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Biomedical applications of mRNA nanomedicine

Nano Research 2018年第10期11卷 5281-5309页

作者： Qingqing Xiong gha Young Lee Jianxun Ding Wenliang Li Jinjun Shi Center for Nanomedicine and Department of Anesthesiology Brigham and Women's Hospital Harvard Medical School Boston MA 02115 USA Department of Hepatobiliary Cancer Tianjin Medical University Cancer Institute & Hospital Tianjin 300060 China School of Pharmacy Jilin Medical University Jilin 132013 China

As an attractive alternative to plasmid DNA, messenger RNA （mRNA） has recently emerged as a promising class of nucleic acid therapeutics for biomedical applications. Advances in addressing the inherent shortcomings of mRNA and in the development of nanoparticle-based delivery systems have prompted the development and clinical translation of mRNA-based medicines. In this review, we discuss the chemical modification strategies of mRNA to improve its stability, minimize immune responses, and enhance translational efficacy. We also highlight recent progress in nanoparticle-based mRNA delivery. Considerable attention is given to the increasingly widespread applications of mRNA nanomedicine in the biomedical fields of vaccination, protein-replacement therapy, gene editing, and cellular reprogramming and engineering.

关键词： messenger RNA chemical modification nanoparticle vaccination gene editing protein-replacement cellular reprogramming and engineering

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High Prevalence of Musculoskeletal Disorders and Self-Medication among Street Vendors in Bangui, Central African Republic (CAR)

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Occupational Diseases and Environmental Medicine 2023年第4期11卷 199-212页

作者： H.D. Mossoro-Kpinde Perrin Ariel Kongbanda Augustin Balekouzou Henri Saint Calvaire Diemer Julienne Anaïs Paola Demba Yabada Chloé Naïgha Liliane Dengue Nzobe Gerard Grésenguet Mor Ndiaye Direction de la Médecine du Travail Ministère du Travail de l’Emploi de la Protection Sociale et de la Formation Professionnelle Bangui Central African Republic Département de Santé Publique Faculté des Sciences de la Santé Université de Bangui Bangui Central African Republic Faculté des Sciences de la Santé Université de Bangui Bangui Central African Republic Comité National de Lutte contre le SIDA Bangui Central African Republic Service de Médecine du Travail et de Médecine Légale Faculté de Médecine de Pharmacie et d’Odontologie Université Cheick Anta Diop Dakar Senegal

Introduction: Musculoskeletal disorders (MSDs) are a set of peri-articular conditions that result mainly in pain and functional discomfort. They represent a major occupational health problem in all areas of activity. The objective of this work was to determine the prevalence of MSDs among street vendors in the city of Bangui in the Central African Republic (CAR). Methods: A cross-sectional study was conducted from September 01 to October 31, 2021 in Bangui, the capital of CAR. The study population consisted of street vendors which were included at the entrance of 4 large markets of Bangui after giving informed consent. The sample size, calculated according to the Schwartz formula, was 384. Sociodemographic data (age, gender, level of education, marital status), professional data (the duration of sale in hours, the distance traveled per day);and health data (the health problems suffered by itinerant sellers and the means of dealing with them) were collected using a pre-established self-questionnaire. This collected data was processed using Microsoft Excel 2013 and Epi-Info version 7 software. Results: Among 384 street vendors included, women represented a quarter (24.9%). The average age was 27 years;the 25-34 age group was the most represented (50%). About two-thirds (64.8%) sold for at least 12 hours and traveled more than 10 km (69.3%) per day. The main health problems reported by street vendors were musculoskeletal disorders (95.8%). Their locations concerned the upper limbs shoulder 65.36% (251), elbow 24.22% (93). Non-ergonomic postures that stress the back and joints all day long, causing pain are risk factors for MSDs. These MSDs were treated by self-medication with non-steroidal anti-inflammatory drugs (22.0%), mainly sold on the street. Conclusion: MSDs dominated the health problems of street vendors. These problems raise the need for recognition and support for these workers to optimize their performance while preserving their health through awareness and

关键词： Street Vendors Musculoskeletal Disorders Ergonomy Self-Medication Central African Republic

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开环与闭环时变人口系统的稳定性

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系统科学与数学 1991年第2期11卷 187-192页

作者：高夯东北师范大学数学系长春130021

其中各人口函数 p(r,t),μ(r,t),f(r),(?)(t)以及 r_m 的实际意义与文[1]相同.系统(1)—(3)(以下简称为系统(Ⅰ))是一开环时变人口系统,(?)(t)为系统(Ⅰ)的控制变量.本文将给出绝对出生率(?)(t)的时变临界值(?)_c(t),并给出系统(Ⅰ)稳... 详细信息

其中各人口函数 p(r,t),μ(r,t),f(r),(?)(t)以及 r_m 的实际意义与文[1]相同.系统(1)—(3)(以下简称为系统(Ⅰ))是一开环时变人口系统,(?)(t)为系统(Ⅰ)的控制变量.本文将给出绝对出生率(?)(t)的时变临界值(?)_c(t),并给出系统(Ⅰ)稳定与渐近稳定的充分条件以及该系统稳定的必要条件.

关键词：时变人口系统稳定性开环闭环

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MIMO Hardware Simulator Using Standard Channel Models and Measurement Data at 2,2 and 3,5 GHz

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通讯和计算机（中英文版） 2013年第4期10卷 525-544页

作者： Bachir Habib Gheorghe Zaharia Hanna Farhat gha'fs El Zein Institute of Electronics and Telecommunications of Rennes IETR UMR CNRS 6164 Rennes 35708 France

A wireless communication system can be tested either in actual conditions or by using a hardware simulator reproducing actual conditions. With a hardware simulator it is possible to freely simulate a desired type of a radio channel. This paper presents architectures for the digital block of a hardware simulator of MIMO (multiple-input multiple-output) propagation channels. This simulator can be used for LTE (long term evolution system) and WLAN (wireless local area networks) 802.11ac applications, in indoor and outdoor environments. The first architecture is appropriate for shipboard environments, while the second corresponds to outdoor-to-indoor environments and considers the wave propagation penetration within buildings. Measurements campaigns carried out at 2.2 and 3.5 GHz have been conducted to obtain the impulse responses of the channel using a MIMO channel sounder designed at IETR. The measurements are processed with an algorithm extracting the dominant paths. The architectures of the digital block are implemented on a Xilinx Virtex-IV FPGA (field programmable gate array). After the implementation of the impulse responses, the accuracy, the occupation on the FPGA and the latency of the architectures are analyzed.

关键词：硬件仿真器 MIMO 测量数据 GHz 信道模型使用标准现场可编程门阵列无线通信系统

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