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A machine learning approach to predict response to immunotherapy in type 1 diabetes

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Cellular & Molecular Immunology 2021年第3期18卷 515-517页

作者： georgia.Fousteri Ely Montee Rodrigues Gian Maria Giamporcaro Marika Falcone Regulation of Adaptive immunity Unit Transplantation and Infectious DiseasesIRCCS San Raffaele Scientific InstituteMilanItaly Experimental Diabetes Unit Division of ImmunologyTransplantation and Infectious DiseasesDiabetes Research Institute(DRI)IRCCS San Raffaele Scientific InstituteMilanItaly

Type 1 diabetes(T1D)is an autoimmune disease mediated by selfreactive T cells that destroy insulin-producing β cells of the pancreatic islets.1 The disease is a complex multifactorial disorder resulting from a poorly defined interaction between genetic and environmental *** 40-50% of the disease risk is linked to genes,with the remaining risk arising from environmental factors.

关键词： diabetes immunotherapy autoimmune

Multimodal Fuzzy Downstream Petroleum Supply Chain:A Novel Pentagonal Fuzzy Optimization

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Computers, Materials & Continua 2023年第3期74卷 4861-4879页

作者： Gul Freen Sajida Kousar Nasreen Kausar Dragan Pamucar georgia.Irina Oros Department of Mathematics and Statistics International Islamic UniversityIslamabadPakistan Department of Mathematics Faculty of Arts and SciencesYildiz Technical UniversityEsenlerIstanbul34210Turkey Department of Logistics University of Defence in BelgradeBelgradeSerbia Department of Mathematics and Computer Science University of OradeaOradea410087Romania

The petroleum industry has a complex,inflexible and challenging supply chain(SC)that impacts both the national economy as well as people’s daily lives with a range of services,including transportation,heating,electricity,lubricants,as well as chemicals and *** the petroleum industry,supply chain management presents several challenges,especially in the logistics sector,that are not found in other *** addition,logistical challenges contribute significantly to the cost of *** regarding customer demand and supply significantly affects SC ***,SC flexibility can be maintained by addressing *** the other hand,in the real world,decision-making challenges are often ambiguous or *** some cases,measurements are incorrect owing to measurement errors,instrument faults,etc.,which lead to a pentagonal fuzzy number(PFN)which is the extension of a fuzzy ***,it is necessary to develop quantitative models to optimize logistics operations and supply chain *** study proposed a linear programming model under an uncertain *** model minimizes the cost along the refineries,depots,multimode transport and demand *** developed pentagonal fuzzy optimization,an alternative approach is developed to solve the downstream supply chain using themixed-integer linear programming(MILP)model to obtain a feasible solution to the fuzzy transportation cost *** this model,the coefficient of the transportation costs and parameters is assumed to be a pentagonal fuzzy ***,defuzzification is performed using an accuracy *** validate the model and technique and feasibility solution,an illustrative example of the oil and gas SC is considered,providing improved results compared with existing techniques and demonstrating its ability to benefit petroleum companies is the objective of this study.

关键词： Downstream petroleum supply chain fuzzy optimization multimodal optimization pentagonal fuzzy number

Bipolar Interval-Valued Neutrosophic Optimization Model of Integrated Healthcare System

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Computers, Materials & Continua 2022年第12期73卷 6207-6224页

作者： Sumbal Khalil Sajida Kousar Nasreen Kausar Muhammad Imran georgia.Irina Oros Department of Mathematics and Statistics International Islamic UniversityIslamabadPakistan Department of Mathematics Faculty of Arts and SciencesYildiz Technical UniversityEsenler34210IstanbulTurkey NUST Business School Islamabad Pakistan Department of Mathematics and Computer Science University of OradeaOradea410087Romania

Bipolar Interval-valued neutrosophic set is another generalization of fuzzy set,neutrosophic set,bipolar fuzzy set and bipolar neutrosophic set and thus when applied to the optimization problem handles uncertain data more efficiently and *** work is an effort to design a flexible optimization model in the backdrop of interval-valued bipolar neutrosophic *** interval-valued neutrosophic membership grades are picked so that they indicate the restriction of the plausible infringement of the inequalities given in the *** prove the adequacy and effectiveness of the method a unified system of sustainable medical healthcare supply chain model with an uncertain figure of product complaints is ***,quality and cost are considered as satisfaction level to choose best supplier for medicine *** proposed model ensures 99%satisfaction for cost reduction,63%satisfaction for the quality of product and 64%satisfaction for total time taken in medicine supply chain.

关键词： Bipolar fuzzy set neutrosophic set interval-valued neutrosophic set bipolar interval-valued neutrosophic set supply chain fuzzy optimization

Role of apoptosis resistance in immune evasion and metastasis of colorectal cancer

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World Journal of Gastrointestinal Oncology 2010年第11期2卷 399-406页

作者： Kebin Liu, Department of Biochemistry and Molecular Biology, Medical College of georgia. georgia.Health Sciences University, Augusta, GA 30912, United States Kebin Liu Department of Biochemistry and Molecular Biology Medical College of Georgia Georgia Health Sciences University Augusta GA 30912 United States.

The host immune system functions as a guardian against tumor development. It has been demonstrated that cytotoxic T lymphocyte (CTL)-mediated cytotoxic pathways function to inhibit or delay human colorectal cancer development. However, the host anti-tumor immune responses also 'edit' the tumor and select for more aggressive variants, resulting in immune evasion and tumor escape. Fas is a death receptor that mediates one of the major cytotoxic effector mechanisms of the CTLs. Fas is highly expressed in normal human colon epithelial cells but is frequently silenced in colorectal carcinoma, especially in metastatic colorectal carcinoma, suggesting that loss of Fas expression and function may be an immune evasion and tumor escape mechanism. In addition, recent studies indicated that Fas also mediates cellular proliferation signaling pathways to promote tumor development. Therefore, the death receptor Fas may not only transduce death signals to suppress tumor development but also activate cellular proliferation and the migration process to promote tumor growth and progression. Thus, understanding the mechanisms by which the Fas receptor and its associated protein complex transduces the death and survival signals may identify molecular targets for the development of therapeutic strategy to enhance the Fas-mediated death signals to increase the efficacy of cancer immunotherapy.

关键词： Apoptosis Fas Metastasis Immune evasion

More than mimicry？ Evaluating scope for flicker-fusion as a defensive strategy in coral snake mimics

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Current Zoology 2014年第1期60卷 123-130页

作者： georgia.C. TITCOMB David W. KIKUCHI David W. PFENNIG Department of Biology University of North Carolina at Chapel Hill Chapel Hill NC 27599-3280

Coral snakes and their mimics often have brightly colored banded patterns, generally associated with warning colora- tion or mimicry. However, such color patterns have also been hypothesized to aid snakes in escaping predators through a ＂flicker-fusion＂ effect. According to this hypothesis, banded color patterns confuse potential predators when a snake transitions from resting to moving because its bands blur together to form a different color. To produce this motion blur, a moving snake＇s bands must transition faster than the critical flicker-fusion rate at which a predator＇s photoreceptors can refresh. It is unknown if coral snakes or their mimics meet this requirement. We tested this hypothesis by measuring the movement speed and color pat- terns of two coral snake mimics, Lampropeltis triangulum campbelli and L. elapsoides, and comparing the frequency of color transitions to the photoreceptor activity of the avian eye. We found that snakes often produced a motion blur, but moving snakes created a blurring effect more often in darker conditions, such as sunrise, sunset, and nighttime when these snakes are often active. Thus, at least two species of coral snake mimics are capable of achieving flicker-fusion, indicating that their color patterns may confer an additional defense aside from mimicry

关键词： Coral snake mimicry Flicker-fusion effect CFF Kingsnake Defensive strategy

Use of digital image analysis combined with fractal theory to determine particle morphology and surface texture of quartz sands

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Journal of Rock Mechanics and Geotechnical Engineering 2017年第6期9卷 1131-1139页

作者： georgia.S.Araujo Kátia V.Bicalho Fernando A.Tristao Federal Institute of Education Science and Technology of the State of Espírito SantoBrazil Department of Civil Engineering Federal University of Espírito SantoBrazil

The particle morphology and surface texture play a major role in influencing mechanical and hydraulic behaviors of sandy soils. This paper presents the use of digital image analysis combined with fractal theory as a tool to quantify the particle morphology and surface texture of two types of quartz sands widely used in the region of Vitória, Espírito Santo, southeast of Brazil. The two investigated sands are sampled from different locations. The purpose of this paper is to present a simple, straightforward,reliable and reproducible methodology that can identify representative sandy soil texture *** test results of the soil samples of the two sands separated by sieving into six size fractions are presented and discussed. The main advantages of the adopted methodology are its simplicity, reliability of the results, and relatively low cost. The results show that sands from the coastal spit(BS) have a greater degree of roundness and a smoother surface texture than river sands(RS). The values obtained in the test are statistically analyzed, and again it is confirmed that the BS sand has a slightly greater degree of sphericity than that of the RS sand. Moreover, the RS sand with rough surface texture has larger specific surface area values than the similar BS sand, which agree with the obtained roughness fractal dimensions. The consistent experimental results demonstrate that image analysis combined with fractal theory is an accurate and efficient method to quantify the differences in particle morphology and surface texture of quartz sands.

关键词： Quartz sands Particle morphology and surface texture Image analysis Fractal theory

Factors affecting effectiveness of vaccination against hepatitis B virus in hemodialysis patients

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World Journal of Gastroenterology 2014年第34期20卷 12018-12025页

作者： Theodoros Eleftheriadis Georgios Pissas georgia.Antoniadi Vassilios Liakopoulos Ioannis Stefanidis Department of Nephrology Medical SchoolUniversity of Thessaly41110 LarissaGreece

Hepatitis B virus(HBV)is a major global health *** the success of the general measures against blood transmitted infections in hemodialysis(HD)units,the prevalence of HBV infection among the HD patients is still *** vaccination against HBV is indicating in this ***,compared with the general population the seroprotection achieved in HD patients remains relatively low,at about 70%.In this review patient,HD procedure and vaccine-associated factors that affect the efficacy of HBV vaccination are *** alternative routes of HBV vaccine administration as well as new and more immunogenic vaccine formulations are ***,besides scientific progress,vigilance of HD physicians and staff regarding the general measures against the transmission of blood borne infections and the vaccination against HBV is also required for reducing the prevalence of this viral infection.

关键词： Hemodialysis Hepatitis B virus epidemiology Hepatitis B virus vaccine Adjuvant Immunostimulant Intradermal

Rescue of autoimmune hepatitis by soluble MHC class II molecules in an altered concanavalin A-induced experimental model

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Animal Models and Experimental Medicine 2020年第3期3卷 264-272页

作者： Katerina Bakela Maria georgia.Dimitraki Evangelia Skoufa Irene Athanassakis Laboratory of Immunology Department of BiologyUniversity of CreteHeraklionCreteGreece

Background:Soluble major histocompatibility complex class II(sMHCII)molecules have been described to maintain tolerance through the suppression of autoreactive T *** order to evaluate their ability to rescue autoimmune hepatitis(AIH)symptoms,the present work attempted to administer sMHCII molecules to an in vitro as well as in vivo concanavalin A(ConA)-induced AIH ***:The in vitro AIH model consisted of splenocyte stimulation with ConA in the presence or absence of serum-isolated sMHCII *** in vivo ConAmodified model with or without sMHCII treatment was *** cytokine profile in culture supernatants and serum was tested by *** markers were evaluated by immunofluorescence,while cell proliferation by tritiated thymidine *** symptoms were assessed by daily observations for the establishment of a disease severity scoring system and liver histology was evaluated using a biomolecular ***:The presence of sMHCII molecules in the ConA-stimulated cell cultures leads to a significant reduction of cell *** administration of sMHCII molecules to the ConA-treated animals showed a significant reduction in the levels of IL-2,IL-4,and IL-10,as well as a decrease in the number of spleen CD4+and CD8+*** development of a scoring system,it was shown that the sMHCII treatment was accompanied by a slower progression of the disease,while rescuing fibrotic liver ***:The results presented in this study confirm the ability of sMHCII proteins to alleviate autoimmune hepatitis,possibly highlighting new therapeutic approaches for autoimmune diseases.

关键词： autoimmune hepatitis cytokines immunosuppression inflammation

Tunable Separation of Single-Walled Carbon Nanotubes by Dual-Surfactant Density Gradient Ultracentrifugation

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Nano Research 2011年第7期4卷 623-634页

作者： Pei Zhao Erik Einarsson georgia.Lagoudas Junichiro Shiomi Shohei Chiashi Shigeo Maruyama Department of Mechanical Engineering The University of Tokyo Tokyo 113-8656 Japan Global Center of Excellence for Mechanical Systems Innovation The University of Tokyo Tokyo 113-8656 Japan Department of Bioengineering Rice University Houston TX 77005 USA

We present a systematic study of the effects of surfactants in the separation of single-walled carbon nanotubes （SWNTs） by density gradient ultracentrifugation （DGU）. Through analysis of the buoyant densities, layer positions, and optical absorbance spectra of SWNT separations using the bile salt sodium deoxycholate （DOC） and the anionic salt sodium dodecyl sulfate （SDS）, we clarify the roles and interactions of these two surfactants in yielding different DGU outcomes. The separation mechanism described here can also help in designing new DGU experiments by qualitatively predicting outcomes of different starting recipes, improving the efficacy of DGU and simplifying post-DGU fractionation.

关键词： Single-walled carbon nanotubes density gradient ultracentrifugation sodium deoxycholate sodium dodecyl sulfate