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Assessment of Serum Magnesium Level in Type 2 Diabetes Mellitus with Diabetic Foot Ulcers (Grade I and II) at Nawabshah, Pakistan

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International Journal of Clinical Medicine 2018年第2期9卷 104-116页

作者： Anwar Ali Jamali ghulam mustafa Jamali Niaz Hussain Jamali Bhojo Mal Tanwani Arslan Ahmer Rajput Ameer Ali Jamali epartment of Medicine Peoples University of Medical and Health Sciences for Women Nawabshah Pakistan Institute of Pharmaceutical Sciences Peoples University of Medical and Health Sciences for Women Nawabshah Pakistan Deapartment of Physiology Peoples University of Medical and Health Sciences for Women Nawabshah Pakistan Deapartment of Paediatrics Medicine Peoples University of Medical and Health Sciences for Women Nawabshah Pakistan

Diabetes Mellitus is a metabolic disorder increasing morbidity and mortality worldwide, which needs exact identification and proper management. Aim of this study was to analyze the serum Mg (magnesium) level in patients with Type 2 Diabetes Mellitus with grade I & II diabetic foot ulcers. This descriptive cross sectional study was conducted at Medicine Department, PMCH Nawabshah from June 2015 to December 2016. A total of 110 Type 2 Diabetes Mellitus with foot ulcer patients, 51 with grade I and 59 with grade II out of total were included by purposive sampling. After consultation, subjects were categorized as gender, age, Type 2 DM and foot ulcer duration, foot ulcer grading and grouping for analyses. Wagner’s classification of diabetic foot ulcers used to analyze the data and blood samples were collected for research purpose in fasting state for serum Magnesium level analyses. Out of 110, 67 (65.5%) males and 43 (34.5%) females were reported with Type 2 diabetic patients. Hypomagnesaemia was reported in 59% patients out of total, 24 found with grade I and 38 found with grade II from the studied subjects. P value ≤0.000 was in the studied population in relation to hypomagnesaemia. In conclusion, Hypomagnesaemia is common in Type 2 Diabetes Mellitus patients with grade I & II foot ulcers. As the duration of Diabetes along with duration of diabetic foot ulcer in Grade I and II increases, the level of serum magnesium decreases. As the duration of Diabetes Mellitus increases, the severity of complications might also increase.

关键词： Magnesium Hypomagnesaemia Type 2 Diabetes Mellitus Foot Ulcers

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Vitamin D3: Association of Low Vitamin D3 Levels with Semen Abnormalities in Infertile Males

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Advances in Sexual Medicine 2018年第4期8卷 39-59页

作者： Anwar Ali Jamali Bhojo Mal Tanwani ghulam mustafa Jamali Ameer Ali Jamali Muhammad Ali Suhail Jagdesh Kumar Rajesh Kumar Department of Medicine Peoples University of Medical and Health Sciences Nawabshah Pakistan Department of Physiology Peoples University of Medical and Health Sciences for Women Sindh Pakistan Department of Medicine Peoples University of Medical and Health Sciences Nawabshah Pakistan Department of Pediatrics Medicine Peoples University of Medical and Health Sciences for Women Nawabshah Pakistan Department of Urology Peoples University of Medical and Health Sciences for Women Nawabshah Pakistan Department of Cardiology Peoples University of Medical and Health Sciences for Women Nawabshah Pakistan Liaquat University of Medical and Health Sciences Jamshoro Pakistan

Background: Insufficiency of vitamin D is one of the utmost general health issues all over the globe, including Pakistan;incompatible data are present on the possible relationship among serum vitamin D values and quality of semen. Objective: Lack of Vitamin D in body is related with a higher risk of various health problems including infertility. In our setup no such type of study had been conducted in the past on the relationship among serum vitamin D levels and infertility. This study was aimed to investigate male subjects with infertility and serum levels of vitamin D. Methods: This study was cross-sectional and performed on 243 male subjects who attended the clinic for evaluation of infertility from January 2016 to December 2017. Mean age of patients was 31.94 years with standard deviation of 7.52 years. The mean age of controls was 32.2 years with SD 8.42 years, age ranged between 20 years as minimum to 46 years as maximum. The minimum vitamin D level was 7.00 ng/dl while maximum 130 ng/dl, mean was 26.20 and standard deviation was 22.06 ng/ml. Levels of vitamin D were significantly low in (67%) male subjects with infertility. The mean vitamin D level of controls was 49.40 with SD of 35.98 ng/ml. 28% of controls had also vitamin D levels below the normal range, which indicates the prevalence of vitamin D deficiency in general population here in our setup. The participants were divided according to WHO (World Health Organization) 2010 criteria along with corresponding healthy control subjects. A questionnaire for evaluation of infertility in male subjects was filled by all the contestants. Results: Levels of vitamin D were significantly low in (67%) male subjects with infertility. While 28% of controls had also vitamin D levels below the normal range. Infertile male subjects with low or no sperm count were found insufficient for vitamin D in comparison to healthy control subjects. Conclusion: It was concluded from the results of current study that low levels of v

关键词： Vitamin D Deficiency Sperm Motility Male Infertility

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Association of Low Serum Magnesium Levels in Type 2 Diabetes Mellitus with &without Hypertension

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Open Journal of Preventive Medicine 2018年第3期8卷 57-69页

作者： Anwar Ali Jamali ghulam mustafa Jamali Ameer Ali Jamali Niaz Hussain Jamali Bhojo Mal Tanwani Muhammad Ali Sohail Arslan Ahmer Rajput Department of Medicine Peoples University of Medical and Health Sciences Nawabshah Pakistan Department of Pediatrics Medicine Peoples University of Medical and Health Sciences for Women Nawabshah Pakistan Institute of Pharmaceutical Sciences Peoples University of Medical and Health Sciences for Women Nawabshah Pakistan Department of Physiology Peoples University of Medical and Health Sciences for Women Nawabshah Pakistan Department of Urology Peoples University of Medical and Health Sciences for Women Nawabshah Pakistan

Background: Diabetes Mellitus is a widespread metabolic abnormality that constitutes a most important physical dilemma in the world. Hypomagnesaemia accelerates the rate of diabetic complications. Objective: To analyze the association of magnesium levels in DM (Type 2 Diabetes Mellitus) with and without complication of Hypertension. Design: It was a comparative analytical study. Setting: This research was carried out in medicine department, Peoples Medical College Hospital, Nawabshah from March 2016 to February 2017. Samples: 245 patients with Type 2 DM after fulfilling the selection criteria were included, out of them 123 with hypertension and 122 without hypertension. Methods: After a short-lived consultation, all the subjects were categorized for variable analyses like age, gender, Type 2 DM with and without hypertension, duration of diabetes and presence of hypomagnesaemia. Joint National Committee (JNC 8) classification of Hypertension was applied to collect data. Blood samples were drawn for research purpose in fasting state for serum magnesium level analyses on the basis of hypertension and without hypertension. Results: In 245 diagnosed Type 2 diabetic patients, 160 were males and 85 were females. Out of them, 123 were hypertensive while 122 were non hypertensive. Normal magnesium was present in 120 (48.97%) and low magnesium was present in 125 (51.02%) patients overall. A decreased serum level of magnesium was observed in 52.04% hypertensive subjects with diabetes and 50% non-hypertensive subjects with diabetes. Conclusion: Frequency of decreased serum magnesium is widespread in T2DM with and without hypertension.

关键词： Type 2 Diabetes Mellitus Hypertension Magnesium Hypomagnesaemia

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Frequency of Various Risk Factors in HCV Positive Patients in Initial Diagnostic Phase

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Occupational Diseases and Environmental Medicine 2018年第2期6卷 23-36页

作者： Anwar Ali Jamali ghulam mustafa Jamali Ameer Ali Jamali Bhojo Mal Tanwani Niaz Hussain Jamali Arsalan Ahmer Rajput Moti Ram Bhatia Department of Medicine Peoples University of Medical and Health Sciences Nawabshah Pakistan Department of Pediatrics Peoples University of Medical and Health Sciences Nawabshah Pakistan Department of Physiology Peoples University of Medical and Health Sciences Nawabshah Pakistan Department of Pharmacy Peoples University of Medical and Health Sciences Nawabshah Pakistan Department of Psychiatry Peoples University of Medical and Health Sciences Nawabshah Pakistan

Viral hepatitis C is a type of illness, which is transmitted to patients by different methods in world. Here we will identify the different common risk factors for transmission of viral hepatitis C in our setup. Aim of study was to determine frequency of various risk factors in HCV positive patients. This study was cross sectional and conducted Department of Medicine PMC Hospital at Nawabshah. Duration of this study was one year from April 2016 to March 2017. After taking informed written consent, 243 diseased persons with positive anti Hepatitis C Antibodies were incorporated in this research. Frequency of variables i.e. Hepatitis C virus risk factors and different other demographic results was collected on preformed proforma. In total of 243 subjects there were 165 (67.9%) male and 78 (32.1%) females respectively. Most of the subjects have more than one risk factor. 19 (7.8%) had history of blood and blood products transfusion. IV drug abuse was detected in 08 (3.3%). Homosexuality and heterosexuality were observed in 14 (5.8%) and 12 (4.9%) subjects respectively. History of dental procedure was seen in 31 (12.8%). 228 (93.8%) had history of needle pricking in different ways. History of different surgical procedures was observed in 33 (13.8%). Calculated Mean and Standard Deviation for age was 39.2 ± 10.3 years. It was concluded that proper implementation of precautionary measures should be carried out for every human being to reduce burden of HCV illness in far near future.

关键词： Viral Hepatitis C Anti HCV Antibodies Risk Factors

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Acute and Chronic Toxicity of Thioacteamide and Alterations in Blood Cell Indices in Rats

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Journal of Cancer Therapy 2013年第1期4卷 251-259页

作者： Muddasir Hassan Abbasi Tasleem Akhtar Ihtzaz A. Malik Sana Fatima Babar Khawar Khawaja Abdul Mujeeb ghulam mustafa Shabir Hussain Javaid Iqbal Nadeem Sheikh Cell and Molecular Biology Lab Department of Zoology University of the Punjab Lahore Pakistan Department of Anatomy Shaikh Zayed Postgraduate Medical Institute Shaikh Khalifa Bin Zayed Medical and Dental College Lahore Pakistan Department of Zoology Govt. College of Science Lahore Pakistan University of Health Sciences Lahore Pakistan

Background: Thioacetamide (TAA) has been used extensively in the development of suitable animal models of acute and chronic liver injury employing various doses, times and routes of its administration, particularly in drinking water due to its resemblance with human liver fibrosis and cirrhosis. The aim of this study was to investigate and compare hematological alteration during the acute and chronic liver inflammation. Methods: Acute Liver inflammation was induced in Wistar rats via intraperitoneal injection of thioacetamide and the animals were sacrificed 12 h after the TAA administration. Induction of chronic liver inflammation was performed by continuous administration of TAA in the drinking water (200 mg/L) during 18 weeks of experiment. After that all animals were sacrificed and Blood samples were collected for further analysis. Results: Single intra peritoneal injection of TAA (300 mg/kg B.W.) induced an acute condition with hematological changes including leukocytosis with marked neutrophilia (P = 0.0429), lymphopenia, thrombocytosis as well as increased hemoglobin concentration (P 0.05) and decline of erythrocytic count (P = 0.0009). Eighteen weeks of uninterrupted supply of TAA (200 mg/L) in drinking water lead to chronic inflammation and the hematological alterations were leucopenia (P = 0.0197) accompanied with neutropenia and thrombocytopenia. Increase in RBCs (P = 0.0073) and Hb contents was also observed with a decline of red cell indices. Conclusion: Taken together these findings we can conclude that the animals respond differently under acute and chronic inflammatory condition with TAA administration. Leukocytosis with marked neutrophilia, thrombocytosis as well as increased hemoglobin concentration and decline of erythrocytic count were observed in acute while leucopenia accompanied with neutropenia and thrombocytopenia and increase in RBCs, Hb and Hct was also observed with a decline of other red cell indices during chronic phase.

关键词： Haematology Inflammation Leucocytosis Leucopenia Neutrophilia Neutropenia Thrombocytosis and Thrombocytopenia

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Vitamin D: Level of Vitamin D3 in AFB Positive PTB Patients in Initial Diagnostic Phase

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Journal of Tuberculosis Research 2018年第4期6卷 251-269页

作者： Anwar Ali Jamali Jawaid Hussain Lighari Shamasddin Shaikh ghulam mustafa Jamali Bhojo Mal Tanwani Muhammad Aslam Channa Ameer Ali Jamali Muhammad Ali Suhail Department of Medicine Peoples University of Medical and Health Sciences Nawabshah Pakistan Department of Community Medicine Peoples University of Medical and Health Sciences Nawabshah Pakistan Department of Physiology Peoples University of Medical and Health Sciences for Women Nawabshah Pakistan Department of Anatomy Gambat Institute of Medical Sciences Khairpur Pakistan Department of Peadiatrics Peoples University of Medical and Health Sciences for Women Nawabshah Pakistan Department of Surgery Peoples University of Medical and Health Sciences for Women Nawabshah Pakistan

Background: A relationship among vitamin D and pulmonary tuberculosis. Objective: To conclude the occurrence of Vitamin D insufficiency in subjects suffering from pulmonary TB. Design: This was a cross sectional study. Setting: Current study was performed at department of medicine, Peoples Medical College Hospital Nawabshah starting from January 2017 to December 2017. Samples: 385 AFB positive subjects of pulmonary tuberculosis after achieving the criteria of selection were recruited. Material and Methods: After a brief discussion, the patients were characterized for variable evaluation such as age, gender, sputum AFB and duration of disease and presence of low vitamin D levels. Sputum AFB criterion was used for Data collection. Fasting blood samples were collected for analysis of vitamin D levels in all subjects of AFB positive pulmonary tuberculosis. Results: In 385 diagnosed patients with smear positive PTB, 273 (70.9%) males and 112 (29.1%) were female. Vitamin D levels were within normal or sufficient range in 134 (34.8%), below normal range in 251 (65.2%) cases (insufficient in 09.56% (24/251) and deficient in 90.43% (227/251) cases). Conclusion: Decreased levels of vitamin D were common in subjects with AFB smear Positive PTB cases.

关键词： Pulmonary Tuberculosis Vitamin D Vitamin D Insufficiency 25-Hydroxyvitamin D

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Assessment of Retreatment Tuberculosis Cases amongst All Tuberculosis Cases Notification in District Swat 2015-2017: A Retrospective Cohort Review

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Journal of Tuberculosis Research 2019年第1期7卷 11-18页

作者： Zahir Shah Maqsood Ali Khan Hina Najmi Razia Fatima Aashifa Yaqoob Abdul Ghafoor Ahmed Wali Amjad Khan Shah Hasan Khan ghulam mustafa Halepota Provincial Tuberculosis Control Program Swat Khyber Pakhtunkhwa Pakistan Sukh Initiative Aman Health Care Services Karachi Pakistan National Tuberculosis Control Program Islamabad Pakistan Provincial Tuberculosis Control Program Quetta Pakistan Pakistan Kidney and Liver Institute & Research Center Lahore Pakistan

Retreatment Tuberculosis (TB) has long been a neglected area in global TB control. To determine the notification of re-treatment Tuberculosis TB cases among all enrolled TB patients, we conducted a retrospective cohort review of routine program data from 2015-2017. A total of 8663 tuberculosis cases (all new and old forms) were registered at the study site. Of these, 1916 (22%) were pulmonary bacteriological confirmed;3498 (40.37%) were pulmonary clinical diagnosed and 3396 (39.20%) were clinically or bacteriological confirmed extra-pulmonary tuberculosis cases. Retreatment cases trend was found to be increased from 1% in 2015 to 1.6% in 2017. Majority of re-treatment cases were in the age group 18 - 43 years and only 7 patients were under the age of 15 years. This concludes that notification of re-treatment cases is very low among all enrolled TB patients and this could be possibly due to the fact that most of the re-treatment cases were registered as new cases or misdiagnosed. There is need and space to increase retreatment cases. Most of the re-treatment cases were usually converted to MDR-TB (Multi-Drug Resistant Tuberculosis) as noted in PMDT (Programmatic management of Drugs resistant tuberculosis) site. Therefore, proper history and diagnosis should be encouraged at the time of case notification.

关键词： Retreatment TB Cases Retrospective Cohort Swat Pakistan

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扩散排序谱数据的组分数确定方法研究

扩散排序谱数据的组分数确定方法研究

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第十九届全国波谱学学术会议

作者：袁斌 ghulam mustafa Kamal 张许刘买利中国科学院武汉物理与数学研究所波谱与原子分子物理国家重点实验室武汉磁共振中心中国科学院大学

扩散排序谱(DOSY)是核磁共振波谱中分析复杂混合物强大有力的工具之一。它根据表观扩散系数来区分不同的组分,是经济有效的"色谱NMR"。但随着样品复杂程度增加,常规DOSY的分辨能力有限,发展行之有效的谱图分析处理方法势在必行。目前基...

扩散排序谱(DOSY)是核磁共振波谱中分析复杂混合物强大有力的工具之一。它根据表观扩散系数来区分不同的组分,是经济有效的"色谱NMR"。但随着样品复杂程度增加,常规DOSY的分辨能力有限,发展行之有效的谱图分析处理方法势在必行。目前基于DOSY的发展主要有三个方向:分离算法;增加谱图维度或直接提高谱图分辨率;添加基质,调控表观扩散系数的差别大小。第一个研究方向简单经济,可与其他方向相结合,但面临两个难题:多组分数和较小表观扩散系数差别分离困难。Morris等人提出的LOCODOSY解决了

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CHAPS胶束聚集形态的溶液PRE研究

CHAPS胶束聚集形态的溶液PRE研究

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第十九届全国波谱学学术会议

作者：张亮孙鹏蒋滨 ghulam mustafa Kamal 张许刘买利中国科学院武汉物理与数学研究所波谱与原子分子物理国家重点实验室武汉磁共振中心中国科学院大学

CHAPS(3-[(3一胆固醇氨丙基)二甲基氨基]-1-丙磺酸)作为胆酸的衍生物兼具了磺基三甲铵乙内酯和胆盐的特点,头部具备类固醇似的凸面(疏水背)和凹面(连有三个亲水的羟基)。这种特别的极性基团分布使得其聚集行为不同于那些合成表面活性剂...

CHAPS(3-[(3一胆固醇氨丙基)二甲基氨基]-1-丙磺酸)作为胆酸的衍生物兼具了磺基三甲铵乙内酯和胆盐的特点,头部具备类固醇似的凸面(疏水背)和凹面(连有三个亲水的羟基)。这种特别的极性基团分布使得其聚集行为不同于那些合成表面活性剂,被广泛用于蛋白质结构研究。但是,CHAPS胶束的聚集形态仍然存在争议。QIN等提出CHAPS胶束可能存在单层和双层球状结构。而Kroflic等运用等温滴定量热法得出,CHAPS胶束具有松

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Mode switching torque distribution strategy of timely four-wheel driven high-gap plant protection machine

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International Journal of Agricultural and Biological Engineering 2024年第4期17卷 176-184页

作者： Haijun Zhang Mingwei Guan Guojun Ji ghulam Hussain Maohua Xiao Yejun Zhu College of Engineering Nanjing Agricultural UniversityNanjing 210031China Essen Agricultural Machinery Changzhou Co. Ltd.Changzhou 213000China Faculty of Mechanical Engineering Ghulam Ishaq Khan Institute of Engineering Sciences&TechnologyTopi 23460Pakistan

The high-gap plant protection machine is taken in this paper as the research object to ensure the good driving power and safety of the high-gap plant protection machine,and the control strategy of inter-shaft torque distribution is established under different working conditions to improve vehicle power and lateral *** anticipated demand torque is initially determined based on the structural characteristics and operational principles of the plant protection ***,a hierarchical control framework is devised by incorporating a formulated switching control ***,a simulation model for torque distribution control strategy between shafts is developed on the Matlab/Simulink platform,followed by simulation and experimental *** results are presented as follows:the inter-shaft torque distribution strategy established in this paper increases the average longitudinal acceleration by 0.13 m/s^(2) and 0.14 m/s^(2) under the control of low and high to low adhesion road surfaces,*** the control of the single-line shifting condition,the yaw velocity can successfully follow the expected value with a maximum value of 0.61 rad/*** side deflection angle of the center of mass does not exceed 2.8°,which can follow the ideal trajectory and improve power and safety.

关键词： plant protection robot torque distribution mode switching

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