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Solid,non-skin,post-liver transplant tumors:Key role oflifestyle and immunosuppression management

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World Journal of Gastroenterology 2016年第1期22卷 427-434页

作者： Christophe Carenco stéphanie Faure JoséUrsic-Bedoya Astrid Herrero georges Philippe Pageaux Liver Transplant Unit CHRU Montpellier34090 MontpellierFrance

Liver transplantation has been the treatment of choice for end-stage liver disease since *** has emerged as a major long-term cause of death for liver transplant *** retrospective studies that have explored standardized incidence ratio have reported increased rates of solid organ cancers postliver transplantation;some have also studied risk *** transplantation results in a two to five-fold mean increase in the rate of solid organ *** of head and neck,lung,esophageal,cervical cancers and Kaposi’s sarcoma is high,but risk of colorectal cancer is not clearly *** appears to be no excess risk of developing breast or prostate *** risk factors such as viral infection and tobacco consumption,and personal risk factors such as obesity play a key role,but recent data also implicate the role of calcineurin inhibitors,whose cumulative and dose-dependent effects on cell metabolism might play a direct role in *** this paper,we review the results of studies assessing the incidence of non-skin solid tumors in order to understand the mechanisms underlying solid cancers in post-liver transplant patients and,ultimately,discuss how to prevent these *** protocol changes,including a calcineurin inhibitor-free regimen,combined with dietary guidelines and smoking cessation,are theoretically the best preventive measures.

关键词： Liver transplantation Tumors Calcineurininhibitors Immunosuppression Risk factors Tacrolimus Review Incidence

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乔治餐厅

城市环境设计 2014年第Z2期 210-215页

作者： Nicolas Borel stéphane Couturier Jakob+MacFarlane建筑事务所

项目名称:乔治餐厅项目地点:法国巴黎委托人:SNC Costes/蓬皮杜艺术中心建筑面积:900m2(室内)/450m2(阳台)建成时间:2000线图提供:Jakob+Mac Farlane建筑事务所雅各布+麦克法兰建筑事务所设计的这座建筑位于蓬皮杜艺术中心的顶层,从概... 详细信息

项目名称:乔治餐厅项目地点:法国巴黎委托人:SNC Costes/蓬皮杜艺术中心建筑面积:900m2(室内)/450m2(阳台)建成时间:2000线图提供:Jakob+Mac Farlane建筑事务所雅各布+麦克法兰建筑事务所设计的这座建筑位于蓬皮杜艺术中心的顶层,从概念上重新组织了空间,并从伦佐·皮亚诺和理查德·罗杰斯设计的初始结构中汲取了灵感,将新的建筑形态融入其中。设计保留了结构框架,地板平面采用了80cm×80cm的网格设计。结构

关键词：餐厅蓬皮杜艺术中心建筑形态项目地点乔治

Defining Velocity and Acceleration Ranges for Time-Motion Analysis from a 7-Sided Game in U11 Soccer Players Using Global Positioning System Devices:A Case study

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Journal of Science in Sport and Exercise 2023年第2期5卷 167-173页

作者： Abd-Elbasset Abaïdia Grégory Dupont georges Baquet Universitéde Lille EA 7369-URePSSS-Unitéde Recherche Pluridisciplinaires Sport SantéSociété59000 LilleFrance Research Institute for Sport and Exercise Sciences Liverpool John Moores University LiverpoolUK

The aims of this study were(1)to define speed and acceleration thresholds from youth match activity of soccer players and(2)to analyze the activity performed by young soccer players during a match using GPS devices and according to these *** U11 soccer players from a professional club participated in a 7-sided match being equipped with global positioning system(GPS)devices(sampling frequency 5 Hz)to measure the speed of each *** Kernel Density Esti-mate(KDE)was used to observe the occurrences of *** range of velocities was described by a distribution curve,from which the speed and acceleration thresholds for each category of movement were defined and time–motion analysis of the match was *** model with 4 Gaussian laws was the best when using the Akaike Information Criterion(AIC).In this study,the thresholds defined for each category of movement were:standing(st running(7.8–12.7 km/h)and sprint(≥12.8 km/h).Acceleration thresholds were calculated to define movement considered as a sprint for each category of movement:standing(0.3 m/s^(2)),walking(0.66 m/s^(2)),slow running(1.01 m/s^(2))or fast running(0.97 m/s^(2)).All the acceleration thresholds were significantly different from each other(Pst running(P=0.41)with a small effect *** U-11 soccer players,time–motion analysis may be performed according to five categories of *** study has also defined sprint and acceleration thresholds for this category of age.

关键词： Football Sprint Accelerations Movement Youth

Probiotic yeasts: Anti-inflammatory potential of various non-pathogenic strains in experimental colitis in mice

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World Journal of Gastroenterology 2010年第17期16卷 2134-2145页

作者： Benot Foligné Jo■lle Dewulf Pascal Vandekerckove georges Pignède Bruno Pot Institut Pasteur of Lille Lactic acid Bacteria & Mucosal ImmunityCenter for Infection and Immunity of Lille1 rue du Pr CalmetteBP 245F-59019 LilleFrance University of Lille Nord de France F-59000 LilleFrance Centre National de la Recherche Scientifique UMR 8204F-59021 LilleFrance Institut National de la Santé et de la Recherche Médicale U1019F-59019 LilleFrance Lesaffre International Direction of Research and Developpement147 rue Gabriel PériBP 602759700 Marcq-en-BaroeulFrance

AIM: To evaluate the in vitro immunomodulation capacity of various non-pathogenic yeast strains and to investigate the ability of some of these food grade yeasts to prevent experimental colitis in ***: In vitro immunomodulation was assessed by measuring cytokines [interleukin (IL)-12p70,IL-10,tumor necrosis factor and interferon γ] released by human peripheral blood mononuclear cells after 24 h stimulation with 6 live yeast strains (Saccharomyces ssp.) and with bacterial reference strains.A murine model of acute 2-4-6-trinitrobenzene sulfonic acid (TNBS)-colitis was next used to evaluate the distinct prophylactic protective capacities of three yeast strains compared with the performance of prednisolone ***: The six yeast strains all showed similar non-discriminating anti-inflammatory potential when tested on immunocompetent cells in vitro .However,although they exhibited similar colonization patterns in vivo ,some yeast strains showed significant anti-inflammatory activities in the TNBS-induced colitis model,whereas others had weaker or no preventive effect at all,as evidenced by colitis markers (body-weight loss,macroscopic and histological scores,myeloperoxidase activities and blood inflammatory markers).CONCLUSION: A careful selection of strains is required among the biodiversity of yeasts for specific clinical studies,including applications in inflammatory bowel disease and other therapeutic uses.

关键词： Yeast Probiotics strain specificity Experimental colitis 2-4-6-trinitrobenzene sulfonic acid

Liver transplantation for alcoholic liver disease: Lessons learned and unresolved issues

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World Journal of Gastroenterology 2015年第39期21卷 10994-11002页

作者： José Ursic-Bedoya stéphanie Faure Hélène Donnadieu-Rigole georges-Philippe Pageaux Liver Transplantation Unit Digestive Department Saint Eloi University Hospital University of Montpellier Addictology Department Saint Eloi University Hospital University of Montpellier

The use of liver transplantation(LT) as a treatment for alcoholic liver disease(ALD) has been highly controversial since the beginning. The ever increasing shortage of organs has accentuated the low priority given to patients suffering from ALD, which is considered a "self-inflicted" condition. However, by improving the long-term survival rates, making them similar to those from other indications, and recognizing that alcoholism is a primary disease, ALD has become one of the most common indications for LT in Europe and North America, a situation thought unfathomable thirty years ago. Unfortunately, there are still many issues with the use of this procedure for ALD. There are significant relapse rates, and the consequences of excessive drinking after LT range from asymptomatic biochemical and histological abnormalities to graft failure and death. A minimum three-month period of sobriety is required for an improvement in liver function, thus making LT unnecessary, and to demonstrate the patient's commitment to the project, even though a longer abstinence period does not guarantee lower relapse rates after LT. Recent data have shown that LT is also effective for severe alcoholic hepatitis when the patient is unresponsive to corticosteroids therapy, with low relapse rates in highly selected patients, although these results must be confirmed before LT becomes a standard procedure in this setting. Finally, LT for ALD is accompanied by an increased risk of de novo solid organ cancer, skin cancer, and lymphoproliferative disorders, which has a large impact on the survival rates.

关键词： Liver transplantation Alcoholic liver disease Cirr

Highly sensitive microfiber ultrasound sensor for photoacoustic imaging

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Opto-Electronic Advances 2023年第6期6卷 4-6页

作者： Perry Ping Shum Gerd Keiser georges Humbert Dora Juan Juan Hu APing Zhang Lei Su Department of Electronic and Electrical Engineering Southern University of Science and Technology1088 Xueyuan AvenueShenzhen 518055China Department of Electrical and Computer Engineering Boston University8 Saint Mary's StreetBoston 02215America XLIM Research Institute-UMR 7252 CNRS University of Limoges123avenue Albert ThomasLimoges 87060France Institute for Infocomm Research Agency for ScienceTechnology and Research1 Fusionopolis Way#21-01Connexis South Tower Singapore 138632Singapore The Hong Kong Polytechnic University Kowloon TongHong Kong 999077China School of Engineering and Materials Science Queen Mary University of LondonMile End RoadLondon E14NSUK

An ultrasound wave is a kind of acoustic signal with a frequency greater than 20 kHz,which is widely used in diverse fields such as medical imaging diagnosis,nondestructive testing and resource exploration.A variety of ultrasound sensors have been developed for ultrasound *** for photoacoustic imaging,specialized ultrasound sensors with high sensitivity,small size,and broad bandwidth are ***,achieving such sensor perform-ance still poses a great challenge to the current state-of-the-art in ultrasound sensor technology.A recent work pub-lished in Opto-Electronic Advances(DOI:10.29026/oea.2022.200076)proposes a microfiber-based ultrasound sensor that breaks the limitations of existing ultrasound *** from the large evanescent field characteristic of mi-crofiber,combined with the coherent detection technology,the proposed sensor realized highly sensitive ultrasound de-tection and demonstrated excellent performance in high-resolution photoacoustic *** highly sensitive and mini-aturized microfiber ultrasound sensor provides a competitive alternative for various applications,such as endoscopic photoacoustic imaging of the intestinal tract and blood vessels in animals.

关键词： Highly sensor competitive

Addictive behaviors in liver transplant recipients: The real problem?

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World Journal of Hepatology 2017年第22期9卷 953-958页

作者： Hélène Donnadieu-Rigole Pascal Perney José Ursic-Bedoya stéphanie Faure georges-Philippe Pageaux Department of Addictology Saint Eloi University Hospital University of Montpellier Department of Addictology Caremeau Hospital Liver Transplantation Unit Saint Eloi University Hospital University of Montpellier

Liver transplantation(LT) is the gold standard treatment for end-stage liver disease. Whatever the primary indication of LT, substance abuse after surgery may decrease survival rates and quality of life. Prevalence of severe alcohol relapse is between 11 and 26%,and reduces life expectancy regardless of the primary indication of LT. Many patients on waiting lists for LT are smokers and this is a major risk factor for both malignant tumors and cardiovascular events post-surgery. The aim of this review is to describe psychoactive substance consumption after LT, and to assess the impact on liver transplant recipients. This review describes data about alcohol and illicit drug use by transplant recipients and suggests guidelines for behavior management after surgery. The presence of an addiction specialist in a LT team seems to be very important.

关键词： Liver transplantation Tobacco use Illicit drugs Behavior management Severe alcohol relapse

Differences and similarities between mesenchymal stem cell and endothelial progenitor cell immunoregulatory properties against T cells

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World Journal of stem Cells 2021年第8期13卷 971-984页

作者： Mehdi Razazian Maryam Khosravi Sheyda Bahiraii georges Uzan Sara Shamdani Sina Naserian Institut national de la santéet de la recherche médicale(Inserm)UnitéMixte de Recherche-Inserm-Ministère de la Défense 1197 Hôpital Paul BrousseVillejuif 94800France Microenvironment&Immunity Unit Institut PasteurParis 75724France Institut national de la santéet de la recherche médicale(Inserm)Unit 1224 Paris 75724France Department of Pharmacognosy University of ViennaVienna 1090Austria Paris-Saclay University Villejuif 94800France CellMedEx Saint Maur Des Fossés 94100France

Bone-marrow-derived mesenchymal stem cells and endothelial progenitor cells have some interesting biological properties that make them unique for cell therapy of degenerative and cardiovascular *** both cell populations have been already studied and used for their regenerative potentials,recently their special immunoregulatory features have brought much more *** stem cells and endothelial progenitor cells have both proangiogenic functions and have been shown to suppress the immune response,particularly T cell proliferation,activation,and cytokine *** makes them suitable choices for allogeneic stem cell ***,these two cells do not have equal immunoregulatory *** elements including their extraction sources,age/passage,expression of different markers,secretion of bioactive mediators,and some others could change the efficiency of their immunosuppressive ***,to our knowledge,no publication has yet compared mesenchymal stem cells and endothelial progenitor cells for their immunological interaction with T *** review aims to specifically compare the immunoregulatory effect of these two populations including their T cell suppression,deactivation,cytokine production,and regulatory T cells induction ***,it evaluates the implications of the tumor necrosis factor alpha-tumor necrosis factor receptor 2 axis as an emerging immune checkpoint signaling pathway controlling most of their immunological properties.

关键词： Endothelial Progenitor Cells Mesenchymal stem Cells T cells Immunosuppression Immunoregulation TNFα-TNFR2 signaling pathway

Is chronic hepatitis C virus infection a risk factor for breast cancer?

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World Journal of Gastroenterology 2010年第29期16卷 3687-3691页

作者： Dominique Larrey Marie-Cécile Bozonnat Ihab Kain georges-Philippe Pageaux Eric Assenat Liver Unit and INSERM Unit 632 Saint-Eloi HospitalMontpellier University Department of Biostatistics Intitut Universitaire de Recherche CliniqueMontpellier University Liver Unit Saint-Eloi HospitalMontpellier University Medical Oncology Unit Saint-Eloi HospitalMontpellier University

AIM:To evaluate the prevalence of breast tumors in adult females with chronic hepatitis C virus(HCV) ***:Prospective,single-center study,based on female outpatients consulting in a liver unit,for 1 *** study group included females with present and/or past history of chronic infection by *** with spontaneous recovery were *** hepatitis had been proved by liver biopsy in the majority of cases and/or biological markers of inflammation and *** control group included female patients with other well documented chronic liver diseases:chronic hepatitis B,alcoholic liver disease,autoimmune hepatitis,hemochromatosis,non alcoholic liver disease,chronic *** patients were prospectively questioned during consultation about past breast history and follow-up by ***:Breast carcinoma was recorded in 17/294 patients with HCV infection(5.8%,95% CI:3.1-8.4) vs 5/107 control patients(4.7%,95% CI:0.67-8.67).Benign tumors of the breast(mastosis,nodules,cysts) were recorded in 75/294 patients with HCV infection(25.5%,95% CI:20.5-30.5) vs 21/107(19.6%,95% CI:12.1-27.1) in the control *** lesion was noted in 202 patients with HCV(68.7%,95% CI:63.4-74) vs 81 control patients(75.7%,95% CI:67.6-83.8).Despite a trend to an increased prevalence in the group with HCV infection,the difference was not significant compared to the control group(P=NS).In patients over 40 years,the results were,respectively,as follows:breast cancer associated with HCV:17/266 patients(6.3%,95% CI:3.4-9.3) vs 5/95 patients(5.2%,95% CI:0.7-9.7) in the control group;benign breast tumors:72/266 patients with HCV infection(27%,95% CI:21.7-32.4) vs 18/95 patients(18.9%,95% CI:11-26.8) in the control group;no breast lesion 177/266(66.5%,95% CI:60.9-72.2) in patients with HCV infection vs 72/95(75.7%,95% CI:67.1-84.4) in the control *** differences were not significant(P=NS).CONCLUSION:These results suggest that chronic HCV infectio

关键词： Breast tumors Breast cancer Hepatitis C virus infection Risk factor