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In vitro and in vivo proves of concept for the use of a chemically cross-linked poly(ester-urethaneurea)scaffold as an easy handling elastomeric biomaterial for bone regeneration

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Regenerative Biomaterials 2019年第6期6卷 311-323页

作者： geraldine rohman Sylvie Changotade Sophie Frasca Salah Ramtani Anne Consalus Credson Langueh Jean-Marc Collombet Didier Lutomski Universite Paris 13 Sorbonne Paris CiteTissue Engineering and Proteomics(TIP)TeamCSPBATUMR CNRS 724474 rue Marcel Cachin93000 BobignyFrance Departement Soutien Medico-Chirurgical des Forces(SMCF) BP73Institut de Recherche Biomedicale des Armees(IRBA)91223 Bretigny-sur-Orge CedexFrance UniversiteParis 13 Sorbonne Paris CiteLBPS TeamCSPBATUMR CNRS 724499 Avenue Jean-Baptiste Clement93430 VilletaneuseFrance

Bone loss can occur as a result of various pathologies,traumas and injuries and poor bone healing leads to functionally debilitating condition,loss of self-sufficiency and deterioration in life *** the increasing incidence of facial trauma and the emergence of new procedural techniques,advanced scaffolds are currently developed as substitutes for bone tissue *** this study,we investigated the capability of a chemically cross-linked e-caprolactone-based poly(esterurethane-urea)(PCLU)scaffold to support bone *** vitro assays demonstrated that PCLU scaffolds could be colonized by cells through direct cell seeding and cell migration from outside to scaffold ***,PCLU scaffolds could provide a suitable environment for stem cells proliferation in a 3D spatial arrangement,and allowed osteogenic differentiation under appropriate *** vivo results revealed the osteogenic properties of PCLU scaffolds through a drilled-hole femoral bone defect repair improvement in *** histology and microtomography analysis,we showed that PCLU scaffolds fit well the bone cavity and were eventually entrapped between the newly formed ***,no sign of inflammation or rejection was *** envision that PCLU scaffolds can provide the clinicians with a substitute having appropriate characteristics for the treatment of bone defects.

关键词： bone regeneration scaffold elastomer PEUU PCLU

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The germline genetics of mild-to-moderate penetrance:An intriguing role of PRAME in multiple carcinogenesis

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Genes & Diseases 2024年第3期11卷 7-10页

作者： Diaddin Hamdan Van Tai Nguyen Justine Paris Christophe Leboeuf Morad El Bouchtaoui Marc Espie Anne Janin geraldine Falgarone Melanie Di Benedetto Guithem Bousquet Universite de Paris Cite INSERMUMR_S942MASCOTParis F-75006France Hopital La Porte Verte Versailles F-78004France National Cancer Hospital Cancer Research and Clinical Trials CenterHaNoi100000VietNam AP-HP-Hopital Saint Louis Centre de Maladies du SeinParisF-75010France Universite Sorbonne Paris Nord Bobigny F-93000France AP-HP-Hopital Avicenne Unite de Medecine AmbulatoireBobigny F-93000France

Germline genetics of high penetrance such as BRCA genes,mutations might be sufficient for carcinogenesis,but this only explains fewer than 10%of *** assume that most cancers are the result of germline mutations of low to moderate penetrance,combined with acquired mutations due to external carcinogenic *** their accumulation over time,aging is associated with an increased risk of multiple cancer development in a given *** decades,germline genetics have been based on familial linkage studies enabling most high-penetrance genes to be *** recently,population-wide studies have led to the identification of considerable numbers of polymorphisms associated with cancer ***,most of them are of unknown functional value,thus limiting their translational application.

关键词： carcinogenesis BRCA linkage

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新马泰全部免签！为何中国游客依旧纠结东南亚之旅

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环球人文地理 2024年第5期 50-59页

作者： Clear 黄元琪 anwar Thirawatana carloscastilla GuyChan billow926 geraldine Ng Kencana Studio

如今，东南亚黄金旅游路线“新马泰”的三个国家已全部对中国游客免签。然而宣布免签后，中国游客似乎依旧犹豫，客流量不如预期。人们还愿意去东南亚旅游吗？除了飞涨的物价，争议已久的安全问题，电信诈骗、大麻合法化……游客又该如...

如今，东南亚黄金旅游路线“新马泰”的三个国家已全部对中国游客免签。然而宣布免签后，中国游客似乎依旧犹豫，客流量不如预期。人们还愿意去东南亚旅游吗？除了飞涨的物价，争议已久的安全问题，电信诈骗、大麻合法化……游客又该如何处之？东南亚，尤其黄金旅游路线“新马泰”，曾经备受中国游客欢迎。

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Effective simulation of flexible lateral boundaries in two-and three-dimensional DEM simulations

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Particuology 2008年第6期6卷 483-500页

作者： geraldine Cheung Catherine O'Sullivan Department of Civil and Environmental Engineering Imperial College London

Discrete element method （DEM） models to simulate laboratory element tests play an important role in advancing our understanding of the mechanics of granular material response, including bonded or cemented, particulate materials. Comparisons of the macro-scale response observed in a real physical test and a ＂virtual＂ DEM-simulated test can calibrate or validate DEM models. The detailed, particle scale information provided in the DEM simulation can then be used to develop our understanding of the material behaviour. It is important to accurately model the physical test boundary conditions in these DEM simulations. This paper specifically considers triaxial tests as these tests are commonly used in soil mechanics. In a triaxial test, the test specimen of granular material is enclosed within a flexible latex membrane that allows the material to deform freely during testing, while maintaining a specified stress condition. Triaxial tests can only be realistically simulated in 3D DEM codes, however analogue, 2D, biaxial DEM simulations are also often considered as it is easier to visualize particle interactions in two dimensions. This paper describes algorithms to simulate the lateral boundary conditions imposed by the latex membrane used in physical triaxial tests in both 2D and 3D DEM simulations. The importance of carefully considering the lateral boundary conditions in DEM simulations is illustrated by considering a 2D biaxial test on a specimen of frictional unbonded disks and a 3D triaxial test on a bonded （cemented） specimen of spheres. The comparisons indicate that the lateral boundary conditions have a more significant influence on the local, particle-scale response in comparison with the overall macro-scale observations.

关键词： Triaxial testing Discrete element simulations Boundary conditions

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Regulation of neuronal survival by DNA methyltransferases

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Neural Regeneration Research 2017年第11期12卷 1768-1775页

作者： Judit Symmank geraldine Zimmer Institute of Human Genetics University Hospital JenaJenaGermany

The limited regenerative capacity of neuronal cells requires tight orchestration of cell death and survival regulation in the context of longevity, age-associated diseases as well as during the development of the nervous system. Subordinate to genetic networks epigenetic mechanisms like DNA methylation and histone modifications are involved in the regulation of neuronal development, function and aging. DNA methylation by DNA methyltransferases （DNMTs）, mostly correlated with gene silencing, is a dynamic and reversible process. In addition to their canonical actions performing cytosine methylation, DNMTs influence gene expression by interactions with histone modifying enzymes or complexes increasing the complexity of epigenetic transcriptional networks. DNMTs are expressed in neuronal progenitors, post-mi- totic as well as adult neurons. In this review, we discuss the role and mode of actions of DNMTs including downstream networks in the regulation of neuronal survival in the developing and aging nervous system and its relevance for associated disorders.

关键词： DNA methyltransferase I cortical interneurons PAK6 neuronal aging neuropsychiatric diseases neurodevelopment neuronal death

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Fine-tuning of cortical progenitor proliferation by thalamic afferents

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Neural Regeneration Research 2015年第6期10卷 887-888页

作者： Katrin Gerstmann geraldine Zimmer Institute of Human Genetics Jena University HospitalFriedrich-Schiller-University Jena CGphi MC UMR CNRS 5534 University Claude Bernard Lyon

During cerebral cortical cortex neurogenesis two major types of progenitors generate a variety of morphologically and functionally diverse projection neurons destined for the different cortical layers in non-gyrified mice. Radial glia cells （RGCs） undergo mitosis in the cortical ventricular zone and exhibit an apical-basal cell polarity, whereas non-polar intermediate progenitor cells （IPCs） divide basally in the subventricular zone （Franco and Muller, 2013; Taverna et al., 2014）.

关键词： Eph Fine-tuning of cortical progenitor proliferation by thalamic afferents

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DNMT1-dependent regulation of cortical interneuron function and survival

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Neural Regeneration Research 2021年第12期16卷 2405-2406页

作者： Daniel Pensold geraldine Zimmer-Bensch RWTH Aachen University Institute for Biology IIDepartment of Functional Epigenetics in the Animal ModelAachenGermany

Increased occurrence of age-associated disabilities and neurodegenerative diseases is the price we pay for the tremendous elevation in life expectancy in our modern *** comes along with structural,neurochemical and physiological alterations in the brain that cause memory decline and cognitive impairments(Rozycka and Liguz-Lecznar,2017).Numerous factors contribute to cognitive aging including hormonal,metabolic,and immune dysregulation,elevated oxidative stress and inflammation,changes in neurotransmission,and diminished neurotrophic support of neurons(Rozycka and Liguz-Lecznar,2017).

关键词： alterations elevated function

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LHX1–a multifunctional regulator in preoptic area-derived interneuron development

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Neural Regeneration Research 2019年第7期14卷 1213-1214页

作者： Judit Symmank geraldine Zimmer-Bensch Polyclinic for Orthodontics University Hospital Jena Department of Functional Epigenetics in the Animal Model Institute for Biology ⅡRWTH Aachen University

In the cerebral cortex,local inhibition is achieved by different types of gamma-aminobutyric(GABA)-expressing interneurons,representing essential key players of cortical information processing(Marin,2012).Their development has to be highly orchestrated to ensure proper numbers and subtype composition in the adult cortex and defects in interneuron development contribute to the pathophysiology of psychiatric diseases(Marin,2012).

关键词： cerebral cortex different types gamma-aminobutyric

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Feminine and Masculine Dimensions of Feminist Thought and Transcultural Modernism in Republican China

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2014年第1期8卷 101-125页

作者： geraldine Fiss Departement of East Asian Languages and Cultures University of Southern California LosAngeles CA 90089 USA

This study examines critical essays and imaginative fiction by three key writers of the Republican period： Mao Dun, Ba Jin and Lu Yin. I argue that, while Mao Dun and Ba Jin fuse elements of classical Chinese and modem Western sources so as to create strong heroines and a critique of ＂new men＂ for the purpose of revolutionary cultural and national reform, Lu Yin foregrounds an inward examination of the self, multiple narrative points of view and a dialogical perspective which fuses her protagonists＇ interior consciousness with external reality as well as other characters＇ streams of feeling and thought. My reading of Lu Yin＇s texts reveals that she not only succeeds in bringing communion and solace to her readers but also creates ＂moments of being,＂ markedly similar to Virginia Woolf＇s modernist aesthetics and Walter Benjamin＇s mosaic-like ＂moments of recognition,＂ which allow her characters to perceive ＂wholeness＂ from fragmentary flashes of understanding. These intense moments of awareness enhance Lu Yin＇s dialogic imagination and enable her to create discursive feminine narratives that convey the full complexity of women＇s consciousness while simultaneously resisting the male realist literary discourse and strengthening her feminist-activist agenda in the national public sphere.

关键词： Chinese feminism feminine modernism masculine feminist discourse transcultural modernism New woman Mao Dun Ba Jin Lu Yin

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Tuberculous otitis media in an adult in a primary care setting:A case report

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Asian Pacific Journal of Tropical Medicine 2010年第9期3卷 754-756页

作者： Paul O Dienye geraldine U Ndukwu Department of Family Medicine University of Port Harcourt Teaching HospitalPort HarcourtNigeria

Tuberculous otitis media is a rare disease,hence not often considered in the differential diagnosis of *** results in late diagnosis with resulting complications such as irreversible hearing loss.A case report with review of the literature is presented,emphasizing that tuberculosis should be considered in the differential diagnosis of otorrhea not responding to commonly prescribed *** also emphasize the importance of awareness creation in the management of such a disease,involving family members to oversee treatment and also research on ways of shortening duration of treatment to avoid default in treatment.

关键词： Tuberculosis Otitis media Deafness Default

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