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Influence of bath composition on the electrodeposition of cobalt-molybdenum amorphous alloy thin films

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Journal of University of Science and Technology Beijing 2008年第5期15卷 611-617页

作者： Qiaoying Zhou Hongliang ge Guoying wei Qiong wu College of Science China Jiliang University Hangzhou 310018 China

Cobalt-molybdenum （Co-Mo） amorphous alloy thin films were deposited on copper substrates by the electrochemical method at pH 4.0. Among the experimental electrodeposition parameters,only the concentration ratio of molybdate to cobalt ions （[MoO4^2-]/[Co^2＋]） was varied to analyze its influence on the mechanism of induced cobalt-molybdenum codeposition. Voltammetry was one of the main techniques,which was used to examine the voltammetric response,revealing that cobalt-molybdenum codeposition depended on the nature of the species in solution. To correlate the type of the film to the electrochemical response,various cobalt-molybdenum alloy thin films obtained from different [MoO4^2-]/[Co^2＋] solutions were tested. Crack-free homogeneous films could be easily obtained from the low molybdate concentrations （[MoO4^2-]/[Co^2＋]≈0.05） applying low deposition potentials. Moreover,the content of molybdenum up to 30wt% could be obtained from high molybdate concentration; in this case,the films showed cracks. The formation of these cracked films could be predicted from the observed distortions in the curves of electric current-time （j-t） deposition transients. The films with amorphous structure were obtained. The hysteresis loops suggested that the easily magnetized axis was parallel to the surface of the films. A saturation magnetization of 137 emu·g^-1 and a coercivity of 87 Oe of the film were obtained when the deposition potential was -1025mV,and [ MoO4^2-]/[Co^2＋] was 0.05 in solution,which exhibited a nicer soft-magnetic response.

关键词： Co-Mo alloy thin films amorphous electrodeposition soft magnetism

Cross-Project Software Defect Prediction Based on SMOTE and Deep Canonical Correlation Analysis

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Computers, Materials & Continua 2024年第2期78卷 1687-1711页

作者： Xin Fan Shuqing Zhang Kaisheng wu wei Zheng Yu ge School of Software Nanchang Hangkong UniversityNanchang330063China Software Testing and Evaluation Center Nanchang Hangkong UniversityNanchang330063China

Cross-Project Defect Prediction(CPDP)is a method that utilizes historical data from other source projects to train predictive models for defect prediction in the target ***,existing CPDP methods only consider linear correlations between features(indicators)of the source and target *** models are not capable of evaluating non-linear correlations between features when they exist,for example,when there are differences in data distributions between the source and target *** a result,the performance of such CPDP models is *** this paper,this paper proposes a novel CPDP method based on Synthetic Minority Oversampling Technique(SMOTE)and Deep Canonical Correlation Analysis(DCCA),referred to as *** Correlation Analysis(CCA)is employed to address the issue of non-linear correlations between features of the source and target projects.S-DCCA extends CCA by incorporating the MlpNet model for feature extraction from the *** redundant features are then eliminated by maximizing the correlated feature subset using the CCA loss ***,cross-project defect prediction is achieved through the application of the SMOTE data sampling *** Under Curve(AUC)and F1 scores(F1)are used as evaluation *** paper conducted experiments on 27 projects from four public datasets to validate the proposed *** results demonstrate that,on average,our method outperforms all baseline approaches by at least 1.2%in AUC and 5.5%in F1 *** indicates that the proposed method exhibits favorable performance characteristics.

关键词： Cross-project defect prediction deep canonical correlation analysis feature similarity

Tumor microenvironment-activatable neuropeptide-drug conjugates enhanced tumor penetration and inhibition via multiple delivery pathways and calcium deposition

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Chinese Chemical Letters 2024年第4期35卷 292-297页

作者： Yi Cao Xiaojiao ge Yuanyuan wei Lulu He Aiguo wu Juan Li Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China University of Chinese Academy of Sciences Beijing 100049China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China

Peptide-drug conjugates have achieved considerable development and application as a novel strategy for targeted delivery of anticancer drugs. Bioactive peptides induced calcium deposition can irreversibly assist inhibition of tumors. However, active regulation of calcium level through signal transduction of bioactive substances has not been reported yet. In this study, novel neuropeptide-doxorubicin conjugates(NP-DOX) with lysosome-specific acid response were described for neuropeptide Y_1 receptor(Y_1R)-overexpressed triple-negative breast cancer. The delivery mechanism of NP-DOX was clarified that diverse pathways were involved, including intracellular and intercellular transport. Importantly, up-regulation of Y_1 R-mediated intracellular calcium level via second messenger inositol triphosphate was presented in NP-DOX treated MDA-MB-231 cells. In vivo antitumor efficacy demonstrated that NP-DOX showed less organ toxicity and enhanced tumor inhibition benefited from its controlled release and Y_1R-mediated calcium deposition, compared with free DOX. This bioconjugate is a proof-of-concept confirming that neuropeptide-mediated control of signaling responses in neuropeptide-drug conjugates enables great potential for further applications in tumor chemotherapy.

关键词： Neuropeptide-drug conjugate Tumor penetration Calcium deposition Tumor inhibition Triple-negative breast cancer

Highly efficient through-space charge transfer TADF molecule employed in TADF-and TADF-sensitized organic light-emitting diodes

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Science China Chemistry 2024年第4期67卷 1270-1276页

作者： Jiasen Zhang Deli Li wei Li Yujie wu Xilin Mu Chunyu Liu Kaibo Fang Ziyi ge Zhejiang Provincial Engineering Research Center of Energy Optoelectronic Materials and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Luminescent Materials and Devices and Institute of Polymer Optoelectronic Materials and Devices South China University of TechnologyGuangzhou 510640China

The inception and harnessing of excitons are paramount for the electroluminescence performance of organic light-emitting devices(OLEDs).Through-space charge transfer(TSCT)via intramolecular interaction has proved to be one of the most potent techniques employed to achieve 100% internal quantum ***,molecular strategies utilized to comprehensively enhance the electroluminescent performance of TSCT emitters regarding improving the photoluminescence quantum yield(PLQY)and elevating the light out-coupling efficiency remain *** surmount this challenge,we deliberately designed and synthesized a proof-of-concept TSCT emitter called CzO-TRZ by incorporating an extra carbazole donor into spiroheterocyclic *** introduction of rigid spiral fragments can immensely boost the horizontal orientation dipole ratio and establish an extra through-bond charge transfer(TBCT)radiative decay *** a result,a very high PLQY of 98.7%,fast kRISCof 2.2×10^(5)s^(-1)and high k_(r)^(s) of 2.2×10^(7)s^(-1),and an ultrahigh horizontal dipolar ratio of 90%were concurrently achieved for Cz O-TRZ blended ***,corresponding thermally activated delayed fluorescence(TADF)-and TADF-sensitized fluorescence(TSF)-OLEDs based on CzO-TRZ demonstrated external quantum efficiencies(EQEs)of 33.4% and 30.3%,respectively,highlighting its versatile applications as both an emitter and sensitized host.

关键词： organic electronics organic light-emitting diodes polycyclic aromatic hydrocarbons multiple-resonance

Association between choroidal thickness and anterior chamber segment in eyes with narrow or open-angle

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International Journal of Ophthalmology(English edition) 2016年第8期9卷 1143-1147页

作者： Song-Feng Li ge-wei wu Chang-Xi Chen Ling Shen Zhi-Bao Zhang Fei Gao Ning-Li Wang Beijing Ophthalmology and Visual Science Key Laboratory Beijing Tongren Eye Center Beijing Institute of Ophthalmology Beijing Tongren Hospital Capital Medical University Department of Ophthalmology Beijing Shi Jing Shan Hospital Department of Ophthalmology The 2~(nd) Affiliated Hospital of Harbin Medical University

AIM: To investigate the relationship between choroidal thickness and anterior chamber segment in subjects with eyes with narrow or open-angle. METHODS: The subfoveal choroidal thickness was measured with enhanced depth -imaging optical coherence tomography and anterior chamber parameters were measured with ultrasound biomicroscopy in one eye of 23 subjects with open-angle eyes and 38 subjects with narrow-angle eyes. The mean age was 59.52 +/- 7.04y for narrow-angle subjects and 60.76 +/- 7.23y for open angle subjects (P=0.514). Multivariate linear regression analysis was performed to assess the association between choroidal thickness and narrow -angle parameters. RESULTS: There were no differences in subfoveal choroidal thickness between open - and narrow-angle subjects (P=0.231). Anterior chamber parameters, including central anterior chamber depth, trabecular iris angle, iris thickness 500 mu m from the scleral spur (IT500), and ciliary body thickness at 1 mm and 2 mm from the sclera! spur (CBT1, CBT2) showed significant differences between the two groups (Pge (beta=-0.442, P=0.003) and 11500 (beta=-0.399, P=0.008) in the narrow-angle group. However, subfoveal choroidal thickness was not correlated with trabecular iris angle, anterior chamber depth, ciliary body thickness, or central corneal thickness in the narrow-angle group. CONCLUSION: Choroidal thickness does not differ in the two groups and has not correlated with anterior chamber parameters in narrow-angle subjects, suggesting a lack of relationship between choroidal thickness and primary angle-closure glaucoma.

关键词： choroidal thickness narrow-angle eye optical coherence tomography primary angle-closure glaucoma

Saturation Estimation with Complex Electrical Conductivity for Hydrate-Bearing Clayey Sediments:An Experimental Study

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Journal of Ocean University of China 2024年第1期23卷 173-189页

作者： XING Lanchang ZHANG Shuli ZHANG Huanhuan wu Chenyutong WANG Bin LAO Liyun wei wei HAN weifeng wei Zhoutuo ge Xinmin DENG Shaogui College of Control Science and Engineering China University of Petroleum(East China)Qingdao 266580China School of Water Energy and EnvironmentCranfield UniversityCranfield MK430ALUnited Kingdom Department of Alternative Energy PetroChina Research Institute of Petroleum Exploration&DevelopmentLangfang 065007China School of geosciences China University of Petroleum(East China)Qingdao 266580China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China

Clays have considerable influence on the electrical properties of hydrate-bearing *** is desirable to understand the electrical properties of hydrate-bearing clayey sediments and to build hydrate saturation(S_(h))models for reservoir evaluation and *** electrical properties of tetrahydrofuran-hydrate-bearing sediments with montmorillonite are characterized by complex conductivity at frequencies from 0.01 Hz to 1 *** effects of clay and Sh on the complex conductivity were analyzed.A decrease and increase in electrical conductance result from the clay-swelling-induced blockage and ion migration in the electrical double layer(EDL),*** quadrature conductivity increases with the clay content up to 10%because of the increased surface site density of counterions in *** the in-phase conductivity and quadrature conductivity decrease consistently with increasing Sh from 0.50 to *** sets of models for Sh evaluation were *** model based on the Simandoux equation outperforms Archie’s formula,with a root-mean-square error(E_(RMS))of 1.8%and 3.9%,respectively,highlighting the clay effects on the in-phase *** fre-quency effect correlations based on in-phase and quadrature conductivities exhibit inferior performance(E_(RMS)=11.6%and 13.2%,re-spectively)due to the challenge of choosing an appropriate pair of frequencies and intrinsic uncertainties from two *** second-order Cole-Cole formula can be used to fit the complex-conductivity *** pair of inverted Cole-Cole parameters,i.e.,characteristic time and chargeability,is employed to predict S_(h) with an E_(RMS) of 5.05%and 9.05%,respectively.

关键词： gas hydrate complex electrical conductivity hydrate-bearing clayey sediment hydrate saturation Simandoux equation frequency dispersion Cole-Cole formula

High-performance anisotropic SmCo-based magnet with novel microstructure

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Journal of Rare Earths 2024年第8期42卷 1539-1545,I0005页

作者： Yingchang Li Zicao Xing Nengjun Yu Zesong Ren Minxiang Pan Qiong wu Hongliang ge Minggang Zhu wei Li College of Materials and Chemistry China jiliang UniversityHangzhou 310018China Division of Functional Materials Research Central Iron and Steel Research InstituteBeijing 100081China

A novel micro structure of magnetically anisotropic Sm Co-based magnet with high-performance is *** magnet consists of SmCo_(7)-H(TbCu_(7)-hexagonal type),Sm_(2)Co_(17)-H(Th_(2)Ni_(17)-hexagonal type)and SmCo_(3)-R(SmCo_(3)-rhombohedral type)*** maximum magnetic energy product of the magnet is 231.69 kj/m^(3),and the intrinsic coercivity is 1005.47 kA/*** outstanding intrinsic coercivity temperature coefficient(β)of-0.125%/K between 298 and 773 K is obtained,which is very close to theβof commercial high-temperature Sm_(2)Co_(17)-based sintered *** initial magnetization curve indicates that the coercivity mechanism is controlled by a domain wall pinning *** SmCo_(3)-R lamellar phase may be a potential pinning center or self-pinning *** microstructure of the magnet is different from that of any previous SmCo-based *** findings provide a new idea for preparing high-performance SmCo-based permanent magnets.

关键词： Rare earths Permanent magnet Composite magnet Melt-spinning Microstructure

Attack-Resilient Distributed Cooperative Control of Virtually Coupled High-Speed Trains via Topology Reconfiguration

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 1066-1068页

作者： Shunyuan Xiao Xiaohua ge Qing wu the Institute of Advanced Technology Nanjing University of Posts and TelecommunicationsNanjing 210023China the School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia the School of Engineering and Technology Central Queensland UniversityRockhampton QLD 4701Australia

Dear Editor,This letter addresses the resilient distributed cooperative control problem of a virtually coupled train convoy under stochastic disturbances and cyber *** main purpose is to achieve distributed coordinati... 详细信息

关键词： prescribed Speed trains

Small molecule conjugates with selective estrogen receptor β agonism promote anti-aging benefits in metabolism and skin recovery

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2137-2152页

作者： Tarik Zahr Vijay K.Boda Jian ge Lexiang Yu Zhongzhi wu Jianwen Que wei Li Li Qiang Naomi Berrie Diabetes Center Columbia UniversityNew YorkNY 10032USA Department of Molecular Pharmacology and Therapeutics Columbia UniversityNew YorkNY 10032USA Department of Pharmaceutical Sciences College of PharmacyUniversity of Tennessee Health Science CenterMemphisTN 38163USA Drug Discovery Center College of PharmacyUniversity of Tennessee Health Science CenterMemphisTN 38163USA Division of Digestive and Liver Diseases Columbia UniversityNew YorkNY 10032USA Center for Human Development Columbia UniversityNew YorkNY 10027USA Department of Pathology and Cell Biology Columbia UniversityNew YorkNY 10032USA Department of Medicine Columbia UniversityNew YorkNY 10032USA

Estrogen is imperative to mammalian reproductivity,metabolism,and ***,the hormone activating estrogen receptor(ERs)αcan cause major safety concerns due to the enrichment of ERαin female tissues and certain *** contrast,ERβis more broadly expressed in metabolic tissues and the ***,it is desirable to generate selective ERβagonist conjugates for maximizing the therapeutic effects of ERs while minimizing the risks of ERα***,we report the design and production of small molecule conjugates containing selective non-steroid ERβagonists Gtx878 or *** of aged mice with our synthesized conjugates improved aging-associated declines in insulin sensitivity,visceral adipose integrity,skeletal muscle function,and skin health,with validation in *** further uncovered the benefits of ERβconjugates in the skin using two inducible skin injury mouse models,showing increased skin basal cell proliferation,epidermal thickness,and wound ***,our ERβ-selective agonist conjugates offer novel therapeutic potential to improve aging-associated conditions and aid in rejuvenating skin health.

关键词： Estrogen receptorβ Aging Metabolism Skin injury Muscle metabolism Small molecule conjugates Regeneration Adiposity