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Gust response of an elasto-flexible morphing wing using fluid–structure interaction simulations

Chinese Journal of Aeronautics 2024年第2期37卷 45-57页

作者： Jonathan PFLÜger Christian BREITSAMTER Department of Mechanical Engineering Technical University of MunichGarching 85748Germany

Small and micro unmanned aircraft are the focus of scientific interest due to their wide range of *** often operate in a highly unstable flight environment where the application of new morphing wing technologies offers the opportunity to improve flight *** investigated concept comprises port and starboard adjustable wings,and an adaptive elastoflexible membrane serves as the lifting *** focus is on the benefits of the deforming membrane during the impact of a one-minus-cosine type *** a low Reynolds number of Re=264000,the morphing wing model is investigated numerically by unsteady fluid-structure interaction ***,the numerical results are validated by experimental data from force and moment,flow field,and deformation ***,with the rigid wing as the baseline,the flexible case is investigated,focusing on the advantages of the elastic *** all configurations studied,the maximum amplitude of the lift coefficient under gust load shows good agreement between the experimental and numerical *** the decay of the gust,they differ more the higher the aspect ratio of the *** considering the flow field,the main differences are due to the separation behavior on the upper side of the *** flow reattaches earlier in the experiments than in the simulations,which explains the higher lift values observed in the *** at one intermediate configuration does the lift amplitude of the rigid configuration exceeds that of the flexible by about 12%,with the elastic membrane resulting in a smaller and more uniform peak load,which is also evident in the wing loading and hence in the root bending moment.

关键词： Membrane wing Morphing wing Flexible wing surface Computational fluid dynam-ics Fluid-structure interaction Unsteady inflow condition Gust response

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A Dietary Supplement Jinghuosu Ameliorates Reproductive Damage Induced by Tripterygium Glycosides

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Chinese Journal of Integrative Medicine 2024年第4期30卷 330-338页

作者： MA Jing SUN Bo TE Li-ger HUANG Xin ZUO Xin HAN Xiao-ke WANG Shu-song Hebei Key Laboratory of Reproductive Medicine Hebei Institute of Reproductive HealthHebei Reproductive Health HospitalShijiazhuang(050071)China Graduate School of Hebei Medical University Shijiazhuang(050017)China School of Chemistry and Materials Science Hebei Normal UniversityShijiazhuang(050024)China Xingtai Infertility Specialist Hospital XingtaiHebei Province(054000)China

Objective To determine the possible protective effects of Jinghuosu,a dietary supplement(DS),on tripterygium glycosides(TG)-induced reproductive system injury in rats and its underlying *** A reproductive damage model was established in rats by feeding of ***-eight male Sprague Dawley rats were randomly divided into 4 groups using a random number table(n=7 in each):control(C)group,model(M)group,DS group and L-carnitine(LC)*** in M,DS and LC groups received 40 mg/kg TGs *** from the 5th week,after administration of TGs for 4 h every day,rats in DS and LC groups were administered with 2.7 g/kg DS and 0.21 g/kg LC,respectively,for protective treatment over the next 4 *** in Group C continued to receive the control ***-eosin staining was used for histopathological analysis of rat testicular ***-linked immunosorbent assay was performed to measure alkaline phosphatase(ALP),lactate dehydrogenase,alcohol dehydrogenase,total antioxidant capacity(T-AOC),superoxide dismutase,glutathione peroxidase(GSH-Px),and malondialdehyde(MDA)*** assay was used to determine the serum testosterone *** real-time PCR and Western blotting were conducted to analyze the expression of genes and proteins related to the testosterone synthesis pathway and the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 antioxidant *** Oral administration of TGs induced significant increases in the testicular levels of zinc transporter 1 and MDA(P0.05).On the other hand,sperm concentration,sperm motility,and serum testosterone,serum zinc,testicular zinc,Zrt-,Irt-like protein 1,ALP,luteinizing hormone(LH)receptor,steroidogenic acute regulatory protein,Cytochrome P450 family 11 subfamily A member 1,3β-hydroxysteroid dehydrogenase 1 T-AOC,GSH-Px,nuclear factor erythroid 2-related factor 2,heme oxygenase-1 and NAD(P)H:quinone oxidoreductase 1 levels decreased following TG

关键词： dietary supplement Jinghuosu tripterygium glycosides reproductive damage infertility

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Subpopulations of regulatory T cells are associated with subclinical atherosclerotic plaques,levels of LDL,and cardiorespiratory fitness in the elderly

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Journal of Sport and Health Science 2024年第3期13卷 288-296,I0002页

作者： Tim Böttrich Pascal Bauer Vincent Gröβer Magdalena Huber Hartmann Raifer Torsten Frech Svenja Nolte Theresa Dombrowski Franz Cemic Natascha Sommer Robert Ringseis Klaus Eder Karsten Krüger Christopher Weyh Department of Exercise Physiology and Sports Therapy Institute of Sports ScienceJustus-Liebig-UniversityGiessen 35394Germany Department of Cardiology and Angiology Justus-Liebig-University GiessenGiessen 35392Germany Institute for Systems Immunology Center for Tumor und ImmunologyMarburg 35032Germany TH Mittelhessen Department of Computer ScienceUniversity of Applied Sciences GiessenGiessen 35390Germany Department of Internal Medicine Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Giessen 35394Germany Excellence Cluster Cardio-Pulmonary Institute(CPI) Justus-Liebig UniversityGiessen 35394Germany Institute of Animal Nutrition and Nutrition Physiology Justus-Liebig-University GiessenGiessen 35390Germany

Background:Atherosclerosis forms the pathological basis for the development of cardiovascular *** pathological processes initially develop without clinically relevant symptoms,the identification of early markers in the subclinical stage plays an important role for initiating early *** is evidence that regulatory T cells(Tregs)are involved in the development of ***,the present study aimed to identify and investigate associations with Tregs and their subsets in a cohort of healthy elderly individuals with and without subclinical atherosclerotic plaques(SAP).In addition,various lifestyle and risk factors,such as cardiorespiratory fitness,were investigated as associated ***:A cross-sectional study was performed in 79 participants(male:n=50;age=63.6±3.7 years;body mass index=24.9±3.1 kg/m2;mean±SD)who had no previous diagnosis of chronic disease and were not taking *** of the carotids to identify SAP,cardiovascular function measurement for vascular assessment and a cardiorespiratory fitness test to determine peak oxygen uptake were ***,tests were conducted to assess blood lipids and determine glucose *** of Tregs and their subtypes(resting(rTregs)and effector/memory(mTregs))was performed by 8-chanel flow *** were categorized according to atherosclerotic plaque *** and logistic regression models were used to analyze associations between ***:SAP was detected in a total of 29 *** participants with plaque were older(64.8±3.6 years vs.62.9±3.5 years)and had higher peripheral systolic blood pressure(133.8±14.7 mmHg vs.125.8±10.9 mmHg).The participants with SAP were characterized by a lower percentage of rTregs(28.8%±10.7%vs.34.6%±10.7%)and a higher percentage of mTregs(40.3%±14.7%vs.30.0%±11.9%).Multiple logistic regression identified age(odds ratio(OR)=1.20(95%confidence interval(95%CI):1.011.42))and

关键词： Cardiorespiratory fitness Elderly Regulatory T cells Subclinical atherosclerosis

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Rethinking neurodegenerative diseases:neurometabolic concept linking lipid oxidation to diseases in the central nervous system

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Neural Regeneration Research 2024年第7期19卷 1437-1445页

作者： Steinunn Sara Helgudóttir Anne Skøttrup Mørkholt Jacek Lichota Preben Bruun-Nyzell Mads Christian Andersen Nanna Marie Juhl Kristensen Amanda Krøger Johansen Mikela Reinholdt Zinn Hulda Maria Jensdóttir John Dirk Vestergaard Nieland 2N Pharma ApS NOVI Science ParkAalborgDenmark Molecular Pharmacology Group Department of Health Science and TechnologyAalborg UniversityAalborgDenmark

Currently,there is a lack of effective medicines capable of halting or reve rsing the progression of neurodegenerative disorde rs,including amyotrophic lateral sclerosis,Parkinson s disease,multiple sclerosis,or Alzheimer s *** the unmet medical need,it is necessary to reevaluate the existing para digms of how to to rget these *** considering neurodegenerative diseases from a systemic neurometabolic perspective,it becomes possible to explain the shared pathological *** innovative approach presented in this paper draws upon exte nsive research conducted by the authors and researchers *** this review,we highlight the importance of metabolic mitochondrial dysfunction in the context of neurodegenerative *** provide an overview of the risk factors associated with developing neurodegenerative disorders,including genetic,epigenetic,and environmental fa ***,we examine pathological mechanisms implicated in these diseases such as oxidative stress,accumulation of misfolded proteins,inflammation,demyelination,death of neurons,insulin resistance,dysbiosis,and neurotransmitter ***,we outline a proposal for the restoration of mitochondrial metabolism,a crucial aspect that may hold the key to facilitating curative therapeutic interventions for neurodegenerative disorders in forthcoming advancements.

关键词： brain disease carnitine palmitoyl transferase 1 epigenetics metabolism gut microbiome mitochondrial dysfunction neurodegeneration oxidative stress

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Generalized Height-Diameter Models for Pinus montezumae Lamb. and Pinus pseudostrobus Lindl. Plantations in Michoacan, Mexico

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Open Journal of Forestry 2024年第3期14卷 214-232页

作者： Jonathan Hernández-Ramos Valentín José Reyes-Hernández Héctor Manuel De los Santos-Posadas Aurelio Manuel Fierros-González Enrique Buendía-Rodríguez gerónimo Quiñonez-Barraza Instituto Nacional de Investigaciones Forestales Agrcolas y Pecuarias (INIFAP)-Campo Experimental Bajo Celaya Guanajuato Mxico Colegio de Postgraduados (COLPOS) Campus Montecillo Mxico INIFAP Campo Experimental Valle de Mxico Texcoco Mxico INIFAP Campo Experimental Valle del Guardiana Durango Mxico

Tree height (H) in a natural stand or forest plantation is a fundamental variable in management, and the use of mathematical expressions that estimate H as a function of diameter at breast height (d) or variables at the stand level is a valuable support tool in forest inventories. The objective was to fit and propose a generalized H-d model for Pinus montezumae and Pinus pseudostrobus established in forest plantations of Nuevo San Juan Parangaricutiro, Michoacan, Mexico. Using nonlinear least squares (NLS), 10 generalized H-d models were fitted to 883 and 1226 pairs of H-d data from Pinus montezumae and Pinus pseudostrobus, respectively. The best model was refitted with the maximum likelihood mixed effects model (MEM) approach by including the site as a classification variable and a known variance structure. The Wang and Tang equation was selected as the best model with NLS;the MEM with an additive effect on two of its parameters and an exponential variance function improved the fit statistics for Pinus montezumae and Pinus pseudostrobus, respectively. The model validation showed equality of means among the estimates for both species and an independent subsample. The calibration of the MEM at the plot level was efficient and might increase the applicability of these results. The inclusion of dominant height in the MEM approach helped to reduce bias in the estimates and also to better explain the variability among plots.

关键词： Random Covariate Random Effects Variance Structure Forest Inventories Forest Management Mixed Models

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Urban Earthquake Vulnerability Assessment and Mapping at the Microscale Based on the Catastrophe Progression Method

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International Journal of Disaster Risk Science 2023年第5期14卷 768-781页

作者： Deniz gerçek İsmail Talih Güven Department of City and Regional Planning Faculty of Architectureİzmir Institute of Technology35430IzmirTurkey Department of Geophysics Engineering Kocaeli University41001KocaeliTurkey

Vulnerability assessment and mapping play a crucial role in disaster risk reduction and planning for adaptation to a future *** is one of the most at-risk countries for earthquake disasters ***,it is imperative to develop effective earthquake vulnerability assessment and mapping at practically relevant *** this study,a holistic earthquake vulnerability index that addresses the multidimensional nature of earthquake vulnerability was *** the aim of representing the vulnerability as a continuum across space,buildings were set as the smallest unit of *** study area is in İzmit City of Turkey,with the exposed human and structural elements falling inside the most hazardous zone of *** index was represented by the building vulnerability,socioeconomic vulnerability,and vulnerability of the built *** minimize the subjectivity and uncertainty that the vulnerability indices based on expert knowledge are suffering from,an extension of the catastrophe progression method for the objective weighing of indicators was *** vulnerability index and components were mapped,a local spatial autocorrelation metric was employed where the hotspot maps demarcated the earthquake vulnerability,and the study quantitatively revealed an estimate of people at *** its objectivity and straightforward implementation,the method can aid decision support for disaster risk reduction and emergency management.

关键词： Catastrophe progression method Earthquake vulnerability index Hotspots Microscale Turkey

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Experimental investigations of a full model with adaptive elasto-flexible membrane wings

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Chinese Journal of Aeronautics 2021年第7期34卷 211-218页

作者： Jonathan PFLU ger Christian BREITSAMTER Chair of Aerodynamics and Fluid Mechanics Technical University of MunichGarching 85748Germany

The morphing wing concept aims to constantly adapt the aerodynamics to different flight *** wing is able to adapt to different flight conditions by an adjustable Aspect Ratio(AR)and sweep.A high AR configuration provides high aerodynamic efficiency,while a low AR configuration,with highly swept wings offers a good ***,the flexible membrane allows the wing surface to stretch and contract in-plane as well as the airfoil to adapt to different aerodynamic *** the context of this work,the aerodynamic characteristics of a full model with form-adaptive elasto-flexible membrane wings are investigated *** focus is on the high-lift regime and on the analysis of the aerodynamic coefficients as well as their ***,the lateral aerodynamic derivatives at asymmetric wing positions are of interest.

关键词： Experimental aerodynamics Flexible wing surface Force and moment measurements Morphing wing Particle image velocimetry

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一种自动驾驶电动汽车线束布局优化方法

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同济大学学报（自然科学版） 2022年第S1期50卷 186-191页

作者： Jonas MAIER Benjamin KRüger Hans-Christian REUSS 斯图加特大学汽车工程学院(IFS) 德国斯图加特70569

近年来,随着汽车自动驾驶、数字化、电动化技术的不断发展,汽车的功能不断增加,车辆内部线束也随之增加。由于过多的线束导致车辆自重增加的问题日益突出。为了实现能源的高效利用和出行方式的可持续性,开发人员需要通过优化线束布置来... 详细信息

近年来,随着汽车自动驾驶、数字化、电动化技术的不断发展,汽车的功能不断增加,车辆内部线束也随之增加。由于过多的线束导致车辆自重增加的问题日益突出。为了实现能源的高效利用和出行方式的可持续性,开发人员需要通过优化线束布置来尽可能多的减轻车辆自重,同时降低成本。由于与线束相连的车辆零件位置固定,因此需要一个算法在车辆零件位置为限制条件下,优化车辆线束布局。之前的研究方法通常只考虑线束设计的部分限制因素,且没有考虑线束三维结构。在本文研究中,开发了一种新型的优化线束布局的方法,该方法考虑了与包装,温度负载以及装配难易相关的各种限制因素。该方法可以根据设计需求来控制线束布置方法,如在沿着车辆纵轴方向布置更多线束,以避免在车辆外围布置线束。通过该方法,可以高效地计算出线束长度、直径,以及精确的布线路径。

关键词：电动汽车汽车线束布线优化 Dijkstra算法

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Automatic route planning for GPS art generation

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Computational Visual Media 2019年第3期5卷 303-310页

作者： Andre Waschk Jens Krüger University of Duisburg-Essen

In this paper, we present a novel approach to automated route generation of global positioning system(GPS) artwork. The term GPS artwork describes the generation of drawings by leaving virtual traces on digital maps. Until now, the creation of these images has required a manual planning phase in which an artist designs the route by hand. Once the route for this artwork has been planned, GPS devices have been used to track the movement. Using our solution, the lengthy planning phase can be significantly shortened,thereby opening art creation to a broader public.

关键词： GPS art walking routing shape detection navigation

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Neuromuscular,biomechanical,and energetic adjustments following repeated bouts of downhill running

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Journal of Sport and Health Science 2022年第3期11卷 319-329页

作者： Arash Khassetarash Gianluca Vernillo Renata L.Krüger W.Brent Edwards Guillaume Y.Millet Human Performance Laboratory Faculty of KinesiologyUniversity of CalgaryCalgary T2N 1N4Canada Department of Biomedical Sciences for Health University of MilanMilan 20133Italy Inter-university Laboratory of Human Movement Biology UJM-Saint-EtienneUniversitéde LyonSaint-Etienne 42023France Institut Universitaire de France(IUF) Paris 75231France

Purpose This study used downhill running as a model to investigate the repeated bout effect(RBE)on neuromuscular performance,running biomechanics,and metabolic cost of *** Ten healthy recreational male runners performed two 30-min bouts of downhill running(DR1 and DR2)at a-20%slope and 2.8 m/s 3 weeks *** fatigue,level running biomechanics during slow and fast running,and running economy parameters were recorded immediately before and after the downhill bouts,and at 24 h,48 h,72 h,96 h,and 168 h thereafter(i.e.,follow-up days).Results An RBE was confirmed by attenuated muscle soreness and serum creatine kinase rise after DR2 compared to *** RBE was also observed in maximum voluntary contraction(MVC)force loss and voluntary activation where DR2 resulted in attenuated MVC force loss and voluntary activation immediately after the run and during follow-up *** downhill running protocol significantly influenced level running biomechanics;an RBE was observed in which center of mass excursion and,therefore,lower-extremity compliance were greater during follow-up days after DR1 compared to *** observed changes in level running biomechanics did not influence the energy cost of *** This study demonstrated evidence of adaptation in neural drive as well as biomechanical changes with the RBE after *** higher neural drive resulted in attenuated MVC force loss after the second *** can be concluded that the RBE after downhill running manifests as changes to global and central fatigue parameters and running biomechanics without substantially altering the energy cost of running.

关键词： Cost of running Eccentric exercise Fatigue Muscle damage

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