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MicroRNA profile in neosquamous esophageal mucosa following ablation of Barrett's esophagus

World journal of Gastroenterology 2017年第30期23卷 5508-5518页

作者： Loveena Sreedharan george C Mayne David I Watson Timothy Bright Reginald V Lord Alfiya Ansar Tingting Wang jakob Kist David Stj Astill Damian j Hussey Department of Surgery Flinders Medical Centre Flinders University St Vincent’s Centre for Applied Medical Research Department of Anatomical Pathology Flinders Medical Centre

To investigate the microRNA expression profile in esophageal neosquamous epithelium from patients who had undergone ablation of Barrett’s esophagus. METHODSHigh throughput screening using TaqMan® Array Human MicroRNA quantitative PCR was used to determine expression levels of 754 microRNAs in distal esophageal mucosa (1 cm above the gastro-esophageal junction) from 16 patients who had undergone ablation of non-dysplastic Barrett’s esophagus using argon plasma coagulation vs pretreatment mucosa, post-treatment proximal normal non-treated esophageal mucosa, and esophageal mucosal biopsies from 10 controls without Barrett’s esophagus. Biopsies of squamous mucosa were also taken from 5 cm above the pre-ablation squamo-columnar junction. Predicted mRNA target pathway analysis was used to investigate the functional involvement of differentially expressed microRNAs. RESULTSForty-four microRNAs were differentially expressed between control squamous mucosa vs post-ablation neosquamous mucosa. Nineteen microRNAs were differentially expressed between post-ablation neosquamous and post-ablation squamous mucosa obtained from the more proximal non-treated esophageal segment. Twelve microRNAs were differentially expressed in both neosquamous vs matched proximal squamous mucosa and neosquamous vs squamous mucosa from healthy patients. Nine microRNAs (miR-424-5p, miR-127-3p, miR-98-5p, miR-187-3p, miR-495-3p, miR-34c-5p, miR-223-5p, miR-539-5p, miR-376a-3p, miR-409-3p) were expressed at higher levels in post-ablation neosquamous mucosa than in matched proximal squamous and healthy squamous mucosa. These microRNAs were also more highly expressed in Barrett’s esophagus mucosa than matched proximal squamous and squamous mucosa from controls. Target prediction and pathway analysis suggests that these microRNAs may be involved in the regulation of cell survival signalling pathways. Three microRNAs (miR-187-3p, miR-135b-5p and miR-31-5p) were expressed at higher levels in post-

关键词： Neosquamous Barrett’s esophagus Ablation

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Basic Neurochemistry : Molecular, Cellular and Medical Aspects 7th

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2006年

作者： Siegel, george j.

ISBN: (纸本)9780120883974;9780080472072

Basic Neurochemistry: Molecular, Cellular and Medical Aspects, a comprehensive text on neurochemistry, is now updated and revised in its Seventh Edition. This well-established text has been recognized worldwide as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for graduate and postgraduate students and instructors in the neurosciences. It is an excellent source of information on basic biochemical processes in brain function and disease for qualifying examinations and continuing medical *** updated with 60% new authors and material, and entirely new chaptersOver 400 fully revised figures in splendid color

关键词： Neurochemistry

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Electrochemical study of different membrane materials for the fabrication of stable,reproducible and reusable reference electrode

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journal of Energy Chemistry 2020年第10期29卷 33-41页

作者： Nawar K.Al-Shara Farooq Sher Sania Z.Iqbal Zaman Sajid george Z.Chen Department of Chemical and Environmental Engineering University of NottinghamUniversity ParkNottingham NG72RDUnited Kingdom School of Mechanical Aerospace and Automotive EngineeringFaculty of EngineeringEnvironmental and ComputingCoventry UniversityCoventry CV12JHUnited Kingdom Department of Biochemistry University of AgricultureFaisalabad 38000Pakistan Department of Process Engineering Memorial University of NewfoundlandSt John’s Newfoundland A1B 3×5Canada

Fabrication of stable,reproducible and reusable reference electrodes for low energy and high-temperature steam splitting is of great interest for hydrogen fuel production without anthropogenic carbon dioxide(CO2)*** study has been conducted for the detection of suitable material for the fabrication of novel reference *** the present scenario,this research is designed to fabricate a novel nickel reference electrode by using operating conditions of eutectic molten hydroxide(NaOH-KOH,49-51 mol%)at temperature 300℃in an ion-conducting membrane of alumina and mullite ***,the designed nickel reference electrode has been examined for its reusability and stability by using electrochemical technique and cyclic *** scans of cyclic voltammetry are performed for both membrane fabricated reference electrode.A slight positive shift in oxidation peaks is observed for mullite membrane electrode(64 mV from scan 1 to 5).The stability measurements are noted by changing the scan rate between 50 and 150 mV s−***,the results show that the Ni/Ni(OH)2 reference electrode covered with a mullite membrane is stable and reusable at 300℃temperature without any *** stability and reusability of prepared nickel reference electrode covered by mullite tube in the eutectic molten hydroxide were up to 9 days to carry out an electrochemical investigation,while for alumina tube reference electrode the stability and reliability were up to 3 *** internal electrolytic material and ionic conductance can play an important role for future studies with this reference electrode along with optimisation of temperature and scan rate parameters.

关键词： Renewable energy Hydrogen production Electrode process Cyclic voltammetry Reference electrode and Molten salts

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电力系统谐波

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作者： (奥)george j.·Wakileh

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Subjective refractions determined by Dyop® and LogMAR chart as fixation targets

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Annals of Eye Science 2022年第4期7卷 19-26页

作者： Rita W.Sum george C.Woo School of Optometry The Hong Kong Polytechnic UniversityHong KongChina

Background:Dyop®is a dynamic optotype with a rotating and segmented visual *** can be used for visual acuity and refractive error *** objective of the study was to compare refractive error measurement using the Dyop®acuity and LogMAR E ***:Fifty subjects aged 18 or above with aided visual acuity better than 6/12 were *** error was measured by subjective refraction methods using the Dyop®acuity chart and LogMAR E charts and the duration of measurement ***’s notation was used to represent the refractive error obtained for ***:There was no significant difference in terms of spherical equivalent(M)(P=0.96)or j0(P=0.78)and j45(P=0.51)components measured using the Dyop®acuity and LogMAR E ***,subjective refraction measurement was significantly faster using the Dyop®acuity chart(t=4.46,Pjective refraction.

关键词： Dyop dynamic optotype visual acuity subjective refraction

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Cannabinoid receptor antagonist SR141716A decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers

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中国药理学报 1999年第12期20卷 1109-1114页

作者： Feinando RODRIGUEZ DE FONSECA Amanda j ROBERTS Ainhoa BILBAO george F KOOB Miguel NAVARRO Instituto Complutense de Drogodependencias Departamenta de PsicobiologiaFacultad de PsicologiaUniversidad Complutense de Madrid28223-MadridSpain Department of Neuropharmacology The Scripps Research InstituteLa Jolla CA 92037USA

AIM:To study the potential role of dependence statuson CB_(1)-mediated blockade of ethanol ***:We examined the effects of thecannabinoid antagonist SR141716A(0,0.03,0.3,and 3 mg/kg)on pperant ethanol(10%v/v)self-administration in male Wistar rats that were madeethanol-dependent by chronic(14 d)exposure toethanol vapor-chambers or exposed to air in identicalvapor ***:Dependent animalsresponded more for ethanol than did air controlnondependent *** acute administration of a 3mg/kg dose of SR141716A almost suppressed ethanolself-administration ouly in ethanol dependent ***,operant responses for food were not afected by the administration of ***:These results further support that cannabinoid CB_(1) receptor blockade may have a potential utility for the treatment of alcobolism.

关键词： ethanol self administration cannabinoid rcceptors SR141716A

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Timing of Hepatitis C Virus Treatment in Liver Transplant Candidates in the Era of Direct-acting Antiviral Agents

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journal of Clinical and Translational Hepatology 2017年第4期5卷 363-367页

作者： george Cholankeril Mairin joseph-Talreja Brandon j.Perumpail Andy Liu Eric R.Yoo Aijaz Ahmed Aparna Goel Division of Gastroenterology and Hepatology Stanford University School of MedicineStanfordCAUSA Department of Medicine Drexel University College of MedicinePhiladelphiaPAUSA Department of Medicine California Pacific Medical CenterSan FranciscoCAUSA Department of Medicine Santa Clara Valley Medical CenterSan JoseCAUSA

Chronic hepatitis C virus(HCV)infection remains the leading indication for liver transplantation(LT)in the United *** most patients with chronic HCV infection remain asymptomatic,up to one-third develop progressive liver disease resulting in *** is often the only curative treatment once significant hepatic decompensation ***,antiviral therapy for HCV infection has advanced markedly in the past 5 years with the discovery and approval of direct-acting antiviral *** new regimens are well tolerated,of short duration and highly effective,unlike the traditional treatment with pegylated-interferon and *** achieving sustained virological response becomes increasingly attainable for a majority of HCV-infected patients,concerns have been raised regarding the optimal timing of treatment for HCV infection in the setting of end-stage liver disease and during the peri-transplant *** one hand,HCV treatment may improve hepatic function and negate the need for LT in some,which is crucial given the scarcity of donor organs and mortality on the waiting list in certain *** the other hand,HCV treatment may result in lowering the priority for LT without improving quality of life,thereby delaying potentially curative LT *** review evaluates the evidence supporting the use of direct-acting antiviral agents in the period before and following LT.

关键词： Hepatitis C virus Direct-acting antiviral therapy Liver transplantation

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HARnesSING ECOLOGICAL PRINCIPLES AND PHYSIOLOGIC MECHANISMS IN DIVERSIFYING AGRICULTURAL SYSTEMS FOR SUSTAINABILITY:EXPERIENCE FROM STUDIES DEPLOYING NATUR-EBASED SOLUTIONS IN SCOTLAND

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Frontiers of Agricultural Science and Engineering 2022年第2期9卷 214-237页

作者： Timothy S.george Cathy HAWES Tracy A.VALENTINE Alison j.KARLEY Pietro P.M.IANNETTA Robin W.BROOKER Ecological Sciences Department The James Hutton InstituteInvergowrieDundeeDD25DAUK

To achieve the triple challenge of food security,reversing biodiversity declines plus mitigating and adapting to climate change,there is a drive to embed ecological principles into agricultural,value-chain practices and *** diversifying cropping systems at several scales there is potential to decrease reliance on inputs,provide resilience to abiotic and biotic stress,enhance plant,microbe and animal biodiversity,and mitigate against climate *** this review we highlight the research performed in Scotland over the past 5 years into the impact of the use of ecological principles in agriculture on sustainability,resilience and provision of ecosystem *** demonstrate that diversification of the system can enhance ecosystem *** and plant management interventions,including nature-based solutions,can also enhance soil quality and utilization of legacy ***,this is facilitated by greater reliance on soil biological processes and trophic *** highlight the example of intercropping with legumes to deliver sustainability through ecological principles and use legumes as an exemplar of the *** conclude that there are many effective interventions that can be made to deliver resilient,sustainable,and diverse agroecosystems for crop and food production,and these may be applicable in any agroecosystem.

关键词： diversification ecological principles legumes plant management soil management soil ecosystem services

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Basic neurochemistry on CD-ROM 6th ed.

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1998年

作者： Siegel george j.

Contains the full text of the printed version with additional videos, animations, and website linkages.

ISBN: (纸本)0781717450

Contains the full text of the printed version with additional videos, animations, and website linkages.

关键词： Neurochemistry.

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Powassan virus:A tick borne flavivirus infecting humans

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Biosafety and Health 2022年第1期4卷 30-37页

作者： Xu Yang george F.Gao William j.Liu CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences(CAS)Beijing 100101China State Key Laboratory of Natural and Biomimetic Drugs Department of Chemical BiologySchool of Pharmaceutical SciencesPeking UniversityBeijing 100191China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention(China CDC)Beijing 102206China

Infection of humans by Powassan virus(POWV)occurs rarely but is potentially life‐*** isolated in Ontario,Canada in 1958,the presence of POWV has been confirmed in three countries:Canada,the USA,and *** a limited number of human cases has been reported thus far,the infection rate has shown signs of increasing during the 21^(st) ***,POWV and a genetically close variant,deer tick virus(DTV),are the only member of the tick‐borne flaviviruses known to be endemic in North America and maintain in respective tick‐host *** this review,we briefly summarize current knowledge involving the epidemiology and etiology,pathogenesis and immunity,molecular evolution,and protein functions of POWV,aiming to increase our understanding of the virus and unlock the potential to control this lethal *** data may also provide tools to minimize the future threat of other emerging and re‐emerging viruses.

关键词： Powassan virus(POWV) Deer tick virus(DTV) Tick‐borne flavivirus(TBFV) Tick Zoonotic disease Encephalitis

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