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Chinese Journal of Chemistry 2024年第1期42卷 43-47页

作者： Li Wang Renwei Xiao Jingyuan Song Long-Sheng Zheng Qiwei Lang gen-qiang chen Xumu Zhang Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis Department of Chemistryand Medi-PingshanSouthern University of Science and TechnologyShenzhenGuangdong 518000China Academy for Advanced Interdisciplinary Studies Southern Universityof Science and TechnologyShenzhenGuangdong 518000China Chemistry and Chemical Engineering Guangdong Laboratory ShantouGuangdong 515031China

Transition metal-catalyzed asymmetric transfer hydrogenation has been proven to be a powerful approach for the synthesis of chiral ***,a highly efficient and enantioselective transfer hydrogenation of dibenzoheptaheterocyclic ketones catalyzed by an arene-tethered TsDPEN-based Rh(ll)catalyst has been successfully developed,and a variety of dibenzoheptaheterocyclic ketones were reduced by a 1/1 mixture of formic acid and DBU(1,8-diazabicyclo[5.4.0]undec-7-ene)with high yields and *** this method,the asymmetric reduction of 7,8-difluorodibenzo[b,e]thiepin-11(6H)-one has been realized,providing the key intermediate of baloxavir marboxil with>99% yield and>99% ee at a substrate/catalyst molar ratio of 1000.

关键词： Asymmetric transfer hydrogenation Baloxavir Chiral alcohol Enantioselectivity Heterocyclic diaryl ketone Rhodium(Ⅱ)

Design and synthesis of novel 1,3-diene bridged chiral atropoisomeric diphosphine ligands for asymmetric hydrogenation ofα-dehydro amino ketones

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Science China Chemistry 2023年第10期66卷 2847-2851页

作者： Xuefeng Tan Shuang Gao Chunyan Yang Qiwei Lang Xiaobing Ding gen-qiang chen Xumu Zhang Laboratory of Small Molecule Drug Discovery and Synthesis Department of ChemistrySouthern University of Science and TechnologyShenzhen 518055China Academy for Advanced Interdisciplinary Studies Southern University of Science and TechnologyShenzhen 518000China Department of Chemistry City University of Hong KongHong Kong 999077China

A series of novel atropisomeric diphosphine ligands termed Tan Phos were designed and synthesized,which has a smaller bite angle compared with that of other ligands such as *** Phos showed high reactivity and enantioselectivity in the rhodiumcatalyzed asymmetric hydrogenation ofα-dehydro amino ketones,and up 99%yield and 99%ee were obtained for a wide range of chiralα-amino ketones.

关键词： diphosphine asymmetric hydrogenation chiral ligand

Highly efficient synthesis of chiralβ-amino phosphine derivatives via direct asymmetric reductive amination with ammonium salts and H_(2)

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Green Synthesis and Catalysis 2022年第3期3卷 298-301页

作者： Yufeng Liu Linzhou Wang Yingjun Li Baode Ma gen-qiang chen Xumu Zhang Medi-X Pingshan Guangdong Provincial Key Laboratory of Catalysisand Department of ChemistrySouthern University of Science and TechnologyShenzhen 518000China Shenzhen Bay Laboratory Shenzhen 518132China Academy for Advanced Interdisciplinary Studies and Southern University of Science and Technology Shenzhen 518000China

A highly efficient and enantioselective method for the asymmetric reductive amination ofβ-keto phosphine de-rivatives was disclosed,and the correspondingβ-amino phosphine oxides could be obtained in high yields(up to 97%yield)and excellent enantioselectivities(up to 97%ee).Moreover,the reaction worked well on a gram scale,indicating that our protocol has potential applications in the synthesis of chiral ligands and organocatalysts.

关键词： Asymmetric reductive amination Chiralβ-amino phosphine Ruthenium-catalysed Ammonium salt

Discovery and development of ferrocene-based tetradentate ligands for Ir-catalysed asymmetric hydrogenation of ketone

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Green Synthesis and Catalysis 2022年第2期3卷 175-178页

作者： Jianfei Yu Fanping Huang Wei Fang Congcong Yin Chuan Shi Qiwei Lang gen-qiang chen Xumu Zhang Medi-X Pingshan Guangdong Provincial Key Laboratory of CatalysisDepartment of ChemistrySouthern University of Science and TechnologyShenzhen 518000China Medi-X Pingshan Academy for Advanced Interdisciplinary StudiesSouthern University of Science and TechnologyShenzhen 518000China

The development of highly active and enantioselective ligands and catalysts for the asymmetric hydrogenation of ketone has been the goal of synthetic chemists for more than fifty ***,a series of ferrocene-based tetradentate ligands were developed and applied in Ir-catalysed asymmetric hydrogenation of *** hydrolytic ring-opening of the oxazoline moiety of ligand f-amphox leads to the accidental discovery of a highly efficient and enantioselective tetradentate ligand f-phamidol which showed extraordinarily high reactivity and enantioselectivity(up to 99%yield,up to>99%ee and up to 1,000,000 TON).In addition,two types of other tetradentate ligands f-phamida and f-phamide were also synthesized and evaluated.

关键词： Asymmetric hydrogenation of ketones Ferrocene-based ligands Iridium-catalysed Tetradentate ligands

Optimal Planning of Hybrid AC/DC Low-voltage Distribution Networks Considering DC Conversion of Three-phase Four-wire Low-voltage AC Systems

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 141-153页

作者： Bo Zhang Lu Zhang Wei Tang gen Li chen Wang the College of Information and Electrical Engineering China Agricultural UniversityBeijing 100083China the Electric Energy Group Department of Engineering TechnologyTechnical University of Denmark(DTU)2750 BallerupDenmark the Power Distribution Technology Center State Grid Beijing Electric Power Research InstituteBeijing 100075China

The increasing integration of distributed household photovoltaics(PVs)and electric vehicles(EVs)may further ag gravate voltage violations and unbalance of low-voltage distribu tion networks(LVDNs).DC distribution networks can increase the accommodation of PVs and EVs and mitigate mutilple pow er quality problems by the flexible power regulation capability of voltage source *** paper proposes schemes to es tablish hybrid AC/DC LVDNs considering the conversion of the existing three-phase four-wire low-voltage AC systems to DC op *** characteristics and DC conversion constraints of typical LVDNs are *** addition,converter configura tions for typical LVDNs are proposed based on the three-phase four-wire characteristics and quantitative analysis of various DC ***,an optimal planning method of hybrid AC/DC LVDNs is proposed,which is modeled as a bi-level programming model considering the annual investments and three-phase *** are conducted to verify the effectiveness of the proposed optimal planning *** ulation results show that the proposed optimal planning method can increase the integration of PVs while simultaneously reduc ing issues related to voltage violation and unbalance.

关键词： Optimal planning low-voltage distribution net work three-phase unbalance DC conversion

Highly Enantioselective Hydrogenation of tetra-and tri-Substitutedα,β-Unsaturated Carboxylic Acids with oxa-Spiro Diphosphine Ligands

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CCS Chemistry 2020年第6期2卷 468-477页

作者： gen-qiang chen Jia-Ming Huang Bi-Jin Lin Chuan Shi Ling-Yu Zhao Bao-De Ma Xiao-Bing Ding Qin Yin Xumu Zhang Department of Chemistry Guangdong Provincial Key Laboratory of CatalysisSouthern University of Science and TechnologyShenzhen 518000 Academy for Advanced Interdisciplinary Studies Southern University of Science and TechnologyShenzhen 518000

We herein present the design and synthesis of a structurally unique oxa-spirocyclic diphosphine ligand,termed as *** diphosphine ligand O-SDP derived from oxa-spirocyclic diphenols(O-SPINOL)has a relatively larger bite angle compared with that of SDP,and O-SDP has been successfully applied in the ruthenium-catalyzed asymmetric hydrogenation ofα,β-unsaturated carboxylic acids under mild reaction *** yields and enantioselectivities were generally achieved for a wide range of substrates(up to 99%yield and>99%ee),and many of the resulting products are key intermediates of important drugs such as Sacubitril,Artemisinin,and Paroxetine.

关键词： asymmetric hydrogenation diphosphine O-SDP O-SPINOL

Micromechanics of Thermal Conductive Composites:Review,Developments and Applications

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Acta Mechanica Solida Sinica 2024年第2期37卷 215-237页

作者： Guannan Wang Yulin Huang Mengyuan Gao qiang chen Department of Civil Engineering Zhejiang UniversityHangzhou310058China Center for Balance Architecture Zhejiang UniversityHangzhou310007China School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an710049China

Micromechanics investigations of composites with fiber-shaped reinforcement are extensively applied in the engineering design and theoretical analysis of thermal composites in the aerospace engineering and high-tech *** this paper,a critical review of various classical micromechanics approaches is provided based on the classification framework and the development of micromechanics *** numerical micromechanics tools have been developed to overcome limitations through exactly/approximately solving the internal governing equations of *** connections and limitations of those models are also investigated and discussed,based on which three recently developed numerical or semi-analytical models are explained,including finite-element micromechanics,finite-volume direct averaging micromechanics,and locally exact homogenization theory,as well as machine learning *** it is almost inevitable to mention the interfacial effects on thermal behavior of fibrous composites,we review the new mathematical relations that interrupt the original continuity conditions due to the existence of interphase/interface within unit *** speaking,the interphase/interface is demonstrated to play a significant role in influencing the effective coefficients and localized thermal *** present work also briefly reviews the application of micromechanics tools in emerging engineered woven composites,natural fibrous composites,and ablative thermal protection *** is demonstrated that sophisticated micromechanics tools are always demanded for investigating the effective and localized responses of thermal fibrous composites.

关键词： Micromechanics models Thermal fibrous composites Microstructural detail-free models Semi-analytical and numerical methods Interfacial effects Woven composites Natural composites

Fe-N_(x) sites coupled with core-shell FeS@C nanoparticles to boost the oxygen catalysis for rechargeable Zn-air batteries

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Journal of Energy Chemistry 2024年第3期90卷 565-577,I0013页

作者： Katam Srinivas Zhuo chen Anran chen Fei Ma Ming-qiang Zhu Yuanfu chen School of Integrated Circuit Science and Engineering and State Key Laboratory of Electronic Thin Films and Integrated DevicesUniversity of Electronic Science and Technology of ChinaChengdu 610054SichuanChina College of Mechanical and Electronic Engineering Northwest A&F UniversityYangling 712100ShaanxiChina School of Materials and Energy Yunnan UniversityKunming 650091YunnanChina

The development of efficient single-atom catalysts(SACs) for the oxygen reduction reaction(ORR)remains a formidable challenge,primarily due to the symmetric charge distribution of metal singleatom sites(M-N_(4)).To address such issue,herein,Fe-N_(x) sites coupled synergistic catalysts fabrication strategy is presented to break the uniform electronic distribution,thus enhancing the intrinsic catalytic ***,atomically dispersed Fe-N_(x) sites supported on N/S-doped mesoporous carbon(NSC)coupled with FeS@C core-shell nanoparticles(FAS-NSC@950) is synthesized by a facile hydrothermal reaction and subsequent *** to the presence of an in situ-grown conductive graphitic layer(shell),the FeS nanoparticles(core) effectively adjust the electronic structure of single-atom Fe sites and facilitate the ORR kinetics via short/long-range coupling ***,FAS-NSC@950displays a more positive half-wave potential(E_(1/2)) of 0.871 V with a significantly boosted ORR kinetics(Tafel slope=52.2 mV dec^(-1)),outpacing the commercial Pt/C(E_(1/2)=0.84 V and Tafel slope=54.6 mV dec^(-1)).As a bifunctional electrocatalyst,it displays a smaller bifunctional activity parameter(ΔE) of 0.673 V,surpassing the Pt/C-RuO_(2) combination(ΔE=0.724 V).Besides,the FAS-NSC@950-based zincair battery(ZAB) displays superior power density,specific capacity,and long-term cycling performance to the Pt/C-Ir/C-based *** work significantly contributes to the field by offering a promising strategy to enhance the catalytic activity of SACs for ORR,with potential implications for energy conversion and storage technologies.

关键词： Fe-N_(x)sites Core-shell FeS@C Synergistic interactions Oxygen reduction reaction Zn-air battery

Homochirality in Ferroelectrochemistry

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Chinese Journal of Chemistry 2024年第10期42卷 1133-1144页

作者： Hang Peng Jun-Chao Qi Yu-Si Liu Jia-Mei Zhang Wei-qiang Liao Ren-gen Xiong Ordered Matter Science Research Center Nanchang UniversityNanchangJiangxi 330031China

What is the most favorite and original chemistry developed in your research group?We originally proposed the design principle for molecular ferroelectrics:ferroelectrochemistry,including quasi-spherical theory,the introduction of homochirality,and H/F *** changed the blind search for molecular ferroelectrics into targeted chemical design,which will develop into a new discipline.

关键词： Molecular ferroelectrics Homochirality Ferroelectricity Chemical design Point groups

Development and validation of a nomogram to predict allograft survival after pediatric liver transplantation

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World Journal of Pediatrics 2024年第3期20卷 239-249页

作者： Guang-Xiang Gu Shu-Ting Pan Yi-chen Fan chen chen qiang Xia Department of Liver Surgery Renji HospitalShanghai Jiaotong University School of MedicineNo.160 Pujian RoadPudong New DistrictShanghai 200128China Department of Liver Transplantation Sun Yet-Sen Memorial HospitalSun Yat-Sen UniversityNo.107 Yanjiang West RoadGuangzhou 510080China Clinical Center for Investigation Renji HospitalShanghai Jiaotong University School of MedicineShanghaiChina Department of Anesthesiology Renji HospitalShanghai Jiaotong University School of MedicineShanghaiChina

Background Liver transplantation is the main treatment for cholestatic liver disease and some metabolic liver diseases in ***,no accurate prediction model to determine the survival probability of grafts prior to surgery *** study aimed to develop an effective prognostic model for allograft survival after pediatric liver *** This retrospective cohort study included 2032 patients who underwent pediatric liver transplantation between January 1,2006,and January 1,2020.A nomogram was developed using Cox regression and validated based on bootstrap *** and discriminatory accuracies were determined using the concordance index and visualized using calibration curves;net benefits were calculated for model *** online Shiny application was developed for easy access to the *** Multivariable analysis demonstrated that preoperative diagnosis,recipient age,body weight,graft type,preoperative total bilirubin,interleukin-1β,portal venous blood flow direction,spleen thickness,and the presence of heart disease and cholangitis were independent factors for survival,all of which were selected in the *** of the nomogram indicated that the 1-,3-,and 5-year predicted survival rates agreed with the actual survival *** concordance indices for graft survival at 1,3,and 5 years were 0.776,0.757,and 0.753,respectively,which were significantly higher than those of the Pediatric End-Stage Liver Disease and Child-Pugh scoring *** allograft dysfunction risk of a recipient could be easily predicted using the following URL:https://***/ASPELT/l Conclusion The allograft survival after pediatric liver transplantation(ASPELT)score model can effectively predict the graft survival rate after liver transplantation in children,providing a simple and convenient evaluation method for clinicians and patients.

关键词： Allograft survival Nomogram Pediatric liver transplantation