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Biomedical applications of mRNA nanomedicine

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Nano Research 2018年第10期11卷 5281-5309页

作者： Qingqing Xiong gha Young Lee Jianxun Ding Wenliang Li Jinjun Shi Center for Nanomedicine and Department of Anesthesiology Brigham and Women's Hospital Harvard Medical School Boston MA 02115 USA Department of Hepatobiliary Cancer Tianjin Medical University Cancer Institute & Hospital Tianjin 300060 China School of Pharmacy Jilin Medical University Jilin 132013 China

As an attractive alternative to plasmid DNA, messenger RNA （mRNA） has recently emerged as a promising class of nucleic acid therapeutics for biomedical applications. Advances in addressing the inherent shortcomings of mRNA and in the development of nanoparticle-based delivery systems have prompted the development and clinical translation of mRNA-based medicines. In this review, we discuss the chemical modification strategies of mRNA to improve its stability, minimize immune responses, and enhance translational efficacy. We also highlight recent progress in nanoparticle-based mRNA delivery. Considerable attention is given to the increasingly widespread applications of mRNA nanomedicine in the biomedical fields of vaccination, protein-replacement therapy, gene editing, and cellular reprogramming and engineering.

关键词： messenger RNA chemical modification nanoparticle vaccination gene editing protein-replacement cellular reprogramming and engineering

Prospects and challenges in electrochemical nitrogen activation for ammonia synthesis

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Science China Chemistry 2024年第11期67卷 3510-3514页

作者： Xianbiao Fu ib Chorkendorff Department of Physics Technical University of DenmarkKongens Lyngby 2800Denmark

“The fixation of atmospheric nitrogen stands as one of the profound discoveries awaiting the ingenuity of chemists,”proclaimed William Crookes in his 1898 speech [1]. This statement swiftly surged like a colossal wa... 详细信息

关键词： activation ammonia synthesis

Exosomes as mediators of neuron-glia communication in neuroinflammation

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Neural Regeneration Research 2020年第5期15卷 796-801页

作者： María Pascual Francesc ibánez Consuelo Guerri Department of Molecular and Cellular Pathology of Alcohol Príncipe Felipe Research CenterValenciaSpain Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain

In recent years,a type of extracellular vesicles named exosomes has emerged that play an important role in intercellular communication under physiological and pathological *** nanovesicles (30–150 nm) contain proteins,RNAs and lipids,and their internalization by bystander cells could alter their normal *** review focuses on recent knowledge about exosomes as messengers of neuron-glia communication and their participation in the physiological and pathological functions in the central nervous *** emphasis is placed on the role of exosomes under toxic or pathological stimuli within the brain,in which the glial exosomes containing inflammatory molecules are able to communicate with neurons and contribute to the pathogenesis of neuroinflammation and neurodegenerative *** the small size and characteristics of exosomes,they can cross the blood-brain barrier and be used as biomarkers and diagnosis for brain disorders and ***,although the application potential of exosome is still limited,current studies indicate that exosomes represent a promising strategy to gain pathogenic information to identify therapeutically targets and biomarkers for neurological disorders and neuroinflammation.

关键词： biomarkers exosomes glial cells neuroinflammation neuron-glia commuication neurons neuropathology therapy

Non-expansive Mappings and Iterative Methods in Uniformly Convex Banach Spaces

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Acta Mathematica Sinica,English Series 2004年第5期20卷 829-836页

作者： ha|YunZHOU Dept.ofMath. ShijiazhuangMechanicalEngineeringCollegeShijiazhuang050003P.R.China

In this article,we will investigate the properties of iterative sequence for non-expansive mappings and present several strong and weak convergence results of successive approximations to fixed points of non-expansive mappings in uniformly convex Banach *** results presented in this article generalize and improve various ones concerned with constructive techniques for the fixed points of non-expansive mappings.

关键词： Non-expansive mapping Mann and lshikawa iteration schemes Convergence theorem Uniformly convex Banach space

Effects of Material and Dimension on TCF,Frequency,and Q of Radial Contour Mode AlN-on-Si MEMS Resonators

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Journal of Electronic Science and Technology 2021年第4期19卷 319-334页

作者： Thi Dep ha with the Faculty of Electronics Technology Industrial University of Ho Chi Minh CityHo Chi Minh City 70000

This paper investigates the effects of material and dimension parameters on the frequency splitting,frequency drift,and quality factor(Q)of aluminium nitride(AlN)-on-n-doped/pure silicon(Si)microelectromechanical systems(MEMS)disk resonators through analysis and *** parameters include the crystallographic orientation,dopant,substrate thickness,and *** resonators operate in the elliptical,higher order,and flexural *** simulation results show that i)the turnover points of the resonators exist at 55°C,-50°C,40°C,and-10°C for n-doped silicon with the doping concentration of 2×1019 cm-3 and the Si thickness of 3.5μm,and these points are shifted with the substrate thickness and mode variations;ii)compared with pure Si,the modal-frequency splitting for n-doped Si is higher and increases from 5%to 10%for all studied modes;iii)Q of the resonators depends on the temperature and ***,the turnover,modal-frequency splitting,and Q of the resonators depend on the thickness and material of the substrate and the *** work offers an analysis and design platform for high-performance MEMS gyroscopes as well as oscillators in terms of the temperature compensation by n-doped Si.

关键词： Anisotropic contour mode doping gyroscope microelectromechanical systems(MEMS)resonator piezoelectric temperature coefficient of frequency(TCF) temperature compensation thin-film piezoelectric-on-substrate(TPoS)

Current state-of-the-art review of footwear–ground friction

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Friction 2024年第10期12卷 2188-2204页

作者： David REBENDA Tomáš SÁha Footwear Research Centre University InstituteTomas Bata University in ZlinZlin 76001Czech Republic Faculty of Mechanical Engineering Brno University of TechnologyBron 61600Czech Republic

The most important role of footwear is to ensure safe,functional walking,and foot *** the proper functionality of not only the work shoes,the anti-slip behavior of the shoe under various conditions and environments plays an important role in the prevention of slips,trips,falls,and consequent *** article is intended to review the current understanding of the frictional mechanisms between shoe outsoles and various counterfaces that impact the evaluation of outsole *** research focuses on the mechanisms driving outsole friction on different ground surfaces or the definition and description of parameters that influence outsole ***,the review discusses the effect of various surface contaminants on footwear ***,challenges and outlooks in the field of footwear outsoles are briefly mentioned.

关键词： shoe outsole composite slipperiness coefficient of friction(COF) adhesion safe walk

Some remarks on the genericity of unique range sets for meromorphic functions

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Science China Mathematics 2005年第Z1期48卷 262-267页

作者： ha Huy Khoai Institute of Mathematics 18 Hoang Quoc Viet 10307HanoiVietnam

In this paper we relate the study of unique range sets for meromorphic functions (URSM) with the hyperbolic hypersurfaces and give some remarks on the genericity of unique range sets for meromorphic functions.

关键词： unique range set for meromorphic functions, hyperbolic surface.

Ligninolytic enzymes production by endophytic fungus Diaporthe phaseolorum(Desm.)*** the influence of different carbon and nitrogen sources

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Studies in Fungi 2021年第1期6卷 531-542页

作者： Kumar V Prasher ib Mycology and Plant Pathology Lab. Department of BotanyPanjab University ChandigarhChandigarh-160014India

Endophytic fungi are being investigated for their ability to create industrially relevant secondary *** recent years,there has been a surge in interest in these fungi as a source of novel enzymes,particularly hydrolytic *** present study investigated the effect of different carbon,organic and inorganic nitrogens on the growth and ligninolytic enzyme production by the endophytic fungus Diaporthe *** fungus was isolated from the leaves of Dillenia indica and analyzed by morpho-molecular *** fungus showed promising results for in vitro production of ligninolytic *** was the most favorable carbon compound for growth among all the carbon compounds *** displayed maximum lignin peroxidase(Lip)activity in fructose(3.5 U/ml),followed by pectin(2.60 U/ml)and glucose(2.53 U/ml).Glucose gave the highest manganese peroxidase(MnP)activity i.e.,6.88 U/ml followed by starch,sucrose and ***,the maximum laccase activity was 44.5 U/ml in *** nitrate and L-asparagine were the best inorganic and organic nitrogen for *** the case of ligninolytic enzyme production,ammonium acetate and ammonium phosphate were the best media for LiP and MnP,whereas laccase production was highest in ammonium nitrate supplemented *** organic nitrogen sources,medium supplemented with DL-tryptophan gave the highest Lip production,whereas MnP and laccase production was observed in the medium containing L-tyrosine and *** the best of our knowledge,this is the first report related to the growth and ligninolytic enzyme production by Diaporthe *** findings from the study will assist researchers in improving the production of ligninolytic enzymes by this fungus under in vitro conditions on an industrial scale.

关键词： Hydrolytic enzymes Industrially In vitro Manganese peroxidase Morpho molecular analysis

Support vector machine based machine learning method for GS 8QAM constellation classification in seamless integrated fiber and visible light communication system

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Science China(Information Sciences) 2020年第10期63卷 182-193页

作者： Wenqing NIU Yinaer ha Nan CHI Key Laboratory for Information Science of Electromagnetic Waves (MoE) Fudan University

Visible light communication(VLC) network over optical fiber has become a potential candidate in ultra-high speed indoor wireless communication. To mitigate signal distortion accumulated in optical fiber and VLC channel, we present to utilize support vector machine(SVM) for constellation classification in two kinds of geometrically-shaped 8 QAM(quadrature amplitude modulation) seamless integrated fiber and VLC system. We introduce 4 sub-bands to simulate multi-user. Experimental results show that system performance can be significantly improved, and transmission at-2.5 dB m input optical power under 7%forward error correction(FEC) threshold can be realized employing Circular(7, 1) geometrically-shaped8 QAM and SVM. At overall capacity of 960 Mbps, Q-factor increases by up to 11.5 dB.

关键词： visible light communication VLC support vector machine SVM geometrically shaping GS VLC network constellation classification