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Continuous culture of urine-derived bladder cancer cells for precision medicine

Protein & Cell 2019年第12期10卷 902-907页

作者： Shuai Jiang Jiaqi Wang Chen Yang Renke Tan Jun Hou Yuan Shi Huihui Zhang Shiyu Ma Jianan Wang Mengmeng Zhang george philips Zengxia Li Jian Ma Wanjun Yu Guohua Wang Yuanming Wu Richard Schlegel Huina Wang Shanbo Cao Jianming Guo Xuefeng Liu Yongjun Dang Department of Urology Zhongshan HospitalFudan UniversityShanghai 200032China Key Laboratory of Metabolism and Molecular Medicine Ministry of Education and Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesFudan UniversityShanghai 200032China Department of Pathology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Respiratory and Critical Care Medicine Yinzhou Hospital Affiliated to Medical school of Ningbo UniversityNingbo 315000China School of Computer Science and Technology Harbin Institute of TechnologyHarbin 150000China AcornMed Biotechnology Co. LtdBeijing 100176China Department of Oncology Lombardi Comprehensive Cancer CenterGeorgetown University Medical SchoolMedStar Georgetown University HospitalWashingtonDC 20001USA Department of Biochemistry and Molecular Biology and Center for DNA Typing Fourth Military Medical UniversityXi'an 710000China Department of Pathology Center for Cell ReprogrammingLombardi Comprehensive Cancer CenterGeorgetown University Medical SchoolWashingtonDC 20001USA E l Correspondence:guo.jianming@***(J.Guo)xl24@georgetown.edu(X.Liu)yongjundang@***(V.Dang

Dear Editor,Bladder cancer is the most common type of genitourinary cancer in China,with an estimated 80,500 new cases and 32,900 related deaths in 2015 alone(Chen et al.,2016).Unlike many other cancers,there has been no significant improvement in survival rates for bladder cancer over the last three *** treatment regimens for bladder cancer and their efficacy vary depending not only on clinical stages,but also on associated risk factors and other personal clinical *** with non-muscle invasive bladder cancer(NMIBC)have a high 5-year recurrence rate of 60%-70%(Berdik,2017)and those with muscle invasive bladder cancer(MIBC)has a relatively poor prognosis with approximately 65%risk of death within 5-year follow-up(Kamat et al.,2016).Therefore,there is an urgent need to develop models for bladder cancer to screen for rational treatment strategies by personalized medicine to improve the clinical assessment and treatment of bladder cancer.

关键词： bladder urine treatment

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Outcomes and Toxicology of Herbal Drugs in Alcoholic Hepatitis-A Single Center Experience from India

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Journal of Clinical and Translational Hepatology 2019年第4期7卷 329-340页

作者： Cyriac Abby philips Sasidharan Rajesh Tom george Rizwan Ahamed Sandeep Kumbar Philip Augustine The Liver Unit and Monarch Liver Lab Cochin Gastroenterology GroupErnakulam Medical CenterKochiKeralaIndia Interventional Radiology Department of Gastroenterology and HepatologyCochin Gastroenterology GroupErnakulam Medical CenterKochiKeralaIndia Gastroenterology and Advanced G.I.Endoscopy Cochin Gastroenterology GroupErnakulam Medical CenterKochiKeralaIndia

Background and Aims:We aimed to study clinical out-comes and liver biopsy features of alcoholic hepatitis(AH)patients on complementary and alternative medicines(CAMs)and to analyze the retrieved drugs for chemical and toxic components linked to drug-induced liver ***:We retrospectively assessed clinical,biochemical and liver bi-opsy features of AH patients on CAM with drug-induced liver injury(AH-CAM,n=27)and compared them to a control group(classical AH,n=29)on standard of *** without liver biopsy evaluation and other causes for liver dis-ease were *** of the CAMs(n=42)from pa-tients were retrieved and assessed for chemical and ***:All were males,and significantly worse clinical pre-sentation,biochemical severity,and liver disease scores were notable in patients with *** Ayurve-dic-polyherbal formulations were the most commonly used *** liver histology,varying grades of severe-necrosis,severe hepatocellular,canalicular,cholangiolar cholestasis with predominant lymphocytic-portal-inflammation and varying grades of interface-hepatitis were noted in *** of CAMs revealed presence of heavy metals up to 100,000 times above detectable range and adulter-ants,such as antibiotics,chemotherapy agents,nonsteroi-dal anti-inflammatory drugs,alcohols,antidepressants,anxiolytics,and recreational *** follow up,a signifi-cantly higher number of patients with AH on CAM died at end of 1,3-and-6-months compared to controls(37%vs.83%,29%vs.62%,18%vs.52%respectively;p<0.001).Conclusions:Patients with AH and CAM-related drug-induced liver injury have extremely poor short-term survival in the absence of liver transplantation compared to those patients with AH on evidence-based *** transplant referral and educating on and curbing of CAM use in severe liver disease through strict monitoring of unregulated traditional health practices can help ease the burden of liver-related death.

关键词： Hepatitis Alcohol CAM DILI Ayurveda

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Repurposing Pirfenidone for Nonalcoholic Steatohepatitis-related Cirrhosis:A Case Series

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Journal of Clinical and Translational Hepatology 2020年第1期8卷 100-105页

作者： Cyriac Abby philips Guruprasad Padsalgi Rizwan Ahamed Rajaguru Paramaguru Sasidharan Rajesh Tom george Pushpa Mahadevan Philip Augustine The Liver Unit and Monarch Liver Lab Cochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Department of Gastroenterology Cochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Department of Pathology Al Salam International HospitalBneid Al QarKuwaitIndia Department of Diagnostic and Interventional Radiology Department of Gastroenterology and The Liver UnitCochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Department of Clinical Pathology VPS Lakeshore HospitalKochiKeralaIndia

We repurposed the antifibrotic drug pirfenidone—which is approved for treatment of idiopathic lung fibrosis—in a series of patients with nonalcoholic steatohepatitis-related *** report demonstrates the observed improvements in necroinflammation and regression of cirrhosis with pirfeni-done use for 12-weeks,associated with classical hepatic repair complex features on follow-up liver *** novel work could help stimulate further randomized trials of pirfe-nidone in patients with nonalcoholic steatohepatitis-related liver fibrosis or cirrhosis,for whom no recommended drug treatments exists currently.

关键词： NASH Fibrosis Antifibrotic Hepatitis Pirfenidone

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Transjugular intrahepatic portosystemic shunt in cirrhosis: An exhaustive critical update

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World Journal of Gastroenterology 2020年第37期26卷 5561-5596页

作者： Sasidharan Rajesh Tom george Cyriac Abby philips Rizwan Ahamed Sandeep Kumbar Narain Mohan Meera Mohanan Philip Augustine Division of Hepatobiliary Interventional Radiology Cochin Gastroenterology GroupErnakulam Medical CenterKochi 682028KeralaIndia The Liver Unit and Monarch Liver Lab Cochin Gastroenterology GroupErnakulam Medical CenterKochi 682028KeralaIndia Gastroenterology and Advanced GI Endoscopy Cochin Gastroenterology GroupErnakulam Medical CenterKochi 682028KeralaIndia Anesthesia and Critical Care Cochin Gastroenterology GroupErnakulam Medical CenterKochi 682028KeralaIndia

More than five decades after it was originally conceptualized as rescue therapy for patients with intractable variceal bleeding,the transjugular intrahepatic portosystemic shunt(TIPS)procedure continues to remain a focus of intense clinical and biomedical *** the impressive reduction in portal pressure achieved by this intervention,coupled with its minimally invasive nature,TIPS has gained increasing acceptance in the treatment of complications of portal *** early years of TIPS were plagued by poor long-term patency of the stents and increased incidence of hepatic ***,the diversion of portal flow after placement of TIPS often resulted in derangement of hepatic functions,which was occasionally *** the incidence of shunt dysfunction has markedly reduced with the advent of covered stents,hepatic encephalopathy and instances of early liver failure continue to remain a significant issue after *** has emerged over the years that careful selection of patients and diligent post-procedural care is of paramount importance to optimize the outcome after *** past twenty years have seen multiple studies redefining the role of TIPS in the management of variceal bleeding and refractory ascites while exploring its application in other complications of cirrhosis like hepatic hydrothorax,portal hypertensive gastropathy,ectopic varices,hepatorenal and hepatopulmonary syndromes,non-tumoral portal vein thrombosis and chylous *** has also been utilized to good effect before extrahepatic abdominal surgery to reduce perioperative morbidity and *** current article aims to review the updated literature on the status of TIPS in the management of patients with liver cirrhosis.

关键词： Early transjugular portosystemic shunt Preemptive transjugular intrahepatic portosystemic shunt Portal hypertension Esophageal varices Gastric varices Refractory ascites

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One disease, many faces-typical and atypical presentations of SARS-CoV-2 infection-related COVID-19 disease

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World Journal of Clinical Cases 2020年第18期8卷 3956-3970页

作者： Cyriac Abby philips Narain Mohan Rizwan Ahamed Sandeep Kumbar Sasidharan Rajesh Tom george Meera Mohanan Philip Augustine The Liver Unit and Monarch Cochin Gastroenterology GroupErnakulam Medical CenterCochin 682025KeralaIndia Gastroenterology and Advanced GI Endoscopy Cochin Gastroenterology GroupErnakulam Medical CenterCochin 682025KeralaIndia Division of Hepatobiliary Interventional Radiology Cochin Gastroenterology GroupErnakulam Medical CenterCochin 682025KeralaIndia Anesthesia and Critical Care Cochin Gastroenterology GroupErnakulam Medical CenterCochin 682025KeralaIndia

Since the appearance of the novel coronavirus(severe acute respiratory syndrome-coronavirus-2)and related coronavirus disease 2019(COVID-19)in China in December 2019,a very high number of small and large patient series have been published in literature from around the *** though the classical presentation of COVID-19 is one with respiratory symptoms with or without pneumonia that can be self-limiting or evolve into severe respiratory distress syndrome with multiple organ failure,and secondary bacterial sepsis,a large body of evidence suggests a plethora of other types of clinical *** this exhaustive review,we reviewed all of the published literature on COVID-19 to identify different types of clinical presentations affecting various organ systems,to provide an in-depth analysis that may prove useful for clinicians and health-workers on the frontline,battling the severe pandemic.

关键词： Adult respiratory distress syndrome Sepsis COVID-19 SARS-CoV-2 World Health Organization Centers for disease control

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Modulating the Intestinal Microbiota:Therapeutic Opportunities in Liver Disease

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Journal of Clinical and Translational Hepatology 2020年第1期8卷 87-99页

作者： Cyriac Abby philips Philip Augustine Praveen Kumar Yerol Ganesh Narayan Ramesh Rizwan Ahamed Sasidharan Rajesh Tom george Sandeep Kumbar The Liver Unit Monarch Liver Lab and Division of GastroenterologyCochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Department of Gastroenterology State Government Medical CollegeThrissurKeralaIndia Department of Gastroenterology Aster MedcityKochiKeralaIndia

Gut microbiota has been demonstrated to have a significant impact on the initiation,progression and development of complications associated with multiple liver ***,nonalcoholic fatty liver diseases,including nonalcoholic steato-hepatitis and cirrhosis,severe alcoholic hepatitis,primary scle-rosing cholangitis and hepatic encephalopathy,have strong links to dysbiosis–or a pathobiological change in the *** this review,we provide clear and concise discussions on the human gut microbiota,methods of identifying gut microbiota and its functionality,liver diseases that are affected by the gut microbiota,including novel associations under research,and provide current evidence on the modulation of gut microbiota and its effects on specific liver disease conditions.

关键词： Microbiome Metagenomics NGS Cirrhosis Illumina

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Update on diagnosis and management of sepsis in cirrhosis: Current advances

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World Journal of Hepatology 2020年第8期12卷 451-474页

作者： Cyriac Abby philips Rizwan Ahamed Sasidharan Rajesh Tom george Meera Mohanan Philip Augustine The Liver Unit and Monarch Liver Lab Cochin Gastroenterology GroupErnakulam Medical CenterKochi 682028KeralaIndia Gastroenterology and Advanced G.I Endoscopy Cochin Gastroenterology GroupErnakulam Medical CenterKochi 682028KeralaIndia Division of Hepatobiliary Interventional Radiology Cochin Gastroenterology GroupErnakulam Medical CenterKochi 682028KeralaIndia Anaesthesia and Critical Care Cochin Gastroenterology GroupErnakulam Medical CenterKochi 682028KeralaIndia

Sepsis and septic shock are catastrophic disease entities that portend high mortality in patients with *** cirrhosis,hemodynamic perturbations,immune dysregulation,and persistent systemic inflammation with altered gut microbiota in the background of portal hypertension enhance the risk of infections and resistance to *** with cirrhosis develop recurrent lifethreatening infections that progress to multiple organ *** definition,pathophysiology,and treatment options for sepsis have been ever *** this exhaustive review,we discuss novel advances in the understanding of sepsis,describe current and future biomarkers and scoring systems for sepsis,and delineate newer modalities and adjuvant therapies for the treatment of sepsis from existing literature to extrapolate the same concerning the management of sepsis in *** also provide insights into the role of gut microbiota in initiation and progression of sepsis and finally,propose a treatment algorithm for management of sepsis in patients with cirrhosis.

关键词： Portal hypertension Sequential organ failure assessment Acute on chronic liver failure Predisposition insult response organ-dysfunction model Intensive care unit Shock

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Role of Granulocyte Colony-stimulating Factor Therapy in Cirrhosis,'Inside Any Deep Asking Is the Answering'

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Journal of Clinical and Translational Hepatology 2019年第4期7卷 371-383页

作者： Cyriac Abby philips Philip Augustine Rizwan Ahamed Sasidharan Rajesh Tom george Gopakumar C.Valiathan Solomon K.John The Liver Unit and Monarch Liver Lab Cochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Department of Gastroenterology Cochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Interventional Radiology Hepatobiliary DivisionCochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Department of Hepatobiliary and Transplant Surgery Cochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia

Liver cirrhosis progresses through multiple clinical stages which culminate in either death or liver *** of organs,timely listing and prompt receipt of donor-livers pose difficulties in improving transplant-listed and transplant *** this regard,regenerative therapies,particularly with granulocyte colony-stimulating factor(GCSF),has become a lucrative option for improving transplant-free ***,the literature is confusing with regards to patient selection and real *** this exhaustive review,we describe the basics of liver fibrosis and cirrhosis through novel insights from a therapeutic point of view,discuss preclinical studies on GCSF in advanced liver disease to improve on clinical utility,shed light on the pertinent literature of GCSF in advanced cirrhosis,and provide astute inputs on growth factor therapy in decom-pensated cirrhosis.

关键词： GCSF Growth factor Portal hypertension Hepatocellular carcinoma Fibrosis

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Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs

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World Journal of Hepatology 2020年第9期12卷 574-595页

作者： Cyriac Abby philips Rizwan Ahamed Sasidharan Rajesh Tom george Meera Mohanan Philip Augustine The Liver Unit and Monarch Liver Lab Cochin Gastroenterology GroupErnakulam Medical CenterKochi 682028KeralaIndia Gastroenterology and Advanced GI Endoscopy Cochin Gastroenterology GroupErnakulam Medical CenterKochi 682028KeralaIndia Division of Hepatobiliary Interventional Radiology Cochin Gastroenterology GroupErnakulam Medical CenterKochi 682028KeralaIndia Anesthesia and Critical Care Cochin Gastroenterology GroupErnakulam Medical CenterKochi 682028KeralaIndia

With growing antipathy toward conventional prescription drugs due to the fear of adverse events,the general and patient populations have been increasingly using complementary and alternative medications(CAMs)for managing acute and chronic *** general misconception is that natural herbal-based preparations are devoid of toxicity,and hence short-and long-term use remain justified among people as well as the CAM practitioners who prescribe these *** this regard,Ayurvedic herbal medications have become one of the most utilized in the East,specifically the Indian sub-continent,with increasing use in the *** well-performed observational studies have confirmed the hepatotoxic potential of Ayurvedic *** stems from direct effects or from indirect effects through herbal metabolites,unknown herb-herb and herbdrug interactions,adulteration of Ayurvedic drugs with other prescription medicines,and contamination due to poor manufacturing *** this exhaustive review,we present details on their hepatotoxic potential,discuss the mechanisms,clinical presentation,liver histology and patient outcomes of certain commonly used Ayurvedic herbs which will serve as a knowledge bank for physicians caring for liver disease patients,to support early identification and treatment of those who present with CAM-induced liver injury.

关键词： Ayurveda Complementary and alternative medicines Drug induced liver injury Herb induced liver injury Chronic liver disease AYUSH system

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LIGHT AND HEALTH:PHOTORECEPTION FOR BIOLOGICAL,BEHAVIORAL AND THERAPEUTIC RESPONSES IN HUMANS

LIGHT AND HEALTH:PHOTORECEPTION FOR BIOLOGICAL,BEHAVIORAL AN...

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26th Session of the CIE

作者： george C.Brainard Ph.D.Neurology Deptartment Thomas Jefferson UniversityPhiladelphiaPA 19107

＜正＞In the past two years,the Commission Internationale de I’Eclairage（CIE）has published a technical committee monograph and hosted two international symposia addressing the broad topic of how light effects human health（1-3）.This emergent topic is important to the science and art of lighting with relevance to several CIE divisions.

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