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Retinoid X receptor α downregulation is required for tail and caudal spinal cord regeneration in the adult newt

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Neural Regeneration Research 2018年第6期13卷 1036-1045页

作者： Sarah e.Walker Rachel Nottrodt Lucas Maddalena Christopher Carter gaynor e.spe.ce. Robert L.Carlone Department of Biological Sciences Brock University Department of Geosciences University of Calgary Biomedical Sciences Cambridge University Pre-Health Sciences Department Niagara College

Some adult vertebrate species,such as newts,axolotls and zebrafish,have the ability to regenerate their central nervous system（CNS）.However,the factors that establish a permissive CNS environment for correct morphological and functional regeneration in these species are not well *** evidence supports a role for retinoid signaling in the intrinsic ability of neurons,in these regeneration-competent species,to regrow after CNS ***,we demonstrated that a specific retinoic acid receptor（RAR）subtype,RARβ,mediates the effects of endogenous retinoic acid（RA）on neuronal growth and guidance in the adult newt CNS after ***,we now examine the expression of the retinoid X receptor RXRα（a potential heterodimeric transcriptional regulator with RARβ）,in newt tail and spinal cord *** show that at 21 days post-amputation（dpa）,RXRαis expressed at temporally distinct periods and in non-overlapping spatial domains compared to RARβ.Whereas RARβprotein levels increase,RXRαproteins level decrease by 21 dpa.A selective agonist for RXR,SR11237,prevents both this downregulation of RXRαand upregulation of RARβand inhibits tail and caudal spinal cord ***,treatment with a selective antagonist for RARβ,Le135,inhibits regeneration with the same morphological consequences as treatment with ***,Le135 treatment also inhibits the normal downregulation of RXRαin tail and spinal cord tissues at 21 *** results reveal a previously unidentified,indirect regulatory feedback loop between these two receptor subtypes in regulating the regeneration of tail and spinal cord tissues in this regeneration-competent newt.

关键词： retinoid X receptor spinal cord regeneration newt retinoic acid ependymoglia retinoic acid receptor

Retroperitoneal kidney transplantation with liver and native kidney mobilization:a safe technique for pediatric recipients

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World Journal of Pediatrics 2023年第5期19卷 489-501页

作者： Juliano Riella Raphealla Ferreira Marina M.Tabbara Phillipe Abreu Lucas ernani Marissa Defreitas Jayanthi Chandar Jeffrey J.gaynor Javier González Gaetano Ciancio Department of Surgery University of Miami Miller School of MedicineJackson Memorial HospitalMiamiFLUSA Department of Urology University of Miami Miller School of MedicineJackson Memorial HospitalMiamiFLUSA Department of Pediatrics Division of NephrologyUniversity of Miami Miller School of MedicineJackson Memorial HospitalMiamiFLUSA Miami Transplant Institute University of Miami Miller School of MedicineJackson Memorial Hospital1801 NW 9Th Ave7Th FloorMiamiFL 33136USA Servicio de Urología Unidad de Trasplante RenalHospital General Universitario Gregorio MarañónMadridSpain

Background Pediatric kidney transplant(KT)using larger,deceased or living donor adult kidneys can be challenging in the pediatric population due to limited space in the *** and native kidney(L/NK)mobilization techniques can be used in smaller and younger transplant recipients to aid in retroperitoneal placement of the renal ***,we compare the clinical outcomes of pediatric retroperitoneal KT with and without L/NK *** We retrospectively analyzed pediatric renal transplant recipients treated between January 2015 and May *** and recipient demographics,intraoperative data,and recipient outcomes were *** were divided into two groups according to the surgical technique utilized:with L/NK mobilization(Group 1)and without L/NK mobilization(Group 2).Baseline variables were described using frequency distributions for categorical variables and means and standard errors for continuous *** of association with the likelihood of using L/NK mobilization were performed using standardχ2 tests,t tests,and the log-rank *** Forty-six pediatric recipients were evaluated and categorized into Group 1(n=26)and Group 2(n=20).Recipients in Group 1 were younger(6.7±0.8 years vs.15.3±0.7,Per(109.5±3.7 vs.154.2±3.8 cm,Peighed less(21.4±2.0 vs.48.6±3.4 kg,Pe in Group *** baseline characteristics did not difer between Groups 1 and *** urologic complication was encountered in Group 2;no vascular or surgical complications were observed in either ***,no stents or drains were used in any of the *** were no cases of delayed graft function or graft primary *** median follow-up of the study was 24.6 months *** patients developed death-censored graft failure(both in Group 2,P=0.22),and there was one death with a functioning graft(in Group 2,P=0.21).Conclusions Retroperitoneal liver/kidney mobilization is a feasible an

关键词： extraperitoneal approach Liver and kidney mobilization Pediatric kidney surgical technique Transplantation

Supported Rehabilitation for Individuals Who Have experienced a Stroke: A Pilot Control Trial

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Open Journal of Therapy and Rehabilitation 2016年第2期4卷 87-98页

作者： Charlotte gaynor Laura Devaux Morley Stephanie Kate Petropoulou Brendon Stubbs Andrew Soundy Department of Physiotherapy School of Sport Exercise and Rehabilitation Sciences University of Birmingham Edgbaston Birmingham England Department of Health Service and Population Research Kings College London England

The purpose of this study was to pilot an innovative and supported intervention for individuals with a stroke. A pilot control trial with qualitative interviews was undertaken within a university- community setting. Thirteen individuals who had experienced a stroke for periods of least 6 months (6 male, average 71 years) were assigned to the intervention group and 7 individuals (2 male, average age 67.9 years) assigned to the control group. eight individuals from the intervention group completed a single interview. The procedures that related to recruitment and retention and data collection methods were considered. Outcome measures including;self-efficacy, falls self-efficacy and group membership, for both groups were taken at baseline, 11 weeks, 22 weeks. There was an additional assessment at 52 weeks for the intervention group. The structured interview was designed to focus on experiences of the intervention. Self-efficacy remained stable across time for both groups. An improvement in falls self-efficacy was noted in the intervention group at 11 weeks. Consistent improvement (from baseline) was observed in the identity scale across the 52 weeks. Qualitative data provided additional findings related to identity and confidence. Details considering recruitment and retention are also provided. This pilot study provided data that can be used for a further full-scale trial to be considered.

关键词： Stroke Pilot Controlled Trial exercise Rehabilitation

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蜂窝电话功率放大器-天线接口的自适应调谐

电子设计应用 2009年第11期7卷 53-55,60页

作者： Mike gaynor Antenova公司

本文分析了目前无线产品设计面临的挑战,提出了一种只需少量电路,占用较少电路板面积的解决方案,即将功率放大器和前端模块RF装置集成到天线结构的蜂窝无线电天线模块中,针对天线负载条件使天线和RF电路实现最佳匹配。

关键词：蜂窝无线电天线 PA RF 无损可调谐匹配

面向SiP封装的层压板与LTCC板射频模块设计

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电子设计技术 eDN CHINA 2004年第6期11卷 116-116,118,119页

作者： MichaeI gaynor

随着移动无线设备面临更大的缩小体积的压力,人们开始采用系统级封装(SiP)来解决这一难题.不过,前端的射频电路通常需要首先集成在一块基板上,形成一个模块,然后再嵌入SiP中,才能保证射频电路的完整性以及与其它电路的隔离.这种射频模... 详细信息

随着移动无线设备面临更大的缩小体积的压力,人们开始采用系统级封装(SiP)来解决这一难题.不过,前端的射频电路通常需要首先集成在一块基板上,形成一个模块,然后再嵌入SiP中,才能保证射频电路的完整性以及与其它电路的隔离.这种射频模块通常有现成的产品可以使用,但有时为了满足特定要求,还要寻求专业厂商的定制设计.

关键词： SiP封装层压板 LTCC板射频模块

如何评价孵化厂的管理水平——监测和提高受精率及孵化率的措施

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国外畜牧学(猪与禽) 1991年第4期 42-45页

作者： gaynor McDonald 李炯美国奥本大学家禽科学系博士

为了获得最大的收益,孵化场的管理,除了上蛋、移蛋、卫生、雏鸡的饲养和处理这些例行工作之外,还包括有大量其它工作。尽管这些常规工作对于保持孵化厂的成功非常重要,但是对孵不出的种蛋进行分析并判定其原因,也同样很重要。在许多情... 详细信息

为了获得最大的收益,孵化场的管理,除了上蛋、移蛋、卫生、雏鸡的饲养和处理这些例行工作之外,还包括有大量其它工作。尽管这些常规工作对于保持孵化厂的成功非常重要,但是对孵不出的种蛋进行分析并判定其原因,也同样很重要。在许多情况下孵化率的问题并非由孵化厂所造成,但是孵化率的担子还是落在了孵化厂经理的肩上。本文的目的是描述一些孵化率分析法,通过这些方法可查明一些蛋孵不出的原因。要完成这项工作,就必须要求孵化管理人员与种蛋供应者或者是种蛋生产管理者之间进行良好的对话。全体养鸡人员和孵化人员都必须认为孵化率的提高是双方共同的责任,而不是认为这只是对方的事情。

关键词：受精率鸡群孵化厂繁殖性能农场孵化率种公鸡

留英中国学生学者活动水平与心理健康的初步调查

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中国心理卫生杂志 2001年第6期15卷 449-449页

作者：谢琴 gaynor Parfitt 王念理湖北襄樊学院体育系 441053 School of Sport Health and Exercise SciencesUniversity of Walesbangor

经常性的体育锻炼能保持和提高身体健康.实验证明身体锻炼与大量的心理指标相关联,其中包括焦虑,积极的情绪和主观健康.Spielberge等人研究发现状态焦虑和特质焦虑受年龄、性别、职业和文化程度的影响.体育活动水平对特质焦虑的影响也... 详细信息

经常性的体育锻炼能保持和提高身体健康.实验证明身体锻炼与大量的心理指标相关联,其中包括焦虑,积极的情绪和主观健康.Spielberge等人研究发现状态焦虑和特质焦虑受年龄、性别、职业和文化程度的影响.体育活动水平对特质焦虑的影响也存在差异.

关键词：中国留学生活动水平心理健康

IBM3370/3880DAS子系统的设计试验

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计算机工程 1981年第4期 75-76页

作者： B.R.gaynor 姚立申

本文描述的技术和方法用于评价IBM3370 DAS和IBM3880存贮器控制器的先进技术和设计方法。测试和评价的目的是为了保证满足设计参数和功能特性,并保证这些产品的正式制造符合用户需要的质量标准。就技术、封装,设计方法和数据结构来说,... 详细信息

本文描述的技术和方法用于评价IBM3370 DAS和IBM3880存贮器控制器的先进技术和设计方法。测试和评价的目的是为了保证满足设计参数和功能特性,并保证这些产品的正式制造符合用户需要的质量标准。就技术、封装,设计方法和数据结构来说,新产品的设计概念和构造有许多是创新的。

关键词： IBM3370/3880DAS 功能特性测试程序逻辑记录 DAS

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三叶草的虫害——线虫

国外畜牧学（草原与牧草） 1991年第4期 5-15页

作者： R.A.skipp D.L.gaynor 南志标

本文总结了目前已发表的茎线虫,三叶草孢囊线虫,根结线虫,根斑线虫以及侵袭白三叶草的土壤游离线虫等的生物学、生态学和致病力等方面的资料。许多关于三叶草线虫的文献是估测土壤中线虫群体密度及其对牧草产量影响的。线虫田间重要性... 详细信息

本文总结了目前已发表的茎线虫,三叶草孢囊线虫,根结线虫,根斑线虫以及侵袭白三叶草的土壤游离线虫等的生物学、生态学和致病力等方面的资料。许多关于三叶草线虫的文献是估测土壤中线虫群体密度及其对牧草产量影响的。线虫田间重要性的资料对农学和植物育种工作者具有极大的价值,因为他们必须要决定,是否对线虫采取防治措施。必要的田间试验不易进行,且极少能够给予非常明确的结果。因此,当据此做出结论时,应当考虑到实验方法的局限性。

关键词：牧草三叶草害虫线虫