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Profiling proteomic responses to hexokinase-II depletion in terpene-producing Saccharomyces cerevisiae

Engineering Microbiology 2023年第3期3卷 1-13页

作者： Zeyu Lu Qianyi Shen Lian Liu gert talbo Robert Speight Matt Trau Geoff Dumsday Christopher B.Howard Claudia E.Vickers Bingyin Peng ARC Centre of Excellence in Synthetic Biology Queensland University of TechnologyBrisbaneQLD4000Australia Australian Institute for Bioengineering and Nanotechnology(AIBN) The University of QueenslandBrisbaneQLD4072Australia Centre of Agriculture and the Bioeconomy School of Biology and Environmental ScienceFaculty of ScienceQueensland University of TechnologyBrisbaneQLD4000Australia CSIRO Synthetic Biology Future Science Platform Commonwealth Scientific and Industrial Research Organisation(CSIRO)Black MountainACT2601Australia School of Chemistry and Molecular Biosciences(SCMB) the University of QueenslandBrisbaneQLD4072Australia Metabolomics Australia(Queensland Node) Australian Institute for Bioengineering and Nanotechnology(AIBN)The University of QueenslandBrisbaneQLD4072Australia CSIRO Manufacturing ClaytonVIC3169Australia Eden Brew Pty Ltd GlenorieNSW2157Australia

Hexokinase II(Hxk2)is a master protein in glucose-mediated transcriptional repression signaling ***-grading Hxk2 through an auxin-inducible protein degradation previously doubled sesquiterpene(nerolidol)pro-duction at gram-per-liter levels in Saccharomyces *** transcriptomics/proteomics profiles in Hxk2-deficient background are important to understanding genetic and molecular mechanisms for improved nerolidol production and guiding further strain ***,proteomic responses to Hxk2 depletion are investi-gated in the yeast strains harboring a GAL promoters-controlled nerolidol synthetic pathway,at the exponential and ethanol growth phases and in GAL80-wildtype and gal80Δ*** metabolic pathways and amino acid metabolic pathways show diversified responses to Hxk2 depletion and growth on ethanol,including upregulation of alternative carbon catabolism and respiration as well as downregulation of amino acid ***-repression of GAL genes may contribute to improved nerolidol production in Hxk2-depleted ***-teen transcription factors associated with upregulated genes are *** Ash1-mediated repression on the RIM4 promoter shows the variation on the regulatory effects of different Ash1-binding sites and the syner-gistic effect of Ash1 and Hxk2-mediated *** validation of individual promoters shows that HXT1 promoter activities are glucose-dependent in hxk2Δbackground,but much weaker than those in HXK2-wildtype *** summary,inactivating HXK2 may relieve glucose repression on respiration and GAL promoters for improved bioproduction under aerobic conditions in *** proteomics profiles provide a better genetics overview for a better metabolic engineering design in Hxk2-deficient backgrounds.

关键词： Proteomics Glucose repression Metabolic engineering Crabtree effect Sesquiterpene Synthetic biology Genetic regulation

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LDH sealing for PEO coated friction stir welded AZ31/AA5754 materials

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Nano Materials Science 2024年第4期6卷 428-442页

作者： Tatsiana Shulha Maria Serdechnova Ting Wu Thymoty Naacke gert Wiesea Carsten Blawert Mikhail L.Zheludkevich Institute of Surface Science Helmholtz-Zentrum Hereon Faculty of Engineering CAU Kiel University

The need to combine various metals in light-weight constructions requires the development of coatings that prevent galvanic corrosion. Layered double hydroxides(LDHs) can be an example of such coatings, which were previously successfully obtained in situ on individual materials. In addition, the possibility of LDH growth(including LDH growth in the presence of chelating agents) on the surface of plasma electrolytic oxidation(PEO)-coated metals was previously shown. This PEO + LDH combination could improve both corrosion and mechanical characteristics of the system. The possibility of LDHs formation in situ on the surface of PEO-coated friction stir welded(FSW) magnesium-aluminum materials(AZ31/AA5754 system was selected as a model one) was demonstrated in the presence of 1,3-diamino-2-hydroxypropane-N,N,N',N'-tetraacetic acid(DHPTA) as a chelating agent, which was selected based on analysis of respective metal-ligand compounds stability. LDHs growth was achieved under ambient pressure without addition of carbonates in the electrolyte. The effectiveness of the resulting coating is shown both for corrosion resistance and hardness.

关键词： Layered double hydroxides (LDHs) Plasma electrolytic oxidation (PEO) Chelating agent Welded magnesium-aluminum materials Functional coatings

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Building an All-Weather Community

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ChinAfrica 2024年第10期16卷 34-35页

作者： gert GROBLER Zhejiang Normal University China

FOCAC sends the powerful message that China and Africa are pursuing joint development,modernisation and *** recently held 2024 Summit of the Forum on China-Africa Cooperation(FOCAC)in Beijing under the theme Joining Hands to Advance Modernisation and Build a High-Level China-Africa Community with a Shared Future unequivocally demonstrated that FOCAC remains the most important flagship collaborative platform between China and Africa and continues to deliver wide-ranging.

关键词： Africa continue deliver

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Advancing oxygen separation:insights from experimental and computational analysis of La_(0.7)Ca_(0.3)Co_(0.3)Fe_(0.6)M_(0.1)O_(3-δ)(M=Cu,Zn)oxygen transport membranes

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Frontiers of Chemical Science and Engineering 2024年第6期18卷 17-29页

作者： Guoxing Chen Wenmei Liu Marc Widenmeyer Xiao Yu Zhijun Zhao Songhak Yoon Ruijuan Yan Wenjie Xie Armin Feldhoff gert Homm Emanuel Ionescu Maria Fyta Anke Weidenkaff Fraunhofer Research Institution for Materials Recycling and Resource Strategies IWKS Alzenau 63755Germany Electrochemistry Laboratory Paul Scherrer InstituteVilligen PSI 5232Switzerland Department of Materials and Earth Sciences Materials and ResourcesTechnical University of DarmstadtDarmstadt 64287Germany Institute of Physical Chemistry and Electrochemistry Leibniz University HannoverHannover 30167Germany Institute for Computational Physics University of StuttgartStuttgart 70569Germany Computational Biotechnology RWTH AachenAachen 52074Germany

In this study,perovskite-type La_(0.7)Ca_(0.3)Co_(0.3)Fe_(0.6)M_(0.1)O_(3-δ)(M=Cu,Zn)powders were synthesized using a scalable reverse co-precipitation method,presenting them as novel materials for oxygen transport *** comprehensive study covered various aspects including oxygen permeability,crystal structure,conductivity,morphology,CO_(2) tolerance,and long-term regenerative durability with a focus on phase structure and *** membrane La_(0.7)Ca_(0.3)Co_(0.3)Fe_(0.6)M_(0.1)O_(3-δ)exhibited high oxygen permeation fluxes,reaching up to 0.88 and 0.64 mL·min^(−1)·cm^(−2) under air/He and air/CO_(2) gradients at 1173 K,*** 1600 h of CO_(2) exposure,the perovskite structure remained intact,showcasing superior CO_(2) resistance.A combination of first principles simulations and experimental measurements was employed to deepen the understanding of Cu/Zn substitution effects on the structure,oxygen vacancy formation,and transport behavior of the *** findings underscore the potential of this highly CO_(2)-tolerant membrane for applications in high-temperature oxygen *** enhanced insights into the oxygen transport mechanism contribute to the advancement of next-generation membrane materials.

关键词： perovskite oxygen permeation membrane oxygennionsdiffusiono xygen vacancy formation energy energy barrier

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Elevated fluid and glycosaminoglycan content in the Achilles tendon contribute to higher intratendinous pressures:Implications for Achilles tendinopathy

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Journal of Sport and Health Science 2024年第6期13卷 863-871页

作者： Lauren Pringels gert-Jan Van Valckenborgh Patrick Segers Amelie Chevalier Hedwig Stepman Evi Wezenbeek Arne Burssens Luc Vanden Bossche Department of Physical and Rehabilitation Medicine Ghent University HospitalGhent 9000Belgium Department of Rehabilitation Sciences and Physiotherapy Ghent UniversityGhent 9000Belgium Department of Electronics and Information Systems Ghent UniversityGhent 9000Belgium Department of Electromechanics University of AntwerpAntwerp 2020Belgium Department of Laboratory Medicine Ghent University HospitalGhent 9000Belgium Department of Orthopedic Surgery Ghent University HospitalGhent 9000Belgium

Background:Tendinopathy alters the compositional properties of the Achilles tendon by increasing fluid and glycosaminoglycan *** has been speculated that these changes may affect intratendinous pressure,but the extent of this relationship remains ***,we aimed to investigate the impact of elevated fluid and glycosaminoglycan content on Achilles tendon intratendinous pressure and to determine whether hyaluronidase(HYAL) therapy can intervene in this potential ***:Twenty paired fresh-frozen cadaveric Achilles tendons were mounted in a tensile-testing machine and loaded up to 5% *** resting(at 0% strain) and dynamic pressure(at 5% strain) were assessed using the microcapillary infusion ***,intratendinous pressure was measured under native conditions before and after infusion of 2 mL physiological ***,80 mg of glycosaminoglycans were administered bilaterally to the paired *** right tendons were additionally treated with 1500 units of ***,both groups were retested,and the glycosaminoglycan content was ***:It was found that both elevated fluid and glycosaminoglycan content resulted in higher intratendinous resting and dynamic pressures(p <0.001).HYAL treatment induced a 2.3-fold reduction in glycosaminoglycan content(p=0.002) and restored intratendinous ***:The results of this study demonstrated that elevated fluid and glycosaminoglycan content in Achilles tendinopathy contribute to increased intratendinous re sting and dynamic pressures,which can be explained by the associated increased volume and reduced permeability of the tendon matrix,*** degrades glycosaminoglycans sufficiently to lower intratendinous pressures and may,therefore,serve as a promising treatment.

关键词： Achilles tendon Achilles tendinopathy Intratendinous pressure Glycosaminoglycans Tendon fluid

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BLADE SECTION DESIGN OF MARINE PROPELLERS WITH MAXIMUM CAVITATION INCEPTION SPEED

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Journal of Hydrodynamics 2012年第1期24卷 65-75页

作者： ZENG Zhi-bo KUIPER gert China Ship Scientific Research Center Wuxi 214082China Soetendaalseweg 106721 XB BennekomThe Netherlands

Kuiper and Jessup（1993）developed a design method for propellers in a wake based on the Eppler foil design *** optimized section is transformed into the three-dimensional propeller flow using the approach of the effective blade *** blade sections are two-dimensional sections in two-dimensional flow which have the same chordwise loading distribution as the three-dimensional blade sections of a ***,the design procedure is laborious in two aspects：finding an optimum blade section using the Eppler program requires much skill of the designer,and transforming the two-dimensional blade section into a propeller blade section in three-dimensional flow is *** this work,these two problems were coped with.A blade section design procedure was presented using an optimization technique and an alternative procedure for the effective blade section is developed using a lifting surface design *** validate the method a benchmark model of a naval ship was *** benchmark model was extended by new appendices and a reference propeller,and designed using conventional design *** reference propeller was optimized using the new design procedure and model tests were carried *** attention was given to the data of the model and the reference propeller,to make the configuration suitable for the Reynolds-Averaged Navier-Stokes（RANS）calculations.

关键词： blade section Eppler foil design method genetic algorithm cavitation inception high speed cavitation observation

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Hydrogeology in the Nordic Countries

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Episodes 2008年第1期31卷 148-154页

作者： gert Knutsson Department of Land and Water Resources Engineering Royal Institute of Technology S-10044 Stockholm Sweden.

Hydrogeology in the Nordic Countries is characterized by many types of aquifers and great differences in groundwater recharge. Fracture aquifers in crystalline, hard rocks are the most common type of aquifer with, in general, low fracture porosity and low well yields. The most productive crystalline rocks are the basalts in Iceland and the rapakivi granite in Finland. The fracture and fault zones have mostly high conductivity. Porous aquifers are found in various types of geology. The most porous ones are the lava-fields and the pyroclastic rocks in the active volcanic zone of Iceland, but glaciofluvial deposits such as eskers and deltas in Finland, Norway and Sweden, outwash plains in SW Denmark and sandurs in Iceland are also very porous and good aquifers, as are some sedimentary rocks in Denmark. The glacial till has, in general, low conductivity. Fractured porous aquifers in consolidated limestones and sandstones have high well yields in relatively young formations in Denmark and Scania in southern Sweden, but medium or low yields in older strata. Karst aquifers have limited extension, but there are some well developed ones in the Caledonian mountain range in Norway and Sweden. Geothermal water with a lot of springs and even geysers are common in Iceland and of great economic importance. The groundwater chemistry of the crystalline, hard rocks is notable for bacteria, brines and mixed water at great depths （more than 500 m） as well as high contents of arsenic, fluoride and radon in drilled wells in certain regions.

关键词：水文地质学北欧国家资源利用科学勘探

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Putative roles of cathepsin B in Alzheimer's disease pathology: the good, the bad, and the ugly in one?

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Neural Regeneration Research 2018年第12期13卷 2100-2101页

作者： Hans-gert Bernstein Gerburg Keilhoff Department of Psychiatry Otto v.Guericke University Magdeburg Institute of Biochemistry and Cell Biology Otto v.Guericke University Magdeburg

Alzheimer＇s disease（AD）is a fatal progressive neurodegenerative disorder characterized by loss in memory,cognition,and executive function and activities of daily *** pathogenesis has been shown to involve loss of neurons and synapses,cholinergic deficits,amyloid-beta protein（Aβ）deposition,tau protein hyperphosphorylation, and neuroinflammation.

关键词： AD and the ugly in one the bad the good Putative roles of cathepsin B in Alzheimer’s disease pathology

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Role of genetics in prediction of disease course and response to therapy

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World Journal of Gastroenterology 2010年第21期16卷 2609-2615页

作者： Severine Vermeire gert Van Assche Paul Rutgeerts Department of Gastroenterology University Hospital Gasthuisberg and Catholic University LeuvenB-3000 LeuvenBelgium

The clinical course of Crohn's disease and ulcerative colitis is highly variable between patients,and this has therapeutic implications.A number of clinical features have been identified,which predict a mild or more severe ***,several of these are subjective and/or not persistent over *** the progress in genetics research in inflammatory bowel disease(IBD),genetic markers are increasingly being proposed to improve stratification of *** have the major advantage of being stable over time and not prone to subjective ***,none of the genetic variants associated with particular outcomes have shown sufficient sensitivity or specificity to have been implemented in daily *** the same line of thinking,pharmacogenetics or the study of association between variability in drug response and genetic variation has also received more attention as part of the endeavor for personalized *** ultimate goal in this area of medicine is to adapt medication to a patient's specific genetic background and therefore improve on efficacy and safety *** pharmacogenetic studies have been performed for all classes of drugs applied in IBD,few have generated consistent findings or have been *** only genetic test approved for clinical practice is thiopurine S-methyltransferase testing prior to starting treatment with thiopurine *** other reported associations have suffered from lack of confirmation or still need replication ***,the importance and necessity of pharmacogenetic studies will increase further as more therapeutic classes are being developed.

关键词： Genetics Inflammatory bowel diseases Pharmacogenetics

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A field parcel-oriented approach to evaluate the crop cover-management factor and time-distributed erosion risk in Europe

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International Soil and Water Conservation Research 2023年第1期11卷 43-59页

作者： Francis Matthews gert Verstraeten Pasquale Borrelli Panos Panagos European Commission Joint Research Centre(JRC)IspraItaly Department of Earth and Environmental Sciences KU LeuvenBelgium Department of Science Roma Tre University00146RomeItaly

The crop cover-management(C-)factor in arable landscapes describes the soil erosion susceptibility associated with seasonally cultivated *** informatic and computational limitations have led many modelling studies to prescribe C-factor values and assume spatial and temporal ***,the multiple influencing factors ranging from parcel-scale crop cultivation and management to regional-scale rainfall regimes motivates new methods to capture this variation when identifying at-risk ***,we define a multi-component method to derive the C-factor by associating time series of canopy and residue surface cover from Sentinel-2 and climate-specific rainfall erosivity with Integrated Administration and Control System(IACS)field parcel data from European Union member states.A scalable and standardised method is emphasised to increase the future interoperability and inter-comparability of soil erosion modelling studies deploying the ***,field parcel simu-lation units with associated crop declarations provide a new reference scale to link predictions of soil erosion risk with specific management decisions and declarations by *** implementing the method on a homogenised subsample of 8600 field parcels covering available IACS regions,several key findings are outlined:1)time series information provides new opportunities to predict the time-criticality of erosion in specific crop cultivations,2)the varying(a-)synchronicity between seasonal crop canopy cover and heavy rainstorms means that spatial variability is inherent within the C-factor across Europe,and 3)the addition of agricultural management practices(*** practice de-scriptions)to open-access IACS repositories can facilitate more comprehensive evaluations of the C-factor and soil erosion risk.

关键词： C-factor Soil erosion Modelling Remote sensing Crop-phenology IACS data Soil conservation Europe

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