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A new hemostatic clip for endoscopic surgery that can maintain blood flow after clipping

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World Journal of Gastroenterology 2014年第5期20卷 1325-1331页

作者： Kyoung Won Nam Sang bong Lee In Young Kim Kwang gi Kim Sang Jae Park Department of Biomedical Engineering Hanyang University Biomedical Engineering Branch National Cancer Center Center for Liver Cancer National Cancer Center

AIM: To develop a new hemostatic device for endoscopic surgery that can control the bleeding without completely occluding the bleeding vessel.

关键词： Vessel bleeding Hemostasis Hemostatic clip Laparoscopic surgery Endoscopic surgery

Indolocarbazole-Based Small Molecule Cathode-Active Material Exhibiting Double Redox for High-Voltage Li-Organic Batteries

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Energy & Environmental Materials 2024年第5期7卷 86-94页

作者： Hyunji Park Hyojin Kye Jong-Sung Lee Young-Chang Joo Dong Joo Min bong-gi Kim Soo Young Park Ji Eon Kwon Laboratory for Supramolecular Optoelectronic Materials(LSOM) Department of Materials Science and EngineeringResearch Institute of Advanced Materials(RIAM)Seoul National University1 Gwanak-roGwanak-guSeoul 08826Korea Functional Composite Materials Research Center Jeonbuk Institute of Advanced Composite MaterialsKorea Institute of Science and Technology(KIST)92 Chudong-roBongdong-eupWanju-gunJeonbuk 55324Korea Department of Organic and Nano System Engineering Konkuk University120 Neungdong-roGwangjin-guSeoul 05029Korea Department of Materials Science and Engineering Seoul National University1 Gwanak-roGwanak-guSeoul 08826Korea Department of JBNU-KIST Industry Academia Convergence Research Jeonbuk National University567 Baekje-daeroDeokjin-guJeonjuJeonbuk 54896Korea

Most organic electrode materials(OEMs)for rechargeable batteries employ n-type redox centers,whose redox potentials are intrinsically limited<3.0 V versus Li^(+)/***,p-type materials possessing high redox potentials experience low specific capacities because they are capable of only a single redox reaction within the stable electrochemical window of typical ***,we report 5,11-diethyl-5,11-dihydroindolo[3,2-b]carbazole(DEICZ)as a novel p-type OEM,exhibiting stable plateaus at high discharge potentials of 3.44 and 4.09 V versus Li^(+)/***,the second redox potential of DEICZ is within the stable electrochemical *** mechanism of the double redox reaction is investigated using both theoretical calculations and experimental measurements,including density functional theory calculations,ex situ electron spin resonance,and X-ray photoelectron ***,hybridization with single-walled carbon nanotubes(SWCNT)improves the cycle stability and rate performance of DEICZ owing to theπ-πinteractions between the SWCNT and co-planar molecular structure of DEICZ,preventing the dissolution of active materials into the *** DEICZ/SWCNT composite electrode maintains 70.4%of its initial specific capacity at 1-C rate and also exhibits high-rate capability,even performing well at 100-C ***,we demonstrate its potential for flexible batteries after applying 1000 bending stresses to the composite electrode.

关键词： composite electrodes flexible batteries indolocarbazoles organic rechargeable batteries p-type

Microstructures and mechanical behavior of the bimetallic additively-manufactured structure(BAMS)of austenitic stainless steel and Inconel 625

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Journal of Materials Science & Technology 2021年第15期74卷 176-188页

作者： Md.R.U.Ahsan Xuesong Fan gi-Jeong Seo Changwook Ji Mark Noakes Andrzej Nycz Peter KLiaw Duck bong Kim Department of Mechanical Engineering Tennessee Technological UniversityCookevilleTN38505United States Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN37996United States Department of Manufacturing and Engineering Technology Tennessee Technological UniversityCookevilleTN38505United States Advanced Forming Process R&D Group Korea Institute of Industrial TechnologyUlsan 44413South Korea Oak Ridge National Laboratory Oak RidgeTN37830United States

Bimetallic additively manufactured structures(BAMSs)can replace traditionally-fabricated functionallygraded-components through fusion welding processes and can eliminate locally-deteriorated mechanical properties arising from *** present work fabricates a BAMS by sequentially depositing the austenitic stainless-steel and Inconel625 using a gas-metal-arc-welding(GMAW)-based wire+arc additive manufacturing(WAAM)*** mapping shows a smooth compositional transition at the interface without any *** materials being the face-center-cubic(FCC)austenite,the electron backscattered diffraction(EBSD)analysis of the interface shows the smooth and cross-interfacecrystallographic growth of long-elongated grains in the*** hardness values were within the range of 220-240 HV for both materials without a large deviation at the *** to the controlled thermal history,mechanical testing yielded a consistent result with the ultimate tensile strength and elongation of 600 MPa and 40%,respectively,with the failure location on the stainless-steel *** study demonstrates that WAAM has the potential to fabricate BAMS with controlled properties.

关键词： WAAM Additive manufacturing BAMS Functionally-graded structures Microstructures Mechanical properties

Synthesis and Gas Sensing of TiO_2 Ultrafine Powders by Precipitating

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稀有金属材料与工程 2006年第A3期35卷 163-164页

作者： Min-Hyun Seo bong-Ho Lee Jong-Won Kim gi-Hong Rue Duk-Dong Lee Jeung-Soo Huh Department of Sensor and Display Engineering Kyungpook National UniversitySangyuk-DongBukguDaegu 1370Korea Department of Materials Science and Metallurgy Kyungpook National UniversitySangyuk-DongBukguDaegu 1370Korea Department of Nano-science and Technology Kyungpook National UniversitySangyuk-DongBukguDaegu 1370Korea School of Electronic Engineering Kyungpook National UniversitySangyuk-DongBukguDaegu 1370Korea Department of Sensor and Display Engineering Kyungpook National UniversitySangyuk-DongBukguDaegu 1370Korea.Department of Nano-science and TechnologyKyungpook National UniversitySangyuk-DongBukguDaegu 1370Korea

We investigated the gas sensing characteristics of rutile and anatase TiO_2 nano-particle sensors for chemical warfare ***_2 nano-powders with rutile and anatase structure were fabricated by controlling pH value without heat treatment *** mean particle size of TiO_2 powders were below 10 ***-prepared TiO_2 powders have several advantages of nano particle size and high surface area and could be a prominent candidate for ***_2 sensors were examined with DMMP for chemical warfare agents detection.

关键词： TiO2 chemical warfare agents sensor nano-sensor pH

Proton pump inhibitors as a risk factor for recurrence of Clostridium-difficile-associated diarrhea

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World Journal of Gastroenterology 2010年第28期16卷 3573-3577页

作者： Ji Won Kim Kook Lae Lee Ji bong Jeong Byeong Gwan Kim Sue Shin Joo Sung Kim Hyun chae Jung In Sung Song Division of Gastroenterology and Hepatology Department of Internal MedicineSeoul National University Boramae Hospital Seoul National University College of Medicine Seoul 156-707South Korea Department of Laboratory Medicine Seoul National University Boramae Hospital Division of Gastroenterology and Hepatology Department of Internal MedicineSeoul National University Hospital Seoul National University College of Medicine Seoul 110-744South Korea

AIM:To investigate the risk factors for Clostridiumdifficile-associated diarrhea(CDAD)recurrence,and its relationship with proton pump inhibitors(PPIs). METHODS:Retrospective data of 125 consecutive hospitalized patients diagnosed with CDAD between January 2006 and December 2007 were collected by medical chart *** data included patient characteristics at baseline,underlying medical disease, antibiotic history before receiving a diagnosis of CDAD, duration of hospital stay,severity of CDAD,concurrenttreatment with PPIs,laboratory parameters,response to CDAD therapy,and recurrence of disease within 90 d of successful *** clinical and laboratory parameters were compared in patients in whom CDAD did or did not recur. RESULTS:Of the 125 patients(mean age,67.6± 13.9 years)that developed CDAD,98(78.4%)did not experience recurrence(non-recurrent group)and 27 (21.6%)experienced one or more recurrences(recurrent group).Prior to the development of CDAD,96% of the 125 patients were prescribed antibiotics,and 56(44.8%)of the patients received *** older than 65 years(P=0.021),feeding via nasogastric tube(NGT)(P=0.045),low serum albumin level(P =0.025),and concurrent use of PPIs(P=0.014) were found to be risk factors for CDAD recurrence by univariate ***,sex,length of hospital stay,duration and type of antibiotics used,severity of disease,leukocyte count and C-reactive protein(CRP) were not associated with risk of CDAD *** multivariate analysis,the important risk factors were advanced age(>65 years,adjusted OR:1.32,95% CI:1.12-3.87,P=0.031),low serum albumin level(< 2.5 g/dL,adjusted OR:1.85,95%CI:1.35-4.91,P= 0.028),and concurrent use of PPIs(adjusted OR:3.48, 95%CI:1.64-7.69,P=0.016). CONCLUSION:Advanced age,serum albumin level< 2.5 g/dL,and concomitant use of PPIs were found to be significant risk factors for CDAD recurrence.

关键词： Clostridium difficile Diarrhea Recurrence Risk factors Proton pump inhibitors

Metachronous bile duct cancer nine years after resection of gallbladder cancer

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World Journal of Gastroenterology 2009年第27期15卷 3440-3444页

作者： Hye Jin Joo gi Hyun Kim Won Joong Jeon Hee Bok chae Seon Mee Par Sei Jin Youn Jae Woon Choi Rohyun Sung Department of Internal Medicine College of Medicine Chungbuk National UniversityGaeshindong 62 Heungdukgu Cheongju 361-711 South Korea Department of General Surgery Chungbuk National UniversityGaeshindong 62 Heungdukgu Cheongju 361-711 South Korea Department of Pathology College of Medicine Chungbuk National UniversityGaeshindong 62 Heungdukgu Cheongju 361-711 South Korea

We report a rare case of a 74-year-old man with metachronous gallbladder cancer and bile duct cancer who underwent curative resection twice, with the operations nine years apart. At the age of 65 years, the patient underwent a cholecystectomy and resection of the liver bed for gallbladder cancer. This was a welldifferentiated adenocarcinoma, with negative resection margins （T2NOM0, stage Ⅰ B）. Nine years later, during a follow-up examination, abdominal computed tomography and MRCP showed an enhanced 1.7 cm mass in the hilum that extended to the second branch of the right intrahepatic bile duct. We diagnosed this lesion as a perihilar bile duct cancer, Bismuth type Ⅲ a, and performed bile duct excision, right hepatic Iobectomy and Roux-en-Y hepaticojejunostomy. The histological diagnosis was a well-differentiated adenocarcinoma with one regional lymph node metastasis （TINIM0, stage Ⅱ B）. Twelve months after the second operation, the patient is well, with no signs of recurrence. This case is compared with 11 other cases of metachronous biliary tract cancer published in the world medical literature.

关键词： Biliary tree Metachronous double cancer Gallbladder cancer Hilar bile duct cancer

Formation of unidirectional nanoporous structures in thickly anodized aluminum oxide layer

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中国有色金属学会会刊：英文版 2009年第4期19卷 1013-1017页

作者： Hyun-chae NA Taek-Jin SUNG Seok-Heon YOON Seung-Kyoun HYUN Mok-Soon KIM Young-gi LEE Sang-Hyun SHIN Seok-Moon CHOI Sung YI Division of Materials Science and Engineering Inha University Samsung Electro-Mechanics Co. Ltd.

A series of anodic aluminum oxide(AAO) was grown on the commercially pure 1050 aluminum sheet by controlling electrolyte temperature(2-15 ℃) and anodizing time(0.5-6 h),using a fixed applied current density of 3 A/dm2 in diluted sulfuric acid electrolyte.A crack-free thick AAO with the thickness of 105-120 μm and containing unidirectional nano sized pores(average pore diameter of 5-7 nm) is successfully achieved in the specimens anodized for 2 h,irrespective of electrolyte *** anodizing time reaches 6 h,very thick AAO with the thickness of 230-284 μm is grown,and average diameter of unidirectional pores is in the range of 6-24 *** higher values in both the AAO thickness and pore diameter are attained for the specimens anodized at higher temperatures of 10-15 ℃.A crack is observed to exist in the AAO after anodizing up to 4 h and more.A higher fraction(more than 9%) of the crack is shown in the specimens anodized at higher temperatures of 10-15 ℃ for 6 h and a considerable amount of giant cracks are contained.

关键词：阳极氧化铝纳米孔单向结构层电解液温度平均直径氧化时间硫酸电解液

Je-Chun-Jun induced apoptosis of human cervical carcinoma HeLa cells

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Acta Pharmacologica Sinica 2004年第10期 132-139页

作者： Han-jung chae,Kyung-mi PARK,Geun-youn LEE,gi-seup JEONG,Hyung-rae PARK,Hyung-min KIM,Soo-wan chae,Shim-keun YOO,Hyung-ryong KIM Department of Pharmacology and the Institute of Cardiovascular Research School of Medicine Chonbuk National University Jeonju Chonbuk 464-701 South Korea Department of Gynecology School of Oriental Medicine Wonkwang University Iksan Chonbuk 470-739 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan Chonbuk 570-749 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan Chonbuk 570-749 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan Chonbuk 570-749 South Korea Department of Pharmacology College of Oriental Medicine Kyung Hee University Seoul South Korea Department of Pharmacology and the Institute of Cardiovascular Research School of Medicine Chonbuk National University Jeonju Chonbuk 464-701 South Korea Department of Gynecology School of Oriental Medicine Wonkwang University Iksan Chonbuk 470-739 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan Chonbuk 570-749 South Korea

AIM: To study the mechanism of Je-Chun-Jun (JCJ)-inducing the apoptosis of the human cervical carcinoma, HeLa cells. METHODS: The cell viability was assessed using MTT assay. The optical density was measured at 570 nm. The caspase activity was measured using 50 mmol/L of fluorogenic substrate, AC-DEVD-AMC (caspase-3), AC-VEID-AMC (caspase-8) or AC-LEHD-AFC (caspase-9). To confirm the expression of proteins, Western blotting was performed. To detect the characteristic of apoptosis chromatin condensation, HeLa cells were stained with Hoechst 33258 in the presence of JCJ. For the cell cycle analysis, HeLa cells were incubated with Propidium iodide (PI) solution. Fluorescence intensity of cell cycle was measured using flow cytometry system. RESULTS: The loss of viability occurred following the exposure of 10 g/L JCJ. Cells treated with 10 g/L JCJ for 3 d exhibited the apoptotic morphology (brightly blue-fluorescent condensed nuclei by Hoechst 33258-staining) and the reduction of cell volume. Cells incubated

关键词： herbal medicine apoptosis p38 MAPK HeLa cells

Mismatched effects of receptor interacting protein kinase-3 on hepatic steatosis and inflammation in nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2018年第48期24卷 5477-5490页

作者： Waqar Khalid Saeed Dae Won Jun Kiseok Jang Sang bong Ahn Ju Hee Oh Yeon Ji chae Jai Sun Lee Hyeon Tae Kang Department of Gastroenterology Hanyang University College of Medicine Seoul 04763 South Korea Department of Pathology Hanyang University College of Medicine Seoul 04763 South Korea Department of Internal Medicine Eulji University Daejeon 34824 South Korea Department of Translational Medicine Hanyang University College of Medicine Seoul 04763 South Korea

AIM To validate the effects of receptor interacting protein kinase-3(RIP3) deletion in non-alcoholic fatty liver disease(NAFLD) and to clarify the mechanism of *** Wild-type(WT) and RIP3 knockout(KO) mice werefed normal chow and high fat(HF) diets for 12 wk. The body weight was assessed once weekly. After 12 wk, the liver and serum samples were extracted. The liver tissue expression levels of RIP3, microsomal triglyceride transfer protein, protein disulfide isomerase, apolipoprotein-B, X-box binding protein-1, sterol regulatory element-binding protein-1c, fatty acid synthase, cluster of differentiation-36, diglyceride acyltransferase, peroxisome proliferator-activated receptor alpha, tumor necrosis factor-alpha(TNF-α), and interleukin-6 were assessed. Oleic acid treated primary hepatocytes from WT and RIP3 KO mice were stained with Nile red. The expression of inflammatory cytokines, including chemokine(C-X-C motif) ligand(CXCL) 1, CXCL2, and TNF-α, in monocytes was *** RIP3 KO HF diet fed mice showed a significant gain in body weight, and liver weight, liver to body weight ratio, and liver triglycerides were increased in HF diet fed RIP3 KO mice compared to HF diet fed WT mice. RIP3 KO primary hepatocytes also had increased intracellular fat droplets compared to WT primary hepatocytes after oleic acid treatment. RIP3 overexpression decreased hepatic fat content. Quantitative real-time polymerase chain reaction analysis showed that the expression of very-low-density lipoproteins secretion markers(microsomal triglyceride transfer protein, protein disulfide isomerase, and apolipoprotein-B) was significantly suppressed in RIP3 KO mice. The overall NAFLD Activity Score was the same between WT and RIP3 KO mice; however, RIP3 KO mice had increased fatty change and decreased lobular inflammation compared to WT mice. Inflammatory signals(CXCL1/2, TNF-α, and interleukin-6) increased after lipopolysaccharide and pancaspase inhibitor(necroptotic conditi

关键词： Necroptosis Receptor interacting protein kinase-3 Mixed lineage kinase domain-like protein Non-alcoholic fatty liver disease Steatosis