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Subacute electroacupuncture at Baihui (GV 20) and Dazhui (GV 14) promotes post-stroke functional recovery via neurogenesis and astrogliosis in a photothrombotic stroke mouse model

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Journal of Traditional Chinese Medicine 2019年第6期39卷 833-841页

作者： Young-Wook Park gi yoon heo Min Jae Kim Seo-Yeon Lee Byung Tae Choi Hwa Kyoung Shin Division of Meridian and Structural Medicine School of Korean MedicinePusan National UniversityYangsanGyeongnam 50612Republic of Korea Department of Korean Medical Science School of Korean MedicinePusan National UniversityYangsanGyeongnam 50612Republic of Korea Graduate Training Program of Korean Medicine for Healthy-Aging Pusan National UniversityYangsanGyeongnam 50612Republic of Korea Korean Medical Science Research Center for Healthy-Aging Pusan National UniversityYangsanGyeongnam 50612Republic of Korea

OBJECTIVE:To investigate the optimal timing and underlying mechanism of electroacupuncture(EA)at Baihui(GV 20)and Dazhui(GV 14)for improved long-term functional recovery after focal cerebral ischemia in a photothrombotic stroke mouse ***:Totally 50 adult male C57 BL/6 J mice were assigned into 5 groups:(a)the control group,sham-operated mice(n=10);(b)the vehicle group,focal cerebral ischemia induction without EA(n=10);(c)the acute EA group,mice received EA immediately post-ischemia,followed by once-daily treatments for 7 consecutive days(n=10);(d)the subacute EA group,mice received EA 4 days post-ischemia,followed by once-daily treatments for 7 consecutive days(n=10);(e)the delayed EA *** stimulation(2 Hz,2 V for 20 min)was applied to acupuncture points(acupoints),Baihui(GV 20)and Dazhui(GV 14),once a day for 7 consecutive days beginning immediately(acute treatment),4 d(subacute treatment)and 10 d(delayed treatment)after focal cerebral ischemia in C57 BL/6 J *** assessments were conducted 21 and 28 d post-ischemia and histopathological analyses were performed 28 days ***:The subacute EA treatment at Baihui(GV20)and Dazhui(GV 14)significantly improved functional recovery compared to the vehicle group 28 d after ischemic brain injury,although brain atrophy was not *** number of Neu N+and Neu N+/Brd U+cells as well as GFAP intensity in the ipsilateral cortex were significantly increased in the subacute group compared to the vehicle group 28 d *** concluded that EA stimulation 4 d post-ischemia(subacute treatment)enhanced neurogenesis and astrogliosis,likely contributing to long-term functional recovery following focal cerebral ***:Our findings suggest that the timing of the EA therapy at Baihui(GV 20)and Dazhui(GV 14)determines the therapeutic effects in mice with focal cerebral ischemia induced by photothrombotic occlusion.

关键词： Electroacupuncture Stroke Astrocytes Neurogenesis Post-stroke remodeling

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基于双能CT深度学习预测取栓术后的脑出血转化

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国际医学放射学杂志 2024年第4期 502-502页

作者： J.heo Y.yoon H.J.Han J.J.Kim K.Y.Park B.M.Kim 常嫣格

摘要目的利用双能CT开发和验证一个深度学习模型，预测血管内取栓术后的脑出血转化。方法该项基于急性缺血性卒中前瞻性登记的回顾性研究，纳入2019年5月—

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Recent trends in molecular aggregates:An exploration of biomedicine

Aggregate

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Aggregate 2022年第2期3卷 72-106页

作者： Jeongyun heo Dhiraj P.Murale Hey Young yoon V.Arun Sangkee Choi Eunha Kim Jun-Seok Lee Sehoon Kim Center for Theragnosis Korea Institute of Science and Technology(KIST)Seoul 02792South Korea Molecular Recognition Research Center Korea Institute of Science and Technology(KIST)Seoul 02792South Korea Department of Pharmacology Korea University College of MedicineSeoul 02841South Korea Department of Molecular Science and Technology Ajou UniversitySuwon 16499South Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea

Molecular aggregates are receiving tremendous attention,demonstrating immense potential for biomedical applications in vitro and in *** instance,the molecular aggregates of conventional fluorophores influence the electronic excitation states of the aggregates,causing characteristic photophysical property changes.A fundamental understanding of this classical relationship between molecular aggregate structures and photophysics has allowed for innovative biological *** chemical characteristics of drug molecules generally trigger the formation of colloidal aggregates,and this is considered detrimental to the drug discovery ***,nano-sized supramolecular aggregates have been used in biomedical imaging and therapy owing to their optimal properties for in vivo utility,including enhanced cell permeability,passive tumor targeting,and convenient surface ***,we provide an overview of the recent trends in molecular aggregates for biomedical *** changes in photophysical properties of conventional fluorophores and their biological applications are discussed,followed by the effects of conventional drug molecule-aggregates on drug discovery and therapeutics *** trends in the investigation of biologically important analytes with aggregation-induced emission are discussed for conventional and unconventional ***,we discuss nano-sized supramolecular aggregates used in imaging and therapeutic purposes,with a focus on in vivo utilization.

关键词： aggregation-induced emission molecular aggregate nanomedicine

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Effective shape-controlled growth of monolayer MoS2 flakes by powder-based chemical vapor deposition

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Nano Research 2017年第1期10卷 255-262页

作者： Sang yoon Yang gi Woong Shim Seung-Bum Seo Sung-Yool Choi Graphene Research Center (GRC) Center for Advanced Materials Discovery for 3D Displays (CAMD3) School of Electrical EngineeringKorea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea

In the recent years, transition-metal dichalcogenides such as MoS2 have attracted considerable attention owing to their unique structure and electronic properties. Chemical vapor deposition （CVD） is a popular method for producing MoS2 flakes with different shapes. Here, we report an effective method for achieving a broad range of shape evolution in CVD-grown monolayer MoS2 flakes. By controlling the S and MoO3 temperatures, the shape of the monolayer MoS2 flakes was varied from hexagonal to triangular via intermediate shapes such as truncated and multi-apex triangles. The shape evolution of the MoS2 flakes can be explained by introducing the term “nominal Mo：S ratio”, which refers to the amount of loaded MoO3 and evaporated S powders. By using the nominal Mo：S ratio, we predicted the potential reaction atmosphere and effectively controlled the actual proportion of MoO3-x with respect to S in the growth region, along with the growth temperature. From the systematic investigation of the behavior of the shape evolution, we developed a shape-evolution diagram, which can be used as a practical guide for producing CVD-grown MoS2 flakes with desired shapes

关键词： molybdenum disulfide CVD growth shape evolution diagram growth condition

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Development of a variable rate applicator for uniform fertilizer spreading

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International Journal of Agricultural and Biological Engineering 2019年第2期12卷 82-89页

作者： Cheol-woo Han Sang-yoon Lee Young-ki Hong gi-young Kweon Department of Bio-Industrial Machinery Engineering(Institute of Agriculture and Life Science) Gyeongsang National UniversityJinju 52828Korea Department of Agriculture Engineering National Academy of Agricultural ScienceRDAJeonju 54875Korea

Environmental impact and economic concerns have driven a variable rate technology(VRT).Spinner spreaders were mainly used for granular fertilizer application since they are simple in design,inexpensive,and can cover large ***,the spreader was not adequate for VRT because uniformity changes drastically while varying application ***,the purpose of this study was to develop a variable rate applicator with uniform spreading patterns.A commercial spreader was modified with a controller and electric actuators for controlling fertilizer discharge directions and *** was established to determine the optimum discharge direction according to the fertilizer application *** uniformity of spreading patterns in accordance with the spread amount per set unit area was evaluated by the statistical coefficient of variation(CV)lower than 15%is assumed to prevent damage to the *** results showed that CVs were 8%,9%,and 8%,respectively,for a tractor in race track mode(adjacent passes in same direction of travel)at 200 kg/hm^(2),300 kg/hm^(2),and 400 kg/hm^(2).This indicates that the fertilizer was spread uniformly,while the coefficient of variation was 12%at 200 kg/hm^(2) in back and forth mode(adjacent passes in the opposite direction of travel).Overall,the results suggest that the race track mode is suitable for operation of a tractor to ensure uniform spreading of fertilizer when applying at variable *** future goal is to establish a system for automatic variable rate application according to location in connection with soil analysis and geographic information systems.

关键词： variable rate technology fertilizer application uniform spreading spinner granular applicator fertilizer amount control

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Review of MXenes as new nanomaterials for energy storage/delivery and selected environmental applications

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Nano Research 2019年第3期12卷 471-487页

作者： Byung-Moon Jun Sewoon Kim Jiyong heo Chang Min Park Namguk Her Min Jang Yi Huang Jonghun Han Yeomin yoon Department of Civil and Environmental Engineering University of South Carolina Columbia 300 Main Street SC 29208 USA Department of Civil and Environmerttal Engineering Korea Army Academy at Young-Cheon 495 Hogook-ro Kokyungmeon Young-Cheon Gyeongbuk 38900 Republic of Korea Department of Environmental Engineering Kyungpook National University 80 Daehak-ro Buk-gu Daegu 41566 Republic of Korea Department of Environmental Engineering Kwangwoon University 447-1 Wolgye-Dong Nowon-Gu Seoul 01897 Republic of Korea School of Engineering Institute for Materials & Processes (IMP) The University of Edinburgh Colin Maclaurin Road Edinburgh EH9 3DW Scotland UK

Energy and environmental issues presently attract a great deal of scientific attention. Recently, two-dimensional MXenes and MXene-based nanomaterials have attracted increasing interest because of their unique properties (e.g., remarkable safety, a very large interlayer spacing, environmental flexibility, a large surface area, and thermal conductivity). In 2011, multilayered MXenes (Ti3C2Tx, a new family of two-dimensional (2D) materials) produced by etching an A layer from a MAX phase of Ti3AlC2, were first described by researchers at Drexel University. The term “MXene” was coined to distinguish this new family of 2D materials from graphene, and applies to both the original MAX phases and MXenes fabricated from them. We present a comprehensive review of recent studies on energy and environmental applications of MXene and MXene-based nanomaterials, including energy conversion and storage, adsorption, membrane, photocatalysis, and antimicrobial. Future research needs are discussed briefly with current challenges that must be overcome before we completely understand the extraordinary properties of MXene and MXene-based nanomaterials.

关键词： MXenes MXene-based nanomaterials energy storage environment applications

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All-Optical WDM Buffer System Realized by NOLM and Feedback Loop Structure

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光学学报 2003年第S1期23卷 765-766页

作者： Seungwoo Yi Kyeong-Mo yoon Yong-gi Lee Jinseob Eom Dept. of Electronic Engineering Kangwon National Univ. Chuncheon 200-701 KoreaKT Technology Laboratory Daejeon 305-811 KoreaKT Technology Laboratory Daejeon 305-811 KoreaDept. of Electronic Engineering Kangwon National Univ. Chuncheon 200-701 Korea

We propose an all-optical WDM buffer for optical packet switching system, which consists of NOLM and feedback loop. The proposed structure provides more than 40 turn buffering and nice output of buffered data when sel... 详细信息

关键词： WDM All-Optical WDM Buffer System Realized by NOLM and Feedback Loop Structure EDFA SOA into by NOLM than

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Continuum understanding of twin formation near grain boundaries of FCC metals with low stacking fault energy

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npj Computational Materials 2017年第1期3卷 275-283页

作者： Jaimyun Jung Jae Ik yoon Jung gi Kim Marat I.Latypov Jin You Kim Hyoung Seop Kim Department of Materials Science and Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea GT-CNRS UMI 2958 Georgia TechLorraine 57070 MetzFrance Pohang Research Laboratory Steel Products Research Group 1POSCOPohang 790-785Republic of Korea Center for High Entropy Alloys Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea

Deformation twinning from grain boundaries is often observed in face-centered cubic metals with low stacking fault *** of the possible factors that contribute to twinning origination from grain boundaries is the intergranular interactions during ***,the influence of mechanical interaction among grains on twin evolution has not been fully *** spite of extensive experimental and modeling efforts on correlating microstructural features with their twinning behavior,a clear relation among the large aggregate of grains is still *** this work,we characterize the micromechanics of grain-to-grain interactions that contribute to twin evolution by investigating the mechanical twins near grain boundaries using a full-field crystal plasticity simulation of a twinning-induced plasticity steel deformed in uniaxial tension at room *** are first observed through electron backscatter diffraction technique to obtain data to reconstruct a statistically equivalent microstructure through synthetic microstructure ***-to-grain micromechanical response is analyzed to assess the collective twinning behavior of the microstructural volume element under tensile *** of the simulated results reveal that grain interactions are capable of changing the local mechanical behavior near grain boundaries by transferring strain across grain boundary or localizing strain near grain boundary.

关键词： grain microstructure steel

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FogQSYM: An Industry 4.0 Analytical Model for Fog Applications

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Computers, Materials & Continua 2021年第12期69卷 3163-3178页

作者： M.Iyapparaja M.Sathish Kumar SSiva Rama Krishnan Chiranji Lal Chowdhary Byungun yoon Saurabh Singh gi Hwan Cho School of Information Technology and Engineering Vellore Institute of TechnologyVellore632014India Department of Industrial and System Engineering Dongguk UniversitySeoulKorea Division of Computer Science Jeonbuk National UniversityJeonjuKorea

Industry 4.0 refers to the fourth evolution of technology development,which strives to connect people to various industries in terms of achieving their expected outcomes ***,resource management in an Industry 4.0 network is very complex and *** manage and provide suitable resources to each service,we propose a FogQSYM(Fog—Queuing system)model;it is an analytical model for Fog Applications that helps divide the application into several layers,then enables the sharing of the resources in an effective way according to the availability of memory,bandwidth,and network *** follows theMarkovian queuing model that helps identify the service rates of the devices,the availability of the system,and the number of jobs in the Industry 4.0 systems,which helps applications process data with a reasonable response *** experiment is conducted using a Cloud Analyst simulator with multiple segments of datacenters in a fog application,which shows that the model helps efficiently provide the arrival resources to the appropriate services with a low response *** implementing the proposed model with different sizes of fog services in Industry 4.0 applications,FogQSYM provides a lower response time than the existing optimized response time *** should also be noted that the average response time increases when the arrival rate increases.

关键词： Fog computing industry 4.0 fog layer Markovian queuing model

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Interplay between ABA and GA Modulates the Timing of Asymmetric Cell Divisions in the Arabidopsis Root Ground Tissue

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Molecular Plant 2016年第6期9卷 870-884页

作者： Shin Ae Lee Sejeong Jang Eun Kyung yoon Jung-Ok heo Kwang Suk Chang Ji Won Choi Souvik Dhar Gyuree Kim Jeong-Eun Choe Jae Bok heo Chian Kwon Jae-Heung Ko Yong-Sic Hwang Jun Lim Department of Systems Biotechnology Konkuk University Seour 05029 Korea Department of Molecular Biotechnology Dong-A University Busan 49201 Korea Department of Molecular Biology Dankook University Yongin 16890 Korea Department of Plant and Environmental New Resources Kyung Hee University Yongin 17104 Korea These authors contributed equally to this article. Present address: The Sainsbury Laboratory University of Cambridge Cambridge CB2 1LR United Kingdom Present address: Department of Life Science Research Institute for Natural Sciences Hanyang University Seoul 04763 Korea

In multicellular organisms, controlling the timing and extent of asymmetric cell divisions （ACDs） is crucial for correct patterning. During post-embryonic root development in Arabidopsis thaliana, ground tissue （GT） maturation involves an additional ACD of the endodermis, which generates two different tissues： the endo- dermis （inner） and the middle cortex （outer）. It has been reported that the abscisic acid （ABA） and gibberellin （GA） pathways are involved in middle cortex （MC） formation. However, the molecular mechanisms under- lying the interaction between ABA and GA during GT maturation remain largely unknown. Through transcriptome analyses, we identified a previously uncharacterized C2H2-type zinc finger gene, whose expression is regulated by GA and ABA, thus named GAZ （GA- AND ABA-RESPONSIVE ZINC FINGER）. Seedlings ectopically overexpressing GAZ （GAZ-OX） were sensitive to ABA and GA during MC formation, whereas GAZ-SRDX and RNAi seedlings displayed opposite phenotypes. In addition, our results indicated that GAZ was involved in the transcriptional regulation of ABA and GA homeostasis. In agreement with pre- vious studies that ABA and GA coordinate to control the timing of MC formation, we also confirmed the unique interplay between ABA and GA and identified factors and regulatory networks bridging the two hor- mone pathways during GT maturation of the Arabidopsis root.

关键词： ABA GA GRAS ground tissue root development transcription factor

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