoliclinico S. OrsolaMalpighi

Colorectal cancer(CRC)in the elderly is extremely common but only a few clinicians are familiar with the complexity of issues which present in the geriatric *** this phase of the life cycle,treatment is frequently *** the fact that,nowadays,older people tend to be healthier than in previous generations,surgical undertreatment is frequently *** the other hand,surgical overtreatment in the vulnerable or frail patient can lead to unacceptable postoperative outcomes with high mortality or persistent ***,due to the geriatric patient being traditionally excluded from randomized controlled trials for a variety of factors(heterogeneity,frailty,etc.),there is a dearth of evidence-based clinical guidelines for the management of these *** objective of this review was to summarize the most relevant clinical studies available in order to assist clinicians in the management of CRC in the *** than in any other patient group,both surgical and non-surgical management strategies should be carefully individualized in the elderly population affected by *** cure and sphincter preservation are the primary goals,many other variables need to be taken into account,such as maintenance of cognitive status,independence,life expectancy and quality of life.

关键词： Elderly Colorectal cancer Surgery Personalized treatment Geriatric assessment

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B cell development is critically dependent on NFATc1 activity

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Cellular & Molecular Immunology 2019年第5期16卷 508-520页

作者： Sabrina giampaolo Gabriela Wojcik Stefan Klein-Hessling Edgar Serfling Amiya K.Patra Department of Molecular Pathology Institute of PathologyUniversity of WürzburgJosef Schneider-Str.297080 WürzburgGermany Institute of Translational and Stratified Medicine Faculty of Medicine and DentistryUniversity of PlymouthPlymouth PL68BUUK Comprehensive Cancer Center Mainfranken University of WürzburgJosef Schneider-Str.697080 WürzburgGermany

B cell development in bone marrow is a precisely regulated complex *** successive stages of differentiation,which are regulated by a multitude of signaling pathways and an array of lineage-specific transcription factors,the common lymphoid progenitors ultimately give rise to mature B *** to early thymocyte development in the thymus,early B cell development in bone marrow is critically dependent on IL-7 *** this IL-7-dependent stage of differentiation,several transcription factors,such as E2A,EBF1,and Pax5,among others,play indispensable roles in B lineage specification and *** recent studies have implicated several other transcription factors in B cell development,the role of NFATc1 in early B cell developmental stages is not ***,using multiple gene-manipulated mouse models and applying various experimental methods,we show that NFATc1 activity is vital for early B cell *** of NFATc1 activity in pro-B cells suppresses EBF1 expression,impairs immunoglobulin gene rearrangement,and thereby preBCR formation,resulting in defective B cell ***,deficiency in NFATc1 activity arrested the pro-B cell transition to the pre-B cell stage,leading to severe B cell *** findings suggest that,along with other transcription factors,NFATc1 is a critical component of the signaling mechanism that facilitates early B cell differentiation.

关键词： Differentiation EBF1 NFATc1 Pro-B Pre-B

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The reuse of abandoned Acquaresi mine voids for storage of the Masua flotation tailings

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International Journal of Coal Science & Technology 2014年第2期1卷 213-220页

作者： Pier Paolo Manca Paolo Desogus giampaolo Orru DICAAR Department of Civil EngineeringEnvironmental and ArchitectureUniversity of CagliariCagliariItaly

Often in abandoned mine sites are present both underground voids produced by mining and the tailings of treatment *** interesting solution for the rehabilitation of the sites would be to place the tailings of the process in the underground mining voids,thus obtaining the reclamation of surface areas and the stabilization of abandoned voids to prevent the dangerous phenomena of ***,these operations require inert waste,which must not be source of pollution,and the choice of a water/solid optimum to ensure good conditions of pumpability.

关键词： Acquaresi mine Mine voids Masua Flotation tailings

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Exocrine pancreatic function assessed by secretin cholangio-Wirsung magnetic resonance imaging

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Hepatobiliary & Pancreatic Diseases International 2008年第2期7卷 192-195页

作者： Lucia Calculli Raffaele Pezzilli Marta Fiscaletti Riccardo Casadei Carla Brindisi giampaolo Gavelli Departments of Radiology Digestive Diseases and Internal Medicineand General SurgerySant'Orsola-Malpighi Hospital Bologna Italy

BACKGROUND:Magnetic resonance cholangiopancreato-graphy (MRCP) is useful to assess exocrine pancreatic function by combining rapid imaging acquisition with the administration of secretin, a gastrointestinal hormone that stimulates the secretion of bile and pancreatic juice. However, extensive data on this method are lacking. This study aimed to determine whether MRCP with secretin administration is able to simultaneously detect alterations of both the pancreatic ducts and exocrine pancreatic function. METHODS:All subjects older than 18 years who underwent magnetic resonance imaging (MRI) and cholangio-Wirsung magnetic resonance imaging (CWMRI) for suspicion of benign or malignant pancreatic diseases from January 2006 to December 2006 were enrolled in the study. MRI and CWMRI were carried out using a dedicated apparatus. RESULTS:Eighty-seven patients (46 males, 41 females, mean age 59.7±14.6, range 27-87 years) were enrolled. Of the 87 patients, 39 had a normal pancreas on imaging, 20 had an intrapapillary mucinous tumor (IPMT), and the rest had chronic pancreatitis (7), serous cystadenoma (6), a previous attack of acute biliary pancreatitis (5), congenital ductal abnormalities (5), mucinous cystadenoma (3), previous pancreatic head resection for autoimmune pancreatitis (1), or cholangiocarcinoma (1). Morphologically, we found two pseudocysts (one of the 7 patients with chronic pancreatitis, and one of the 5 patients after an attack of acute pancreatitis;the latter pseudocyst communicated with the main pancreatic duct). Calcifications were found in 3 of the 7 patients with chronic pancreatitis. All patients with IPMT and mucinous cystadenoma and 3 patients with serous cystadenoma were histologically confirmed. The remaining patients were followed up adequately to confirm the diagnosis by imaging. According to the Matos criteria, 73 patients (83.9%) were of grade 3, 8 grade 2, 4 grade 1, and 2 grade 0. The only pancreatic diseases which impaired the exocrine pancreati

关键词： chronic pancreatitis magnetic resonance cholangiopancreatography pancreatic neoplasms pancreatic insufficiency

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