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Development of donor specific antibodies after SARS-CoV-2 vaccination:What do we know so far?

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World Journal of Meta-Analysis 2024年第2期12卷 1-4页

作者： Ahmed Daoud Karim Soliman Maria Aurora Posadas Salas Sakshi Vaishnav genta Uehara AhmedAbdelkader Tibor Fulop Michael J Casey Department of Medicine Division of NephrologyMedical University of South CarolinaCharlestonSC 29425United States Department of Medicine Cairo University Medical SchoolCairo 11211Egypt Department of Medicine Medical ServicesRalph H.Johnson VA Medical CenterCharlestonSC 29425United States Department of Medicine Division of NephrologyMedical ServicesRalph H.Johnson VA Medical CenterCharlestonSC 29425United States

Vaccination against Coronavirus disease-19(COVID-19)was pivotal to limit spread,morbidity and mortality.Our aim is to find out whether vaccines against COVID-19 lead to an immunological response stimulating the production of de novo donor specific antibodies(DSAs)or increase in mean fluorescence intensity(MFI)of pre-existing DSAs in kidney transplant recipients(KTRs).This study involved a detailed literature search through December 2nd,2023 using PubMed as the primary database.The search strategy incorporated a combination of relevant Medical Subject Headings terms and keywords:"COVID-19","SARS-CoV-2 Vaccination","Kidney,Renal Transplant",and"Donor specific antibodies".The results from related studies were collated and analyzed.A total of 6 studies were identified,encompassing 460 KTRs vaccinated against COVID-19.Immunological responses were detected in 8 KTRs of which 5 had increased MFIs,1 had de novo DSA,and 2 were categorized as either having de novo DSA or increased MFI.There were 48 KTRs with pre-existing DSAs prior to vaccination,but one study(Massa et al)did not report whether pre-existing DSAs were associated with post vaccination outcomes.Of the remaining 5 studies,35 KTRs with pre-existing DSAs were identified of which 7 KTRs(20%)developed de novo DSAs or increased MFIs.Overall,no immunological response was detected in 452(98.3%)KTRs.Our study affirms prior reports that COVID-19 vaccination is safe for KTRs,especially if there are no pre-existing DSAs.However,if KTRs have pre-existing DSAs,then an increased immunological risk may be present.These findings need to be taken cautiously as they are based on a limited number of patients so further studies are still needed for confirmation.

关键词： COVID-19 SARS-CoV-2 vaccination Kidney Renal transplant Donor specific antibodies

BK viral infection: A review of management and treatment

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World Journal of Transplantation 2023年第6期13卷 309-320页

作者： June Hayrelle Gorriceta Amy Lopez Otbo genta Uehara Maria Aurora Posadas Salas Department of Medicine St Francis Hospital-BartlettBartlettTN 38133United States Department of Medicine St.Luke’s Medical CenterQuezon 1112Philippines Department of Medicine Division of NephrologyMedical University of South CarolinaCharlestonSC 29425United States

BK viral infection remains to be a challenging post-transplant infection,which can result in kidney dysfunction.The mainstay approach to BK infection is reduction of immunosuppression.Alterations in immunosuppressive regimen with minimization of calcineurin inhibitors,use of mechanistic target of rapamycin inhibitors,and leflunomide have been attempted with variable outcomes.Over the past few years,investigators have explored potential therapeutic options for BK infection.Fluoroquinolone prophylaxis and treatment was found to have no benefit in kidney transplant recipients.The utility of cidofovir is limited by its nephrotoxicity.Intravenous immunoglobulin is becoming a popular option for treatment and prophylaxis for BK infection,as it increases the neutralizing antibody titers against the most common BK virus serotypes.Virus-specific T cell therapy is an emerging treatment option for BK viremia.In this review,we will explore management and therapeutic options for BK infection and recent evidence available in literature.

关键词： BK infection Kidney transplant Treatment Management

Effects of Pressure, Solvent, and Substituent on the Thermal Isomerization of 2-Oxo- spiro[diazirine-3,3'-indoline]

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Chemical Research in Chinese Universities 2001年第1期17卷 95-101页

作者： Yoshimi Sueishi genta Okazaki Department of Chemistry Faculty of ScienceOkayama UniversityTsushima Naka 3-1-1Okayama 700-8530Japan

The kinetic effects of pressure, solvent, and substituent on the thermal isomerization from 2 oxospiro[diazirine 3,3 indoline] to 3 diazo 2 oxo indoline have been examined. The rate constants of the thermal isomerization increased with increasing external pressure and were related to the σ + P substituent constant of Hammett correlation. The results suggest that the thermal isomerization proceeds via a dipolar transition state involving heterolytic bond fission. However, the kinetic solvent effects on the thermal isomerization were not observed. The special solvent effects were discussed on the basis of the linear free energy relationship.

关键词： Kinetic study Pressure effect Substituent effect Thermal isomerization Diazirine

Dynamics of Rotating Systems 1

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Bangkok to Sendai and Beyond: Implications for Disaster Risk Reduction in Asia

丛书名： Mechanical Engineering Series

2005年

作者： Giancarlo genta

来源：畅想之星图书光盘版（南... 评论

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International Journal of Disaster Risk Science 2015年第2期6卷 177-188页

作者： Ranit Chatterjee Koichi Shiwaku Rajarshi Das Gupta genta Nakano Rajib Shaw Graduate School of Global Environmental Studies Kyoto University

The recently concluded World Conference on Disaster Risk Reduction(WCDRR) in Sendai, Japan and the Sendai Framework for Disaster Risk Reduction2015–2030(SFDRR) have set renewed priorities for disaster risk reduction(DRR) for the next 15 years. Due to Asia’s high exposure to natural hazards, the implications of the new SFDRR have major significance for the future development of the region. The 6th Asian Ministerial Conference on Disaster Risk Reduction(AMCDRR), held in Bangkok in 2014, was a regional preparatory meeting for the WCDRR, and proposed various targets and indicators for DRR in Asia. The AMCDRR recommended inclusion of these goals in the SFDRR. This study focuses on the WCDRR negotiations, particularly outcomes that affect four major groups: local authorities; children and youth;science and technology; and business and industry. An analysis is undertaken of the overlaps and gaps in the outcomes of the 6th AMCDRR and other preceding conferences that fed into the WCDRR. A set of recommendations has evolved from this examination for consideration at the upcoming 7th AMCDRR in 2016. The areas that merit consideration in the upcoming AMCDRR2016 are:(1) development of baseline data and quantitative indicators for monitoring progress in DRR;(2) creation of a common stakeholder platform;(3) construction of city typologies for consideration in all future local level planning;(4) promotion of a culture of safety by linking large enterprises with small and medium enterprises; and(5) exchange and sharing of information and databases between regions at all scales.

关键词：灾难风险减小上的亚洲部的会议曼谷灾难风险减小仙台灾难风险减小上的世界会议

Seatbelt paths of the pregnant women sitting in the rear seat of a motor vehicle

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Chinese Journal of Traumatology 2017年第6期20卷 343-346页

作者： Masahito Hitosugi Takeshi Koseki Yuka Kinugasa Tomokazu Hariya genta Maeda Yasuki Motozawa Department of Legal Medicine Shiga University of Medical Sdence Shiga 520-2192 Japan

PurposeSeatbelt 使用在怀孕期间是重要的在机动车辆碰撞以后改进母亲、胎儿的幸存。然而，因为，机动车辆的后面的安全带趋于联系颈，它足够地被使用，坐在后面的位子的一些怀孕女人抉择不系住带。这研究的目的是探索安全带颈接触因为... 详细信息

PurposeSeatbelt 使用在怀孕期间是重要的在机动车辆碰撞以后改进母亲、胎儿的幸存。然而，因为，机动车辆的后面的安全带趋于联系颈，它足够地被使用，坐在后面的位子的一些怀孕女人抉择不系住带。这研究的目的是探索安全带颈接触因为坐在马达 vehicle.MethodsWe 的后面的位子的怀孕女人执行了人体测量的研究。30 个星期怀孕的日本女人(n ?=? 12 ) 在一个典型中型的旅客轿子的后面的位子的左边坐了并且系住安全带。座位姿势被测量怀孕女人(头，肩膀，新潮的关节，和膝关节) 的人体测量的数据点的坐标调查。带路径被测量在带和胸骨或 navel.ResultsAmong 之间的清理分析在 33.9 星期的 12 个怀孕女人 ? 祲映潲吗？

关键词：怀孕女人后面的位子安全带人体测学机动车辆

LONG-TERM RIGOROUS NUMERICAL INTEGRATION OF NAVIER-STOKES EQUATION BY NEWTON-GMRES ITERATION

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Transactions of Nanjing University of Aeronautics and Astronautics 2013年第3期30卷 248-251页

作者： Julius Rhoan T.Lustro Lennaert van Veen genta Kawahara College of Engineering and Agro-Industrial Technology University of the Philippines Los Banos Faculty of Science University of Ontario Institute of Technology Department of Mechanical Science and Bioengineering Osaka University1-3 Machikaneyama

The recent result of an orbit continuation algorithm has provided a rigorous method for long-term numerical integration of an orbit on the unstable manifold of a periodic solution.This algorithm is matrix-free and employs a combination of the Newton-Raphson method and the Krylov subspace method.Moreover,the algorithm adopts a multiple shooting method to address the problem of orbital instability due to long-term numerical integration.The algorithm is described through computing the extension of unstable manifold of a recomputed Nagata′s lowerbranch steady solution of plane Couette flow,which is an example of an exact coherent state that has recently been studied in subcritical transition to turbulence.

关键词： long-term numerical integration Newton-Raphson iteration general minimal residual(GMRES) multiple shooting unstable manifold

Assessing risks for gastric cancer: New tools for pathologists

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World Journal of Gastroenterology 2006年第35期12卷 5622-5627页

作者： Robert M genta Massimo Rugge Department of Pathology University of Texas Southwestern Medical Center at Dallas Texas United states Department of Oncological and Surgical Sciences University of Padova Italy

Although the Sydney Systems (original and updated) for the classification of gastritis have contributed substantially to the uniformity of the reporting of gastric conditions, they lack immediacy in conveying to the user information about gastric cancer risk. In this review, we summarize the current understanding of the gastric lesions associated with an increased risk for cancer, and present the rationale for a proposal for new ways of reporting gastritis. In addition to the traditional histopathological data gathered and evaluated according to the Sydney System rules, pathologists could add an assessment expressed as grading and staging of the gastric inflammatory and atrophic lesions and integrate these findings with pertinent laboratory information on pepsinogens and gastrin levels. Such an integrated report could facilitate clinicians’ approach to the management of patients with gastric conditions.

关键词：胃癌病理机制治疗临床

The neutrophil-to-lymphocyte ratio at the prostate-specific antigen nadir predicts the time to castration-resistant prostate cancer

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Asian Journal of Urology 2021年第3期8卷 332-334页

作者： genta Iwamoto Takashi Kawahara Yumiko Yokomizo Yasuhide Miyoshi Masahiro Yao Hiroji Uemura Department of Urology and Renal Transportation Yokohama City University Medical CenterYokohamaKanagawaJapan Department of Urology Yokohama City University Graduate School of MedicineYokohamaKanagawaJapan

Dear editor,With the spread of prostate-specific antigen(PSA)screening,an increasing number of early-stage prostate cancers have been diagnosed recently,although many patients are still diagnosed in the advanced stage[1].Although most prostate cancers with metastatic lesions respond to initial androgen ablation therapy,responders ultimately develop progressive disease due to hormone-refractory cancer.

关键词： editor prostate specific