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Effect of testosterone replacement on feeding behaviors after acute and chronic stress in gonadectomized male NMRI mice

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Frontiers in Biology 2017年第6期12卷 430-441页

作者： Sara Salehi Shemiran gholam hossein meftahi q Hedayat Sahraei Negin Ghobadi Department of Biology School of Biological Sciences Islamic Azad University North Tehran Branch Tehran Iran Neuroscience Research Centez Baqiyatallah University of Medical Sciences Tehran Iran

We study the role of gonadectomy on the response to unavoidable stress and the role of testosterone replacement on gonadectomy in the male Naval Medical Research Institute mice (30±5 g) were studied. For this purpose, the hormonal and metabolic changes were investigated. In the experimental group, the gonads were surgically removed, and a cannula was inserted into the left lateral ventricle. For acute and chronic stress induction, animals were placed in the communication box for 30 min for one day and four consecutive days, respectively. The animals received different doses of intraventricular (ICV) testosterone (0.01, 0.05, 0.1 μg/mouse) 5 minutes or intraperitoneal (IP) testosterone (0.05, 0.01, 0.1 mg/kg) 30 minutes before the stress induction. The results showed that acute and chronic stress increases plasma cortisol concentration. IP testosterone injections of testosterone did not decrease cortisol concentrations in response to acute stress, whereas ICV injections did reduce cortisol concentrations. The stress reduced anorexia time, while the administration of testosterone increased anorexia time. In addition, acute stress reduced food intake in the gonadectomized mice. IP testosterone at 0.01 and 0.05 mg/kg increased food intake. Additionally, stress in gonadectomized mice reduced water intake, while the IP injection of testosterone in chronic stress further reduced water intake. Also, stress reduced the animals’ brain/adrenal volumes, while the IP and ICVinjection of testosterone at 0.01 mg/kg inhibited this effect. The results showed that the IP (0.05, 0.01, 0.1 mg/kg) and ICV (0.01, 0.05, 0.1 μg/mouse) administration of testosterone in the gonadectomized mice can modulate hormonal and metabolic changes induced by stress.

关键词： anorexia cortisol food intake gonadectomy water intake

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Investigating the inhibition of NMDA glutamate receptors in the basolateral nucleus of the amygdala on the pain and inflammation induced by formalin in male Wistar rats

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Frontiers in Biology 2018年第2期13卷 149-155页

作者： Nima Heidary Hedayat Sahraei Mohammad Reza Afarinesh Zahra Bahari gholam hossein meftahi Department of Physiology School of Medicine Zanjan University of Medical Sciences Zanjan Iran Neuroscience Research Center Baqiyatallah University of Medical Sciences Tehran Iran Kerman Cognitive Research Center and Neuroscience Research Center Institute of Neuropharmachology Kerman University of MedicalSciences Kerman Iran Department of Physiology and Biophysics Faculty of Medicine Baqiyatallah University of Medical Sciences Tehran Iran

BACKGROUND： The role of the amygdala in controlling emotional pain has been emphasized in several studies. In this study, the role of the NMDA glutamate receptors in the basolateral nucleus of the amygdala （BLA） in regulating inflammation and emotional pain, induced by formalin, was studied in male rats. METHODS： Male Wistar rats, weighing 250±0 g, were injected with 20 μL of 2% formalin into the paw of the right hind limb. Memantine, at doses of 1 and 5 μg/rat, was injected bilaterally into the BLA five minutes prior to injecting formalin. Following the injection, the pain and inflammation of the paws were measured using Dubbison-Dennis and mercury immersion methods, respectively. The behavior of the animals, including licking time and foot volume, was assessed. RESULTS： The results showed that the inactivation of the NMDA receptors in the BLA in the acute phase of pain reduced the licking time （the emotional aspect of pain）. However, at a high dose （5μg/rat）, memantine exacerbates the pain induced by formalin in the chronic phase. Additionally, the inhibition of the NMDA receptors in the BLA by memantine enhanced the formalin-induced increase in foot volume （inflammation） in a dose-dependent manner. CONCLUSION： The study showed that the NMDA glutamate receptors in the BLA are crucial for the emotional pain and inflammation in both chronic and acute phases of formalin-induced pain. However, their roles are more pronounced in the chronic phase than in the acute phase of pain.

关键词： basolateral nucleus of amygdala formalin test inflammation licking time memantine

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Mechanical characterization of Mg-B4C nanocomposite fabricated at different strain rates

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International Journal of Minerals,Metallurgy and Materials 2020年第2期27卷 252-263页

作者： gholam hossein Majzoobi Kaveh Rahmani Mechanical Engineering Department Bu-Ali Sina University

Magnesium has wide application in *** main purpose of this investigation was to improve the properties of magnesium by reinforcing it using B4C *** reinforced nanocomposites were fabricated using a powder compaction technique for 0,1.5vol%,3vol%,5vol%,and 10vol% of *** compaction was conducted using a split Hopkinson bar(SHB),drop hammer(DH),and Instron to reach different compaction loading *** compressive stress–strain curves of the samples were captured from quasi-static and dynamic tests carried out using an Instron and split Hopkinson pressure bar,*** revealed that,to achieve the highest improvement in ultimate strength,the contents of B4C were 1.5vol%,3vol%,and 3vol% for Instron,DH,and SHB,*** results also indicated that the effect of compaction type on the quasi-static strength of the samples was not as significant,although its effect on the dynamic strength of the samples was *** improvement in ultimate strength obtained from the quasi-static stress–strain curves of the samples(compared to pure Mg)varied from 9.9% for DH to 24% for *** dynamic strength of the samples was improved(with respect to pure Mg)by 73%,116%,and 141%for the specimens compacted by Instron,DH,and SHB,*** improvement in strength was believed to be due to strengthening mechanisms,friction,adiabatic heating,and shock waves.

关键词： powder compaction B4C magnesium strain rate ultimate strength sintering

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Perfect GMR effect in gapped graphene-based ferromagnetic normal ferromagnetic junctions

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Chinese Physics B 2015年第4期24卷 405-410页

作者： hossein Karbaschi gholam Reza Rashedi Department of Physics University of Isfahan

We investigate the quantum transport property in gapped graphene-based ferromagnetic/normal/ferromagnetic （FG/NG/FG） junctions by using the Dirac-Bogoliubov-de Gennes equation. The graphene is fabricated on SiC and BN substrates separately, so carders in FG/NG/FG structures are considered as massive relativistic particles. Transmission prob- ability, charge, and spin conductances are studied as a function of exchange energy of ferromagnets （h）, size of graphene gap, and thickness of normal graphene region （L） respectively. Using the experimental values of Fermi energy in the normal graphene part （EFN - 400 meV） and energy gap in graphene （260 meV for SiC and 50 meV for BN substrate）, it is shown that this structure can be used for both spin-up and spin-down polarized current. The latter case has different behavior of gapped FG/NG/FG from that of gapless FG/NG/FG structures. Also perfect charge giant magnetoresistance is observed in a range of E FN - mv 2 F〈h〈E FN＋mv 2 F.

关键词： graphene spin-polarized current giant magnetoresistance nanoscale structures

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Maximum mass of a hot neutron star with a quark core

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Research in Astronomy and Astrophysics 2011年第4期11卷 471-481页

作者： Tayebeh Yazdizadeh gholam hossein Bordbar Islamic Azad University Bafgh Branch Department of Physics Shiraz University Research Institute for Astronomy and Astrophysics of Maragha

We have considered a hot neutron star with a quark core, a mixed phase of quark-hadron matter, and a hadronic matter crust and have determined the equation of state of the hadronic phase and the quark phase. We have then found the equation of state of the mixed phase under the Gibbs conditions. Finally, we have computed the structure of a hot neutron star with a quark core and compared our results with those of the neutron star without a quark core. For the quark matter calculations, we have used the MIT bag model in which the total energy of the system is considered as the kinetic energy of the particles plus a bag constant. For the hadronic matter calculations, we have used the lowest order constrained variational formalism. Our calculations show that the results for the maximum gravitational mass of a hot neutron star with a quark core are substantially different from those of a neutron star without the quark core.

关键词： dense matter -- equation of state -- stars fundamental parameters(masses, radii, temperatures)

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A Cu-Cr alloy with nano and microscale Cr particles produced in a water-cooled copper mold

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International Journal of Minerals,Metallurgy and Materials 2010年第5期17卷 629-634页

作者： Seyyed Mohammd hossein Hejazi Fatemeh Majidi gholam hossein Akbari Mining Industries Research Center Shahid Bahonar University of Kerman Department of Material Science and Engineering Faculty of Engineering Shahid Bahonar University of Kerman

Microstructures have profound effects on the hardness and strength of Cu-Cr alloys. The microstructures of a Cu-Cr alloy cast in a water-cooled copper mold were studied in the present work. The scanning electron microscopy （SEM） results show that there are the copper matrix saturated with chromium, spherical precipitates of chromium separated from liquid phase during cooling before the initiation of so- lidification, and a eutectic phase in grain boundary areas. To investigate the effect of age-hardening treatment on the microstructures and properties of the material, some samples were subsequently age-hardened in a salt bath and investigated by transmission electron microscopy （TEM）. The results show that coherent precipitates with the diameter of 11 nm are detectable in the samples before and after the age-hardening stage. Of course, the volume fraction of coherent precipitates is higher after the aging process.

关键词： copper alloys chromium molding precipitation hardening nanoparticles

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Calculation of the structural properties of asymmetrical nuclear matter

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Research in Astronomy and Astrophysics 2012年第3期12卷 345-358页

作者： gholam hossein Bordbar Hamideh Nadgaran Department of Physics Shiraz University Research Institute for Astronomy and Astrophysics of Maragha

The structural properties of asymmetrical nuclear matter have been calculated,employing the AV 18 potential for different values of proton to neutron *** calculations have also been made for the case of symmetrical nuclear matter with the UV14,AV14 and AV 18 *** our calculations,we used the lowest order constrained variational method to compute the correlation function of the system.

关键词： stars:neutron—dense matter—equation of state

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The effects of strong magnetic fields on neutron star structure:lowest order constrained variational calculations

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Research in Astronomy and Astrophysics 2013年第2期13卷 197-206页

作者： gholam hossein Bordbar Zeinab Rezaei Department of Physics Shiraz University Center for Excellence in Astronomy and Astrophysics(CEAA-RIAAM)-Maragha

We investigate the effects of strong magnetic fields upon the large-scale properties of neutron and protoneutron stars. In our calculations, the neutron star mat- ter was approximated by pure neutron matter. Using the lowest order constrained vari- ational approach at zero and finite temperatures, and employing AV18 potential, we present the effects of strong magnetic fields on the gravitational mass, radius, and gravitational redshift of neutron and protoneutron stars. It is found that the equation of state for a neutron star becomes stiffer with an increase of magnetic field and tem- perature. This leads to larger values of the maximum mass and radius for the neutron stars.

关键词： dense matter -- equation of state -- stars magnetic fields -- stars fundamental parameters (masses, radii, temperatures)

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The effect of dynamical quark mass on the calculation of a strange quark star's structure

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Research in Astronomy and Astrophysics 2012年第5期12卷 540-550页

作者： gholam hossein Bordbar Babak Ziaei Department of Physics Shiraz UniversityShiraz 71454Iran Research Institute for Astronomy and Astrophysics of Maragha P.O.Box 55134-441Maragha 55177-36698Iran

We discuss the dynamical behavior of strange quark matter components, in particular the effects of density dependent quark mass on the equation of state of strange quark matter. The dynamical masses of quarks are computed within the Nambu-Jona-Lasinio model, then we perform strange quark matter calculations em- ploying the MIT bag model with these dynamical masses. For the sake of compar- ing dynamical mass interaction with QCD quark-quark interaction, we consider the one-gluon-exchange term as the effective interaction between quarks for the MIT bag model. Our dynamical approach illustrates an improvement in the obtained equation of state values. We also investigate the structure of the strange quark star using Tolman- Oppenheimer-Volkoff equations for all applied models. Our results show that dynamical mass interaction leads to lower values for gravitational mass.

关键词： Stars dense matter - equation of state - ISM structure -- supemova remnants

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MCM-41 anchored sulfonic acid (MCM-41-R-SO_3H):A mild,reusable and highly efficient heterogeneous catalyst for the Biginelli reaction

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Chinese Chemical Letters 2008年第12期19卷 1435-1439页

作者： gholam hossein Mahdavinia Hamid Sepehrian Department of Chemistry Islamic Azad University-Marvdasht BranchMarvdashtIran Jaber lbn Hayan Research Laboratories Nuclear Science and Technology Research InstituteAEOIP.O.Box 11365/8486TehranIran

An efficient three-component synthesis of 3,4-dihydropyrimidinones using MCM-41 anchored sulfonic acid （MCM-41-R-SO3H） as a mild, heterogeneous catalyst for Biginelli reaction in CH3CN under reflux condition is desc... 详细信息

关键词： One-pot MCM-41-R-SO3H Heterogeneous Biginelli reaction Multicomponent

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