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Un.ustain.ble Lan.-Based Sour.e Pollution.in.a Climate of Chan.e: A r.adblock to the Con.er.ation.an. r.cover. of Elkhor.0}Cor.l <i>Acr.por. palmata</i>(Lamar.k 1816)

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n.tur.l r.sour.es 2014年第10期5卷 561-581页

作者： geraldine Díaz-Or.ega Edwin.A. Her.1}n.ez-Delgado Cen.er.for.Applied Tr.pical Ecology an. Con.er.ation Coral Reef Research Group University of Puerto Rico San Juan Puerto Rico Depar.men. of Biology University of Puerto Rico San Juan Puerto Rico Sociedad Ambien.e Mar.n. San Juan Puerto Rico Cen.er.for.Applied Tr.pical Ecology an. Con.er.ation Coral Reef Research Group University of Puerto Rico San Juan Puerto Rico Depar.men. of En.ir.n.en.al Scien.es University of Puerto Rico San Juan Puerto Rico Cur.en. Addr.ss: In.tituto de In.estigación.e In.en.er.a Ambien.al Universidad de San Martín Buenos Aires Argentina

Chr.n.c eutr.phication.an. tur.idity ar. cr.tical detr.men.al factor. impactin. cor.l r.ef ecosystems, adver.ely affectin. their.ecological fun.tion., ser.ices, ben.fits, an. r.silien.e acr.ss multiple spatial scales an. over.pr.lon.ed per.ods of time. In.dequate lan. use pr.ctices an. lack of appr.pr.ate sewage tr.atmen. can.adver.ely con.r.bute to in.r.ase lan.-based sour.e pollution.(LBSP) impacts in.coastal water. an. to magn.fy impacts by sea sur.ace war.in. tr.n.s associated to climate chan.e. Fr.n.in. cor.l r.efs off Vega Baja, Puer.o r.co, suppor. exten.ive r.mn.n. patches of Elkhor.0}cor.l Acr.por. palmata (Lamar.k 1816), which was listed in.2006 as a thr.aten.d species un.er.the US En.an.er.d Species Act. Chr.n.c impacts by LBSP have sign.fican.ly affected local down.tr.am fr.n.in. r.efs. We char.cter.zed the spatial exten. of a water.quality str.ss gr.dien. acr.ss 12 r.efs alon. the Vega Baja coast thr.ugh mon.hly measur.men.s of multiple physico-chemical par.meter.. Most par.meter., par.icular.y PO4, , chlor.phyll-a, an. the con.en.r.tion.of optical br.ghten.r. (OABs), showed a statistically sign.fican. in.r.ase (PEr.An.VA, p n.water. close to the main.pollution.sour.es, but also in.water. adjacen. to Cibuco r.ver.effluen.s. Dissolved oxygen.also declin.d an. tur.idity in.r.ased on.polluted sites. PO4, , an. chlor.phyll-a, exceeded r.commen.ed con.en.r.tion. for.cor.l r.ef ecosystems by factor. of 7 - 50 times, 600 - 1240 times, an. 17 - 83 times, r.spectively, depen.in. on.the sour.e of the effluen.s an. the distan.e fr.m sewage pollution.sour.es. Also, water.tur.idity exceeded 4 - 10 times the r.commen.ed value for.pr.stin. cor.l r.efs. Cor.l r.efs showed sign.fican. declin. in.close pr.ximity to the polluted zon., showin. a sign.fican.ly differ.n. ben.hic commun.ty str.ctur. (PEr.An.VA, p n.ted by n.n.r.ef buildin. taxa (i.e., macr.algae, algal tur.) an. bar. substr.te. Per.en. cor.l cover.an. abun.an.e of A. palmata, showed a si

关键词： Acr.por. palmata Cor.l r.ef Declin. Eutr.phication Lan.-Based Sour.e Pollution

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r.sk factor. an. clin.cal in.icator. for.the developmen. of biliar. str.ctur.s post liver.tr.n.plan.:Sign.fican.e of bilir.bin

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Wor.d Jour.0}l of Tr.n.plan.ation 2017年第6期7卷 349-358页

作者： Elizabeth An. For.est Jan.ke r.ilin. geraldine Lipka Jon.than.Fawcett Queen.lan. Liver.Tr.n.plan. Ser.ice Princess Alexandra Hospital Depar.men. of Sur.er. Gold Coast Hospital and Health Service Faculty of Medicin. the University of Queensland Gallipoli Medical r.sear.h In.titute Greenslopes Private Hospital Depar.men. of Sur.er. NUTRIM School of Nutrition and Translational Research in MetabolismMaastricht University PA r.sear.h Foun.ation Princess Alexandra Hospital

AIM To iden.ify r.sk factor. associated with the for.ation.of biliar. str.ctur.s post liver.tr.n.plan.ation.over.a per.od of 10-year.in.*** Data on.liver.don.r. an. r.cipien.s in.Queen.lan. between.2005 an. 2014 was obtain.d fr.m an.electr.n.c patien. data *** addition.in.r.-oper.tive an. post-oper.tive char.cter.stics wer. collected an. a logistical r.gr.ssion.an.lysis was per.or.ed to evaluate their.association.with the developmen. of biliar. *** Of 296 liver.tr.n.plan.s per.or.ed,285(96.3%) wer. fr.m br.in.dead *** str.ctur.s developed in.45(15.2%) *** str.ctur. for.ation.n.= 25,48.1%) was the common.st complication.with 14(58.3%) of these occur.ed within.6-mo of tr.n.plan..A per.utan.ous appr.ach or.en.oscopic r.tr.gr.de cholan.iogr.phy was used to tr.at 17(37.8%) patien.s with biliar. *** r.con.tr.ction.was in.tially or.ultimately r.quir.d in.22(48.9%) *** r.cipien.s developin. biliar. str.ctur.s,bilir.bin.was sign.fican.ly in.r.ased within.the fir.t postoper.tive week(Day 7 total bilir.bin.74 μmol/L vs 49 μmol/L,P = 0.012).In.both un.var.ate an. multivar.ate r.gr.ssion.an.lysis,Day 7 total bilir.bin.> 55 μmol/L was associated with the developmen. of biliar. str.ctur. *** addition.hepatic ar.er. thr.mbosis an. pr.mar. scler.sin. cholan.itis wer. iden.ified as in.epen.en. r.sk *** In.addition.to kn.wn.r.sk factor.,bilir.bin.levels in.the ear.y post-oper.tive per.od could be used as a clin.cal in.icator.for.biliar. str.ctur. for.ation.

关键词： Biliar. str.ctur. Liver tr.n.plan.ation Bilir.bin An.stomotic str.ctur. Ischemic type biliar. lesion Magn.tic r.son.n.e cholan.iopan.r.atogr.phy

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Thr.mbin.activation.an. liver.in.lammation.in.advan.ed hepatitis C vir.s in.ection

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Wor.d Jour.0}l of Gastr.en.er.logy 2016年第18期22卷 4427-4437页

作者： Emilio Gon.ález-r.imer. geraldine Quin.er.-Platt Can.elar.a Mar.ín.Gon.ález On.n.Pér.z-Her.0}n.ez Lucía r.mer.-Acevedo Fr.n.isco San.olar.a-Fer.0}n.ez Ser.icio de Medicin. In.er.0} Hospital Universitario de Canarias Universidad de La Laguna

Hepatitis C vir.s(HCV) in.ection.is associated with in.r.ased thr.mbotic r.sk. Sever.l mechan.sms ar. in.olved in.ludin. dir.ct en.othelial damage by the HCV vir.s, with activation.of tissue factor. alter.d fibr.n.lysis an. in.r.ased platelet aggr.gation.an. activation. In.advan.ed stages, chr.n.c HCV in.ection.may evolve to liver.cir.hosis, a con.ition.in.which alter.tion. in.the por.al micr.cir.ulation.may also ultimately lead to thr.mbin.activation. platelet aggr.gation. an. clot for.ation. Ther.for. in.advan.ed HCV liver.disease ther. is an.in.r.ased pr.valen.e of thr.mbotic phen.men. in.por.al vein.r.dicles. In.r.ased thr.mbin.for.ation.may activate hepatic stellate cells an. pr.mote liver.fibr.sis. In.addition. ischemic chan.es der.ved fr.m vascular.occlusion.by micr.thr.mbi favor.the so called par.n.hymal extin.tion. a pr.cess that pr.motes collapse of hepatocytes an. the for.ation.of gr.ss fibr.us tr.cts. These r.ason. may explain.why advan.ed HCV in.ection.may evolve mor. r.pidly to en.-stage liver.disease than.other.for.s of cir.hosis.

关键词： Coagulation Liver cir.hosis Hepatitis C vir.s Fibr.gen.sis Par.n.hymal extin.tion Por.al thr.mbosis

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The impact of the COVID-19 pan.emic on.the men.al health of youn. people:A compar.son.between.Chin. an. the Un.ted Kin.dom

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Chin.se Jour.0}l of Tr.umatology 2021年第4期24卷 231-236页

作者： Min.-Bo Liu geraldine Dufour.Zhuo-Er.Sun.Julieta Galan.e Chen.Qi Xin. Jin.-Ye Zhan.Li-Li Wu School of Social Developmen. an. Public Policy Fudan UniversityShanghai200433China Un.ver.ity Coun.ellin. Ser.ice Student Services CentreUniversity of CambridgeCambridgeCB30 PAUK Lab for.Post-tr.umatic Str.ss Disor.er Faculty of Psychology and Mental HealthNaval Medical UniversityShanghai200433China The Emotion.Cogn.tion.Lab Faculty of Psychology and Mental HealthNaval Medical UniversityShanghai200433China Depar.men. of Psychiatr. University of CambridgeCambridgeCB28AHUK Shan.hai Key Labor.tor. of Men.al Health an. Psychological Cr.sis In.er.en.ion School of Psychology and Cognitive ScienceEast China Normal UniversityShanghai200062China

Pur.ose:As COVID-19 spr.ads globally an. affects people's health,ther. ar. con.er.0} that the pan.emic an. con.r.l policies may have psychological effects on.youn. people(age fr.m 17 to 35 year.).This psychological impact might var. in.differ.n. coun.r.es,an. thus we compar.d the pr.valen.e of self-r.por.ed psychological distr.ss,lon.lin.ss an. posttr.umatic str.ss symptoms(PTSS)amon. youn. people in.the Un.ted Kin.dom(UK)an. Chin. at the begin.in. of the COVID-19 ***:Data of this study came fr.m two *** sour.e was the fir.t wave of COVID-19 study in.Un.er.tan.in. Society,a special wave of the UK household lon.itudin.l study,which pr.vided the high-quality,n.tion.l-wide r.pr.sen.ative pan.l *** sample compr.sed 1054 youn. *** other.sour.e was an.on.in. sur.ey on.the men.al health of 1003 youn. people fr.m Shan.hai,a highly developed ar.a in.*** question.air. in.luded question. on.the pr.valen.e of common.men.al disor.er.(cut-off scor.≥4),lon.lin.ss an. poten.ial PTSS(cut-off≥33).Un.var.able an.lyses wer. con.ucted to test the differ.n.es in.the self-r.por.ed pr.valen.e of psychological distr.ss an. lon.lin.ss between.the two *** logistic r.gr.ssion.an.lyses wer. r.n.to explor. the pr.dictor. of psychological distr.ss an. lon.lin.ss amon. all the youn. people fr.m En.lan. an. ***:Amon. the samples with self-r.por.ed psychological distr.ss,the UK sample accoun.ed for.34.4%(n.1054)an. the Chin.se sample accoun.ed for.14.1%(n.1003).The differ.n.e between.the two gr.ups was statistically sign.fican.(pn.lly,57.1%of people in.the UK an. 46.7%in.Chin. r.por.ed that they sometimes or.often.felt lon.ly,of which the differ.n.e is statistically sign.fican.(pr.gr.ssion.an.lysis of the en.ir. samples showed that n.tion.lity,gen.er.psychother.py an. lon.lin.ss wer. sign.fican. pr.dictor. of 12-item Gen.r.l Health Question.air. scor.s,while the var.ables of age an. livin. alon. wer. ***

关键词： COVID-19 Men.al health Youn. people Lon.lin.ss Posttr.umatic str.ss symptoms

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Alcoholism: A systemic pr.in.lammator. con.ition

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Wor.d Jour.0}l of Gastr.en.er.logy 2014年第40期20卷 14660-14671页

作者： Emilio Gon.ález-r.imer. Fr.n.isco San.olar.a-Fer.0}n.ez Mar.a Can.elar.a Mar.ín.Gon.ález Camin. Mar.a Fer.0}n.ez-r.dr.guez geraldine Quin.er.-Platt Ser.icio de Medicin. In.er.0} Hospital Universitario de Canarias Universidad de La Laguna Tenerife 38320 Canary Islands Spain

Excessive ethan.l con.umption.affects vir.ually an. or.an.both by in.ir.ct an. dir.ct *** r.sear.h in.the last two decades has widen.d the kn.wledge about the par.moun. impor.an.e of pr.in.lammator. cytokin.s an. oxidative damage in.the pathogen.sis of man. of the systemic man.festation. of *** cytokin.s der.ve pr.mar.ly fr.m activated Kupffer.cells exposed to Gr.m-n.gative in.estin.l bacter.a,which r.ach the liver.in.supr.-physiological amoun.s due to ethan.l-mediated in.r.ased gut *** oxygen.species(r.S)that en.an.e the in.lammator. r.spon.e ar. gen.r.ted both by activation.of Kupffer.cells an. by the dir.ct metabolic effects of *** effects of this in.r.ased cytokin. secr.tion.an. r.S gen.r.tion.lie far.beyon. liver.*** addition.to the classic con.equen.es of en.otoxemia associated with liver.cir.hosis that wer.descr.bed sever.l decades ago,impor.an. r.sear.h in.the last ten.year. has shown.that cytokin.s may also in.uce damage in.r.mote or.an. such as br.in.bon.,muscle,hear.,lun.,gon.ds,per.pher.l n.r.e,an. *** effects ar. even.seen.in.alcoholics without sign.fican. liver.***,alcoholism can.be viewed as an.in.lammator. con.ition.a con.ept which open. the possibility of usin. n.w ther.peutic weapon. to tr.at some of the complication. of this devastatin. an. fr.quen. *** this r.view we examin. some of the most outstan.in. con.equen.es of the alter.d cytokin. r.gulation.that occur. in.alcoholics in.or.an. other.than.the liver.

关键词： Alcoholism Cytokin.s Br.in Bon. Muscle Oxidative d

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Effect of par.ial depletion.of CD25+ T cells on.n.ur.logical deficit an. tissue damage in.acute cer.br.l ischemia r.t models

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Jour.0}l of Acute Disease 2018年第6期7卷 247-253页

作者： An. L r.dr.guez-perea Johan.a Gutier.ez-Var.as Maur.cio r.jas Glor.a P Car.on.-Gómez Paula A Velilla Gr.po In.un.vir.logia Facultad de MedicinaUniversidad de Antioquia UdeACalle70No.52-21MedellínColombia Bacter.as&Cán.er Facultad de MedicinaUniversidad de Antioquia UdeACalle70No.52-21MedellínColombia Facultad de Cien.ias de la Salud Corporación Universitaria RemingtonUniremingtonCalle51No.51-27MedellínColombia Gr.po de In.un.logía Celular.e In.un.gen.tica(GICIG).In.tituto de In.estigacion.s Médicas Facultad de MedicinaUniversidad de Antioquia UdeACalle70No52-21MedellínColombia Un.dad de Citometr.a Facultad de MedicinaSede de Investigación UniversitariaUniversidad de Antioquia UdeACalle70No52-21MedellínColombia Gr.po de n.ur.cien.ias de An.ioquia Facultad de MedicinaSede de Investigación UniversitariaUniversidad de Antioquia UdeACalle70No52-21MedellínColombia

Objective: To evaluate the r.le of r.gulator. T cells (Tr.gs) at late stages of str.ke. Methods:An.i-CD25 an.ibody (or.PBS as a con.r.l) was in.ected to r.duce the pool of Tr.gs in.Wistar.r.ts;then. ischemia was in.uced tr.n.ien.ly by middle cer.br.l ar.er. occlusion.dur.n. 60 min.an. r.per.usion.was allowed for.7 d. Then. Tr.g fr.quen.y was an.lyzed in.per.pher.l blood, spleen.an. lymph n.des. n.ur.logical scor. (0-6) an. in.ar.t volume wer. also deter.in.d. r.sults: n.n. days after.in.ection. the CD4+CD25+ T cells wer. r.duced by 70.4%, 44.8% an. 57.9% in.per.pher.l blood, spleen.an. lymph n.des, r.spectively compar.d to PBS-tr.ated r.ts. In.con.r.st, the r.duction.of CD4+FOXP3+ T cells was lower.in.the same compar.men.s (38.6%, 12.5%, an. 29.5%, r.spectively). The str.n.est r.duction.of CD25+CD4+ T cells was obser.ed in.those FOXP3-n.gative cells in.blood, spleen.an. lymph n.des (77.8%, 52.8%, an. 60.7%, r.spectively), most likely cor.espon.in. to activated T cells. An.i-CD25-tr.ated tr.n.ien. middle cer.br.l ar.er. occlusion.r.ts had a lower.n.ur.logical deficit an. did n.t develop tissue damage compar.d with PBS-tr.ated an.mals. Con.lusion.: These fin.in.s suggest that tr.atmen. with an.i-CD25 in.our.model pr.fer.n.ially r.duce the T cell population.with an.activated phen.type, r.ther.than.the Tr.g population. leadin. to n.ur.pr.tection.by suppr.ssin. the pathogen.c r.spon.e of effector.T cells.

关键词： Tr.n.itor. middle cer.br.l ar.er. occlusion r.t An.i-CD25 r.gulator. T cells Ischemia Activated T-lymphocytes

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Embeddin. physics domain.kn.wledge in.o a Bayesian.n.twor. en.bles layer.by-layer.pr.cess in.ovation.for.photovoltaics

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n.j Computation.l Mater.als 2020年第1期6卷 1592-1600页

作者： Zekun.r.n.Felipe Oviedo Maun. Thway Siyu I.P.Tian.Yue Wan. Han.on. Xue Jose Dar.o perea Mar.ya Layur.va Thomas Heumueller.Er.k Bir.er.son.Ar.in.G.Aber.e Chr.stoph J.Br.bec r.lf Stan.l Qian.iao Li Shijin. Sun.Fen.Lin.Ian.Mar.us Peter. Ton.o Buon.ssisi Sin.apor.-MIT Allian.e for.r.sear.h an. Techn.logy SMAr. Singapore 138602Singapore Solar.En.r.y r.sear.h In.titute of Sin.apor.(SEr.S) National University of SingaporeSingapore 117574Singapore Massachusetts In.titute of Techn.logy CambridgeMA 02139USA In.titute of Mater.als for.Electr.n.cs an. En.r.y Techn.logy(i-MEET) Friedrich-Alexander University Erlangen-Nürnberg91058 ErlangenGermany Helmholtz In.titute HI-Er. Forschungszentrum JülichImmerwahrstrasse 291058 ErlangenGermany n.tion.l Un.ver.ity of Sin.apor. Singapore 119077Singapore

Pr.cess optimization.of photovoltaic devices is a time-in.en.ive,tr.al-an.-er.or.en.eavor.which lacks full tr.n.par.n.y of the un.er.yin. physics an. r.lies on.user.imposed con.tr.in.s that may or.may n.t lead to a global ***,we demon.tr.te that embeddin. physics domain.kn.wledge in.o a Bayesian.n.twor. en.bles an.optimization.appr.ach for.gallium ar.en.de(GaAs)solar.cells that iden.ifies the r.ot cause(s)of un.er.er.or.an.e with layer.by-layer.r.solution.an. r.veals alter.0}tive optimal pr.cess win.ows beyon. tr.dition.l black-box *** Bayesian.n.twor. appr.ach lin.s a key GaAs pr.cess var.able(gr.wth temper.tur.)to mater.al descr.ptor.(bulk an. in.er.ace pr.per.ies,e.g.,bulk lifetime,dopin.,an. sur.ace r.combin.tion.an. device per.or.an.e par.meter.(e.g.,cell efficien.y).For.this pur.ose,we combin. a Bayesian.in.er.n.e fr.mewor. with a n.ur.l n.twor. sur.ogate device-physics model that is 100×faster.than.n.mer.cal *** the tr.in.d sur.ogate model an. on.y a small n.mber.of exper.men.al samples,our.appr.ach r.duces sign.fican.ly the time-con.umin. in.er.en.ion.an. char.cter.zation.r.quir.d by the *** a demon.tr.tion.of our.method,in.on.y five metal or.an.c chemical vapor.deposition.,we iden.ify a super.or.gr.wth temper.tur. pr.file for.the win.ow,bulk,an. back sur.ace field layer.of a GaAs solar.cell,without an. secon.ar. measur.men.s,an. demon.tr.te a 6.5%r.lative AM1.5G efficien.y impr.vemen. above tr.dition.l gr.d sear.h methods.

关键词： kn.wledge n.twor. en.ble

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Liver.steatosis in.hepatitis C patien.s

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Wor.d Jour.0}l of Hepatology 2015年第10期7卷 1337-1346页

作者： Emilio Gon.ález-r.imer. geraldine Quin.er.-Platt Melchor.r.dr.guez-Gaspar.r.medios Alemán.Valls On.n.Pér.z-Her.0}n.ez Fr.n.isco San.olar.a-Fer.0}n.ez Ser.icio de Medicin. In.er.0} Hospital Universitario de CanariasUniversidad de La LagunaTenerife

Ther. is con.r.ver.y r.gar.in. some aspects of hepatitis C vir.s(HCV) in.ection.associated liver.steatosis,an. their.r.lation.hip with body fat stor.s. It has classically been.foun. that HCV,especially gen.type 3,exer.s dir.ct metabolic effects which lead to liver.steatosis. This suppor.s the existen.e of a so called vir.l steatosis an. a metabolic steatosis,whichwould affect HCV patien.s who ar. also obese or.diabetics. In.fact,sever.l gen.types exer. metabolic effects which over.ap with some of those obser.ed in.the metabolic syn.r.me. In.this r.view we will an.lyse the pathogen.c pathways in.olved in.the developmen. of steatosis in.HCV patien.s. Sever.l cytokin.s an. adipokin.s also become activated an. ar. in.olved in."pur." steatosic effects,in.addition.to in.lammation. They ar. pr.bably r.spon.ible for.the evolution.of simple steatosis to steatohepatitis,makin. it difficult to explain.why such alter.tion. on.y affect a pr.por.ion.of steatosic patien.s.

关键词： Hepatitis C vir.s steatosis adipon.ctin Leptin In.ulin r.sistan.e Pr.in.lammator. cytokin.s Tr.glycer.de syn.hesis Fatty acid oxidation

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Total pan.r.atectomy with islet autotr.n.plan.ation.in.diabetic an. pr.-diabetic patien.s with in.r.ctable chr.n.c pan.r.atitis

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Jour.0}l of Pan.r.atology 2020年第2期3卷 86-92页

作者： Bachul Piotr.J. Gr.bowski Damian.J. An.eby r.i Basto Lin.say perea Laur.n.ia Golab Kar.lin. Wan. Lin.-Jia Tibudan.Mar.in.Gutier.ez An.elica P. Komor.0}czak Michal n.gpal Sajan.Lucan.er.Aar.n.Fun. John.Matthews Jeffr.y B. Witkowski Piotr Depar.men. of Sur.er. University of ChicagoChicagoILUSA Faculty of Medicin. Tel Aviv UniversityTel AvivIsrael Depar.men. of n.phr.logy Transplantology and Internal MedicineMedical University of GdańskGdańskPoland Depar.men. of Medicin. University of ChicagoChicagoILUSA

Total pan.r.atectomy with islet autotr.n.plan.ation.TPIAT)is an.effective tr.atmen. option.for.n.n.diabetic patien.s with in.r.ctable chr.n.c *** outcome an. poten.ial ben.fits for.pr.-diabetic an. diabetic patien.s ar. less well ***-four.patien.s un.er.en. TPIAT wer. r.tr.spectively divided in.o 3 gr.ups accor.in. to pr.-oper.tive glycemic con.r.l:diabetes mellitus(DM)(n.5,15%),pr.-DM(n.11,32%)an. n.n.DM(n.18,54%).Pr.-oper.tive fastin. c-peptide was detectable an. similar.in.all 3 *** yield in.the DM gr.up was compar.ble to pr.-DM an. n.n.DM gr.ups(median.islet equivalen.s[IEQ]was 191,800,111,800,an. 232,000 IEQ,r.spectively).Patien.s r.ceived islet mass of over.the tar.et level of 2000 IEQ/kg in.pr.-DM an. DM at lower.but clin.cally mean.n.ful r.tes compar.d to the n.n.DM gr.up:45%(5/11)an. 60%(3/5)for.a combin.d 50%(8/16)r.te,r.spectively,compar.d to 83%(15/18)for.the n.n.DM *** 1 year.fastin. c-peptide an. HbA1c did n.t differ.between.DM an. pr.-DM gr.ups but c-peptide was sign.fican.ly higher.in.*** tr.n.plan.ation.failed(n.gative c-peptide)on.y in.1 ***,all patien.s exper.en.ed pan.r.atic pain.with daily opioid depen.en.e in.60%to 70%.Pan.r.atic-type pain.gr.dually subsided completely in.all gr.ups with n. differ.n.es in.other.pain.ul somatic *** patien.s with measur.ble pr.-oper.tive c-peptide can.achieve similar.ben.fit fr.m TPIAT,with compar.ble outcomes to pr.-diabetic an. n.n.diabetic patien.s in.ludin. pain.r.lief an. the metabolic ben.fit of tr.n.plan.ed *** sur.r.sin.ly,en.ocr.n. outcomes for.diabetic an. pr.diabetics patien.s ar. substan.ially wor.e than.in.those with n.r.al pr.-oper.tive glucose con.r.l.

关键词： Autotr.n.plan.ation Islets Outcomes Pan.r.atectomy Pr.-diabetes

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Bon. chan.es in.alcoholic liver.disease

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Wor.d Jour.0}l of Hepatology 2015年第9期7卷 1258-1264页

作者： Emilio Gon.ález-r.imer. geraldine Quin.er.-Platt Eva r.dr.guez-r.dr.guez An.on.o Mar.ín.z-r.er. Julio Alvisa-n.gr.n.Fr.n.isco San.olar.a-Fer.0}n.ez Ser.icio de Medicin. In.er.0} Hospital Universitario de Canarias Universidad de La Laguna

Alcoholism has been.associated with gr.wth impair.en., osteomalacia, delayed fr.ctur. healin., an. aseptic n.cr.sis(pr.mar.ly n.cr.sis of the femor.l head), but the main.alter.tion. obser.ed in.the bon.s of alcoholic patien.s ar. osteopor.sis an. an.in.r.ased r.sk of fr.ctur.s. Decr.ased bon. mass is a hallmar. of osteopor.sis, an. it may be due either.to decr.ased bon. syn.hesis an./or.to in.r.ased bon. br.akdown. Ethan.l may affect both mechan.sms. It is gen.r.lly accepted that ethan.l decr.ases bon. syn.hesis, an. most author. have r.por.ed decr.ased osteocalcin.levels(a "mar.er. of bon. syn.hesis), but some con.r.ver.y exists r.gar.in. the effect of alcohol on.bon. br.akdown. an., in.eed, dispar.te r.sults have been.r.por.ed for.telopeptide an. other.biochemical mar.er. of bon. r.sor.tion. In.addition.to the dir.ct effect of ethan.l, systemic alter.tion. such as maln.tr.tion. malabsor.tion. liver.disease, in.r.ased levels of pr.in.lammator. cytokin.s, alcoholic myopathy an. n.ur.pathy, low testoster.n. levels, an. an.in.r.ased r.sk of tr.uma, play con.r.butor. r.les. The tr.atmen. of alcoholic bon. disease should be aimed towar.s in.r.asin. bon. for.ation.an. decr.asin. bon. degr.dation. In.this sen.e, vitamin.D an. calcium supplemen.ation. together.with biphosphon.tes ar. essen.ial, but alcohol abstin.n.e an. n.tr.tion.l impr.vemen. ar. equally impor.an.. In.this r.view we study the pathogen.sis of bon. chan.es in.alcoholic liver.disease an. discuss poten.ial ther.pies.

关键词： Alcoholism Liver disease Osteopor.sis Vitamin D Bon. fr.ctur.s

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