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Infectious Disease Modelling 2022年第3期7卷 526-534页

作者： Nobuaki Matsunaga Keisuke Kamata Yusuke Asai Shinya Tsuzuki Yasuaki Sakamoto Shinpei Ijichi Takayuki Akiyama a Jiefu Yu gen yamada Mari Terada Setsuko Suzuki Kumiko Suzuki Sho Saito Kayoko Hayakawa Norio Ohmagari AMR Clinical Reference Center National Center for Global Health and MedicineTokyoJapan DataRobot Inc. TokyoJapan Disease Control and Prevention Center National Center for Global Health and MedicineTokyoJapan Biostatistics Division Center for Research Administration and SupportNational Cancer CenterTokyoJapan

With the rapid increase in the number of COVID-19 patients in Japan,the number of patients receiving oxygen at home has also increased rapidly,and some of these patients have *** efficient approach to identify high-risk patients with slowly progressing and rapidly worsening COVID-19,and to avoid missing the timing of therapeutic intervention will improve patient prognosis and prevent medical *** admitted to medical institutions in Japan from November 14,2020 to April 11,2021 and registered in the COVID-19 Registry Japan were *** factors for patients with High Flow Nasal Cannula invasive respiratory management or higher were comprehensively explored using machine ***-specific cohorts were created,and severity prediction was performed for the patient surge *** were able to obtain a model that was able to predict severe disease with a sensitivity of 57%when the specificity was set at 90%for those aged 40e59 years,and with a specificity of 50%and 43%when the sensitivity was set at 90%for those aged 60e79 years and 80 years and older,*** were able to identify lactate dehydrogenase level(LDH)as an important factor in predicting the severity of illness in all age *** machine learning,we were able to identify risk factors with high accuracy,and predict the severity of the *** plan to develop a tool that will be useful in determining the indications for hospitalisation for patients undergoing home care and early hospitalisation.

关键词： COVID-19 Machine learning Severity Risk prediction Japan

Exploring the novel role of oligodendrocyte precursor cells in phagocytosis:beyond myelinogenesis

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Neural Regeneration Research 2025年第2期20卷 473-474页

作者： gen Hamanaka Ken Arai Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General Hospital and Harvard Medical SchoolCharlestownMAUSA

Roles of oligodendrocyte precursor cells in the central nervous system:Oligodendrocyte precursor cells(OPCs)have long been recognized for their critical role as precursors to oligodendrocytes,the primary myelin-producing *** precursors,OPCs mature and differentiate into oligodendrocytes,which contribute significantly to the formation of myelin sheaths around *** myelination,which is critical for the conduction of salutatory nerve impulses in the cerebral white matter,underscores the classical role of oligodendrocytes in central nervous system(CNS)***,because oligodendrocytes are differentiated cells that cannot proliferate.

关键词： critical system conduction

小鼠雌性生殖系统电穿孔与微泡增强超声波转EGFP基因的研究(简报)

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分子细胞生物学报 2006年第4期39卷 378-382页

作者：雷蕾刘忠华太田将山田源哈尔滨医科大学组织学与胚胎学教研室哈尔滨150081 东北农业大学生命科学学院哈尔滨150030 熊本大学生命资源研究支援中心日本熊本8600811

In the present study,the efficiency of in vivo transduction of EGFP plasmid DNA into adult female mouse reproductive system by means of electroporation and microbubble-enhanced sonoporation are discussed. In the first experiment,EGFP plasmid DNA was injected into the ovary and following electroporation (square electric pulses were applied five times at 60V with a constant time of 20ms). Green fluorescence was detected 10h after transduction. In the second experiment, plasmid DNA was mixed with the microbubble at different ratio and injected into the uterus and the ovary separately. The tissues were exposed to different combined ultrasound parameters immediately after injection. We found that the suitable parameter was 2 w/cm2 intensity,20% duty cycle and 5min. Under this condition, green fluorescence was expressed in the uterus endometrium and ovarian cortex 12 h post-sonoporation and the expression lasted up to 5 days.

关键词：电穿孔超声波穿孔绿色荧光蛋白转导

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人教版初中化学新教材语境变化分析与启示

教学与管理 2025年第1期 53-57页

作者：杨加根江苏省东台市安丰镇中学江苏东台224221

2024年人教版义务教育化学教材在继承传统教材的基础上有所发展和创新。从新教材的“本土化语境”“思辨性语境”“人民性语境”三个方面进行梳理,发现新教材的“本土化语境”进一步强化,“思辨性语境”负消正长,“人民性语境”更加理... 详细信息

2024年人教版义务教育化学教材在继承传统教材的基础上有所发展和创新。从新教材的“本土化语境”“思辨性语境”“人民性语境”三个方面进行梳理,发现新教材的“本土化语境”进一步强化,“思辨性语境”负消正长,“人民性语境”更加理性科学,继而针对语境调整变化探讨对今后教学的启示,为一线教师化学教学实践提供参考。

关键词：人教版初中化学新教材语境分析

Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue Lin gen Wei Jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

Contact theory and algorithm

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Science China(Technological Sciences) 2021年第8期64卷 1775-1790页

作者： SHI gen-Hua University of Chinese Academy of Sciences Beijing100049China DDA-NMM Company Beijing100026China School of Qilu Transportation Shandong UniversityJinan250100China

In discontinuous computations,contacts between two general blocks A and B are common and represent a fundamental *** paper presents a mathematically proven theory and algorithm to address this *** the proposed approach,a reference point a0 is selected from block A,and the contacts between blocks A and B are transferred to the contact of the reference point a0 and the entrance block E(A,B).Discontinuity related computations DEM,DDA,and FEM can use this mathematically proven theory and algorithm directly.

关键词： contact discontinuity entrance block computational geometry

人参皂苷 Rg3激活线粒体功能改善慢性疼痛的机制

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中国药理学通报 2025年第1期41卷 94-100页

作者：张培根朱海丽高卉湖北科技学院医学部药学院湖北咸宁437100

目的探究人参皂苷Rg3在慢性神经性疼痛中的作用及机制。方法筛选并分析慢性神经性疼痛数据中前额叶皮层内差异性表达基因;小鼠随机分为假手术组、模型组及给药组;采用坐骨神经慢性压迫损伤模型构建神经病理性疼痛动物模型,腹腔注射人参... 详细信息

目的探究人参皂苷Rg3在慢性神经性疼痛中的作用及机制。方法筛选并分析慢性神经性疼痛数据中前额叶皮层内差异性表达基因;小鼠随机分为假手术组、模型组及给药组;采用坐骨神经慢性压迫损伤模型构建神经病理性疼痛动物模型,腹腔注射人参皂苷Rg3给药;记录小鼠痛觉行为变化;HE染色、尼氏染色、免疫印迹及免疫组化检测各组PFC脑组织神经和线粒体损伤情况;分子对接探究人参皂苷Rg3的作用靶点;Mito-Tracker检测线粒体膜电位;ATP试剂盒分析ATP含量。结果与假手术组相比,模型组小鼠表现为痛觉过敏和运动能力受损;PFC内神经及线粒体损伤(P<0.05)。与模型组相比,人参皂苷Rg3给药可增加小鼠机械痛阈值、热缩足潜伏期和转棒停留时间;同时降低PFC内炎性细胞、尼氏小体及Dnm1l阳性细胞数,下调c-Fos、IL-1β和Dnm1l蛋白表达水平(P<0.05)。分子对接显示人参皂苷Rg3可结合Dnm1l。在细胞水平,人参皂苷Rg3给药可升高线粒体膜电位和ATP含量(P<0.05)。结论人参皂苷Rg3可通过调控降低PFC内炎症因子和线粒相关蛋白表达,改善线粒体功能,缓解CCI小鼠痛觉过敏。

关键词：人参皂苷Rg3 慢性神经性疼痛线粒体前额叶皮层 CCI PFC

High-temperature failure mechanism and defect sensitivity of TC17 titanium alloy in high cycle fatigue

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Journal of Materials Science & Technology 2022年第27期122卷 128-140页

作者： gen Li Chengqi Sun State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of Sciences School of Engineering Science University of Chinese Academy of Sciences

Crack initiation is an essential stage of fatigue process due to its direct effect on fatigue ***,for titanium alloys in high-temperature high cycle fatigue(HCF),the crack initiation mechanisms remain unclear and the understanding for the defect sensitivity is also *** this study,a series of fatigue tests and multi-scale microstructure characterizations were conducted to explore the high-temperature failure mechanism,and the coupled effect of temperature and defect on TC17 titanium alloy in *** was found that an oxygen-rich layer(ORL)was produced at specimen surface at elevated temperatures,and brittle fracture of ORL at surface played a critical role for surface crack initiation in ***,internal crack initiation with nanograins at high temperatures was a novel finding for the titanium *** on energy dispersive spectroscopy,electron backscatter diffraction and transmission electron microscope characterizations,the competition between surface and internal crack initiations at high temperatures was related to ORL at surface and dislocation resistance in inner *** fatigue strengths of smooth specimens decreased at elevated temperatures due to the lower dislocation *** the fatigue strengths of the specimens with defect were not very sensitive to the ***,a fatigue strength model considering the coupled effect of temperature and defect was proposed for TC17titanium alloy.

关键词： TC17 titanium alloy High temperature Defect High cycle fatigue Oxygen-rich layer Rough area

Monge–Ampère Type Equations on Almost Hermitian Manifolds

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Acta Mathematica Sinica,English Series 2023年第5期39卷 749-772页

作者： Jiao gen ZHANG School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026P.R.China

In this paper we consider the Monge–Ampère type equations on compact almost Hermitian *** derive C∞a priori estimates under the existence of an admissible ***,we obtain an existence result if there exists an admiss... 详细信息

关键词： Monge-Ampere type equations almost Hermitian manifold a priori estimates subsolution