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Cellular & Molecular Immunology 2005年第6期2卷 411-417页

作者： Zheng Zhang~1 Fu-Sheng Wang~(1,2) ~1Research Center of Biological Therapy,beijing 302 hospital,beijing 100039,china ~2Research Centre of Biological Therapy,beijing Institute of Infectious Diseases,beijing 302 hospital,100 Xi Si Huan Middle Road,beijing 100039,china. Research Center of Biological Therapy Beijing 302 Hospital Beijing 100039 China.

Appropriate in vivo control of plasmacytoid dendritic cell (pDC) recruitment and activation is a fundamentalrequirement for defense against viral *** this process,a pivotal event that influences the outcome ofviral infection is the production of high levels of type I interferon by *** particular,recent research findingsshowed that pDCs not only shape the nature of innate resistance,but are also responsible for the successfultransition from innate to adaptive immunity for viral *** addition,pDCs can differentiate into antigenpresenting cells that may regulate tolerance to a given ***,in a series of recent clinical studies,pDCs appeared to be defective in number and function in conditions of chronic viral diseases such as infected withHIV-1,HBV or ***-associated clinical antiviral therapy is also *** review describes researchfindings examining the functional and antiviral properties of in vivo pDC *** & MolecularImmunology.2005;2(6):411-417.

关键词： virus plasmacytoid dendritic cell innate immunity adaptive immunity

Overview of HBV whole genome data in public repositories and the Chinese HBV reference sequences

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Progress in Natural Science:Materials International 2008年第1期18卷 13-20页

作者： Guanghua Wu a,b, Huiguo Ding c, Changqing Zeng b,* a Graduate School of Chinese Academy of Sciences, beijing 100049, china b beijing Institute of Genomics, Chinese Academy of Sciences, beijing 101300, china c beijing Youan hospital, Capital Medical University, beijing 100069, china Graduate School of Chinese Academy of Sciences Beijing 100049 China beijing Institute of Genomics Chinese Academy of Sciences Beijing 101300 China beijing Youan hospital Capital Medical University Beijing 100069 China

The number of Hepatitis B virus (HBV) whole genomic sequences in public nucleotide databases (GenBank, EMBL, and DDBJ) had reached 866 by January 1, 2007. Coming from 46 countries and regions, these sequences were categorized as eight genotypes (A–H). With the statistical and phylogenetic analysis on all available complete genomic data of HBV, we here present an overview of HBV sequences in public databases. From all registered 229 HBV genomes in Chinese regions as well as 59 sequencing data from our research group, we report the establishment of reference sequences of HBV strains prevailing in china. These analyses provide clues for the effects of HBV genotypes in host clinical progressions, geographic distribution of the infection, and the viral evolutionary history. Moreover, the viral sequence reference would be helpful in the identiffcation of various HBV mutations. Based on the analysis of various public databases, we suggest that the Chinese HBV database with the clinical information should be constructed.

关键词： Public databases HBV genomic sequences Genotype Subtype Chinese reference sequences

Combined laparoscopic and endoscopic treatment for bile duct diseases

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Hepatobiliary & Pancreatic Diseases International 2004年第2期3卷 284-287页

作者： Ming-Fang Qin and Hong-Bing Xu Tianjin, china Department of Endoscopic Surgery, Nankai hospital, Tianjin 300100. china and Department of Hepatobiliary Surge- ry, pla 309 hospital, beijing 100091 , china Department of Endoscopic Surgery Nankai Hospital Tianjin 300100 China. qins@***

BACKGROUND: Clinical application of laparoscopy, duo- denoscopy and choledochoscopy has been accepted as a mini-invasive surgical therapy for bile duct diseases; but ei- ther endoscopic or laparoscopic therapy alone is disadvanta- geous in its narrow indications and in failure to give full play to the individual superiority. The present study was to evaluate the procedures and therapeutic results of combined laparoscopic and endoscopic treatment for bile duct disea- ses. METHODS: Clinical data of 1990 patients with bile duct diseases treated by combination of laparoscopy, duodenos- copy and choledochoscopy in two hospitals were reviewed and analyzed. RESULTS: Patients with cholecystolithiasis and choledo- cholithiasis were treated with combined laparoscopy and duodenoscopy (n =1350) in a single operation with a cure rate of 93.6%. Those with choledocholithiasis (n =332) were treated with combined laparoscopy and choledocho- scopy with a cure rate of 100%. Combined laparoscopy, duo- denoscopy and choledochoscopy was used in 258 patients with choledocholithiasis (29 of them complicated with pan- creatitis) and 24 patients with Mirizzi's syndrome, with a cure rate of 100%. Laparoscopic choledochoenterostomy and preoperative endoscopic nasobiliary drainage were done in 26 patients with a cure rate of 100%. There were no serious operative complications. A follow-up study of 1051 patients for 3 months to 12 years (mean 7.8 years) showed that 10 patients had recurrence of stones but no stenosis of the bile duct. CONCLUSION: Combined laparoscopic and endoscopic procedures are mini-invasive and cause less pain and mini- mal operative complications.

关键词： laparoscopy duodenoscopy choledochoscopy bile duct disease

Identification of Genes Underlying Hereditary Nonsyndromic Hearing Loss among Chinese Population

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Identification of Genes Underlying Hereditary Nonsyndromic H...

Effects of Tryptergium Wilfordii Polyglyco-sidium on the Tumour Necrosis Factor Levels in Aqueous Humor after Intraocular Lens Implantation

2010中国青年遗传学家论坛

作者： Huijun Yuan Institute Of Otolaryngology,Chinese pla general hospital,beijing 100853,china

Hereditary nonsyndromie hearing loss(NSHL) is extremely *** the past decade, remarkable progress has been made towards determining the deafness-causing *** date,over 139 loci have been mapped for NSHL,and 62 deafness genes from these loci have been *** the enormous research resources in china,we have identified several genes and mutations by linage

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眼科学报 1999年第1期15卷 29-31,28页

作者： Zhaohui Zhou, Shouzhi HeDepartment of Ophthalmology, No. 304 hospital, beijing 100037, china Department of Ophthalmology, pla general hospital, beijing 100853 , china Department of Ophthalmology No. 304 Hospital Beijing 100037 China.

Purpose : Effects of Tryptergium Wilfordii Polyglycosidium (TWP) on the Tumour Necrosis Factor (TNF) levels in aqueous humor after intraocular lens (IOL) implantation were studied in ***: Twenty-seven pigmented rabbits were divided into three groups. In the first group, the IOL were placed in the capsular bag after lens extraction. In the second group, rabbits received TWP therapy after IOL implantation. And in the third group, rabbit received prednisone therapy after IOL implantation. Aqueous humor samples were aspirated on the 1st, 3rd, 7th, and 14th postoperative day. A modified double antibodies indirect sandwich EL ISA was used to detect for the presence of TNF. The data were closely studied by means of analysis of variance with SAS ***; It was found that TNF level in aqueous humor reached its maximum on the 7th postoperative day in the group with IOL implantation. It was also found that the TNF levels in aqueous humor on the 7th and 14th postoperative day were

关键词：眼玻璃体肿瘤坏死因子 TWP

Pericardial devascularization combined with preservation of Latarjet's nerves trunk in treatment of patients with portal hypertension

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Hepatobiliary & Pancreatic Diseases International 2003年第1期2卷 66-68页

作者： Shi-Yong Li En Wu Zhen-Jia Liang Shu-Jun Yuan Bo Yu the Department of general Surgery, beijing Military Command general hospital. beijing 100700, china Department of general Surgery Beijing Military Command General Hospital Beijing 100700 China. lishiyong66@***

OBJECTIVE: To investigate the effect of perieardial devascularization combined with preservation of Latarjet's innervation on portal hypertension. METHODS: Sixty-two patients (57 men and 5 women) have been undergone pericardial devascularization combined with Latarjet's innervation since 1984. Clinical results and postoperative complications were evaluated. RESULTS: The incidence of upper-digestive tract bleeding was 3.2% (2 patients) within 1 month after operation. Four patients (6.5%) died within 1 month atier operation (3 patients received emergency operation and 1 selective operation). Among them, 3 patients died from hepatic failure, and one patient from sepsis due to subphrentic infection. Among these deaths, 3 were evaluated Child's C. After operation, the number of patients with abdominal distension, sudden diarrhea and gastric retension was 7 (11. 3%), 3 (4.8%) and 0, respectively. CONCLUSION: Pericardial devascularization combined with Latarjet's innervation can preserve the normal function of gastric emptying, prevent acute lesion of the gastric mucosa, and reduce the incidence of esophageal varices rebleeding after operation.

关键词： vagus nerve hypertension portal

HISTOPATHOLOGICAL CHARACTERISTICS OF LYMPH NODE SINUS CONTAINING BLOOD

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中国体视学与图像分析 2001年第3期6卷 129-132页

作者： YIN Tong, JI Xiao-long (Department of Pathology, general hospital of the Chinese pla, beijing 100853,china) Department of Pathology General Hospital of the Chinese PLA Beijing 100853China

This study is to find out the histopathological characteristics of lymph node sinus containing blood. Routine autopsy was carried out in the randomly selected 102 patients(among them, 100 patients died of various diseases, and 2 of non-diseased causes),their superficial lymph nodes locating in the bilateral neck, axilla, inguina, thorax and abdomen were sampled. Haematoxylin-eosin staining was performed on 10% formalin-fixed and paraffin-embedded lymph node tissue sections(5μm). The histological characteristics of the lymph node sinuses containing blood were observed under light microscope. Among the 1362 lymph nodes sampled from the 100 autopsies, lymph sinuses containing blood were found in 809 lymph nodes sampled from 91 cases, but couldn’t be seen in the lymph nodes sampled from the non-diseased cases. According to histology, five kinds of lymph sinuses containing blood were found:vascular-opening sinus, blood-deficient sinus, erythrophago-sinus, blood-abundant sinus, and vascular-formative sinus. It is concluded that in the state of disease, the phenomenon of blood in the lymph sinus is not uncommon. Blood could possibly enter into lymph sinus through lymphatic-venous communications between the veins and sinuses in the node. Lymph circulation and blood circulation could communicate with each other in the lymph sinus.

关键词：尸体解剖淋巴结瘘血液组织病理学

A new clinical entity: multi-etiological heart failure in the elderly and its therapeutic implication

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Journal of Geriatric Cardiology 2005年第2期2卷 109-113页

作者： Shiwen WANG Haiyun WU Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China

Heart failure (HF) is a major health problem for the geriatric population. In the United States, most of the 5 millions patients with HF are elderly.1 Seventy-five percent of HF hospitalizations occurred in patients older than 65 years and 50% in patients 75 years and older.1 In the Framingham population, the prevalence of HF increased eightfold among men from the fifth decade of life to the seventh decade.2 However, despite of considerable improvement in the treatment, the mortality of HF patients remained relatively constant between 1948 and 1997.

关键词： CHF multi-etiological heart failure in the elderly and its therapeutic implication A new clinical entity

Primary jejunoileal neoplasmas:a review of 60 cases

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World Journal of Gastroenterology 2003年第4期9卷 862-864页

作者： Yun-Sheng Yang Qi-Yang Huang Wei-Feng Wang Gang Sun Li-Hua Peng Department of Gastroenterology,china pla general hospital,beijing 100853,china Department of Gastroenterology China PLA General Hospital Beijing 100853 China. yangys@***

AIM: Primary neoplasmas of the jejunum and ileum are infrequent and lack specific manifestations and inaccessibility of conventional endoscopy, so the diagnosis of these tumors are usually delayed. So far the data of primary jejunoileal neoplasmas is still scarce, especially in Chinese medical literature in English. There may be some differences among the Chinese and the westerners in jejunoileal ***: A retrospective analysis was made on clinical findings and pathological ***: Of the 60 patients with jejunal or ileal neoplasmas, the most frequent symptom was abdominal pain (57%), followed by tarry stool (43%) and hematochezia (10%). Abdominal mass (40%) was the most common finding on physical examination, followed by anemia and weight loss (35%). 67% of the jejunoileal neoplasms were located in the jejunum. Among the malignant neoplasmas (68%), malignant stroma (47%) was most common, while the benign stromoma (20%) was the most common benign neoplasmas. Preoperatively, 40 patients (67%) were diagnosed as small bowel neoplasmas, of which 34 were found by enteroclysis. Abdominal mass was shown by CT in 18 cases and by ultrasonography in 13. The mean duration of symptoms before diagnosis was 7 months. In 41 patients with malignant tumors, the duration of symptoms before diagnosis exceeded 12 months in 21 cases, lymphatic or distant metastases were found in 26 (63%)cases during operation. An emergency laparotomy was performed in 4patients (7%) owing to intestinal obstruction or ***: Primary jejunoileal neoplasmas in Chinese present some difference from Westerners on clinical features and histopathologic types. Enteroclysis remains the major relevant diagnostic procedure in this study, the misdiagnotic rate is high preoperatively due to failure of detection by conventional imaging procedures such as CT and inaccessibility of routine endoscopy. For the suspected patients, combined application of aforementioned procedures may fac

关键词：原发性空回肠肿瘤临床症状病理特点诊断外科治疗

Management of endolymphatic sac tumors:a case series report

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Journal of Otology 2009年第2期4卷 119-123页

作者： HUANG De-liang, YUAN Yong-yi, HAN Dong-yi, SHEN Wei-dong, LIU Jun, LI Qi Department of Otolaryngology-Head and Neck Surgery, Chinese pla general hospital, beijing 100853, china Department of Otolaryngology – Head and Neck Surgery Chinese PLA General Hospital Beijing 100853 China

Objective To study clinical characteristics of endolymphatic sac tumor (ELST) and its diagnosis and treatment. Methods ELST was diagnosed in 6 cases based on surgical and histological findings. These cases were reviewed for their clinical manifestations, differential diagnosis and surgical treatment techniques. Results There were 1 male and 5 females in this group, aged from 28 to 59 years (mean age=38.7 years). The tumor was in left ear in 4 cases and in right ear in the other 2 cases. Disease courses ranged from 5 to 30 years (mean duration=12.6 years). Clinical presentations included sensorineural hearing loss (n=4), otorrhea and tinnitus (n=2), tinnitus and facial spasm(n=1), otorrhea with facial paralysis(n=1), and hearing loss with tinnitus (n=2). None of the cases was diagnosed as ELST preoperatively. Two cases were misdiagnosed as glomus jugulare tumor, 2 as chronic suppurative otitis media, 1 as sweat gland adenoma on biopsy and 1 as temporal bone tumor. Tumors were surgically resected in all 6 cases via the mastoidectomy (n=2) or combined oto-cervical or cranio-oto-cervical approaches(n=4). Postoperative cerebrospinal fluid otorrhea occurred in 1 case. The tumors were confirmed on histological examination to be a low -grade adenocarcinoma. All patients have survived at the time of this paper. Conclusion ELST is rare and commonly misdiagnosed and inadequately treated. Its prognosis is relatively favorable because of its slow growth rate.

关键词： Endolymphatic sac neoplasm