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PIM1-HDAC2 axis modulates intestinal homeostasis through epigenetic modification

Acta Pharmaceutica Sinica B 2024年第7期14卷 3049-3067页

作者： Jianming Yang Yawen Xiao Ningning Zhao geng pei Yan Sun Xinyu Sun Kaiyuan Yu Chunhui Miao Ran Liu Junqiang Lv Hongyu Chu Lu Zhou Bangmao Wang Zhi Yao Quan Wang Key Laboratory of Immune Microenvironment and Disease(Ministry of Education) Tianjin Institute of ImmunologyState Key Laboratory of Experimental Hematologythe Province and Ministry Co-sponsored Collaborative Innovation Center for Medical EpigeneticsDepartment of ImmunologySchool of Basic Medical SciencesTianjin Institute of Urologythe Second Hospital of Tianjin Medical UniversityTianjin Key Laboratory of Cellular and Molecular ImmunologyTianjin Medical UniversityTianjin 300070China Department of Pathology Tianjin Medical University Cancer Institute and Hospital/National Clinical Research Center of Cancer/Key Laboratory of Cancer Prevention and TherapyTianjin/Tianjin’s Clinical Research Center of CancerTianjin 30060China Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300070China

The mucosal barrier is crucial for intestinal homeostasis,and goblet cells are essential for maintaining the mucosal barrier *** proviral integration site for Moloney murine leukemia virus-1(PIM1)kinase regulates multiple cellular functions,but its role in intestinal homeostasis during colitis is ***,we demonstrate that PIM1 is prominently elevated in the colonic epithelia of both ulcerative colitis patients and murine models,in the presence of intestinal *** PIM1 leads to decreased goblet cells,thus impairing resistance to colitis and colitis-associated colorectal cancer(CAC)in ***,PIM1 modulates goblet cell differentiation through the Wnt and Notch signaling ***,PIM1 interacts with histone deacetylase 2(HDAC2)and downregulates its level via phosphorylation,thereby altering the epigenetic profiles of Wnt signaling pathway ***,these findings investigate the unknown function of the PIM1-HDAC2 axis in goblet cell differentiation and ulcerative colitis/CAC pathogenesis,which points to the potential for PIM1-targeted therapies of ulcerative colitis and CAC.

关键词： PIM1 HDAC2 Goblet cell Gut microbiota Intestinal homeostasis Epigenetic modification Ulcerative colitis CAC

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非遗保护视角下传统陶瓷工坊文化基因图谱构建——以罗山土陶基地为例

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河南科学 2024年第7期42卷 977-986页

作者：张涵刘文佳裴赓郑州大学建筑学院郑州450000

在现代工业的冲击和市场需求的压缩下,传统陶瓷制作技艺面临着逐渐衰弱的局面.为保护和传承该技艺,现将文化基因理论引入传统陶瓷工坊研究,通过对符合研究要求的3个国内既有传统陶瓷工坊案例进行调研和特征解构分析,识别其文化基因,并... 详细信息

在现代工业的冲击和市场需求的压缩下,传统陶瓷制作技艺面临着逐渐衰弱的局面.为保护和传承该技艺,现将文化基因理论引入传统陶瓷工坊研究,通过对符合研究要求的3个国内既有传统陶瓷工坊案例进行调研和特征解构分析,识别其文化基因,并构建出文化基因图谱,分为主体、自然环境、人际关系以及传统村落四个层级.并以河南省信阳市周党镇桂店村罗山土陶非遗基地实践项目为例,从文化基因的角度对其基地的保护、规划及建筑更新进行全面剖析.研究传统陶瓷工坊文化基因,不仅仅是为了识别出构成工坊的各类要素,更是要摸清传统陶瓷工坊能够传承延续的必要条件,为推动非物质文化遗产保护的系统化与现代化以及为同类非遗村落的保护更新提供可行性策略.

关键词：陶瓷工坊文化基因更新设计非遗保护乡村振兴

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叶面喷施硒肥对香榧幼苗叶片代谢组的影响

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林业科学研究 2024年第3期37卷 203-212页

作者：陈振生李爱华杜拾平黄培耕许秀环宁博林李文广西国有博白林场广西博白537617 湖北省林业科学研究院湖北武汉430075

[目的]分析亚硒酸钠叶面喷施后对香榧(Torreya grandis)幼苗叶片代谢组的影响,探究亚硒酸钠喷施后香榧叶片次生代谢物的累积情况及其对果实品质的影响。[方法]以苗龄2年的香榧幼苗为供试材料,叶面喷施亚硒酸钠(浓度为100μg·L^(-1))2次... 详细信息

[目的]分析亚硒酸钠叶面喷施后对香榧(Torreya grandis)幼苗叶片代谢组的影响,探究亚硒酸钠喷施后香榧叶片次生代谢物的累积情况及其对果实品质的影响。[方法]以苗龄2年的香榧幼苗为供试材料,叶面喷施亚硒酸钠(浓度为100μg·L^(-1))2次,间隔15 d。第二次喷施后15 d,采取1年生叶片进行代谢组分析,以色谱-质谱研究香榧幼苗叶片代谢物差异。[结果]在正离子模式下,处理组和对照组之间有909种差异代谢物,其中69种显著变化(27种显著上调,42种显著下调)。在负离子模式下,出现433种差异代谢物,其中43种显著变化(11种显著上调,32种显著下调)。对人体有益的一些次生代谢物显著增加,如车前苷(2.827倍)、川芎内酯(2.524倍)、6-唾液乳糖(2.021倍)、阿齐沙坦(1.931倍)。[结论]香榧叶片喷施亚硒酸钠有利于促进对人体有益的次生代谢物的生物合成及其在叶片中的累积。

关键词：香榧硒肥代谢组生物强化

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Effect and mechanism of miR-34a on proliferation, apoptosis and invasion of laryngeal carcinoma cells

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Asian Pacific Journal of Tropical Medicine 2016年第5期9卷 480-484页

作者： Ju-Xiang Wang Qing-Jun Zhang Shi-geng pei Bao-Liang Yang Affiliated Hospital of Hebei University of Engineering

Objective: To discuss the effect and mechanism of miR-34 a on the proliferation, apoptosis and invasion of laryngeal carcinoma cells. Methods: The laryngeal squamous carcinoma Hep2 cells were transiently transfected with miR-34 a mimics and miR-34 a NC. The MTT, colony-forming assay, Hoechst staining and Annexin V-PI double staining flow cytometry were employed to detect the effect of miR-34 a on the viability and apoptosis of laryngeal squamous carcinoma Hep2 cells; Transwell assay to defect the effect of miR-34 a on the migration and invasion of laryngeal squamous carcinoma Hep2 cells; western blot and RTPCR assay to defect the effect of miR-34 a mimics on the expression of survivin and Ki-67 m RNA in laryngeal squamous carcinoma Hep2 cells. Results: Compared with miR-34 a NC group, the cell viability in miR-34 mimics group was significantly decreased(P<0.01), the cell apoptosis rate was significantly increased(P<0.01), the abilities of cell migration and invasion were significantly reduced(P<0.01) and the expression of survivin and Ki-67 m RNA was significantly decreased(P<0.01). Conclusions: The increased expression of miR-34 a can induce the apoptosis of Hep2 laryngeal carcinoma cells and inhibit the cell proliferation and invasion, which is related to the down-regulated expression of survivin and Ki-67.

关键词： Mi R-34a Laryngeal squamous carcinoma Hep2 cells Proliferation Apoptosis Invasion

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Correlation of survivin,p53 and Ki-67 in laryngeal cancer Hep-2 cell proliferation and invasion

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Asian Pacific Journal of Tropical Medicine 2015年第8期8卷 626-631页

作者： Shi-geng pei Ju-Xiang Wang Xue-Ling Wang Qing-Jun Zhang Hong Zhang Department of Otolaryngology Head and Neck Surgery Affiliated Hospital of Hebei Engineering University Hebei Engineering University Medical College

Objective: To investigate the mechanism of survivin, p53 and Ki-67 on Hep-2 human laryngeal cancer endothelial cell proliferation and invasion. Methods: Laryngeal squamous cell carcinoma and paracancerous normal tissues were collected, total RNA was extracted from tissues, survivin, p53 and Ki-67 gene m RNA expression levels in laryngeal cancer and the adjacent tissues were detected by Real-time PCR. Human laryngeal cancer Hep-2 epithelial cells were selected, survivin gene was overexpressed, and cell proliferation was detected by MTT. p53 and Ki-67 gene expression changes in overexpressed survivin gene were detected by Western blot. Changes in Hep-2 cell invasive ability were studied when survivin was overexpressed as detected by Transwell invasion assay. Results: In the adjacent tissues, survivin, p53 and Ki-67 gene relative expression levels were 1.72 ± 0.9, 13.7 ± 5.7 and 5.7 ± 1.3, respectively; while in cancer tissues, gene relative expression levels were 53.7 ± 8.3, 66.7 ± 5.2 and 61.0 ± 3.1, respectively, which was significantly increased. As detected by MTT, relative cell survival rate within 12 h of survivin overexpression were: load control group,(88.5±1.6)%; overexpressed group,(90.3±1.9)%. Transwell invasion assay results indicated that overexpressed survivin could significantly increase the relative survival rate of cells. Conclusions: Expressions of p53, Ki67 and survivin are increased in cancer; and there is a positive correlation between survivin, p53 and Ki67 expressions in laryngeal carcinoma.

关键词： Survivin p53 Ki67 Hep-2 Transwell laryngeal cancer

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Surface enhanced Raman spectroscopy signals of mixed pesticides and their identification

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Chinese Chemical Letters 2011年第12期22卷 1477-1484页

作者： Hui Rong Tang Qing Qing Li Yu Lan Ren Jin pei geng Peng Cao Tao Sui Xuan Wang Yi Ping Du Shanghai Key Laboratory of Functional Materials Chemistry and Research Centre of Analysis and Test East China University of Science and TechnologyShanghai 200237China Mudanjiang Normal University Mudanjiang 157012China Yantai Entry-Exit Inspection and Quarantine Bureau Yantai 264000 China

A rapid and sensitive method to identify and analyze mixed pesticides of tricyclazole,paraquat and flusilazole by surface-enhanced Raman scattering has been *** samples can be detected by SERS in low concentrations of 0.01 mg/L, 0.1 mg/L and 2.85 mg/L for individual tricyclazole,paraquat and flusilazole *** mixing the three pesticides in the low concentrations,their characteristic peaks can still be identified from the SERS spectrum of the mixture.

关键词： Surface-enhanced Raman scattering(SERS) Pesticide Mixed pesticides Identification

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Rapid and sensitive detection of pesticides by surface-enhanced Raman spectroscopy technique based on glycidyl methacrylate-ethylene dimethacrylate(GMA-EDMA) porous material

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Chinese Chemical Letters 2013年第4期24卷 332-334页

作者： Qing-Qing Li Yi-Ping Du Ying Xu Xuan Wang Shi-Qian Ma Jin-pei geng Peng Cao Tao Sui Shanghai Key Laboratory of Functional Materials Chemistry & Research Centre of Analysis and Test East China University of Science and Technology Yantai Entry-Exit Inspection and Quarantine Bureau

A novel method of fast and sensitive SERS detection using GMA-EDMA porous material combined with a miniature device was reported in this study. A 100 μL solution containing sample, silver colloid and NaC1 was evenly mixed to ensure the sample molecules would adsorb onto silver nanoparticles. Then the mixture was added onto the porous material surface slowly, so that the aggregation of silver colloid would stay on the surface while the liquid components would flow away. This technology can improve the sensitivity of SERS detection. By this method, two pesticides tricyclazole and paraquat were successfully detected at concentrations of 5 × 10 3 mg/L and I × 10-3 mg/L, respectively.

关键词： rSurface-enhanced Raman spectroscopyGMA-EDMA porous materialTricyclazoleParaquat

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空间遥控作业机器人系统的内模控制研究

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宇航学报 2006年第4期27卷 735-739页

作者：鉴萍李歧强耿陪陪山东大学控制科学与工程学院济南250061

针对空间遥控作业机器人系统通讯时延严重破坏系统性能的问题,为力反馈遥作业系统建立了内模结构,对系统的透明性和稳定性进行分析并给出了控制器设计结果。给出的控制方法不仅能兼顾系统在时延下的稳定性和透明性,而且可以实现主从机... 详细信息

针对空间遥控作业机器人系统通讯时延严重破坏系统性能的问题,为力反馈遥作业系统建立了内模结构,对系统的透明性和稳定性进行分析并给出了控制器设计结果。给出的控制方法不仅能兼顾系统在时延下的稳定性和透明性,而且可以实现主从机械手速度与力的动静态跟踪,使系统具有良好的力觉临场感。借助于内模结构,以透明性为目标的控制器设计独立于稳定性来进行,降低了设计的复杂度,增强了控制的灵活性。理论分析和仿真实验证明该方法有效。

关键词：遥控作业系统时延内模控制稳定性透明性

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抗战时期甘肃农贷及对河西农业的扶持

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中南民族大学学报（人文社会科学版） 2008年第4期28卷 95-98页

作者：裴庚辛商丘师范学院历史学与社会学系河南商丘476000

抗战时期甘肃的农贷由国家银行提供,主要分合作信用贷款和农田水利贷款两类。农贷是在战时背景下进行的,在一定程度上缓解了资金和粮籽周转困难,为复苏农村经济作出了贡献。但由于合作社为富户豪绅把持,农贷并未达到有效遏制高利贷的目... 详细信息

抗战时期甘肃的农贷由国家银行提供,主要分合作信用贷款和农田水利贷款两类。农贷是在战时背景下进行的,在一定程度上缓解了资金和粮籽周转困难,为复苏农村经济作出了贡献。但由于合作社为富户豪绅把持,农贷并未达到有效遏制高利贷的目的。河西走廊是甘肃农贷的重点。特别是河西水利专款公程的实施,直接推动了河西水利建设和粮食增长。

关键词：抗战时期甘肃农贷合作贷款河西农业

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Regulating interfacial chemistry and kinetic behaviors of F/Mo co-doping Ni-rich layered oxide cathode for long-cycling lithium-ion batteries over-20°C-60°C

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Journal of Energy Chemistry 2024年第7期94卷 449-457页

作者： Siqi Guan Lin Tao pei Tang Ruopian Fang Huize Wu Nan Piao Huicong Yang Guangjian Hu Xin geng Lixiang Li Baigang An Feng Li Institute of Energy Materials and Electrochemistry Research University of Science and Technology LiaoningAnshan 114051LiaoningChina Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016LiaoningChina School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016LiaoningChina Shenyang King Power Tech.Co. Ltd.Shenyang 110016LiaoningChina School of Chemical Engineering The University of New South WalesSydney 2052NSWAustralia

Ni-rich layered oxide cathodes have shown promise for high-energy lithium-ion batteries(LIBs)but are usually limited to mild environments because of their rapid performance degradation under extreme temperature conditions(below0°C and above 50 °C).Here,we report the design of F/Mo co-doped LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(FMNCM)cathode for high-performance LIBs from-20 to 60°C.F^(-) doping with high electronegativity into the cathode surface is found to enhance the stability of surface lattice structure and protect the interface from side reactions with the electrolyte by generating a LiF-rich surface ***,the Mo^(6+) doping suppresses phase transition,which blocks Li^(+)/Ni^(2+) mixing,and stabilizes lithium-ion diffusion ***,the FMNCM cathode demonstrates excellent cycling stability at a high cutoff voltage of 4.4 V,even at 60°C,maintaining 90.6%capacity retention at 3 C after 150 ***,at temperatures as low as-20°C,it retains 77.1%of its room temperature capacity,achieving an impressive 97.5%capacity retention after 500 *** stable operation under wide temperatures has been further validated in practical Ah-level *** study sheds light on both fundamental mechanisms and practical implications for the design of advanced cathode materials for wide-temperature LIBs,presenting a promising path towards high-energy and long-cycling LIBs with temperatureadaptability.

关键词： Anion-cation co-doping Wide temperature operation Ni-richlayered cathode Phase transition Surface/interface

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