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Cardiac rehabilitation and mid-term follow-up after transcatheter aortic valve implantation

Journal of Geriatric Cardiology 2014年第4期11卷 279-285页

作者： Renzo Zanettini gemma gatto Ileana Mori Maria Beatrice Pozzoni Stefano Pelenghi Luigi Martinelli Silvio Klugmann Cardiac Rehabilitation Centre Istituti Clinici di Perfezionamento Hospital via Bignami 1 20126 Milan Italy De Gasperis Cardiology and Cardiac Surgery Department Niguarda Ca' Granda Hospital Piazza Ospedale Maggiore 3 20162 Milan Italy

Background Evaluation of patient outcomes following transcatheter aortic valve implantation （TAVI） has usually been based on survival and clinical improvement. Studies on quality of life are limited, and data from comprehensive assessments after the procedure are lacking. Methods Sixty patients referred for cardiac rehabilitation after TAVI underwent in-hospital and after-discharge multidimensional assessments to evaluate clinical, functional, and nutritional statuses, degree of autonomy, cognitive impairment, depression and quality of life. Results On admission to rehabilitation, approximately half of the patients had severe functional impairment and dependence for basic activities of daily living. During their hospital stay, one-third of the patients suffered significant clinical complications and two had to be transferred to the implantation center. Despite this, the overall outcome was very good. All of the remaining patients were clinically stable at discharge and functional status, autonomy and quality of life were improved in most. During a mean follow-up of 540 days （range： 192-738 days）, five patients died from noncardiac causes, three were hospitalized for cardiac events, and nine for non cardiac reasons. Functional status and autonomy remained satisfactory in the majority of patients and most continued to live independently. Conclusions Patients referred for rehabilitation after TAVI are often very frail, with a high grade of functional impairment, dependence on others and high risk of clinical complications. During a rehabilitation programme, based on a multidimensional assessment and intervention, most patients showed significant improvement in functional status, quality of life, and autonomy, which remained stable in the majority of subjects during mid-term follow-up.

关键词： Cardiac rehabilitation Comprehensive assessment Follow-up Transcatheter aortic valve implantation

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Adapt or perish:SARS-CoV-2 antibody escape variants defined by deletions in the Spike N-terminal Domain

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1416-1417页

作者： Marta Ribes Carlos Chaccour gemma Moncunill ISGlobal Hospital Clínic-Universitat de BarcelonaBarcelonaSpain Ifakara Health Institute IfakaraUnited Republic of Tanzania Facultad de Medicina Universidad de NavarraPamplonaSpain

In a recent report in Science,McCarthy et *** observed a pattern of recurrent deletions in four discrete regions of the N-terminal Domain(NTD)of the Spike protein,which provide resistance to antibody neutralization,su... 详细信息

关键词： al. prompt Domain

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Occupational exposures and colorectal cancers:A quantitative overview of epidemiological evidence

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World Journal of Gastroenterology 2014年第35期20卷 12431-12444页

作者： Enrico Oddone Carlo Modonesi gemma Gatta Department of Public Health Experimental and Forensic MedicineOccupational Medicine UnitUniversity of Pavia Department of Biosciences Natural History MuseumUniversity of Parma Department of Preventive and Predictive Medicine Evaluative Epidemiology UnitFondazione IRCCS Istituto Nazionale dei Tumori

A traditional belief widespread across the biomedical community was that dietary habits and genetic predisposition were the basic factors causing colorectal *** more recent times,however,a growing evidence has shown that other determinants can be very important in increasing(or reducing) incidence of this *** hypothesis that environmental and occupational risk factors are associated with colorectal cancer is gaining ground,and high risks of colorectal cancer have been reported among workers in some industrial *** aim of this study was to investigate the epidemiologic relationship between colorectal cancer and occupational exposures to several industrial activities,by means of a scientific literature review and *** work pointed out increased risks of colorectal cancer for labourers occupied in industries with a wide use of chemical compounds,such as leather(RR = 1.70,95%CI:1.24-2.34),basic metals(RR = 1.32,95%CI:1.07-1.65),plastic and rubber manufacturing(RR = 1.30,95%CI:0.98-1.71 and RR = 1.27,95%CI:0.92-1.76,respectively),besides workers in the sector of repair and installation of machinery exposed to asbestos(RR = 1.40,95%CI:1.07-1.84).Based on our results,the estimated crude excess risk fraction attributable to occupational exposure ranged from about 11% to about 15%.However,homogeneous pattern of association between colorectal cancer and industrial branches did not emerge from this review.

关键词： Colorectal cancer Occupational exposures Public health Chemical compounds Basic metals Meta analysis

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Blood-brain barrier pathology in cerebral small vessel disease

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Neural Regeneration Research 2024年第6期19卷 1233-1240页

作者： Ruxue Jia gemma Solé-Guardia Amanda J.Kiliaan Department of Medical Imaging AnatomyRadboud University Medical CenterDonders Institute for BrainCognition&BehaviorCenter for Medical NeurosciencePreclinical Imaging Center PRIMERadboud Alzheimer CenterNijmegenthe Netherlands

Cerebral small vessel disease is a neurological disease that affects the brain microvasculature and which is commonly observed among the *** at first it was considered innocuous,small vessel disease is nowadays regarded as one of the major vascular causes of *** signs of small vessel disease include small subcortical infarcts,white matter magnetic resonance imaging hyperintensities,lacunes,enlarged perivascular spaces,cerebral microbleeds,and brain atrophy;however,great heterogeneity in clinical symptoms is observed in small vessel disease *** pathophysiology of these lesions has been linked to multiple processes,such as hypoperfusion,defective cerebrovascular reactivity,and blood-brain barrier ***,studies on small vessel disease suggest that blood-brain barrier dysfunction is among the earliest mechanisms in small vessel disease and might contribute to the development of the hallmarks of small vessel ***,the purpose of this review is to provide a new foundation in the study of small vessel disease ***,we discuss the main structural domains and functions of the blood-brain ***,we review the most recent evidence on blood-brain barrier dysfunction linked to small vessel ***,we conclude with a discussion on future perspectives and propose potential treatment targets and interventions.

关键词： blood-brain barrier dysfunction cerebral blood flow cerebral hypoperfusion endothelial dysfunction hypertension inflammation magnetic resonance imaging neurovascular unit oxidative stress small vessel disease tight junctions transcytosis

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2020 tropical cyclones in the Philippines: A review

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Tropical Cyclone Research and Review 2021年第3期10卷 191-199页

作者： gemma Dela Cruz Santos College of Education Nueva Ecija University of Science and TechnologyPhilippines

The official website of the Philippine Atmospheric Geophysical and Astronomical Services Administration(PAG AS A)said more tropical cyclones(TCs)enter the Philippine Area of Responsibility(PAR)than anywhere else in the *** the average of 20 TCs per year,about eight(8)or nine(9)of them are crossing the *** peak of the typhoon season is July through October,when nearly 70%of all typhoons develop(http://***/climate/tropical-cyclone-information).Based on the report of the Asian Disaster Reduction Center(ADRC),five of the typhoons that visit the country are destructive and being situated in the"Pacific Ring of Fire"makes the country vulnerable to frequent earthquakes and volcanic *** geographical location and physical environment also contribute to its high susceptibility to tsunami,sea-level rise,storm surges,landslides,flash/flood/flooding,and drought(https://***/***?NationCode=608&Lang=en).For the past years,some typhoons that visited the country brought serious damages and kill many Filipinos by floods and *** researcher comes up with the idea of assessing the aftermath of 2020 typhoons that visited the *** data used by the researcher were collected from different sources,namely NDRRMC(National Disaster Risk Reduction and Management Council),PAGASA,social media and other *** result of the study reveals that the most destructive typhoon in 2020 that caused huge damage on the infrastructure and agriculture is Ulysses followed by Rolly,Quinta,Ambo,Vicky,Pepito,Ofel,and *** of the affected areas are those nearer to water bodies,surrounded by mountains with few trees to absorb a huge amount of water and situated in the low-lying areas.

关键词： ADRC NDRRMC PAGASA TC Pacific ring of fire

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Discussion of some‘knowns’and some‘unknowns’about the tumour suppressor p53

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Journal of Molecular Cell Biology 2019年第3期11卷 212-223页

作者： Elizabeth Lieschke Zilu Wang gemma L Kelly Andreas Strasser The Walter and Eliza Hall Institute of Medical Research Melbourne 3052Australia Department of Medical Biology University of MelbourneMelbourne 3050Australia

Activation of the tumour suppressor p53 upon cellular stress can induce a number of different cellular processes?The diverse actions of these processes are critical for the protective function of p53 in preventing the development of ***,it is still not fully understood which process(es)activated by p53 is/are critical for tumour suppression and how this might differ depending on the type of cells undergoing neoplastic transformstion and the nature of the drivers of ***,it is not clear why upon activation of p53 some cells undergo cell cycle arrest and senescence whereas others die by *** we discuss some of the cellular processes that are crucial for p53-mediated tumour suppression and the factors that could impact cell fate upon p53 ***,we describe therapies aimed either at activating wild-type p53 or at changing the behaviour of mutant p53 to unleash tumour growth suppressive processes for therapeutic benefit in malignant disease.

关键词： p53 tumour suppression cell death cell cycle arrest/senescenee

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Oral health of adolescents in West Africa:prioritizing its social determinants

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Global Health Research and Policy 2023年第1期8卷 253-261页

作者： Deborah Oluwaseun Shomuyiwa gemma Bridge Faculty of Pharmacy University of LagosLagosNigeria School of Earth and Environment University of LeedsLeedsUK

Oral health is a major public health issue in West Africa,yet it has gotten little *** and group disparities in health status are influenced by social determinants of health(SDH),which also affect oral *** is a significant transition into adulthood,a time when the SDH can contribute to lifelong health *** article explored the SDH associated with oral health behaviour,perception,and oral health development amongst adolescents in West *** article engaged articles published in peer-reviewed journals relating to adolescents’oral health and West *** authors undertook this desk review to determine the social determinants of adolescents’oral health in West *** literacy levels and oral health awareness of adolescents,family and social circle influences,socioeconomic status,nutritional levels,and cultural and environmental factors have been identified as important social *** policy implementation with the integration of oral health in schools’curriculum,health systems reorientation with the adoption of oral health delivery in primary health care and expansion in oral health research with the assessment of cultural influences on oral health development have been recommended as interventions to reduce oral health inequalities in West Africa.

关键词： Social determinants of health Oral health Adolescents Dental caries Periodontitis West Africa

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Evaluation of xylanase and a fermentable xylo-oligosaccharide on performance and ileal digestibility of broiler chickens fed energy and amino acid deficient diets

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Animal Nutrition 2021年第2期7卷 488-495页

作者： gemma González-Ortiz Tiago T.dos Santos Michael R.Bedford AB Vista 3Woodstock CourtMarlborough Business ParkMarlboroughWiltshireSN84ANUK

The objective of this study was to evaluate the effect of a product consisting of a combination of xylanase and xylo-oligosaccharide(STBIO)on performance and ileal digestibility of broiler chickens fed energy and amino acid(AA)deficient ***-old male Ross 308 broiler chicks were randomly allocated to 8 pens per treatment,with 25 chicks per *** based on wheat-corn-soybean meal diets were arranged in a 3×2 factorial design:a positive control that met or exceeded nutrient recommendations(PC),a negative control diet with a 50 kcal/kg apparent metabolizable energy(AME)reduction(NC1)and NC1 with a 3%reduction in AA content(NC2),each with or without supplementation of 100 g/t of the *** weight gain(BWG),feed intake,feed conversion ratio corrected for mortality(FCR)and the European production efficiency factor(EPEF)were recorded from 0 to 42 *** d 42,ileal samples were collected to determine dry matter(DM),organic matter(OM),ash,protein and energy digestibility.A significant interaction was observed for BWG and feed intake(P<0.001).The energy and AA reduction reduced(P<0.05)BWG when compared to the *** effect of STBIO on BWG was greater in NC1(+451 g/bird)than in NC2(+314 g/bird)or PC(+176 g/bird)diets(P<0.05),and that in NC2 with STBIO was equal to that in PC without STBIO,and that in NC1 with STBIO was equal to that in PC with *** interactions were observed on the EPEF or FCR;however,STBIO improved EPEF(P<0.001)and FCR(P<0.001)irrespective of the energy reduction or AA *** intake of digestible DM,OM,ash and energy for the finisher period was increased with STBIO supplementation(P<0.01).A significant interaction was observed for the intake of digestible ***1 and NC2 reduced the intake of digestible protein;however,when STBIO was supplemented,it was improved in both diets to similar levels to the *** stimbiotic supplementation improved performance of broiler chickens fed all diets,particularly those deficient in AME and AA.

关键词： Xylanase Fermentable oligosaccharide Broiler Stimbiotic

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Genetic variants of innate immune receptors and infections after liver transplantation

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World Journal of Gastroenterology 2014年第32期20卷 11116-11130页

作者： gemma Sanclemente Asuncion Moreno Miquel Navasa Francisco Lozano Carlos Cervera Department of Infectious Diseases Hospital Clinic of BarcelonaIDIBAPS University of Barcelona Liver Transplant Unit Hospital Clinic of Barcelona IDIBAPS University of Barcelona Immunology Hospital Clinic of BarcelonaIDIBAPS University of Barcelona

Infection is the leading cause of complication after liver transplantation, causing morbidity and mortality in the first months after surgery. Allograft rejection is mediated through adaptive immunological responses, and thus immunosuppressive therapy is necessary after transplantation. In this setting, the presence of genetic variants of innate immunity receptors may increase the risk of post-transplant infection, in comparison with patients carrying wild-type alleles. Numerous studies have investigated the role of genetic variants of innate immune receptors and the risk of complication after liver transplantation, but their results are discordant. Tolllike receptors and mannose-binding lectin are arguably the most important studied molecules; however, many other receptors could increase the risk of infection after transplantation. In this article, we review the published studies analyzing the impact of genetic variants in the innate immune system on the development of infectious complications after liver transplantation.

关键词： Innate immunity Genetic variants Single nucleotide polymorphisms Liver transplantation Post-transplant infections Toll-like receptors Mannose-binding lectin

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Diagnostic value of sperm DNA fragmentation and sperm high-magnification for predicting outcome of assisted reproduction treatment

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Asian Journal of Andrology 2013年第6期15卷 790-794,I0008-I0009页

作者： gemma López Rafael Lafuente Miguel A Checa Ramón Carreras Mario Brassesco Centre de Infertilidad y Reproduccion Humana (ClRH) E-08017 Barcelona Spain Department of Obstetrics and Gynecology Hospital Universitari del Mar Universitat AutOnoma de Barcelona E-08003 Barcelona Spain

Over the last years, major improvements in the field of male infertility diagnosis have been achieved. The aim of this study was to determine the diagnostic usefulness of sperm DNA integrity and sperm vacuolisation for predicting outcome in infertile couples undergoing in vitroferti lisation （IVF） and intracytoplasmic sperm injection （ICSI） treatments. A cohort study from 152 infertile couples undergoing sperm DNA fragmentation and high-magnification tests prior to an assisted reproduction treatment was designed. We found that the most predictive cutoff for pregnancy was 25.5% of DNA fragmentation with a negative predictive value of 72.7% （P=0.02）. For the degree of vacuolisation, the best predictor of pregnancy was 73.5% of vacuolated sperm grades Ⅲ ＋ Ⅳ with a negative predictive value of 39.4% （P=0.09）, which was not statistically significant. In conclusion, sperm DNA fragmentation greater than 25.5% could be associated with higher probability of failure IVF treatment. Regarding the results of the sperm analysis at high magnification, they do not allow us to predict whether or not oatients will become pregnant.

关键词： DNA fragmentation high-magnification IVF vacuoles

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