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Research in Astronomy and Astrophysics 2017年第10期17卷 33-40页

作者： Ze-Xi Niu george Hobbs jing-Bo Wang Shi Dai Department of Astronomy Beijing Normal University Australia Telescope National Facility CSIRO Xinjiang Astronomical Observatory Chinese Academy of Sciences Key Laboratory of Radio Astronomy Chinese Academy of Sciences

The primary goal of pulsar timing array projects is to detect ultra-low-frequency gravitational waves. Pulsar data sets are affected by numerous noise processes including varying dispersive delays in the interstellar medium and from the solar wind. The solar wind can lead to rapidly changing variations that, with existing telescopes, can be hard to measure and then remove. In this paper we study the possibility of using a low frequency telescope to aid in such correction for the Parkes Pulsar Timing Array （PPTA） and also discuss whether the ultra-wide-bandwidth receiver for the FAST telescope is sufficient to model solar wind variations. Our key result is that a single wide-bandwidth receiver can be used to model and remove the effect of the solar wind. However, for pulsars that pass close to the Sun such as PSR j1022＋ 1022, the solar wind is so variable that observations at two telescopes separated by a day are insufficient to correct the solar wind effect.

关键词： stars: pulsars -- gravitational waves

Prognostic impact of the Bismuth-Corlette classification:Higher rates of local unresectability in stageⅢb hilar cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2020年第2期19卷 157-162页

作者： Michael j Passeri Maria R Baimas-george jesse K Sulzer David A Iannitti john B Martinie Erin H Baker Lee M Ocuin Dionisios Vrochides Division of HPB Surgery Department of SurgeryCarolinas Medical Center1025 Morehead Medical Dr.Suite 600CharlotteNC 28204USA

Background:The Bismuth-Corlette(BC)classification is used to categorize hilar cholangiocarcinoma by proximal extension along the biliary *** the right hepatic artery crosses just behind the left bile duct,we hypothesized that BCⅢb tumors would have a higher likelihood of local unresectability due to involvement of the contralateral ***:A retrospective review of a prospectively maintained database identified patients with hilar cholangiocarcinoma taken to the operating room for intended curative resection between April 2008 and September *** were assigned BC stages based on preoperative ***:Sixty-eight patients were included in the *** underwent staging laparoscopy after which 16 cases were aborted for metastatic *** the remaining 52 cases,14 cases were explored and aborted for locally advanced ***-eight underwent attempt at curative *** exclud-ing cases aborted for metastatic disease,the chance of proceeding with resection was 55.6%for BCⅢb staged lesions compared to 80.0%of BCⅢa lesions and to 82.4%for BCⅠ-Ⅲa staged lesions(P<0.05).About 44.4%of BCⅢb lesions were aborted for locally advanced disease versus 17.6%of remaining BC ***:When hilar cholangiocarcinoma is preoperatively staged as BCⅢb,surgeons should antici-pate higher rates of locally unresectable disease,likely involving the right hepatic artery.

关键词： Bismuth-Corlette stage Cholangiocarcinoma Biliary tract surgical procedures Biliary tree Liver surgery

Lipid nanoparticles deliver mRNA to the blood-brain barrier

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Nano Research 2024年第10期17卷 9126-9134页

作者： Yanina Kuzminich Avraham Shakked Randi Calkins Sebastian Rudden Camille jones jessie Doan Bora jang Elisa Schrader Echeverri Ryan Zenhausern Liming Lian David Loughrey Hannah E.Peck Rachelle Wiese Dorothy Koveal Philip j.Santangelo james E.Dahlman george C.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Parker H.Petit Institute for Bioengineering and Biosciences Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical Engineering Emory University School of Medicine and Georgia Institute of TechnologyAtlantaGA 30332USA

Lipid nanoparticles(LNPs)have delivered RNA to hepatocytes in patients after intravenous *** clinical data support efforts to design LNPs that transfect cells in the central nervous system(CNS).However,delivery to the CNS has been difficult,in large part because quantifying on-target delivery alongside common off-target cell types in adult mice remains *** we report methods to isolate different cell types from the CNS,and subsequently present mRNA delivery readouts using a liver-detargeted *** data suggest that LNPs without targeting ligands can transfect cerebral endothelial cells in mice after intravenous *** the difficulty of crossing the blood-brain barrier,they also underscore the value of quantifying delivery in the CNS with cell-type resolution instead of whole-tissue resolution.

关键词： lipid nanoparticle mRNA nanomedicine central nervous system blood-brain barrier

Hexachlorobenzene Episode in Turkey

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Biomedical and Environmental Sciences 1989年第1期2卷 36-43页

作者： AYHAN GOCMEN HENRY A.PETERS DEREK j.CRIPPS george T.BRYAN CARL R.MORRIS Department of Pediatrics School of Medicine University of Hacettepe 06100 Ankara Turkey Center for Health Sciences University of Wisconsin Madison Wisconsin 53706 International Chemical Consultants Alexandria Virginia 22312

During the period 1955-1959, approximately 4000 people in southeast Anatolia developed porphyria due to the ingestion of hexachlorobenzene (HCB), a fungicide added to wheat seedlings. These HCB exposures subsequently led to the development of bullae on sun-exposed areas, hyperpigmentation, hypertrichosis, and porphyrinuria. The condition was called kara yara or 'black sore.' Many of the breast-fed children under the age of 2 years whose mothers had ingested HCB-treated grain died from a disease known as pembe yara or 'pink sore.' In this follow-up study of 252 patients, 20-30 years postexposure, there were 162 males and 90 females, with an average current age of 35.7 years, an average of onset of 7.6 years, and a duration of 2.2 years. Many patients had dermatologic, neurologic, and orthopedic symptoms and signs. The observed clinical findings include scarring of the face and hands (83.7％), hyperpigmentation (65％), hypertrichosis (44.8％), pinched facies (40.1％), painless arthritis (70.2％), small hands (66.6％), sensory shading (60.6％), myotonia (37.9％), cogwheeling (41.9％), enlarged thyroid (34.9％), and enlarged liver (4.8％). Urine and stool porphyrin levels were determined in all patients, and 17 have at least one of the porphyrins elevated. A total of 56 specimens of human milk obtained from mothers with porphyria were analyzed for HCB. The average value was 0.51 ppm in HCB-exposed patients compared to 0.07 ppm in unexposed controls. Offspring of mothers with three decades of HCB-induced porphyria appear normal. 1989 Academic Press, Inc.

关键词： Hexachlorobenzene Episode in Turkey HCB

Corneal collagen crosslinking in patients treated with dextran versus isotonic hydroxypropyl methylcellulose (HPMC) riboflavin solution: a retrospective analysis

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Eye and Vision 2018年第1期5卷 211-216页

作者： Patrick B.Rapuano Priya M.Mathews george j.Florakis Stephen L.Trokel Leejee H.Suh Department of Ophthalmology Edward S.Harkness Eye InstituteColumbia College of Physicians and Surgeons635 West 165th StreetNew YorkNY 10032USA

Background:Corneal collagen crosslinking(CXL)is a widely used treatment for halting the progression of *** initial studies of CXL were performed with a riboflavin solution containing dextran,recent protocols for CXL have indicated the use of a riboflavin solution containing isotonic hydroxypropyl methylcellulose(HPMC).This study was performed to investigate differences in visual outcomes and Scheimpflug(Pentacam)analysis in patients who have undergone epithelium-off CXL with riboflavin solution containing either 20%dextran versus 1.1%***:All patients in this non-randomized,non-masked,retrospective cohort analysis were treated at Edward *** Eye Institute,Columbia University Medical Center,New York,NY,***-seven eyes of 33 patients were crosslinked with a dextran solution and 19 eyes of 19 patients crosslinked with an isotonic HPMC solution,both using an epithelium-off 30-min,3 mW/cm2 *** patients had a diagnosis of keratoconus or postrefractive surgery *** spectacle corrected visual acuity(BSCVA)and Pentacam parameters were compared at all follow up visits(1,6,12,and 24 months).Differences between groups treated with HPMC and dextran were compared using student’s *** between treated eye and fellow eye were calculated and compared between HPMC and dextran groups using paired ***:Patients treated with a dextran solution had significantly greater improvement in BSCVA at 1,6,and 24 months(p<0.05)compared to the isotonic HPMC-treated *** increased in both groups at 1 month;however,HPMC-treated patients had a greater increase compared to dextran-treated patients(p=0.01).Kmax decreased in both groups at 6 and 12 months,although this finding was only significant in the HPMC-treated group at 12 ***:Our data suggest that crosslinking with the dextran solution may result in significantly better visual outcomes(demonstrated by visual acuity)compared to the isotonic HPMC ribof

关键词： Corneal crosslinking Isotonic HPMC Dextran

A COVID-19 T-Cell Response Detection Method Based on a Newly Identified Human CD8+T Cell Epitope from SARS-CoV-2—Hubei Province,China,2021

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China CDC weekly 2022年第5期4卷 83-87,I0005页

作者： jie Zhang Dan Lu Min Li Maoshun Liu Sijia Yao jianbo Zhan William j.Liu george F.Gao NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Savaid Medical School University of Chinese Academy of SciencesBeijingChina College of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityWenzhouZhejiangChina Hubei Provincial Center for Disease Control and Prevention WuhanHubeiChina

Introduction:Similar to antibody detection,severe acute respiratory syndrome coronavirus type 2(SARSCoV-2)-specific T-cell response evaluation is also pivotal among the coronavirus disease 2019(COVID-19)convalescents and the vaccinated ***(N)protein is one of the main structural proteins of SARS-CoV-2 and can trigger T-cell responses in ***:An overlapping peptide pool covering the full length of the N protein was designed,peptides with positive T-cell activating potency in COVID-19 convalescents were screened,and CD8^(+)T cell epitopes were further *** epitope was used to detect the SARS-CoV-2-specific CD8^(+)T cell responses in COVID-19 convalescents based in intracellular cytokine staining and tetramer staining in flow ***:A human leukocyte antigen A(HLAA)*1101-restricted CD8^(+)T cell epitope,which could stimulate the production of IFN-γvia peripheral blood mononuclear cells(PBMCs)of the convalescents was defined,and the tetramer generated with this epitope could detect SARS-CoV-2-specific T cells in the PBMCs of the *** structural investigation eliminated that the epitope was a typical HLA-A^(*)1101-restricted T-cell epitope which was conserved among all the ***:The newly identified SARS-CoV-2-derived T-cell epitope was helpful to detect the cellular immunity against different sarbecoviruses including SARS-CoV and *** study provided an evaluation method and also a peptide candidate for the research and development of T-cell based vaccine for the virus.

关键词： restricted immunity Human

Analytical Modeling to Predict the Strain Energy of Circular GLARE Fiber-Metal Laminates Under Lateral Indentation

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材料科学与工程（中英文A版） 2013年第8期3卷 569-583页

作者： george j. Tsamasphyros george S. E. Bikakis Strength of Materials Laboratory National Technical University of Athens Athens 157 73 GR Greece

This article deals with the strain energy calculation of thin circular clamped Glass Reinforced (GLARE) fiber-metal laminates subjected to static indentation by a lateral hemispherical indentor. Using one-, two- and three-parameter Ritz approximations, analytical equations of the strain energy as a function of the central plate deflection are derived. Previously published analytical formulas, concerning the load-indentation response of circular GLARE plates, are used in order to determine the Ritz parameters and the first failure load and deflection due to tensile fracture of glass-epoxy layers. In this study, the membrane and bending strain energy components of aluminum and prepreg layers are determined. Also, the elastic and plastic strain energy absorbed during the indentation loading are calculated. The derived formulas are applied successfully for GLARE 2-2/1-0.3, GLARE 3-3/2-0.4 and GLARE 3I (special lay-up) circular plates subjected to lateral indentation. The strain energy results converge satisfactorily in all examined cases. The predicted strain energy-indentation response is compared with published experimental data and a good agreement is found. No other solution of this problem is known to the authors.

关键词：纤维金属层板弯曲应变能压痕预测建模解析公式金属层压板塑性应变能

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职场英语写作实战速成

NOTCH3 is expressed in human apical papilla and in subpopulations of stem cells isolated from the tissue

作者： (美)乔治·j. 塞拉斯(george j. Searles)

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Genes & Diseases 2015年第3期2卷 261-267页

作者： Mohamed jamal Sami M.Chogle Sherif M.Karam george T-j.Huang Boston University Henry M.Goldman School of Dental MedicineDepartment of EndodonticsBostonMA 02118USA United Arab Emirates University Department of AnatomyFaculty of Medicine and Health SciencesAl-AinUnited Arab Emirates University of Tennessee Health Science Center College of DentistryDepartment of Bioscience ResearchMemphisTN 38163USA Current address:Department of Bioscience Research College of DentistryUniversity of Tennessee Health Science Center875 Union AvenueMemphisTN 38163USA

NOTCH plays a role in regulating stem cell function and fate *** is involved in tooth development and injury *** regarding NOTCH expression in human dental root apical papilla(AP)and its residing stem cells(SCAP)is *** we investigated the expression of NOTCH3,its ligand jAG1,and mesenchymal stem cell markers CD146 and STRO-1 in the AP or in the primary cultures of SCAP isolated from *** in situ immunostaining showed that in the AP NOTCH3 and CD146 were co-expressed and associated with blood vessels having NOTCH3 located more *** cultured SCAP,NOTCH3 and jAG1 were *** cytometry analysis showed that 7%,16%and 98%of the isolated SCAP were positive for NOTCH3,STRO-1 and CD146,respectively with a rare 1.5%subpopulation of SCAP co-expressing all three *** expression level of NOTCH3 reduced when SCAP underwent osteogenic *** findings are the first step towards defining the regulatory role of NOTCH3 in SCAP fate decision.

关键词： Apical papilla CD146 jAG1 NOTCH3 Osteogenesis SCAP Stemness STRO-1

Cost of treating chronic hepatitis B:Comparison of current treatment guidelines

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World journal of Gastroenterology 2012年第42期18卷 6106-6113页

作者： Monica Robotin Yumi Patton Melanie Kansil Andrew Penman jacob george Medical and Scientific Issues Unit Cancer Council NSW153 Dowling StWooloomoolooSydney 2011Australia School of Public Health University of SydneySydney 2006Australia Cathedral Street Partners 1/96 Cathedral StWoollomoolooSydney 2011Australia Faculty of Medicine University of SydneySydney 2006Australia Storr Liver Unit Westmead Millennium Institute Westmead HospitalSydney 2145Australia

AIM:To compare program costs of chronic hepatitis B(CHB) screening and treatment using Australian and other published CHB treatment ***:Economic modeling demonstrated that in Australia a strategy of hepatocellular cancer(HCC) prevention in patients with CHB is more cost-effective than current standard care,or HCC *** upon this model,we developed the B positive program to optimize CHB management of Australians born in countries of high CHB *** estimated CHB program costs using the B positive program algorithm and compared them to estimated costs of using the CHB treatment guidelines published by the AsianPacific,American and European Associations for the Study of Liver Disease(APASL,AASLD,EASL) and those suggested by an independent United States hepatology *** used a Markov model that factored in the costs of CHB screening and treatment,individualized by viral load and alanine aminotransferase levels,and calculated the relative costs of program *** were discounted by 5% and calculated in Australian dollars(AUD).RESULTS:Using the B positive algorithm,total program costs amount to 13 979 224 AUD,or 9634 AUD per *** least costly strategy is based upon using the AASLD guidelines,which would cost 34% less than our B positive *** the EASL and the United States Expert Group guidelines would increase program costs by 46%.The largest expenditure relates to the cost of drug treatment(66.9% of total program costs).The contribution of CHB surveillance(20.2%) and HCC screening and surveillance(6.6%) is small-and together they represent only approximately a quarter of the total program ***:The significant cost variations in CHB screening and treatment using different guidelines are relevant for clinicians and policy makers involved in designing population-based disease control programs.

关键词： Chronic hepatitis B Markov model Hepatocellular cancer Treatment guidelines