检索结果-南通市图书馆

Science China Chemistry 2023年第10期66卷 2847-2851页

作者： Xuefeng Tan Shuang Gao Chunyan Yang Qiwei Lang Xiaobing Ding gen-qiang chen Xumu Zhang Laboratory of Small Molecule Drug Discovery and Synthesis Department of ChemistrySouthern University of Science and TechnologyShenzhen 518055China Academy for Advanced Interdisciplinary Studies Southern University of Science and TechnologyShenzhen 518000China Department of Chemistry City University of Hong KongHong Kong 999077China

A series of novel atropisomeric diphosphine ligands termed Tan Phos were designed and synthesized,which has a smaller bite angle compared with that of other ligands such as *** Phos showed high reactivity and enantioselectivity in the rhodiumcatalyzed asymmetric hydrogenation ofα-dehydro amino ketones,and up 99%yield and 99%ee were obtained for a wide range of chiralα-amino ketones.

关键词： diphosphine asymmetric hydrogenation chiral ligand

Rhodium-Catalyzed Asymmetric Transfer Hydrogenation of Heterocyclic Diaryl Ketones:Facile Access to Key Intermediate of Baloxavir

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2024年第1期42卷 43-47页

作者： Li Wang Renwei Xiao Jingyuan Song Long-Sheng Zheng Qiwei Lang gen-qiang chen Xumu Zhang Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis Department of Chemistryand Medi-PingshanSouthern University of Science and TechnologyShenzhenGuangdong 518000China Academy for Advanced Interdisciplinary Studies Southern Universityof Science and TechnologyShenzhenGuangdong 518000China Chemistry and Chemical Engineering Guangdong Laboratory ShantouGuangdong 515031China

Transition metal-catalyzed asymmetric transfer hydrogenation has been proven to be a powerful approach for the synthesis of chiral ***,a highly efficient and enantioselective transfer hydrogenation of dibenzoheptaheterocyclic ketones catalyzed by an arene-tethered TsDPEN-based Rh(ll)catalyst has been successfully developed,and a variety of dibenzoheptaheterocyclic ketones were reduced by a 1/1 mixture of formic acid and DBU(1,8-diazabicyclo[5.4.0]undec-7-ene)with high yields and *** this method,the asymmetric reduction of 7,8-difluorodibenzo[b,e]thiepin-11(6H)-one has been realized,providing the key intermediate of baloxavir marboxil with>99% yield and>99% ee at a substrate/catalyst molar ratio of 1000.

关键词： Asymmetric transfer hydrogenation Baloxavir Chiral alcohol Enantioselectivity Heterocyclic diaryl ketone Rhodium(Ⅱ)

Ate complexes in organic synthesis:From ate reagents to ate catalysts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green Synthesis and Catalysis

Green Synthesis and Catalysis 2024年第3期5卷 141-152页

作者： Yang'en You Congcong Yin Liren Xu gen-qiang chen Xumu Zhang Department of Chemistry Southern University of Science and Technology1088 Xueyuan RoadShenzhen 518055China School of Chemistry and Chemical Engineering Hefei University of Technology and Anhui Province Key Laboratory of Value-Added Catalytic Conversion and Reaction EngineeringHefei 230009China Hubei Key Laboratory of Natural Products Research and Development College of Biological and Pharmaceutical SciencesChina Three Gorges UniversityYichang 443002China

The realm of application of organometallic catalysis to organic synthesis has witnessed a transformative shift in recent years,owing much to the evolution of ate complexes from mere reagents to versatile *** complexes,formed through the coordination of a neutral Lewis acid with an organic anionic base,have emerged as pivotal intermediates that not only facilitate organic transformations but also serve as efficient catalysts in a wide range of chemical *** review presents the fascinating journey of ate complexes,highlighting their development from stoichiometric reagents to active ***,ate complexes were primarily regarded as stoichiometric species essential for various metal-catalyzed ***,constant research has unveiled their potential as catalysts in their own right,reshaping the landscape of modern organic *** this minireview,we discuss the pivotal role of ate complexes in the evolution of organic synthesis,from their early days as reactive intermediates to their current stature as catalytic pioneers offering a glimpse into the exciting future of this dynamic field.

关键词： Ate complexes Ate catalysis Anionic Hydrogenation Cross-coupling

Highly efficient synthesis of chiralβ-amino phosphine derivatives via direct asymmetric reductive amination with ammonium salts and H_(2)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green Synthesis and Catalysis 2022年第3期3卷 298-301页

作者： Yufeng Liu Linzhou Wang Yingjun Li Baode Ma gen-qiang chen Xumu Zhang Medi-X Pingshan Guangdong Provincial Key Laboratory of Catalysisand Department of ChemistrySouthern University of Science and TechnologyShenzhen 518000China Shenzhen Bay Laboratory Shenzhen 518132China Academy for Advanced Interdisciplinary Studies and Southern University of Science and Technology Shenzhen 518000China

A highly efficient and enantioselective method for the asymmetric reductive amination ofβ-keto phosphine de-rivatives was disclosed,and the correspondingβ-amino phosphine oxides could be obtained in high yields(up to 97%yield)and excellent enantioselectivities(up to 97%ee).Moreover,the reaction worked well on a gram scale,indicating that our protocol has potential applications in the synthesis of chiral ligands and organocatalysts.

关键词： Asymmetric reductive amination Chiralβ-amino phosphine Ruthenium-catalysed Ammonium salt

Discovery and development of ferrocene-based tetradentate ligands for Ir-catalysed asymmetric hydrogenation of ketone

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green Synthesis and Catalysis 2022年第2期3卷 175-178页

作者： Jianfei Yu Fanping Huang Wei Fang Congcong Yin Chuan Shi Qiwei Lang gen-qiang chen Xumu Zhang Medi-X Pingshan Guangdong Provincial Key Laboratory of CatalysisDepartment of ChemistrySouthern University of Science and TechnologyShenzhen 518000China Medi-X Pingshan Academy for Advanced Interdisciplinary StudiesSouthern University of Science and TechnologyShenzhen 518000China

The development of highly active and enantioselective ligands and catalysts for the asymmetric hydrogenation of ketone has been the goal of synthetic chemists for more than fifty ***,a series of ferrocene-based tetradentate ligands were developed and applied in Ir-catalysed asymmetric hydrogenation of *** hydrolytic ring-opening of the oxazoline moiety of ligand f-amphox leads to the accidental discovery of a highly efficient and enantioselective tetradentate ligand f-phamidol which showed extraordinarily high reactivity and enantioselectivity(up to 99%yield,up to>99%ee and up to 1,000,000 TON).In addition,two types of other tetradentate ligands f-phamida and f-phamide were also synthesized and evaluated.

关键词： Asymmetric hydrogenation of ketones Ferrocene-based ligands Iridium-catalysed Tetradentate ligands

Emerging progress: photochemical transformation of nitroso compounds

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第1期68卷 118-133页

作者： Ze-Le chen qiang-qiang Li Armido Studer Jun Xuan Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials School of Chemistry & Chemical Engineering Anhui University Organisch-Chemisches Institut Universitat Münster

Nitroso compounds have emerged as highly valuable reaction partners or reagents in organic synthesis due to their rich *** versatile profile of these compounds allows them to function as electrophiles, nucleophiles, diradicals, and radical acceptors in diverse transformations. In recent years, notable progress has been made in harnessing photochemical reactions with nitroso compounds to prepare N,O-containing structures using mild and eco-friendly conditions. Various nitroso compounds like nitrosoarenes, acyloxy nitroso compounds, N-nitrosoamines and nitrites have received significant attention for their ability to introduce NO moieties into complex molecules that are otherwise difficult to access. In this review, we provide an overview of the recent advancements in the visible light-induced conversion of nitroso compounds, with particular emphasis on their role as bifunctional reagents and acceptors of radicals, carbenes and nitrenes.

关键词： nitroso compounds photochemistry radical reaction carbene transformation nitrosoarenes

Highly Enantioselective Hydrogenation of tetra-and tri-Substitutedα,β-Unsaturated Carboxylic Acids with oxa-Spiro Diphosphine Ligands

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

CCS Chemistry 2020年第6期2卷 468-477页

作者： gen-qiang chen Jia-Ming Huang Bi-Jin Lin Chuan Shi Ling-Yu Zhao Bao-De Ma Xiao-Bing Ding Qin Yin Xumu Zhang Department of Chemistry Guangdong Provincial Key Laboratory of CatalysisSouthern University of Science and TechnologyShenzhen 518000 Academy for Advanced Interdisciplinary Studies Southern University of Science and TechnologyShenzhen 518000

We herein present the design and synthesis of a structurally unique oxa-spirocyclic diphosphine ligand,termed as *** diphosphine ligand O-SDP derived from oxa-spirocyclic diphenols(O-SPINOL)has a relatively larger bite angle compared with that of SDP,and O-SDP has been successfully applied in the ruthenium-catalyzed asymmetric hydrogenation ofα,β-unsaturated carboxylic acids under mild reaction *** yields and enantioselectivities were generally achieved for a wide range of substrates(up to 99%yield and>99%ee),and many of the resulting products are key intermediates of important drugs such as Sacubitril,Artemisinin,and Paroxetine.

关键词： asymmetric hydrogenation diphosphine O-SDP O-SPINOL

The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying chen Yinyi Xiong Qin Zhou Ling-qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

二茂铁骨架三齿配体在2-丁酮不对称氢化中的应用

在线全文

学校读者我要写书评

暂无评论

中国科学：化学 2023年第3期53卷 558-563页

作者：方伟肖人玮宋静远陈根强张绪穆南方科技大学化学系深圳518055 南方科技大学前沿与交叉科学研究院深圳518055

尽管酮的不对称氢化已经被研究得非常充分,但是能够应用于脂肪酮不对称氢化的催化体系屈指可数,主要难点在于对映选择性的控制.本文中,我们开发了一系列基于二茂铁骨架的手性PNN和PNP类型的三齿配体,并考察了这些手性配体的铱络合物在2... 详细信息

尽管酮的不对称氢化已经被研究得非常充分,但是能够应用于脂肪酮不对称氢化的催化体系屈指可数,主要难点在于对映选择性的控制.本文中,我们开发了一系列基于二茂铁骨架的手性PNN和PNP类型的三齿配体,并考察了这些手性配体的铱络合物在2-丁酮不对称氢化中催化活性和对映选择性.当采用手性PNP配体时,最高可以获得99%的转化率和79%的对映选择性.

关键词：手性三齿配体不对称氢化二茂铁 2-丁酮

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan cheng Zhaoli Han Bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong qiang Liu Fanglian chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K