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Effect of WNT5A on epithelial-mesenchymal transition and its correlation with tumor invasion and metastasis in nasopharyngeal carcinoma

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Asian Pacific Journal of Tropical Medicine 2014年第6期7卷 488-491页

作者： Hong-Hai Zhu Xiao-Yuan Zhu Ming-Hui Zhou gen-yang cheng Wei-Hua Lou Rhinology of the First Affiliated Hospital of Zhengzhou University Department of Otolaryngology-Head and Neck Surgery the First Affiliated Hospital of Zhengzhou University Department of Nephrology of the First Affiliated Hospital of Zhengzhou University

Objective:To investigate the correlation between nasopharyngeal carcinoma cell WNT5A and epithelial-mesenchytnal transition(emt)/metastasis,and investigate its possible ***:RT-PCR and gene transfection were used to detect the expression of nasopharyngeal carcinoma cell strains WNT5A and EMT related factor *** transfcction of NPC cell line 5-8F was determined by liposome of plasmid with WNT5A *** differential expressions of WNTSA and EMT-related factors in cells before and after transfection were detected by *** scratch assay and Transwell assay were used to detect the motility abilities of cells before and after 5-8F ***:The expressions of WNT5A and EMT related factors matrix metalloproleinasc-2 of the WNTSA transferred group in the nasopharyngeal carcinoma cell line 5-8F were higher than the blank control group and the empty vector transferred group,and the transfer ability of the WNTSA transferred group was higher than that in the blank control group and the empty vector transferred group,while the expressions of EMT related factors E-cadherin were lower than that in the blank control group and the empty vector transferred group,and the transfer ability of the WNT5A transferred group was higher than that in the blank control group and the empty vector transferred ***:In nasopharyngeal carcinoma cells,WNT5A can regulate the epithelial-mesenchymal transition and affect the ability of tumor invasion and metastasis of nasopharyngeal carcinoma.

关键词： WNT5A Epithelial-mesenchymal transition Matrix metalloproteinase-2 E-cadherin Nasopharyngeal cancer Metastasis

Influences of shale microstructure on mechanical properties and bedding fractures distribution

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Petroleum Science 2024年第3期21卷 1944-1954页

作者： Ming-Zhe Gu Mao Sheng Shi-Zhong cheng Fan-Hao Gong gen-Sheng Li State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum-BeijingBeijing2249China College of Petroleum Engineering China University of Petroleum-BeijingBeijing102249China Shenyang Center of China Geological Survey ShenyangLiaoning110034China

The difference in microstructure leads to the diversity of shale mechanical properties and bedding fractures distribution *** this paper,the microstructure and mechanical properties of Longmaxi marine shale and Qingshankou continental shale were studied by X-ray diffractometer(XRD),field emission scanning electron microscope(FE-SEM)with mineral analysis system,and ***,the typical bedding layers area was properly stratified using Focused Ion Beam(FIB),and the effects of microstructure and mechanical properties on the distribution patterns of bedding fractures were *** results show that the Longmaxi marine shale sample contains more clay mineral grains,while the Qingshankou continental shale sample contains more hard brittle mineral grains such as *** Longmaxi marine shale sample,hard brittle minerals with grain sizes larger than 20μm is18.24%and those with grain sizes smaller than 20μm is 16.22%.For Qingshankou continental shale sample,hard brittle minerals with grain sizes larger than 20μm is 40.7%and those with grain sizes smaller than 20μm is 11.82%.In comparison to the Qingshankou continental shale sample,the Longmaxi marine shale sample has a lower modulus,hardness,and *** shales are formed by alternating coarse-grained and fine-grained layers during *** average single-layer thickness of Longmaxi marine shale sample is greater than Qingshankou continental shale *** two types of shale have similar bedding fractures distribution patterns and fractures tend to occur in the transition zone from coarse-grained to fine-grained *** orientation of the fracture is usually parallel to the bedding plane and detour occurs in the presence of hard brittle *** fracture distribution density of the Longmaxi marine shale sample is lower than that of the Qingshankou continental shale sample due to the strong heterogeneity of the Qingshankou continental *** current resea

关键词： Shale Nanoindentation Microstructure Mechanical property Fracture

Polyphenol-mediated interfacial deposition strategy for supported manganese oxide catalysts with excellent pollutant degradation performance

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Chinese Chemical Letters 2024年第5期35卷 493-498页

作者： Dong cheng Youyou Feng Bingxi Feng Ke Wang Guoxin Song gen Wang Xiaoli cheng Yonghui Deng Jing Wei The Key Laboratory of Biomedical Information Engineering of Ministry of Education State Key Lab of Transducer TechnologySchool of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China School of Environmental and Municipal Engineering Xi’an University of Architecture and TechnologyXi’an 710055China Department of Chemistry State Key Laboratory of Molecular Engineering of PolymersState Key Laboratory of Transducer TechnologyFudan UniversityShanghai 200433China Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150080China

In persulfate-based advanced oxidation process(PS-AOPs),fixing nanosized metal oxide on processable substrates is highly desirable to avoid the aggregation and loss of nanocatalysts during the practical ***,it is still challenging to develop a versatile strategy for the deposition of metal oxide nanocatalysts on various substrates with different physicochemical ***,polyphenols are utilized as a“molecular glue”and reductant to mediate the interfacial deposition of MnO_(2) nanocatalysts on different ***_(2) nanocatalysts were in-situ grown on macroscope mineral substrates(e.g.,airstone)via an interfacial redox strategy between tannic acid(TA)and oxidized KMnO4,and then employed as a fixed catalyst of peroxymonosulfate(PMS)activation for treating pharmaceutical and personal care products(PPCPs)in *** fixed MnO_(2) exhibited superior catalytic performance toward different PPCPS via a singlet oxygen(^(1)O_(2))-dominated nonradical oxidation *** in the secondary effluent of wastewater treatment plants could be effectively removed by a fixed-bed column of the fixed MnO_(2) with long term *** cycle of Mn^(4+)/Mn^(3+)and surface hydroxyl group of the fixed MnO_(2) was proved to be responsible for the activation of *** work provides a new avenue for developing fixed metal oxides for sustainable water treatment.

关键词： Redox strategy Manganese oxides Fixed catalyst Peroxymonosulfate PPCPs

In situ protonation in a locally flexible porous coordination polymer for enhancing proton-carrier loading and proton conductivity

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Science China Chemistry 2024年第10期67卷 3432-3437页

作者： Xianzhe Wei Jincheng Liu Yan Su Weitao Wang Guixiang Wang gen Zhang Ping Wang cheng Gu State Key Laboratory of Luminescent Materials and Devices Institute of Polymer Optoelectronic Materials and DevicesSouth China University of Technology College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan University Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education School of Chemistry and Chemical EngineeringNanjing University of Science and Technology

Designing efficient proton-conductive materials is crucial in fuel cells. Yet, it remains a substantial challenge because of the issues in proton mobility, proton-carrier amount, and orientation of proton host materials. Herein, we report an in-situ protonation strategy to produce a locally flexible porous coordination polymer(PCP) to enhance the proton-carrier loading and proton conductivity. The local dipole flipping of the ligand allows effective proton exchange with low activation energy, promoting interpore proton transport through the pore apertures and pore walls. The protonation induces substantial charges to the frameworks and enhances the interaction with proton carriers, thereby increasing the loading of the proton carriers. By this design strategy, the resulting PCP exhibits enhanced phosphoric acid loading and extraordinary proton conductivities under both aqueous and anhydrous conditions compared to its isoreticular analog that features rigidity without proton-exchange *** work provides a new avenue for designing proton-conductive materials that combine structural dynamics with performance merits.

关键词： porous coordination polymers in-situ protonation local flexibility proton-exchange mechanism proton conduction

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CO_(2)flooding in shale oil reservoir with radial borehole fracturing for CO_(2)storage and enhanced oil recovery

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Petroleum Science 2024年第1期21卷 519-534页

作者： Jia-cheng Dai Tian-Yu Wang Jin-Tao Weng Kang-Jian Tian Li-Ying Zhu gen-Sheng Li State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China China National Oil and Gas Exploration and Development Company Limited Beijing100034China

This study introduces a novel method integrating CO_(2)flooding with radial borehole fracturing for enhanced oil recovery and CO_(2)underground storage,a solution to the limited vertical stimulation reservoir volume in horizontal well fracturing.A numerical model is established to investigate the production rate,reservoir pressure field,and CO_(2)saturation distribution corresponding to changing time of CO_(2)flooding with radial borehole fracturing.A sensitivity analysis on the influence of CO_(2)injection location,layer spacing,pressure difference,borehole number,and hydraulic fractures on oil production and CO_(2)storage is *** CO_(2)flooding process is divided into four *** in layer spacing will significantly improve oil production rate and gas storage ***,serious gas channeling can occur when the spacing is lower than 20 *** the pressure difference between the producer and injector,the borehole number,the hydraulic fracture height,and the fracture width can also increase the oil production rate and gas storage *** analysis shows that layer spacing and fracture height greatly influence gas storage and oil *** outcomes are expected to provide a theoretical basis for the efficient development of shale oil reservoirs in the vertical direction.

关键词： Shale oil Radial borehole fracturing Embedded discrete fracture model Enhanced oil recovery Carbon storage

Influence of meteorological factors on open biomass burning at a background site in Northeast China

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Journal of Environmental Sciences 2024年第4期138卷 1-9页

作者： Yulong Wang Linlin Liang Wanyun Xu Chang Liu Hongbing cheng Yusi Liu gen Zhang Xiaobin Xu Dajiang Yu Peng Wang Qingli Song Jiumeng Liu Yuan cheng State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin 150090China State Key Laboratory of Severe Weather&Key Laboratory for Atmospheric Chemistry Chinese Academy of Meteorological SciencesBeijing 100081China Longfengshan Regional Background Station China Meteorological AdministrationHeilongjiang 150200China Heilongjiang Climate Center Heilongjiang 150030China

Biomass burning(BB)is a very important emission source that significantly adversely impacts regional air *** produces a large number of primary organic aerosol(POA)and black carbon(BC).Besides,BB also provides many precursors for secondary organic aerosol(SOA)*** this work,the ratio of levoglucosan(LG)to organic carbon(OC)and the fire hotspots map was used to identify the open biomass burning(OBB)events,which occurred in two representative episodes,October 13 to November 30,2020,and April1 to April 30,*** ratio of organic aerosol(OA)to reconstructed PM_(2.5)concentration(PM_(2.5)^(*))increased with the increase of LG/*** LG/OC ratio is higher than 0.03,the highest OA/PM_(2.5)^(*)ratio can reach 80%,which means the contribution of OBB to OA is *** to the ratio of LG to K^(+),LG to mannosan(MN)and the regional characteristics of Longfengshan,it can be determined that the crop residuals are the main *** occurrence of OBB coincides with farmers’preferred choices,i.e.,burning biomass in“bright weather”.The“bright weather”refers to the meteorological conditions with high temperature,low humidity,and without *** factors indirectly affect regional biomass combustion pollution by influencing farmers’active choices.

关键词： Air pollution Biomass burning Meteorological factors Organic trace Agricultural fires

Room-temperature Self-healing and Recyclable PDMS Elastomers with Superior Mechanical Properties for Triboelectric Nanogenerators

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Chinese Journal of Polymer Science 2024年第10期42卷 1566-1577页

作者： Shu-Juan Wang Lu Wang Hong-Zhe Su Zhi-cheng Wu Qiao-gen Zhang Wei Fan Xin-Li Jing School of Chemistry Joint Innovation Center of Thermal Protection Materials Xi'an Jiaotong University School of Electrical Engineering Xi'an Jiaotong University School of Textile Science and Engineering Xi'an Polytechnic University

Polydimethylsiloxane (PDMS) is an electron-withdrawing material that is widely used in triboelectric nanogenerators (TENGs). However, PDMS has poor mechanical properties after curing and is easily damaged when subjected to long-term workloads. Thus, the long-term stable operation of TENGs under mechanical deformation cannot be guaranteed. In this work, multiple hydrogen bonds and aromatic disulfide bonds were introduced into PDMS elastomers. These elastomers exhibited high toughness (a tensile strength of 1.91 MPa and an elongation at break of 340%), good recyclability, and room-temperature self-healing properties (healing efficiency of 96.4%in 24 h). Recyclable sandwich-like triboelectric nanogenerators with excellent electrical output performance (13.5 V) and room-temperature self-healing performance (24 h, 98% recovery of self-generating performance) were prepared by utilizing the hydrogen bonding between the PDMS elastomer and MXene. The work reported herein offers theoretical guidance and a compelling strategy for developing high-performance TENG negative friction layers.

关键词： Aromatic disulfide bonds Hydrogen bonds Polydimethylsiloxane Room temperature self-healing Triboelectric nanogenerator

基于增量式Q学习的固定翼无人机跟踪控制性能优化

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控制与决策 2024年第2期39卷 391-400页

作者：赵振根程磊南京航空航天大学自动化学院南京211106

针对固定翼无人机纵向控制的高性能需求,提出一种控制系统性能优化结构.该结构包括一个使系统稳定的标称控制器和一个参与性能优化的增量式控制器.控制系统增量式的实现不会改变原有的控制系统,而是仅对标称控制系统做控制输入的补偿与... 详细信息

针对固定翼无人机纵向控制的高性能需求,提出一种控制系统性能优化结构.该结构包括一个使系统稳定的标称控制器和一个参与性能优化的增量式控制器.控制系统增量式的实现不会改变原有的控制系统,而是仅对标称控制系统做控制输入的补偿与控制性能的优化.基于Q学习理论进行增量式控制器设计,针对状态信息完全可获得的系统,设计一种基于状态反馈的增量式Q学习算法.当状态信息不能完全获得时,利用系统输入、输出和参考信号数据,设计一种基于输出反馈的增量式Q学习算法.两种增量式控制器均是在数据驱动环境下自适应学习增量式控制律,无需提前知道系统动力学模型以及标称控制器的控制增益.此外,证明了增量式Q学习方法在满足持续激励条件的激励噪声下,对Q函数贝尔曼方程的求解没有偏差.最后,通过对F-16飞行器纵向模型实例的仿真验证该方法的有效性.

关键词：强化学习 Q学习增量式控制性能优化跟踪控制无人机

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环境模块课程教学实践

思茅师范高等专科学校学报 2009年第3期25卷 126-129页

作者：苏成西杨根成思茅师范高等专科学校生命科学系云南普洱665000 思茅师范高等专科学校教务处云南普洱665000

为了配合新形式下高等教育改革的要求,思茅师范高等专科学校生命科学系化学教育专业的课程设置进行改革,采用必修课加模块选修课的模式教学。对化学教育专业开设环境模块课的教学实践进行分析和总结,提出改进建议,以期促进教学改革。

关键词：环境保护环境模块课教学实践