Recent trends in molecular aggregates:An exploration of biomedicine

作     者：Jeongyun Heo Dhiraj P.Murale Hey Young Yoon V.Arun Sangkee Choi Eunha Kim Jun-Seok Lee Sehoon Kim 

作者机构：Center for TheragnosisKorea Institute of Science and Technology(KIST)Seoul 02792South Korea Molecular Recognition Research CenterKorea Institute of Science and Technology(KIST)Seoul 02792South Korea Department of PharmacologyKorea University College of MedicineSeoul 02841South Korea Department of Molecular Science and TechnologyAjou UniversitySuwon 16499South Korea KU-KIST Graduate School of Converging Science and TechnologyKorea UniversitySeoul 02841Republic of Korea 

出 版 物：《Aggregate》 (聚集体（英文）)

年 卷 期：2022年第3卷第2期

页      面：72-106页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Korea Institute of Science and Technology,Grant/Award Number:2E31093 Korea University,Grant/Award Number:K2110571 National Research Foundation of Korea,Grant/Award Numbers:2017M3A9D8029942,2018M3A9H4079286,2019M3D1A1078941,2019R1A6A1A11051471,2020R1A2C2004422,2020R1C1C1010044,2021R1A2C2005418 

主　　题：aggregation-induced emission molecular aggregate nanomedicine 

摘      要：Molecular aggregates are receiving tremendous attention,demonstrating immense potential for biomedical applications in vitro and in *** instance,the molecular aggregates of conventional fluorophores influence the electronic excitation states of the aggregates,causing characteristic photophysical property changes.A fundamental understanding of this classical relationship between molecular aggregate structures and photophysics has allowed for innovative biological *** chemical characteristics of drug molecules generally trigger the formation of colloidal aggregates,and this is considered detrimental to the drug discovery ***,nano-sized supramolecular aggregates have been used in biomedical imaging and therapy owing to their optimal properties for in vivo utility,including enhanced cell permeability,passive tumor targeting,and convenient surface ***,we provide an overview of the recent trends in molecular aggregates for biomedical *** changes in photophysical properties of conventional fluorophores and their biological applications are discussed,followed by the effects of conventional drug molecule-aggregates on drug discovery and therapeutics *** trends in the investigation of biologically important analytes with aggregation-induced emission are discussed for conventional and unconventional ***,we discuss nano-sized supramolecular aggregates used in imaging and therapeutic purposes,with a focus on in vivo utilization.