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Outpa.ient insulin use in type 2 dia.etes mellitus a.d a.ute respira.ory distress syndrome outcomes:a.retrospective cohort study

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World Journa. of Clinica. Ca.es 2024年第17期12卷 2966-2975页

作者： georges Kha.ta. Sa.er a.ma. La.rence a.un Fa.es Sa.iba.Sha.a.a.ma.dini Sa.f a.u Ba.er Ca.herine Hong Ca.olla.El Cha.ieh Fa.i Ha.da.in Toni Ha.ib Oma. Moura. Zeina.Morcos Fa.ema.a.a.a.Jona.ha. Mina.Kha.il El Gha.ib Moha.ma. a.da.a.meh Sa.ma. Kha. Elie Bou Sa.a.eh Depa.tment of Medicine Holy Spirit University of KaslikJounieh 00000Lebanon Depa.tment of Interna. Medicine Staten Island University HospitalStaten IslandNY 10305United States Public Hea.h a.d Biosta.istics Independent ResearchBeirut 0000Lebanon Depa.tment of Medicine Lebanese UniversityBeirut 00000Lebanon Depa.tment of Medicine University of BalamandBeirut 00000Lebanon Depa.tment of Medicine Lebanese American UniversityBeirut 00000Lebanon Depa.tment of Medicine Northwell Health Staten Island University HospitalNew YorkNY 10305United States

Ba.KGROUND The impa.t of type 2 dia.etes mellitus(T2DM)on a.ute respira.ory distress syndrome(a.DS)is deba.a.le.T2DM wa. suspected to reduce the risk a.d complica.ions of ***,during corona.irus disea.e 2019(COVID-19),T2DM predisposed pa.ients to a.DS,especia.ly those who were on insulin a. *** eva.ua.e the impa.t of outpa.ient insulin use in T2DM pa.ients on non-COVID-19 a.DS *** We conducted a.retrospective cohort a.a.ysis using the Na.ionwide Inpa.ient Sa.ple *** pa.ients dia.nosed with a.DS were stra.ified into insulin-dependent dia.etes mellitus(DM)(IDDM)a.d non-insulindependent DM(NIDDM)*** a.plying exclusion criteria.a.d ma.ching over 20 va.ia.les,we compa.ed cohorts for morta.ity,dura.ion of mecha.ica. ventila.ion,incidence of a.ute kidney injury(a.I),length of sta.(LOS),hospita.iza.ion costs,a.d other clinica. *** Following 1:1 propensity score ma.ching,the a.a.ysis included 274 pa.ients in ea.h ***,no sta.istica.ly significa.t differences emerged between the IDDM a.d NIDDM groups in terms of morta.ity ra.es(32.8%vs 31.0%,P=0.520),media. hospita. LOS(10 d,P=0.537),requirement for mecha.ica. ventila.ion,incidence ra.es of sepsis,pneumonia.or a.I,media. tota. hospita.iza.ion costs,or pa.ient disposition upon *** Compa.ed to a.terna.ive a.ti-dia.etic medica.ions,outpa.ient insulin trea.ment does not a.pea. to exert a. independent influence on in-hospita. morbidity or morta.ity in dia.etic pa.ients with non-COVID-19 a.DS.

关键词： a.ute respira.ory distress syndrome Type 2 dia.etes mellitus Insulin Length of sta. Morta.ity Endotra.hea. intuba.ion a.ute kidney injury Corona.irus disea.e 2019

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Profile of a.toa.tibodies a.d Clinica. Symptoms in Guinea. Pa.ients with Connective Tissue Disea.es

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Open Journa. of Immunology 2024年第1期14卷 1-10页

作者： Ma.ia.a.Sa.jo Dia.lo Doufin Tra.re a.a.e Diouf Djiba.Ka.a.Issia.a.Dia.lo Doudou georges Ma.sa. Nia.g a.imou Ca.a.a.Ouma. Moucta. Dia.lo Boh Fa.ta.Dia.e a.doula.e Ba.ry Ouo-Ouo Ya.a.on Kolie Mousta.ha.Mbow a.y Ba.ra.Ka.issoko Djibril Sylla.Ba.a.a. Mbengue Moha.ed Cisse Fa.ulté des Sciences et Techniques de la.Sa.té Université Gamal Abdel Nasser de Conakry Conakry Guinée La.ora.oire de Biologie Molécula.re Nestor Ba.goURa.Helene La.ROUSSE H&#244pital de jour Donka CHU Donka Conakry Guinée Centre d’Excellence a.rica.n Pour la.Prévention et le Contrô le des Maladies Transmissibles Conakry Guinée La.ora.oire d’Immunologie Université Cheikh Anta Diop Dakar Sénégal Service de Derma.ologie-Vénérologie CHU Donka Conakry Guinée Service de Rhuma.ologie H&#244pital National Ignace Deen Conakry Guinée Service de Médecine Interne CHU Donka Conakry Guinée

Connective tissue disea.es (CTDs) a.e a.toimmune disea.es (a.Ds) cha.a.terized by the a.pea.a.ce of a.toa.tibodies, which a.e dia.nostic ma.kers. Investiga.ions of these a.toa.tibodies pla. a.ma.or role in the ma.a.ement of severa. a.toimmune disea.es. The objective of this study wa. to describe the profile of a.ti-ENa.a.tibodies a.cording to the clinica. symptoms of mixed CTDs in Cona.ry tea.hing Hospita.. We performed a.cross-sectiona. study during six months. a.tota. of 20 pa.ients wa. recruited a.d we mea.ured a.tibodies using the ELISa.technique. The mea. a.e of our pa.ients wa. 36.5 yea.s, with a.predomina.ce of fema.es. Cuta.eous a.d rheuma.ologica. signs were the ma.n clinica. ma.ifesta.ions. SLP wa. the most frequent CTDs;the threshold of ENa.a.tibodies positivity wa. higher in scleroderma.with a.d SLP. a.ti-ENa.identifica.ion revea.s the frequency of a.ti-SSa.(83.33%), a.ti-U1RNP (66.66%) a.d a.ti-histone (50%) a.tibodies. a.tinuclea. a.tibodies (a.a. rea.t with va.ious components of the cell nucleus. Their detection is of ma.or interest in the dia.nosis of CTDs. Our results highlight the importa.ce of determining the specificity of these a.tibodies to guide differentia. dia.nosis.

关键词： a.toa.tibodies Extra.tible Nuclea. a.tigen (ENa. Connective Tissue Disea.es ELISA

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Wa.elet Neura. Networks for a.a.tive Equa.iza.ion by Using the Orthogona. Lea.t Squa.e a.gorithm

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Tsinghua.Science a.d Technology 2004年第1期9卷 24-29,37页

作者：江铭虎邓北星 georges Gielen La. of Computa.iona. Linguistics Department of Chinese Language Tsinghua University Beijing 100084 China Depa.tment of Electronic Engineering Tsinghua University Beijing 100084 China Depa.tment of Electrica. Engineering K.U.Leuven Kasteelpark Arenberg 10 B3001 Heverlee Belgium

Equa.izers a.e widely used in digita. communica.ion systems for corrupted or time va.ying cha.nels. To overcome performa.ce decline for noisy a.d nonlinea. cha.nels, ma.y kinds of neura. network models ha.e been used in nonlinea. equa.iza.ion. In this pa.er, we propose a.new nonlinea. cha.nel equa.iza.ion, which is structured by wa.elet neura. networks. The orthogona. lea.t squa.e a.gorithm is a.plied to upda.e the weighting ma.rix of wa.elet networks to form a.more compa.t wa.elet ba.is unit, thus obta.ning good equa.iza.ion performa.ce. The experimenta. results show tha. performa.ce of the proposed equa.izer ba.ed on wa.elet networks ca. significa.tly improve the neura. modeling a.cura.y a.d outperform conventiona. neura. network equa.iza.ion in signa. to noise ra.io a.d cha.nel non-linea.ity.

关键词： a.a.tive equa.iza.ion wa.elet neura. networks (WNNs) orthogona. lea.t squa.e (OLS)

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Comment on:loca. control a.d surviva. a.ter induction chemothera.y a.d a.la.ive ra.ia.ion versus resection for pa.crea.ic ducta. a.enoca.cinoma.with va.cula. involvement

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Hepa.obilia.y Surgery a.d Nutrition 2021年第5期10卷 672-674页

作者： Pa.line georges a.exa.dre Doussot Depa.tment of Digestive Surgica. Oncology-Liver Tra.spla.ta.ion Unit CHU BesanconBesanconFrance

We rea. with interest the study from Jolissa.nt et *** issued in the a.na.s of Surgery(1).In this single center retrospective study,the a.thors compa.ed oncologica. outcomes in pa.ients with pa.crea.ic ducta. a.enoca.cinoma.PDa.)a.d va.cula. involvement who underwent pa.crea.ectomy(n=105)*** dose a.la.ive ra.ia.ion(a.RT,n=104).a.l pa.ients received induction chemothera.y first,over a.recent study period[2014-2018].While the ra.iona.e for submitting pa.ients to pa.crea.ectomy or a.RT wa. not clea.ly sta.ed in the Methods section,compa.ison between the two groups showed tha. pa.ients a.loca.ed to a.RT were fra.ler with higher Cha.lson Comorbidity indexes a.d Ea.tern Coopera.ive Oncology Group(ECOG)scores a.d ha.bored significa.tly la.ger tumors,more often left-sided,with more a.teria. involvement a. compa.ed to pa.ients in the pa.crea.ectomy group.

关键词： involvement a.enoca.cinoma Surgery

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EXPERIMENTa. a.D NUMERICa. INVESTIGa.ION OF BUBBLE a.GMENTED Wa.ERJET PROPULSION

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Journa. of Hydrodyna.ics 2012年第5期24卷 635-647页

作者： CHOI Jin-Keun SINGH Sowmitra.HSIa. Cha.-Tsung CHa.INE georges L DYNa.LOW INC. JessupMarylandUSA

This contribution presents experimenta. a.d numerica. investiga.ions of the concept jet propulsion a.gmenta.ion using bubble injection. a.ha.f-3D （D-sha.ed cylindrica. configura.ion to ena.le optima. visua.iza.ions） divergent-convergent nozzle wa. designed, built, a.d used for extensive experiments under different a.r injection conditions a.d thrust mea.urement schemes. The design, optimiza.ion, a.d a.a.ysis were conducted using numerica. simula.ions. The more a.va.ced model wa. ba.ed on a.two-wa. coupling between a. Euleria. description of the flow field a.d a.La.ra.gia. tra.king of the injected bubbles using our Surfa.e a.era.ed Pressure （Sa.） model. The numerica. results compa.e very fa.ora.ly with nozzle experiments a.d both experiments a.d simula.ions va.ida.ion the thrust a.gmenta.ion concept. For a.properly designed nozzle a.d a.r injection system, a.r injection produces net thrust a.gmenta.ion, which increa.es with the ra.e of bubble injection. Doubling of thrust wa. mea.ured for a.50% a.r injection ra.e. This beneficia. effect rema.ns a. 50% a.ter a.count for liquid pump a.ditiona. work to overcome increa.ed pressure by a.r injection.

关键词： wa.erjet propulsion bubble dyna.ics multi-pha.e flow

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High-ma.nifica.ion observa.ion of seminiferous tubules through the tunica.a.buginea.by two-photon la.er sca.ning microscopy

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a.ia. Journa. of a.drology 2011年第5期13卷 774-776页

作者： Vincent a.ha.d Pa.ca. Weber georges Mercier Ma.ie-Pierre Bla.cha.d La.ora.oire d＇Histologie-Cytologie Faculte de Medecine secteur Timone Universite de la Mediterranee Marseille 13385 France Centre d＇a.sista.ce Medica.e a.la.Procrea.ion AP-HM Conception Marseille 13385 France CNRS - IBDML - UMR6216 Service Imagerie - Case 907 Faculte des Sciences de Luminy Marseille 13288 France and Centre de Microscopie et Ima.erie IFR Jean Roche Universite de la Mediterranee Marseille 13916 France

Testicula. sperm extra.tion is widely used in the trea.ment of ma.e infertility in ca.es of non-obstructive a.oospermia. Identifying sperma.ogenetic foci within the testes is critica. for testicula. sperm extra.tion. Two-photon la.er sca.ning microscopy （TPLSM） is a. a.tofluorescence-ba.ed microscopy technique tha. a.lows observa.ion a. a.cellula. level in the depth of fresh living tissues a.d does not require a.y histologica. processing （fixa.ion or sta.ning）. The wa.elengths previously used ha.e shown no phototoxicity on sperm. We used TPLSM to detect sperma.ogenetic foci in fresh mouse testicula. pa.enchyma.without disrupting the tunica.a.buginea. Fresh surgica.ly retrieved testes were observed using TPLSM within 1 h a.ter extra.tion. Contra.a.era. testes for ea.h a.ima. were observed using sta.da.d histology. Using TPLSM we were a.le to observe a.d mea.ure the dia.eter of seminiferous tubules through the tunica.a.buginea. simila. to the histologica. control. Structures within epithelia. tubules were a.so observed, a.though their na.ure ha. yet to be identified. TPLSM is a.rea.-time microscopy technique tha. could detect sperma.ogenetic foci.

关键词： seminiferous epithelium sperma.ogenesis

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a.discrete-time susceptible-infectious-recovered-susceptible model for the a.a.ysis of influenza.da.a

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Infectious Disea.e Modelling 2023年第2期8卷 471-483页

作者： georges Bucyiba.uta.C.B.Dea. Ma.moud Tora.i Depa.tment of Sta.istics a.d a.tua.ia. Science University of Waterloo200 University Ave WWaterlooONN2L 3G1Canada Depa.tment of Community Hea.th Sciences University of ManitobaWinnipegManitobaR3E 0W3Canada

We develop a.discrete time compa.tmenta. model to describe the sprea. of sea.ona. influenza.*** time a.d disea.e sta.e va.ia.les a.e a.sumed to be discrete,this model is considered to be a.discrete time,stocha.tic,Susceptible-Infectious-RecoveredSusceptible(DT-SIRS)model,where weekly counts of disea.e a.e a.sumed to follow a.Poisson *** a.low the disea.e tra.smission ra.e to a.so va.y over time,a.d the disea.e ca. only be reintroduced a.ter extinction if there is a.conta.t with infected individua.s from other host *** ca.ture the va.ia.ility of influenza.a.tivities from one sea.on to the next,we define the sea.ona.ity with a.4-week period effect tha. ma. cha.ge over *** exa.ine three different tra.smission ra.es a.d compa.e their performa.ce to tha. of existing *** though there is limited informa.ion for susceptible a.d recovered individua.s,we demonstra.e tha. the simple models for tra.smission ra.es effectively ca.ture the beha.iour of the disea.e *** use a.Ba.esia. a.proa.h for *** fra.ework is a.plied in a. a.a.ysis of the tempora. sprea. of influenza.in the province of Ma.itoba.Ca.a.a.2012e2015.

关键词： Discrete-time epidemic model Infectious disea.es Influx process Non-linea. stocha.tic dyna.ics Sea.ona. influenza SIRS model Tra.smission pa.a.eter

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Probiotic yea.ts: a.ti-infla.ma.ory potentia. of va.ious non-pa.hogenic stra.ns in experimenta. colitis in mice

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World Journa. of Ga.troenterology 2010年第17期16卷 2134-2145页

作者： Benot Foligné Jo■lle Dewulf Pa.ca. Va.dekerckove georges Pignède Bruno Pot Institut Pa.teur of Lille Lactic acid Bacteria & Mucosal ImmunityCenter for Infection and Immunity of Lille1 rue du Pr CalmetteBP 245F-59019 LilleFrance University of Lille Nord de Fra.ce F-59000 LilleFrance Centre Na.iona. de la.Recherche Scientifique UMR 8204F-59021 LilleFrance Institut Na.iona. de la.Sa.té et de la.Recherche Médica.e U1019F-59019 LilleFrance Lesa.fre Interna.iona. Direction of Research and Developpement147 rue Gabriel PériBP 602759700 Marcq-en-BaroeulFrance

a.M: To eva.ua.e the in vitro immunomodula.ion ca.a.ity of va.ious non-pa.hogenic yea.t stra.ns a.d to investiga.e the a.ility of some of these food gra.e yea.ts to prevent experimenta. colitis in ***: In vitro immunomodula.ion wa. a.sessed by mea.uring cytokines [interleukin (IL)-12p70,IL-10,tumor necrosis fa.tor a.d interferon γ] relea.ed by huma. periphera. blood mononuclea. cells a.ter 24 h stimula.ion with 6 live yea.t stra.ns (Sa.cha.omyces ssp.) a.d with ba.teria. reference stra.ns.a.murine model of a.ute 2-4-6-trinitrobenzene sulfonic a.id (TNBS)-colitis wa. next used to eva.ua.e the distinct prophyla.tic protective ca.a.ities of three yea.t stra.ns compa.ed with the performa.ce of prednisolone ***: The six yea.t stra.ns a.l showed simila. non-discrimina.ing a.ti-infla.ma.ory potentia. when tested on immunocompetent cells in vitro .However,a.though they exhibited simila. coloniza.ion pa.terns in vivo ,some yea.t stra.ns showed significa.t a.ti-infla.ma.ory a.tivities in the TNBS-induced colitis model,wherea. others ha. wea.er or no preventive effect a. a.l,a. evidenced by colitis ma.kers (body-weight loss,ma.roscopic a.d histologica. scores,myeloperoxida.e a.tivities a.d blood infla.ma.ory ma.kers).CONCLUSION: a.ca.eful selection of stra.ns is required a.ong the biodiversity of yea.ts for specific clinica. studies,including a.plica.ions in infla.ma.ory bowel disea.e a.d other thera.eutic uses.

关键词： Yea.t Probiotics Stra.n specificity Experimenta. colitis 2-4-6-trinitrobenzene sulfonic a.id

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Defining Velocity a.d a.celera.ion Ra.ges for Time-Motion a.a.ysis from a.7-Sided Ga.e in U11 Soccer Pla.ers Using Globa. Positioning System Devices:a.Ca.e Study

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Journa. of Science in Sport a.d Exercise 2023年第2期5卷 167-173页

作者： a.d-Elba.set a.a.dia.Grégory Dupont georges Ba.uet Universitéde Lille EA 7369-URePSSS-Unitéde Recherche Pluridisciplinaires Sport SantéSociété59000 LilleFrance Resea.ch Institute for Sport a.d Exercise Sciences Liverpool John Moores University LiverpoolUK

The a.ms of this study were(1)to define speed a.d a.celera.ion thresholds from youth ma.ch a.tivity of soccer pla.ers a.d(2)to a.a.yze the a.tivity performed by young soccer pla.ers during a.ma.ch using GPS devices a.d a.cording to these *** U11 soccer pla.ers from a.professiona. club pa.ticipa.ed in a.7-sided ma.ch being equipped with globa. positioning system(GPS)devices(sa.pling frequency 5 Hz)to mea.ure the speed of ea.h *** Kernel Density Esti-ma.e(KDE)wa. used to observe the occurrences of *** ra.ge of velocities wa. described by a.distribution curve,from which the speed a.d a.celera.ion thresholds for ea.h ca.egory of movement were defined a.d time–motion a.a.ysis of the ma.ch wa. *** model with 4 Ga.ssia. la.s wa. the best when using the a.a.ke Informa.ion Criterion(a.C).In this study,the thresholds defined for ea.h ca.egory of movement were:sta.ding(a.king(0.1–5.6 km/h),slow running(5.7–7.7 km/h),fa.t running(7.8–12.7 km/h)a.d sprint(≥12.8 km/h).a.celera.ion thresholds were ca.cula.ed to define movement considered a. a.sprint for ea.h ca.egory of movement:sta.ding(0.3 m/s^(2)),wa.king(0.66 m/s^(2)),slow running(1.01 m/s^(2))or fa.t running(0.97 m/s^(2)).a.l the a.celera.ion thresholds were significa.tly different from ea.h other(Pa.ge effect sizes,excepting the compa.ison between slow a.d fa.t running(P=0.41)with a.sma.l effect *** U-11 soccer pla.ers,time–motion a.a.ysis ma. be performed a.cording to five ca.egories of *** study ha. a.so defined sprint a.d a.celera.ion thresholds for this ca.egory of a.e.

关键词： Footba.l Sprint a.celera.ions Movement Youth

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Differences a.d simila.ities between mesenchyma. stem cell a.d endothelia. progenitor cell immunoregula.ory properties a.a.nst T cells

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World Journa. of Stem Cells 2021年第8期13卷 971-984页

作者： Mehdi Ra.a.ia. Ma.ya. Khosra.i Sheyda.Ba.ira.i georges Uza. Sa.a.Sha.da.i Sina.Na.eria. Institut na.iona. de la.sa.téet de la.recherche médica.e(Inserm)UnitéMixte de Recherche-Inserm-Ministère de la.Défense 1197 Hôpital Paul BrousseVillejuif 94800France Microenvironment&Immunity Unit Institut PasteurParis 75724France Institut na.iona. de la.sa.téet de la.recherche médica.e(Inserm)Unit 1224 Paris 75724France Depa.tment of Pha.ma.ognosy University of ViennaVienna 1090Austria Pa.is-Sa.la. University Villejuif 94800France CellMedEx Saint Maur Des Fossés 94100France

Bone-ma.row-derived mesenchyma. stem cells a.d endothelia. progenitor cells ha.e some interesting biologica. properties tha. ma.e them unique for cell thera.y of degenera.ive a.d ca.diova.cula. *** both cell popula.ions ha.e been a.rea.y studied a.d used for their regenera.ive potentia.s,recently their specia. immunoregula.ory fea.ures ha.e brought much more *** stem cells a.d endothelia. progenitor cells ha.e both proa.giogenic functions a.d ha.e been shown to suppress the immune response,pa.ticula.ly T cell prolifera.ion,a.tiva.ion,a.d cytokine *** ma.es them suita.le choices for a.logeneic stem cell ***,these two cells do not ha.e equa. immunoregula.ory *** elements including their extra.tion sources,a.e/pa.sa.e,expression of different ma.kers,secretion of bioa.tive media.ors,a.d some others could cha.ge the efficiency of their immunosuppressive ***,to our knowledge,no publica.ion ha. yet compa.ed mesenchyma. stem cells a.d endothelia. progenitor cells for their immunologica. intera.tion with T *** review a.ms to specifica.ly compa.e the immunoregula.ory effect of these two popula.ions including their T cell suppression,dea.tiva.ion,cytokine production,a.d regula.ory T cells induction ***,it eva.ua.es the implica.ions of the tumor necrosis fa.tor a.pha.tumor necrosis fa.tor receptor 2 a.is a. a. emerging immune checkpoint signa.ing pa.hwa. controlling most of their immunologica. properties.

关键词： Endothelia. Progenitor Cells Mesenchyma. Stem Cells T cells Immunosuppression Immunoregula.ion TNFα-TNFR2 signa.ing pa.hwa.

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