检索结果-南通市图书馆

Multicellular Systems Biology: Quantifying Cellular Patterning and Function in Plant Organs Using Network Science

Molecular Plant 2019年第6期12卷 731-742页

作者： george W.bassel School of Biosciences University of Birmingham Birmingham B15 2TT UK

Organ function is at least partially shaped and constrained by the organization of their constituent cells. Extensive investigation has revealed mechanisms explaining how these patterns are generated, with less being known about their functional relevance. In this paper, a methodology to discretize and quantitatively analyze cellular patterning is described. By performing global organ-scale cellular interaction mapping, the organization of cells can be extracted and analyzed using network science. This provides a means to take the developmental analysis of cellular organization in complex organisms beyond qualitative descriptions and provides data-driven approaches to inferring cellular function. The bridging of a structure- function relationship in hypocotyl epidermal cell patterning through global topological analysis provides support for this approach. The analysis of cellular topologies from patterning mutants further enables the contribution of gene activity toward the organizational properties of tissues to be linked, bridging molecular and tissue scales. This systems-based approach to investigate multicellular complexity paves the way to uncovering the principles of complex organ design and achieving predictive genotypephenotype mapping.

关键词： organ network connectivity transport tissue topology connectome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Regulatory Module Controlling CA-Mediated Endosperm Cell Expansion Is Critical for Seed Germination in Arabidopsis

引用

Molecular Plant 2019年第1期12卷 71-85页

作者： Rocio Sanchez-Montesino Laura Bouza-Morcillo Julietta Marquez Melania Ghita Salva Duran-Nebreda Luis Gomez Michael J.Holdsworth george bassel Luis Onate-Sanchez Centro de Biotecnologia y Genomica de Plantas Universidad Politecnica de Madrid-lnstituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria Campus de MontegancedoPozuelo de AlarconMaddd 28223Spain School of Biosciences University of NottinghamLoughborough LE12 5RDUK School of Biosciences University of BirminghamBirmingham B15 23-rUK Departamento de Sistemas y Recursos Naturales E.T.S.I.MontesForestal y del Medio NaturalCampus de Moncloa28040 MadridSpain

A key component of seed germination is the interplay of mechanical forces governing embryo growth and the surrounding restraining endosperm *** cell separation is therefore thought to play a critical role in the control of this developmental *** we demonstrate that in Arabidopsis thaliana seeds,endosperm cell expansion is a key component of *** cells expand to accommodate embryo growth prior to *** show that this is an actively regulated process supported by spatiotemporal control of the cell expansion gene EXPANSIN 2 (EXPA2).The NAC transcription factors NAC25 and NACIL were identified as upstream regulators of EXPA2 expression,gibbereliinmediated endosperm expansion,and seed *** DELLA protein RGL2 repressed activation of the EXPA2 promoter by NAC25/*** together,our findings uncover a key role of the GA/ DELLA-NAC25/NACIL-EXPA2 network in regulating endosperm cell expansion to control the seed-toseedling transition.

关键词： cell expansion cell-wall remodeling enzymes endosperm expansin NAC transcription factors seed germination

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A single-cell morpho-transcriptomic map of brassinosteroid action in the Arabidopsis root

引用

Molecular Plant 2021年第12期14卷 1985-1999页

作者： Moritz Graeff Surbhi Rana Jos R.Wendrich Julien Dorier Thomas Eekhout Ana Cecilia Aliaga Fandino Nicolas Guex george W.bassel Bert De Rybel Christian S.Hardtke Department of Plant Molecular Biology University of LausanneBiophore Building1015 LausanneSwitzerland Ghent University Department of Plant Biotechnology and BioinformaticsTechnologiepark 719000 GhentBelgium VIB Center for Plant Systems Biology Technologiepark 719000 GhentBelgium Bioinformatics Competence Center University of LausanneGenopode Building1015 LausanneSwitzerland School of Life Sciences The University of WarwickCoventryCV47ALUK Lead contact

The effects of brassinosteroid signaling on shoot and root development have been characterized in great detail but a simple consistent positive or negative impact on a basic cellular parameter was not *** this study,we combined digital 3D single-cell shape analysis and single-cell mRNA sequencing to charac-terize root meristems and mature root segments of brassinosteroid-blind mutants and wild *** resul-tant datasets demonstrate that brassinosteroid signaling affects neither cell volume nor cell proliferation ***,brassinosteroid signaling is essential for the precise orientation of cell division planes and the extent and timing of anisotropic cell ***,we found that the cell-aligning effects of brassinosteroid signaling can propagate to normalize the anatomy of both adjacent and distant brassinosteroid-blind cells through non-cell-autonomous functions,which are sufficient to restore growth ***,single-cell transcriptome data discern directly brassinosteroid-responsive genes from genes that can react non-cell-autonomously and highlight arabinogalactans as sentinels of brassinosteroid-dependent anisotropic cell expansion.

关键词： Arabidopsis root meristem brassinosteroid single-cell mRNA sequencing segmentation morphology BRI1 digital single-cell analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Comparison of Patient Outcomes Following Prosthetic Knee Replacement Using a Variety of Knee Prosthesis: A Ten-Year Study

引用

Open Journal of Orthopedics 2014年第9期4卷 249-256页

作者： bassel El-Osta Ali Ghoz Alice Dawson Mark Andrews St. george’s Hospital London UK Scarborough General Hospital Scarborough UK

There are several prosthetic knee designs currently in use. There are however very few studies comparing long-term functional outcomes between patients using different models of knee pros-thesis in elective knee replacement. In this study, we used the validated Oxford Knee Score (OKS) to retrospectively compare the outcomes of a total of 1635 patients who had an elective total knee replacement in a large District General Hospital, using fifteen different models of knee prosthesis, over a ten-year period. The average scores reported by all patient groups showed significant improvement by three months post-operatively (pre-operative mean score 15.8, post-operative mean score 39.4, p < 0.05), and remained similar for all models of prosthesis used over the total ten-year period. Based on the OKS as an assessment tool, we report no significant difference in long-term functional outcomes for this group of patients following an elective knee replacement, regardless of the type of prosthesis used.

关键词： Patients Outcome Knee Prosthesis Total Knee Replacement Variable Knee Prosthesis OKS on Prosthesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：