Design and synthesis of novel 1,3-diene bridged chiral atropoisomeric diphosphine ligands for asymmetric hydrogenation ofα-dehydro amino ketones

作     者：Xuefeng Tan Shuang Gao Chunyan Yang Qiwei Lang Xiaobing Ding Gen-Qiang Chen Xumu Zhang 

作者机构：Laboratory of Small Molecule Drug Discovery and SynthesisDepartment of ChemistrySouthern University of Science and TechnologyShenzhen 518055China Academy for Advanced Interdisciplinary StudiesSouthern University of Science and TechnologyShenzhen 518000China Department of ChemistryCity University of Hong KongHong Kong 999077China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2023年第66卷第10期

页      面：2847-2851页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 

基　　金：the National Key R&D Program of China(2021YFA1500201) the Stable Support Plan Program of Shenzhen Natural Science Fund(20200925161222002) the Key-Area Research and Development Program of Guangdong Province(2020B010188001) the Innovative Team of Universities in Guangdong Province(2020KCXTD016) the National Natural Science Foundation of China(21991113) the Guangdong Basic and Applied Basic Research Foundation(2022B1515020055) the National Natural Science Foundation of China(22171129) Shenzhen Science and Technology Innovation Committee(JCYJ20210324104202007)for financial support 

主　　题：diphosphine asymmetric hydrogenation chiral ligand 

摘      要：A series of novel atropisomeric diphosphine ligands termed Tan Phos were designed and synthesized,which has a smaller bite angle compared with that of other ligands such as *** Phos showed high reactivity and enantioselectivity in the rhodiumcatalyzed asymmetric hydrogenation ofα-dehydro amino ketones,and up 99%yield and 99%ee were obtained for a wide range of chiralα-amino ketones.