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Validation and Comparison of Two Calibration Methods for the Measurement of Stable Iodine in the Urinary Matrix by ICP-MS:Standard Addition *** Calibration

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American Journal of Analytical Chemistry 2017年第4期8卷 245-263页

作者： geraldine Landon Celine Bouvier-Capely Alexandre Legrand Thibaud Sontag Gregory Finance Mailie Saint-Hilaire Francois Rebiere Xavier Millot Valerie Renaud-Salis Michelle Agarande Institute for Radiological Protection and Nuclear Safety(IRSN) Fontenay-aux-RosesFrance The French Alternative Energies and Atomic Energy Commission(CEA) Gif-sur-YvetteFrance

Background: In the context of a nuclear reactor accident, thyroid is the main target organ of radioactive iodines. To avoid as much as possible thyroid disorders or even cancer development, it is recommended to administer a single dose of potassium iodide to people at risk of exposure. Nevertheless, the Fukushima Dai-ichi disaster has pointed out many questions about the conditions of stable iodine prophylaxis implementation highlighting the need for reflection further revision of the actual “iodine doctrine”. Therefore, providing useful data is required notably through the implementation of animal experiments to strengthen current knowledge and to edit new recommendations. Methods: Urinary iodine constitutes a very good indicator to investigate the function of thyroid, its interpretation demands reliable analyses. Prior to perform animal experiments, two calibration methods were designed by our lab and compared together (standard addition and external calibration) to assess the urinary concentration of stable iodine in urine by ICP-MS. They were validated based on several key parameters especially linearity, accuracy and limits of detection (LOD) and quantification (LOQ). Results: The results were nicely satisfying. Indeed, both calibration methods have indicated very good coefficients of correlations, accuracies with low expanded relative uncertainties were obtained. The estimated LOD in the sample for standard addition method and external calibration were fully acceptable, 0.39 μg·L-1 and 0.35 μg·L-1, respectively. All performance criteria have been thus fulfilled successfully. The established methods were proven to be accurate, robust and sensitive. Once validated, both calibration methods were applied to rat urine samples and the results of z-score and Wilcoxon W test concluded that there were no statistically significant differences between both methods.

关键词： Stable Iodine Urine Standard Addition External Calibration Validation

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探地雷达检测混凝土内含水量梯度

无损检测 2017年第10期39卷 17-20,23页

作者：肖小汀田贵云高斌 geraldine Villain XAVIER Derobert 电子科技大学自动化工程学院成都611731 IFSTTAR研究所布格奈44344

由于水分是引起混凝土劣化的主要原因之一,混凝土含水量的检测问题也成为近年来的研究热点。利用材料的毛细管效应设计了一个吸水试验装置来模拟混凝土中的水分传递。其主要目的是通过电磁(EM)导波监测水分在混凝土板中随时间的变化过... 详细信息

由于水分是引起混凝土劣化的主要原因之一,混凝土含水量的检测问题也成为近年来的研究热点。利用材料的毛细管效应设计了一个吸水试验装置来模拟混凝土中的水分传递。其主要目的是通过电磁(EM)导波监测水分在混凝土板中随时间的变化过程。混凝土的渗吸试验中使用了新的经验模型arctan(x),且以γ射线的测量结果作为试验的参考数据。结果显示,融合使用多层波导(WG)模型和探地雷达(GPR)检测,可以有效估计混凝土板的内部梯度曲线。

关键词：探地雷达混凝土含水量梯度波导

家庭病床模式下社区患者敏锐度评估工具的研究进展

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上海护理 2023年第4期23卷 34-37页

作者：王喜益 LEE geraldine 许莉白子璇宋安泰上海交通大学护理学院上海200025 伦敦国王学院英国伦敦SE18WA 上海交通大学医学院附属仁济医院上海200127

文章综述了国内外医疗系统在家庭病床模式下用于量化社区患者敏锐度的评估工具研究及应用进展,并探讨了对我国患者敏锐度评估工具研究的启示。后续研究可在借鉴国外评估工具的基础上,发展适合我国国情的评估工具,以促进我国医院-社区-... 详细信息

文章综述了国内外医疗系统在家庭病床模式下用于量化社区患者敏锐度的评估工具研究及应用进展,并探讨了对我国患者敏锐度评估工具研究的启示。后续研究可在借鉴国外评估工具的基础上,发展适合我国国情的评估工具,以促进我国医院-社区-家庭照护效率提升。

关键词：社区家庭病床居家护理患者敏锐度评估工具

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为患者提供用药信息应该更为可及并以患者为中心

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英国医学杂志中文版 2006年第1期9卷 5-6页

作者： Joanne M Shaw geraldine Mynors 李小飞（译）张拓红（校）不详 Medicines Partnership London SE1 7JN Caroline Kelham project manager Medicines Partnership London SE1 7JN

医患沟通用药信息的传统模式是医生决定最佳治疗方案,而患者只能遵从医生的指导,自己单独获得治疗信息的途径极为有限。英国制药工业协会(ABPI)现正在反思自己的实践准则,这对于构建一种更现代的患者观无疑是一次重要的机会,即在遇到与... 详细信息

医患沟通用药信息的传统模式是医生决定最佳治疗方案,而患者只能遵从医生的指导,自己单独获得治疗信息的途径极为有限。英国制药工业协会(ABPI)现正在反思自己的实践准则,这对于构建一种更现代的患者观无疑是一次重要的机会,即在遇到与自己健康有关的问题时,患者应该作为医学专家的合作者和最终决定者。准则的主要目标应该是保护患者免受可能出现的伤害性影响。而目前该准则却主要关注规范制药工业和医学专家之间的交流,高度限制和患者间的直接沟通。这种模式可谓大错特错。[第一段]

关键词：以患者为中心用药信息最佳治疗方案医学专家医患沟通直接沟通伤害性医生制药工业

晚期Luminal(HER2阴性)型乳腺癌患者的MDT诊疗

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实用肿瘤杂志 2018年第6期33卷 502-509页

作者：曹文明邓雪英陈波杜向慧陈占红郑亚兵 Hope Rugo geraldine M.Jacobson 郑鸿钧王晓稼浙江省肿瘤医院乳腺癌MDT团队浙江杭州310022 卡罗尔·法郎巴克乳腺中心加州大学旧金山分校医学院美国加利福尼亚州旧金山94115 西弗吉尼亚大学放射肿瘤科美国西弗吉尼亚州摩根城26506 台湾和信治癌中心医院放射治疗部中国台湾地区台北112

本文介绍1例激素受体阳性、人表皮生长因子受体-2(human epidermal growth factor receptor-2,HER2)阴性晚期乳腺癌多线内分泌治疗的多学科诊疗过程。该病例有较长的无瘤生存期(10年),初始复发转移肿瘤分布范围广,涉及两肺多发、多处骨... 详细信息

本文介绍1例激素受体阳性、人表皮生长因子受体-2(human epidermal growth factor receptor-2,HER2)阴性晚期乳腺癌多线内分泌治疗的多学科诊疗过程。该病例有较长的无瘤生存期(10年),初始复发转移肿瘤分布范围广,涉及两肺多发、多处骨骼及颈部锁骨上等区域多发淋巴结转移,经锁骨上转移淋巴结穿刺病理证实,免疫组织化学检测仍为雌激素受体(estrogen receptor,ER)强阳性/HER2阴性,但是孕激素受体(progesterone receptor,PR)仅小区阳性。经过多学科讨论后患者依次一线接受高剂量氟维司群(500 mg,肌注,28 d/次,首月第14天负荷剂量)内分泌治疗,二线选择哌柏西利(125 mg/d,服21 d,休7 d)+来曲唑(2. 5 mg/d),三线接受哌柏西利+氟维司群(同前),其2次进展仅表现为新发淋巴结转移或胸腔积液,并未发现内脏新发病灶或者病灶增大。其一、二线内分泌治疗的无进展生存期(progression free survival,PFS)均为12个月,三线内分泌治疗保留哌柏西利,换用一线的内分泌治疗药物(氟维司群)。临床上,还有全身化疗和局部放疗等选择。由于患者自发病以来一直拒绝接受化疗,术后辅助仅选择阿那曲唑(1 mg/d)辅助内分泌治疗(5年),解救治疗期间同样要求仅选择内分泌治疗。鉴于患者的意愿和肿瘤特征与演变、分子检测与监测,结合MDT专家意见,连续选择内分泌治疗作为解救治疗,取得较长的疾病控制实践,患者维持较好的生活质量。

关键词：乳腺肿瘤骨肿瘤/继发性肺肿瘤/继发性诊断药物治疗 CDK4/6抑制剂内分泌药物/治疗应用

Adipokines,cytokines and body fat stores in hepatitis Cvirus liver steatosis

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World Journal of Hepatology 2016年第1期8卷 74-82页

作者： emilio gonzález-reimers javier lópez-prieto geraldine quintero-platt ricardo pelazas-gonzález m remedios alemán-valls onán pérez-hernández m joséde-la-vega-prieto m angeles gómez-rodríguez candelaria martín-gonzález francisco santolaria-fernández Servicio de Medicina Interna Hospital Universitario de CanariasUniversidad de La Laguna38320 Canary IslandsSpain

AIM: To identify patients with or without liver steatosis and its severity in treatment-na?ve patients affected by hepatitis C virus(HCV) ***: We included 56 HCV infected patients, and assessed the amount of liver fat by histomorphometry, and its relationships with fat and lean mass at different parts of the body(by densitometry), hormones [insulin, homeostatic model assessment(HOMA)], adipokines(resistin, adiponectin, leptin), and cytokines(tumor necrosis factor α, interleukin-6).RESULTS: Although the intensity of liver steatosis is related to trunk fat mass and HOMA, 33% of patients showed no liver steatosis, and this finding was not related to body mass index or genotype. Besides trunkfat mass, no other factor was related to the presence or not of liver steatosis, or to the intensity of it, by multivariate analysis. Lean mass was not related to liver steatosis. Adiponectin levels were lower among patients. No differences were observed in leptin and ***: Steatosis in HCV infection is common(67.2%), and closely related to trunk fat, and insulin resistance, but not with leg fat mass or adipokines.

关键词： Resistin Adiponectin Insulin resistance Proinflammatory cytokines Leptin Hepatitis C virus Liver steatosis

Repeated stimulation of the posterior parietal cortex in patients in minimally conscious state:a sham-controlled randomized clinical trial

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Repeated stimulation of the posterior parietal cortex in pat...

The impact of the COVID-19 pandemic on the mental health of young people:A comparison between China and the United Kingdom

作者： Wangshan Huang Aurore Thibaut Sarah Wannez Felipe Fregni Xiaohua Hu Shan Jing geraldine Martens Minhui He Haibo Di Steven Laureys Hangzhou Normal University International Vegetative State and Consciousness Science Institute University of Liege and University Hospital of LiegeCyclotron Research Center and Neurology DepartmentComa Science Group Spaulding Rehabilitation Hospital/Harvard Medical School Spaulding Neuro--modulation Center Hangzhou Wujing Hospital Department of Rehabilitation

Objective:We assessed the effects of transcranial direct current stimulation(tDCS) targeted to posterior parietal cortex in patients in minimally conscious state(MCS).Methods:In a randomized double-blind sham-controlled crossover study,MCS patients at least 1 month after traumatic or nontraumatic insult received one sham and one real tDCS session(2 mAduring 20 minutes once a day for five days) in a randomized order separated by five days of washout over the posterior parietal *** Recovery Scale-Revised(CRS-R) assessments were performed directly on enrollment,before the first session and after each real and sham tDCS as well as five days ***-up outcome data were acquired 1,3,6,12 months after inclusion using the ***:33 MCS patients were enrolled(mean age:57±11 years;interval 6±5 months;20 traumatic).Atreatment effect(p=0.012;effect size:0.31) was observed after real tDCS session but did not last for 5 days after the end of the session(p=0.135).We identified 9(27%)tDCS-responders(i.e.,showing new sign(s) of consciousness that was never observed before,lasting at least 5 days after the end of the stimulation).Conclusion:Five days of tDCS over the posterior parietal cortex has a small and short-lasted beneficial effect on consciousness in MCS.

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Chinese Journal of Traumatology 2021年第4期24卷 231-236页

作者： Ming-Bo Liu geraldine Dufour Zhuo-Er Sun Julieta Galante Chen-Qi Xing Jing-Ye Zhan Li-Li Wu School of Social Development and Public Policy Fudan UniversityShanghai200433China University Counselling Service Student Services CentreUniversity of CambridgeCambridgeCB30 PAUK Lab for Post-traumatic Stress Disorder Faculty of Psychology and Mental HealthNaval Medical UniversityShanghai200433China The Emotion&Cognition Lab Faculty of Psychology and Mental HealthNaval Medical UniversityShanghai200433China Department of Psychiatry University of CambridgeCambridgeCB28AHUK Shanghai Key Laboratory of Mental Health and Psychological Crisis Intervention School of Psychology and Cognitive ScienceEast China Normal UniversityShanghai200062China

Purpose:As COVID-19 spreads globally and affects people's health,there are concerns that the pandemic and control policies may have psychological effects on young people(age from 17 to 35 years).This psychological impact might vary in different countries,and thus we compared the prevalence of self-reported psychological distress,loneliness and posttraumatic stress symptoms(PTSS)among young people in the United Kingdom(UK)and China at the beginning of the COVID-19 ***:Data of this study came from two *** source was the first wave of COVID-19 study in Understanding Society,a special wave of the UK household longitudinal study,which provided the high-quality,national-wide representative panel *** sample comprised 1054 young *** other source was an online survey on the mental health of 1003 young people from Shanghai,a highly developed area in *** questionnaire included questions on the prevalence of common mental disorders(cut-off score≥4),loneliness and potential PTSS(cut-off≥33).Univariable analyses were conducted to test the differences in the self-reported prevalence of psychological distress and loneliness between the two *** logistic regression analyses were run to explore the predictors of psychological distress and loneliness among all the young people from England and ***:Among the samples with self-reported psychological distress,the UK sample accounted for 34.4%(n=1054)and the Chinese sample accounted for 14.1%(n=1003).The difference between the two groups was statistically significant(p<0.001).Additionally,57.1%of people in the UK and 46.7%in China reported that they sometimes or often felt lonely,of which the difference is statistically significant(p<0.001).Regression analysis of the entire samples showed that nationality,gender,psychotherapy and loneliness were significant predictors of 12-item General Health Questionnaire scores,while the variables of age and living alone were ***

关键词： COVID-19 Mental health Young people Loneliness Posttraumatic stress symptoms

The Search for Eros： A Hazardous Journey for Children of Divorce

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Psychology Research 2011年第1期1卷 1-11页

作者： geraldine K. Piorkowski The University of Illinois at Chicago Chicago USA