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Chitosan-based nanoparticles in Alzheimer’s disease:messenger or message?

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Neural Regeneration Research 2021年第11期16卷 2204-2205页

作者： Eniko Manek georg A.Petroianu College of Medicine&Health Sciences Khalifa UniversityAbu DhabiUnited Arab Emirates

Cellulose is the most common natural(plant)polymer while its animal-kingdom close relative chitin comes in *** is estimated that there are some 10 billion tons of chitin in the world(d’Ayala et al.,2008).Chitin may be described as cellulose with one hydroxyl group on each monomer replaced with an acetyl amine ***-producing organisms like protozoa,fungi,arthropods,and nematodes are often pathogens in other *** the absence of endogenous chitin,mammals express chitinases(E.C 3.***.2.14)with enzymatic activity.

关键词： spite cellulose nanoparticles

Evolutionary computing and machine learning for discovering of low-energy defect configurations

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npj Computational Materials 2021年第1期7卷 628-640页

作者： Marco Arrigoni georg K.H.Madsen Institute of Materials Chemistry TU WienViennaAustria

Density functional theory(DFT)has become a standard tool for the study of point defects in ***,finding the most stable defective structures remains a very challenging task as it involves the solution of a multimodal optimization problem with a high-dimensional objective ***,the approaches most commonly used to tackle this problem have been mostly empirical,heuristic,and/or based on domain *** this contribution,we describe an approach for exploring the potential energy surface(PES)based on the covariance matrix adaptation evolution strategy(CMA-ES)and supervised and unsupervised machine learning *** resulting algorithm depends only on a limited set of physically interpretable hyperparameters and the approach offers a systematic way for finding low-energy configurations of isolated point defects in *** demonstrate its applicability on different systems and show its ability to find known low-energy structures and discover additional ones as well.

关键词： function configuration finding

On the experimental characterization of the fluid volume influence on the friction between rough surfaces

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Friction 2023年第7期11卷 1334-1348页

作者： Lukas STAHL Michael MÜLLER georg-Peter OSTERMEYER Institute of Dynamics and Vibrations Technische Universität BraunschweigBraunschweig 37106Germany

The load-bearing behaviour of lubricated contacts depends primarily on the normal force,the relative velocity,and the ***,with the aid of the Stribeck curve,it is usually well possible to characterize whether hydrodynamics,mixed friction,or boundary friction is more likely to be *** fact that the load regime can also depend on the fluid quantity is obvious,but has hardly been systematically investigated so *** for contacts with microscopic roughness,the defined application of a very small amount of fluid is a very challenging *** this paper,a very fundamental study shows how a pin-on-disc tribometer can be used to achieve the transition from dry friction via mixed friction to predominant hydrodynamics by the amount of supplied *** experiments are carried out on samples filed with different *** addition,the simultaneous influence of partial filling and normal force as well as relative velocity is also *** good reproducibility has been practically reached over the entire range of the *** the quantities for the coefficient of friction(COF),it was concluded that close to full filling,a reduction of the fluid quantity has a similar effect on the COF as the reduction of the *** property goes along with the common theory of starved lubricated *** behaviour was not observed to the same extent for the normal *** the vicinity of smaller fluid quantities,the COF increases very rapidly with further reduction in fluid quantity,far more disproportionately than that with reduction in *** a deeper understanding of this problem,various practical issues such as idling or the run-up process in bearings can also be studied in a more focused manner.

关键词： starved lubrication Stribeck curve pin-on-disc tribometer fluid supply experimental studies

Corrigendum to“Towards a business model for second-life batteries:Barriers,opportunities,uncertainties,and technologies”[*** Chem.78(2023)507–525]

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Journal of Energy Chemistry 2024年第4期91卷 684-684页

作者： Carlos Antônio Rufino Júnior Eleonora Riva Sanseverino Pierluigi Gallo Daniel Koch Yash Kotak Hans-georg Schweiger Hudson Zanin Advanced Energy Storage Division New Energy Innovation CenterUniversity of Campinas(UNICAMP)Campinas 13083-852Brazil Engineering Department University of Palermo(UNIPA)Palermo 90128Italy Consorzio Nazionale Interuniversitario per le Telecomunicazioni(CNIT) Parma 43124Italy Technische Hochschule Ingolstadt Institute for ElectricConnected and Safe Mobility(C-ECOS)Ingolstadt 85049Germany

In the Acknowledgments Section,please replace“Shell oil”for“TotalEnergies”.The authors would like to apologise for any inconvenience *** the sake of clarity(“Shell oil”should be removed and in boldblack“TotalEn... 详细信息

关键词： please replace removed

New Insight in Ethylene Signaling： Autokinase Activity of ETR1 Modulates the Interaction of Receptors and EIN2

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Molecular Plant 2010年第5期3卷 882-889页

作者： Melanie M.A. Bisson georg Groth Heinrich-Heine Universitat Dusseldorf Biochemie der Pflanzen Universitatsstr. 1 40225 Dosseldorf Germany

Ethylene insensitive 2 （EIN2）, an integral membrane protein of the ER network, has been identified as the central regulator of the ethylene signaling pathway. Still, the mechanism by which the ethylene signal is transferred from the receptors to EIN2 has not been solved yet. Here, we show that protein phosphorylation is a key mechanism to control the interaction of EIN2 and the receptors. In vivo and in vitro fluorescence studies reveal that the kinase domain of the receptors is essential for the interaction. Cyanide, an ethylene agonist, which is known to reduce auto-phosphorylation of the ethylene receptor ethylene resistant 1 （ETR1） or a mutation in the kinase domain of ETR1 that prevents autophosphorylation （H353A）, increases the affinity of the receptors for EIN2. On the other hand, mimicking permanent auto-phosphorylation of ETR1 as in the mutant H353E releases the EiN2-ETR1 interaction from the control by the plant hormone. Based on our data, we propose a novel model on the integration of EIN2 in the ethylene signaling cascade.

关键词： Membrane biochemistry protein phosphorylation/dephosphorylation receptors signal transduction membrane proteins ethylene protein-protein interaction.

Targeting Plant Ethylene Responses by Controlling Essential Protein-Protein Interactions in the Ethylene Pathway

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Molecular Plant 2015年第8期8卷 1165-1174页

作者： Melanie M.A. Bisson georg Groth Institute of Biochemical Plant Physiology Heinrich-Heine University Dusseldorf D-40204 Dusseldorf Germany

The gaseous plant hormone ethylene regulates many processes of high agronomic relevance throughout the life span of plants. A central element in ethylene signaling is the endoplasmic reticulum （ER）-Iocalized membrane protein ETHYLENE INSENSITIVE2 （EIN2）. Recent studies indicate that in response to ethylene, the extra-membranous C-terminal end of EIN2 is proteolytically processed and translocated from the ER to the nucleus. Here, we report that the conserved nuclear localization signal （NLS） mediating nuclear import of the EIN2 C-terminus provides an important domain for complex formation with ethylene receptor ETHYLENE RESPONSE1 （ETR1）. EIN2 lacking the NLS domain shows strongly reduced affinity for the receptor. Interaction of EIN2 and ETR1 is also blocked by a synthetic peptide of the NLS motif. The corre- sponding peptide substantially reduces ethylene responses in planta. Our results uncover a novel mecha- nism and type of inhibitor interfering with ethylene signal transduction and ethylene responses in plants. Disruption of essential protein-protein interactions in the ethylene signaling pathway as shown in our study for the EIN2-ETR1 complex has the potential to guide the development of innovative ethylene antagonists for modern agriculture and horticulture.

关键词： fruit ripening ethylene responses peptide protein-protein interactions inhibitor

Proposed Methodology for Generation of Building Information Model with Laserscanning

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Tsinghua Science and Technology 2008年第S1期13卷 138-144页

作者： Jrg Isele georg Bretthauer Institute for Applied Computer Science Forschungszentrum Karlsruhe

For refurbishment and state review of an existing old building, a new model reflecting the current state is often required especially when the original plans are no longer accessible. Laser scanners are used more and more as surveying instruments for various applications because of their high-precision scanning abilities. For buildings, the most notable and widely accepted product data model is the IFC product data model. It is designed to cover the whole lifecycle and supported by various software vendors and enables applications to efficiently share and exchange project information. The models obtained with the laser scanner, normally sets of points ('point cloud'), have to be transferred to an IFC compatible building information model to serve the needs of different planning states. This paper presents an approach designed by the German Research Center in Karlsruhe (Forschungszentrum Karlsruhe) to create an IFC compatible building information model from laser range images. The methodology through the entire process from data acquisition to the IFC compatible product model was proposed in this paper. In addition, IFC-Models with different level of detail (LoDs) were introduced and discussed within the work.

关键词： laserscanning building information model (BIM) industry foundation classes (IFC) object rec-ognition simultaneous localization and mapping (SLAM)

Different Conceptions and a General Concept of Human Rights

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Fudan Journal of the Humanities and Social Sciences 2015年第3期8卷 369-385页

作者： georg Lohmann Friedbergstr. 38 14057 Berlin Germany

In this study, I show that human fights are historical projects. They are legal inventions and institutional structures and respond to historical injustices and serious atrocities suffered by people, or which threaten them. It is useful therefore to first distinguish, both historically and systematically, different conceptions of human fights from a concept of human fights. I will distinguish three conceptions： national, international and transnational. Included in national conceptions are the human fights declarations of North America （1776） and France （1789）. The starting event of the international conception is the Universal Declaration of Human Rights by the United Nations after the Second World War in 1948. And it can be argued that a transnational conception of human fights that better fits the globalised world and the already global developments in intemational law and governance is needed.

关键词： Human rights International law Cultural relativism and universality Transnational human fights conception Moral justification and legal institutionalisation of human fights

Individual Human Rights and Obligations Towards Communities

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Fudan Journal of the Humanities and Social Sciences 2015年第3期8卷 387-399页

作者： georg Lohmann Friedbergstr.38 14057 BerlinGermany

Tensions and oppositions between the individual and community have accompanied the discourse on human rights from the beginning. I want to first recall how in the UDHR （1948） and in the major human rights treaties, the rights and obligations of individuals are regulated towards communities. I then want to investigate whether the talk of ＂collective human rights＂, understood as ＂third- generation＂ rights, are of equal value to be set with individual human rights. Against communitarian arguments for the primacy of community-related duties one can stress an expansion of a liberal concept of human rights by the inclusion of justice demands and social human rights. To show that special community needs can be protected and promoted through individual human rights and national col- lective rights, I used the example of the protection of minorities. Finally, I will explain why human rights are not a comprehensive theory of the good and illustrate with this the limits, and also the original strength of human rights. We should not overestimate human rights, but also we should be aware that a sober understanding of human rights is philosophically reasonable, legally possible and politically of great importance.

关键词： Individualism of human rights Collective rights Third generation of human rights Communitarianism Cultural relativism and universality Protectionof minorities Social human rights A sober conception of human rights Limits and strength of human rights