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Colonoscopy in rats:An endoscopic,histological and tomographic study

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World Journal of Gastrointestinal Endoscopy 2013年第5期5卷 226-230页

作者： Ramon Bartolí Jaume Boix gemma ódena Napoleón D De la Ossa Vicente Moreno de Vega Vicente Lorenzo-Zúiga Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBEREHD) 08916 BadalonaSpain Endoscopy Unit Department of GastroenterologyHospital Universitari Germans Trias i Pujol08916 BadalonaSpain Department of Pathology Hospital Universitari Germans Trias i Pujol08916 BadalonaSpain Endoscopy Unit Department of GastroenterologyHospital Universitari Germans Trias i PujolCarretera del Canyet s/n08916 BadalonaSpain

AIM:To describe colon anatomy with colonoscopy and computed tomography(CT) to develop a rat model for future studies of therapeutic ***:Eighteen male Sprague-Dawley rats,on average 400-420 g,underwent total colonoscopy,CT and histological *** was performed after bowel preparation with a baby upper gastrointestinal endoscopy with an outer diameter of 6.7 *** obtained a 3D image of total colon after a rectal enema with radiological *** and microscopic examinations were examined with a conventional technique(hematoxylin and eosin).Colonic wall thickness,length and diameter measurements were taken from the anus,3,7,14 and 20 cm from the anal ***:The median colonoscope depth was 24 cm(range 20-28 cm).Endoscopic and tomographic study of colon morphology showed an easy access with tubular morphology in the entire left colon(proximal left colon and rectum).Transverse colon was unapparent on *** colon,proximal to the splenic flexure,was the largest part of the colon and assumed saccular morphology with tangential *** measurements of the colonic length and diameter substantiate a subdivision of the right colon into two parts,the cecum and distal right *** addition,histological measurement of the colonic wall thickness confirmed a progressive decrease from rectum to *** muscular layer was thinner in the proximal left ***:The combination of colonoscopy,tomography and histology leads to a better characterization of the entire *** data are important for deciding when to perform endoscopic resections or when to induce perforations to apply endoscopic treatments.

关键词： Rat Colonoscopy Tomography Colon anatomy Histological measurements

Risk Factors for Postoperative Acute Exacerbation of Idiopathic Interstitial Pneumonia Following Surgery for Primary Lung Cancer

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Open Journal of Respiratory Diseases 2014年第2期4卷 48-54页

作者： Toru Tanaka Shinji Abe Hiroki Hayashi Koichiro Kamio Yoshinobu Saito Jiro Usuki Arata Azuma Iwao Mikami Shuji Haraguchi Kiyoshi Koizumi Jitsuo Usuda Akihiko gemma Department of Pulmonary Medicine and Oncology Nippon Medical School Tokyo Japan Department of Thoracic Surgery Graduate School of Medicine Nippon Medical School Tokyo Japan

Objective: Postoperative acute exacerbation of idiopathic interstitial pneumonia (IIP) is a serious complication in patients with lung cancer. This study was aimed to investigate risk factors for postoperative acute exacerbation of IIP in surgery for primary lung cancer. Method: We evaluated retrospectively 37 IIP patients combined with primary lung cancer who underwent lung resection for lung cancer from January 2006 and March 2010. Preoperative and perioperative clinical data were collected and analyzed. Results: Ten of 37 patients (27.0%) developed acute exacerbation of IIP after surgery for primary lung cancer and five patients (13.5%) died of progressive respiratory failure. There was no significant difference in preoperative clinical factors between acute exacerbation (AE) group and non-acute exacerbation (non-AE) group. In perioperative factors, the duration of anesthesia is significantly longer in AE group than in non-AE group. Conclusion: These data suggest that it is unable to predict postoperative acute exacerbation of IIP from preoperative clinical data. Perioperative and postoperative management might be important to prevent acute exacerbation of IIP combined lung cancer.

关键词： Postoperative Acute Exacerbation Idiopathic Interstitial Pneumonia Lung Cancer

D-Aspartate, a Key Element for the Improvement of Sperm Quality

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Advances in Sexual Medicine 2012年第4期2卷 45-53页

作者： gemma D’Aniello Salvatore Ronsini Tiziana Notari Natascia Grieco Vincenzo Infante Nicola D’Angel Fara Mascia Maria Maddalena Di Fiore George Fisher Antimo D’Aniello Department of Clinical Chemistry Diagnostic Center “Fleming Laboratory” Brescia Italy Department of Human Clinical Chemistry of Poly-Diagnostic Center “Igea Sant’Antimo” Via degli Oleandri Sant’Antimo (NA) Italy Department of Life Science University of Naples Federico II Naples Italy Department of Obstetrics Gynaecology and Physiology of Human Reproductive (IVF Unit) Hospital “<i.S. Luca” Vallo della Lucania (SA) Italy Department of Physical Sciences Barry University Miami Schores USA

Introduction: D-Aspartate is an endogenous amino acid involved in LH and testosterone release in humans. In this study we investigate the impact of nutritional supplementation of sodium D-aspartate on the improvement of sperm quality in sub-fertile patients and the rate of pregnancies that occurred with their partners. Materials and Methods: A group of 30 patients affected by oligo-asthenozoospermia and a group of 30 patients affected by asthenozoospermia were treated with a daily dose of sodium D-aspartate for 90 days. After which, the change in spermatozoa concentration and their motility and the pregnancies that occurred with their partners were recorded. Results: We found that the supplementation of D-aspartate significantly increased the concentration and the motility of spermatozoa. In oligo- asthenozoospermic patients the increase of sperm concentration was found to be 2.0-fold, P Conclusions:Treatment of sub-fertile patients with sodium D-aspartate improved the number and the motility of the spermatozoa and consequently improved the rate of pregnancies of their partners.

关键词： D-Aspartate Oligo-Asthenozoospermia Asthenozoospermia Pregnancies

Analysis of Aroma Volatile Profile of Philippine Durian Pulp （Durio zibethinus Rumph, ex Murray） Using HS-SPME Coupled with GC-MS

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Journal of Food Science and Engineering 2014年第3期4卷 155-159页

作者： Princess Tiffany G. Dantes John S. Maninang Arnold R. Elepano Hiroshi gemma Sumiko Sugaya Engelbert K. Peralta Linda B. Mabesa Institute of Agricultural Engineering College of Engineering and Agro-lndustrial Technology University of the Philippines Los Banos Laguna 4031 Philippines International Agro-Biological Resources Tokyo University of Agriculture and Technology Tokyo 183-8509 Japan Graduate School of Life and Environmental Sciences University of Tsukuba Tsukuba 305-8577 Japan Food Science Cluster College of Agriculture University of the Philippines Los Bahos Laguna 4031 Philippines

Durian （Durio zibethinus Rumph. ex Murray） is an exotic tropical fruit known for its excellent flavor and strong distinctive aroma. Volatiles of durian pulp from different cultivars in Thailand, Malaysia and Indonesia were already reported. However, no study of volatiles from Philippine ＂Puyat＂ durian is available. ＂Puyat＂ is the most preferred by consumers in the Philippines due to its firm flesh with sweet and buttery taste. Aroma volatile compounds were analyzed by headspace solid phase microextraction （HS-SPME） method and gas chromatography-mass spectrometry （GC-MS）. Volatiles were extracted for 1 h using 65 μm PDM/DVB SPME fiber and separated by DB-WAX capillary column （30 m × 0.25 mm id × 0.25 μm film thickness）. Durian pulp produced 22 volatiles composed of 15 esters, six sulfurs and one thioacetal. Ethyl propanoate, ethyl octanoate, propyl propanoate, ethyl 2-methyl butanoate and diethyl disulfide were the major compounds identified. These compounds were also reported to be the most abundant in durian cultivars of other countries. Results of this study can then be used for future development of postharvest technologies to control the production of volatiles from Philippine durian pulp.

关键词： Durian SPME GC-MS volatile compounds.

Testing Multisensory Stimuli to Drive Thermal Comfort and Space Perception using VR/AR:A Design Strategy to Achieve Energy Saving

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Journal of Architectural Research and Development 2020年第1期4卷 1-11页

作者： Lavinia Chiara Tagliabue Giulia Wally Scurati gemma Massetti Roberta Etzi Siyuan Huang Francesco Ferrise Alberto Gallace Serena Graziosi Marina Carulli Monica Bordegoni Angelo Luigi Camillo Ciribini Department of Civil EnvironmentalArchitectural Engineering and MathematicsUniversity of BresciaItaly Department of Mechanical Engineering Politecnico di MilanoItaly School of Medicine and Surgery UniversitàMilano-BicoccaItaly Department of Design Politecnico di MilanoItaly Mind and Behavior Technological Center Department of PsychologyUniversitàMilano-BicoccaItaly

Energy consumption of the EU has a crucial environmental impact;several efforts are nowadays thus directed into massively reducing energy consumption by envelope improvement,system efficiency and smart *** the other hand,the indoor thermal and lighting conditions significantly influence users’wellbeing and productivity,which is especially important when dealing with educational and working *** to enhance system efficiency are focused on design and construction *** strategies ease to promote a powerful approach which is needed when focusing on existing buildings in need of retrofit *** dealing with new or refurbished buildings,energy saving has a further step to *** the last years,research trends moved towards an increasing inclusion of human factors in energy *** allows to account for the occupancy variability in the energy analyses,considering how to bridge the performance gap between predictive models and actual consumptions due to indoor thermal *** empty buildings energy consumption is huge and economic efforts are wasted,due to unconscious energy-wasting *** studies with Interactive Virtual Environments confirmed that indoor environments illuminated by different color lights lead to the perception of different levels of thermal *** results of the present paper replicate previous evidence collected in real conditions,suggesting that Virtual Reality is a valid and reliable tool to assess thermal comfort more quickly and *** paper provides a further perspective on this topic,including also the use of different fragrances to understand how the indoor environment could be enhanced and manipulated to increase wellbeing,thermal perception and finally energy saving.

关键词： Energy saving Virtual reality Multisensory stimulation

发展于西方的纠正“以瘦为美”的认知疗法是否有助于减缓非西方国家进食障碍患病率的增长?(英文)

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上海精神医学 2013年第6期25卷 332-341页

作者： gemma L. WITCOMB Jon ARCELUS 陈珏 Loughborough University Centre for Research into Eating Disorders School of Sport Exercise and Health SciencesLoughborough UniversityLoughborough Leicestershire UK Leicester Eating Disorder Service Bennion Centre Leicester Glenfield HospitalLeicester UK 上海交通大学医学院附属精神卫生中心

进食障碍,这种威胁生命的疾病在西方国家很常见,直到最近,进食障碍还被认为在非西方文化地区是罕见的。然而,进食障碍的患病率在很多相对富裕的非西方国家中迅速增长,因为这些地区的民众,特别是年轻的女性,在国际媒体的影响下,把"以瘦为... 详细信息

进食障碍,这种威胁生命的疾病在西方国家很常见,直到最近,进食障碍还被认为在非西方文化地区是罕见的。然而,进食障碍的患病率在很多相对富裕的非西方国家中迅速增长,因为这些地区的民众,特别是年轻的女性,在国际媒体的影响下,把"以瘦为美"这个已经被广泛传播的概念内在化了。这篇综述讨论了非西方地区中影响进食障碍发生的因素,特别关注了城市化、现代化、西方化和女性角色转变的影响。本文还介绍了在西方国家发展起来的、已经被证明可以成功消除"以瘦为美"的负面影响的认知失调纠正项目,并讨论了其在东亚和其它非西方国家中的应用价值。

关键词：西方文化失调进食理想西部开发西方国家媒体宣传

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囊性纤维化的诊断和治疗:NICE指南摘要

英国医学杂志中文版 2022年第7期25卷 406-411页

作者： gemma Villanueva gemma Marceniuk M Stephen Murphy Martin Walshaw Rami Cosulich 齐进春(译) 董强(校) National Guideline Alliance Royal College of Obstetricians and GynaecologistsLondon Regional Cystic Fibrosis Clinic Liverpool Heart and Chest HospitalUniversity of LiverpoolUK 河北医科大学第二医院泌尿外科四川大学华西医院泌尿外科

囊性纤维化是一种影响寿命的常染色体隐性遗传疾病,在英国出生的婴儿中,该病的发病率为1/2500。囊性纤维化是一种多系统疾病,它的发病原因为细胞膜表面的囊性纤维化跨膜传导调节蛋白突变,进而影响体内所有产生黏液的器官,包括肺、胰腺... 详细信息

囊性纤维化是一种影响寿命的常染色体隐性遗传疾病,在英国出生的婴儿中,该病的发病率为1/2500。囊性纤维化是一种多系统疾病,它的发病原因为细胞膜表面的囊性纤维化跨膜传导调节蛋白突变,进而影响体内所有产生黏液的器官,包括肺、胰腺、肝和肠。在英国,该病通常通过新生儿筛查即可做出诊断,确诊的平均年龄为2月龄,也有一些患者在更大年龄甚至在成年后才被发现1。

关键词：囊性纤维化新生儿筛查多系统疾病常染色体隐性遗传疾病发病原因

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尿皮素肽在犬心肌及血浆的表达

中国畜牧兽医 2011年第6期38卷 185-185页

作者： gemma Fraga Veloso 于琳琳

尿皮素(Ucn)肽是促肾上腺皮质激素释放因子2型受体(CRFR2)的内源性配体,在健康和患病犬的心血管生理机能中都有潜在的重要作用,并显示对充血性心力衰竭有治疗的作用。犬心脏组织的分析结果表明,Ucn 1、Ucn 3和CRFR2 mRNA均能在心室中表... 详细信息

尿皮素(Ucn)肽是促肾上腺皮质激素释放因子2型受体(CRFR2)的内源性配体,在健康和患病犬的心血管生理机能中都有潜在的重要作用,并显示对充血性心力衰竭有治疗的作用。犬心脏组织的分析结果表明,Ucn 1、Ucn 3和CRFR2 mRNA均能在心室中表达。免疫组织化学试验结果显示,Ucns 1和3在心肌细胞表达。为了评估Ucns能否作为心脏疾病标志物,对45个来自犬心脏病犬的血浆样品和15个对照样品用放射免疫分析,所有样品中均检测到Ucns 1和3,但心脏病并没有使其浓度发生改变。因此,虽然Ucns在犬心肌(Ucns可能在此对心脏病和心力衰竭的内源性神经体液反应中起重要作用)中表达,但其并不能成为犬心脏疾病的敏感标志物。

关键词：尿皮素犬促肾上腺皮质激素释放因子受体心脏心脏病

Clinical applications of high-throughput genetic diagnosis in inherited retinal dystrophies: Present challenges and future directions

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World Journal of Medical Genetics 2015年第2期5卷 14-22页

作者： gemma Marfany Roser gonzàlez-Duarte Departament de Genètica Facultat de Biologia Universitat de Barcelona CIBER Instituto de Salud Carlos Ⅲ IBUB Institut de Biomedicina de la Universitat de Barcelona

The advent of next generation sequencing(NGS) tech-niques has greatly simplified the molecular diagnosis and gene identification in very rare and highly heterogeneous Mendelian disorders. Over the last two years, these approaches, especially whole exome sequencing(WES), alone or combined with homozygosity mapping and linkage analysis, have proved to be successful in the identification of more than 25 new causative retinal dystrophy genes. NGS-approaches have also identified a wealth of new mutations in previously reported genes and have provided more comprehensive information concerning the landscape of genotype-phenotype correlations and the genetic complexity/diversity of human control populations. Although whole genome sequencing is far more informative than WES, the functional meaning of the genetic variants identified by the latter can be more easily interpreted, and final diagnosis of inherited retinal dystrophies is extremely successful, reaching 80%, particularly for recessive cases. Even considering the present limitations of WES, the reductions in costs and time, the continual technical improvements, the implementation of refined bioinformatic tools and the unbiased comprehensive genetic information it provides, make WES a very promising diagnostic tool for routine clinical and genetic diagnosis in the future.

关键词： Next generation sequencing Identification of novel causative genes Inherited retinal dystrophies Genetic diagnosis Whole exome sequencing