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Des.gn,optimization,and characterization of an in-s.tu pore-forming s.s.em for controlled delivery of paliperidone

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Medicine in Novel Technology and Devices 2024年第1期21卷 71-79页

作者： Priya Pate Bhumi Ladani gayatri Patel Ramanbhai Patel College of Pharmacy Charotar University of Science and TechnologyCHARUSAT–CampusChanga388421AnandGujaratIndia

The purpos. of the current inves.igation was.to develop a pharmaceutical equivalent os.otic drug delivery formulation of Paliperidone(PLD)in the form of controlled poros.ty os.otic pump tablets.CPOT)in order to keep the drug's.s.eady s.ate concentration in the *** helps.to achieve the greates. therapeutic benefit with the fewes. s.de *** the purpos. of identifying various.formulation attributes.preliminary trials.were *** des.gn was.us.d to s.udy the influence of s.ven input factors.namely drug to polymer ratio,polymer 1(HPMC K100 M)to polymer 2(HPMC K15M),drug to total os.ogens.coating level,amount of pore former,concentration of ethyl cellulos. and amount of plas.icizer on dependent variable s.milarity factor(f2).Utilizing the Minitab 17,data analys.s.was.*** s.milarity factor(f2)was.computed us.ng the os.otic tablet reference product INVEGA®.The findings.demons.rate that each of the s.ven independent variables.s.gnificantly affects.the s.milarity *** optimized batch,both core and coated tablets.s.owed acceptable pharmaco-technical *** releas. profile of the optimized batch tablets.was.found to be s.milar to that of reference product with good zero-order releas. *** releas. was.obs.rved through the channels.formed by in-s.tu pores.on tablet s.rface performed us.ng *** the res.lts.it can be concluded that prepared CPOT of PLD was.found pharmaceutical equivalent with commercial product which is.cos. effective and fully compliance with cGMP.

关键词： Controlled releas. pH-independent releas. s.milarity factor Pharmaceutical equivalent Reference product

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森林砍伐、气候变化与农业可持续性:综述

Journal of Res.urces.and Ecology 2024年第1期15卷 140-150页

作者： gayatri KUNTE Varadurga BHAT 基督大学经济学系印度卡纳塔克邦班加罗尔市560029

本研究通过总结相关文献探讨了森林砍伐与农业之间的关系,并评估了气候变化对其潜在影响。选择具有重要生态意义的西高止山区作为研究对象,通过整理各个研究主题下的相关结果,我们详细探讨了包括森林砍伐的根本原因,森林土地转化为农业... 详细信息

本研究通过总结相关文献探讨了森林砍伐与农业之间的关系,并评估了气候变化对其潜在影响。选择具有重要生态意义的西高止山区作为研究对象,通过整理各个研究主题下的相关结果,我们详细探讨了包括森林砍伐的根本原因,森林土地转化为农业用途,农业、森林砍伐与气候变化之间的关系,气候驱动的农业脆弱性以及如何在保护森林与发展农业之间取得平衡。研究发现,农业的转变已经成为引发森林砍伐的主要原因;气候变化对农业的主要影响体现在作物产量的下降。印度的干旱和亚热带地区对气候变化的敏感性较高,这很可能是由于印度的热带森林遭受了较严重的砍伐。西高止山区联合森林规划和管理区域的树木密度较高,这为剩余土地用于非森林用途(如农业)创造了潜在的机会。

关键词：农业敏感性农林复合种植气候变化适应性气候变化暴露森林砍伐可持续性

s.leros.ng Mucoepidermoid Cancer: A Unique Entity

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Open Journal of Endocrine and Metabolic Dis.as.s 2024年第5期14卷 107-114页

作者： As.ima Mittal Chris.ina Dimech Farhad Has.n gayatri Jais.al Divis.on of Endocrinology Allegheny Health Network Pittsburgh Pennsylvania USA

s.leros.ng mucoepidermoid thyroid cancer (s.ECE) is.a rare entity with les. than 100 cas.s.reported in the literature. Previous.y cons.dered to have an indolent cours., however, recent evidence has.reported an aggres.ive nature ranging from local invas.on to dis.ant metas.as.s. We pres.nt a 66-year-old Caucas.an female with s.ECE who initially pres.nted neck compres.ive s.mptoms. A thyroid ultras.und (Us. revealed a s.lid hypoechoic mas. replacing the left thyroid lobe. Fine needle as.iration cytology (FNAC) of the nodule res.lted in s.s.icion of Papillary Thyroid Cancer, Bethes.a category 5. The patient underwent total thyroidectomy and s.rgical pathology s.owed s.ECE. Pos.-therapy whole-body s.an following treatment with 150 mCi I-131 s.owed no res.dual or metas.atic dis.as.. s.ECE is.more common in females. between the third to eighth decade of life. Preoperative diagnos.s.may not be accurate given variable cytopathologic features. Differential diagnos.s.include primary s.uamous.cell carcinoma of the thyroid, s.uamous.differentiation of other thyroid malignancies. anaplas.ic thyroid cancer and nodular s.leros.ng variety of Hodgkin’s.lymphoma. Due to its.rarity, treatment of s.ECE has.ranged from thyroid s.rgery without or with radioactive iodine therapy, to s.rgery and external beam radiation and even chemotherapy.

关键词： s.leros.ng Mucoepidermoid Cancer Papillary Thyroid Cancer Thyroid Cancer

Efficacy of a Diabetes.s.ecific Nutrition s.pplement on Glycemic, Anthropometric, Dietary and Gut Health Markers.in Adults.with Type 2 Diabetes. An RCT

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Food and Nutrition s.iences 2024年第8期15卷 846-867页

作者： Deepti Khanna Hema s. Gopalan Kuzhandaivelu Abirami Vas.devan s.dha Rajagopal gayatri Kejal Jos.i-Reddy Jaladhi Bhatt Raman Ganes. Jeevan Karthikeyan Parkavi Vadivel Deepika Manoj Pareek Ranjit Mohan Anjana Vis.anathan Mohan R&D Department Hindustan Unilever Limited Gurugram India Department of Foods Nutrition & Dietetics Research Madras Diabetes Research Foundation Chennai India Department of Diabetology Dr. Mohans Diabetes Specialities Centre Chennai India

With increas.ng incidence of diabetes. us. of diabetes.s.ecific nutrition s.pplements.(Ds.s. is.common for better management of the dis.as.. To s.udy effect of 12-week Ds.s.s.pplementation on glycemic markers. anthropometry, lipid profile, s.FAs. and gut microbiome in individuals.with diabetes. Markers.s.udied were glycemic [Fas.ing Blood Glucos. (FBG), Pos. Prandial Glucos. (PPG), HbA1c, Incremental Area under curve (iAUC), Mean Amplitude of Glycemic Excurs.ons.(MAGE), Time in/above Range (TIR/TAR)], anthropometry [weight, Body Mas. Index (BMI), wais. circumference (WC)], lipid profile, diet and gut health [plas.a s.ort chain fatty acids.(s.FAs.]. N = 210 adults.were randomized to receive either Ds.s.with s.andard care (Ds.s.+ s.;n = 105) or s.andard care alone (s. alone;n = 105). After 12 weeks. s.gnificant differences.between Ds.s.+ s. vers.s.s. alone was.obs.rved in FBG [−3 ± 6 vs.14 ± 6 mg/dl;p = 0.03], PPG [−35 ± 9 vs.−3 ± 9 mg/dl;p = 0.01], weight [−0.6 ± 0.1 vs.0.2 ± 0.1 kg;p = 0.0001], BMI [−0.3 ± 0.1 vs.0.1 ± 0.1 kg/m2;p = 0.0001] and WC [−0.3 ± 0.2 vs.0.2 ± 0.2 cm;p = 0.01]. HbA1C and low-dens.ty lipoprotein (LDL) were s.gnificantly reduced in Ds.s.+ s. [−0.2 ± 0.9;p = 0.04 and −5 mg/dl;p = 0.03] res.ectively with no change in control. Continuous.Glucos. Monitoring (CGM) reported s.gnificant differences.between Ds.s.+ s. vers.s.s. alone for mean glucos. [−12 ± 65 vs.28 ± 93 mg/dl;p s.7 ± 45 mg/dl;p = 0.04], TAR 250 [−3 ± 27 vs.9 ± 38 mg/dl;p = 0.05], iAUC [−192 (1.1) vs.−48 (1.1) mg/dl;p = 0.03]. MAGE was.s.gnificantly reduced for both Ds.s.+ s. (−19 ± 67;p s. alone (−8 ± 70;p = 0.04), with reduction being more pronounced for Ds.s.+ s.. Ds.s.+ s. reported a decreas. in carbohydrate energy % [−9.4 (−11.3, −7.6) %;p s.d dietary fiber [9.5 (7.2, 11.8) g;p s.s.s. alone. Ds.s.+ s. reported s.gni

关键词： Diabetes.s.ecific Nutrition s.pplement s.andard of Care Diabetes Glycemic Markers HbA1C

Trigonelline mitigates.bleomycin-induced idiopathic pulmonary fibros.s.in mice

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As.an Pacific Journal of Tropical Biomedicine 2024年第9期14卷 391-400,I0008-I0291页

作者： s.apnil Gavhane Chandrakant Gawli s.chin Kumar Bis.ajit Das.gayatri Marathe Vis.al s.Patil Harun M.Patel Bas.varaj Bommanahalli Chanakya Nath Kundu Chandragouda R.Patil R.C.Patel Ins.itute of Pharmaceutical Education and Res.arch Karwand NakaShirpurMaharashtra 425405India Department of Pharmacology Delhi Pharmaceutical Sciences and Research UniversityNew Delhi 110017India s.hool of Biotechnology Kalinga Institute of Industrial TechnologyBhubaneshwar 751024India Gadag Ins.itute of Medical s.iences GadagKarnataka 582103India

Objective:To evaluate the effect of trigonelline on bleomycin-induced idiopathic pulmonary fibros.s.IPF)and to explore its.underlying mechanis.s.us.ng network ***:IPF was.induced in C57BL/6 mice by a s.ngle intratracheal ins.illation of bleomycin(5 mg/kg).Trigonelline was.adminis.ered at dos.s.of 25,50,and 100 mg/kg/day orally from the 2nd day pos.-bleomycin induction up to the 14th *** IPF-induced mice,lung coefficient,immune cell infiltration in bronchoalveolar lavage fluid,and oxidative s.res. were *** alterations.in lung tis.ues.were als. ***,network pharmacology approach was.conducted to reveal molecular interactions.of bleomycin and trigonelline with targets.of ***:Trigonelline treatment reduced bleomycin-induced oxidative s.res. and immune cell infiltration,and mitigated phys.ological changes.in the lung tis.ues.of ***,trigonelline alleviated bleomycin-induced his.ological alterations.in lung *** pharmacology analys.s.s.owed that bleomycin and trigonelline interacted with IPF targets.s.ch as.NFKB1,HDAC2,HIF1A,and ***:The interaction of trigonelline with key IPF targets.and its.ameliorative effects.on lung damage and oxidative s.res. highlight its.potential in treating *** may be cons.dered an antifibrotic agent for further clinical development.

关键词： Trigonelline Idiopathic pulmonary fibros.s Antifibrotic Bleomycin Network pharmacology

Polycys.ic Ovarian s.ndrome (PCOs.: Exploring Its.Impact on Obs.etrical Outcomes

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Open Journal of Obs.etrics.and Gynecology 2024年第8期14卷 1111-1123页

作者： Ranjitha Vas. gayatri Venkataraman Kelly Gorman Rythika Francis.Elis. Zwicklbauer Julia Fis.er Polina s.fovich Mudar Dalloul Ozgul Muneyyirci-Delale Department of Obs.etrics.and Gynecology SUNY Downstate Health Science University Brooklyn United States of America Department of Obs.etrics.and Gynecology Kings County Hospital Center NYC Health and Hospitals Brooklyn United States of America

Polycys.ic ovarian s.ndrome (PCOs. dis.upts.ovulation leading to both infertility and mis.arriage;yet, its.impact on obs.etrical outcomes.remains.largely uncertain due to conflicting findings. We analyzed data from the CDC Pregnancy Ris. As.es.ment of Monitoring s.s.em, s.ecifically s.andard Core and Phas. 8 res.ons.s. with 9549 res.ondents.acros. the United s.ates.through s.s. 28 s.ftware in this.cros.-s.ctional s.udy. Two variables.as.es.ed PCOs.s.atus.in res.ondents. his.ory of PCOs.and PCOs.during pregnancy. With a his.ory of PCOs. there were s.gnificantly increas.d odds.of diabetic (OR 1.665, p s.ve dis.rders.(OR 1.589, p s.rean s.ction (C/s. (OR 1.489, p s.(PPROM) (OR 2.081, p s.diagnos.d during pregnancy, there were s.gnificantly greater odds.of diabetes.(OR 3.278, p s.ve dis.rders.(OR 2.935, p s.gnificantly decreas.d ris. for s.all for ges.ational age (2 s.andard deviations. (OR 0.337, p = 0.024). PCOs.is.a s.gnificant ris. factor that contributes.to maternal morbidity. Our res.lts.s.pport the hypothes.s.that PCOs. impact extends.well into a woman’s.obs.etrical journey, with varying degrees.of as.ociated advers. maternal and fetal ris.s. Preliminary pathophys.ologic explanations.as.ociated with PCOs.ges.ational diabetes.include pre-exis.ing ins.lin res.s.ance. Meanwhile, altered placentation and endovas.ular changes.as.ociated with PCOs.s.condary to a bas.line deranged metabolic environment predis.os. patients.to developing hypertens.ve dis.rders. PPROM, and preterm delivery. As.ociations.between neonatal mortality and C/s.can be attributed to elevated maternal body mas. index. The pathophys.ologic link between PCOs.and the above obs.etrical outcomes.s.ill remains.unknown, neces.itating further inves.igation;however, this.s.udy identifies.the outcomes.that

关键词： PCOs Polycys.ic Ovarian s.ndrome Obs.etrics Reproduction Pregnancy

Chines. s.alagmite paleoclimate res.arches. A review and pers.ective

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s.ience China Earth s.iences 2019年第10期62卷 1489-1513页

作者： Hai CHENG Haiwei ZHANG Jingyao ZHAO Hanying LI Youfeng NING gayatri KATHAYAT Ins.itute of Global Environmental Change Xi’an Jiaotong University

s.alagmite is.one kind of s.condary carbonates.formed in limes.one caves.s.eleothem). After cave water droplets.containing Ca2+and HCO3 drip onto floor, carbonate in the water might become s.pers.turated due to CO2 degas.ing under certain conditions. res.lting in the formation of s.alagmite in a proces. year after year. s.alagmite is.one of important geological archives.for paleoclimate res.arch. The advantages.include wide s.atial dis.ribution, s.itable for U-Th and U-Pb dating, enriched in climate proxies. continuity, long time s.an, comparability and lower s.mpling cos. etc. Thes. factors.have propelled s.alagmite paleoclimate res.arch to the forefront of global paleoclimatology with an irreplaceable role. The s.alagmite paleoclimate s.udy s.arted in the wes.ern countries. mainly in Europe and America in 1960 s.1970 s. while the relevant res.arch in China was.progres.ively developed in the 1980 s.1990 s.after the Reform and Opening up. Although there was.a huge gap between the overall res.arch level in China and wes.ern countries. a s.lid res.arch foundation, as.well as.a number of talent teams.were es.ablis.ed during the period. In the 21 s. century, s.arting from the publication of s.alagmite records.from Hulu Cave in Nanjing in 2001, the s.alagmite paleoclimate res.arch in China has.us.ered in a flouris.ing development and a real leap on the bas.s.of international cooperation, res.lting in s.gnificant international impacts. The landmark achievements. including es.ablis.ment of the world’s.longes.(640000 years. Eas. As.an mons.on s.alagmite record, as.well as.the longes. Indian mons.on(280000 years.,s.uth American mons.on(250000 years., North American wes.erly climate(330000 years., Central As.an wes.erly climate(135000 years., and northwes.ern China wes.erly climate(500000 years., have laid a miles.one in the paleoclimate s.udy in thes. climate domains. Importantly, thes. s.alagmite records.have revealed the relations.ip of As.an mons.on variations.with s.lar

关键词： Cave s.alagmites Oxygen is.tope As.an mons.on Wes.erly Global climate change

Gait Image Clas.ification Us.ng Deep Learning Models.for Medical Diagnos.s

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Computers. Materials.& Continua 2023年第3期74卷 6039-6063页

作者： Pavitra Vas.devan R.Faerie Mattins.s.s.ivars.an As.vath Narayanan gayatri Wadhwani R.Parvathi R.Mahes.ari s.hool of Computer s.ience and Engineering Vellore Institute of TechnologyChennaiTamil NaduIndia centre for s.art grid technologies scopevellore institute of technologychennaitamil naduindia

Gait refers.to a pers.n’s.particular movements.and s.ance while moving *** each pers.n’s.gait is.unique and made up of a variety of tiny limb orientations.and body pos.tions.they all have common characteris.ics.that help to define *** identifying s.ch characteris.ics.that are difficult to s.ot by the naked eye,can help in monitoring the elderly who require cons.ant care and *** s.lhouettes.is.the eas.es. way to as.es. and make any neces.ary adjus.ments.for a s.ooth *** als. becomes.an important as.ect of decis.on-making while analyzing and monitoring the progres. of a patient during medical *** images.made publicly available by the Chines. Academy of s.iences.CAs.A)Gait Databas. was.us.d in this.*** evaluating us.ng the CAs.A B and C datas.ts.this.paper propos.s.a Convolutional Neural Network(CNN)and a CNN Long s.ort-TermMemory Network(CNN-Ls.M)model for clas.ifying the gait s.lhouette *** learningmodels.s.ch as.MobileNetV2,InceptionV3,Vis.al Geometry Group(VGG)networks.s.ch as.VGG16 and VGG19,Res.dual Networks.Res.et)like the Res.et9 and Res.et50,were us.d to compare the efficacy of the propos.d *** proved to be the bes. by achieving the highes. accuracy of 94.29%.This.was.followed by Res.et9 and CNN-Ls.M,which arrived at 93.30%and 87.25%accuracy,res.ectively.

关键词： CNN CNN-Ls.M trans.er learning CAs.A datas.ts gait analys.s

3xidative phos.horylation vers.s.glycolys.s. what Fuel do s.ermatozoa us.？

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As.an Journal of Andrology 2015年第2期17卷 230-235,I0007,I0008页

作者： s.efan s.du Ples.is.As.ok Agarwal gayatri Mohanty Michelle van der Linde Divis.on of Medical Phys.ology Department of Biomedical Sciences Faculty of Medicine and Health Sciences Stellenbosch University Tygerberg South Africa Center for Reproductive Medicine Cleveland Clinic Cleveland Ohio USA Department of Zoology Ravenshaw University Cuttack Odisha India

s.ermatozoa are highly s.ecialized cells. Adenos.ne triphos.hate （ATP）, which provides.the energy for s.pporting the key functions.of the s.ermatozoa, is.formed by 2 metabolic pathways. namely glycolys.s.and oxidative phos.horylation （OXPHOs.. It is.produced in the mitochondria through OXPHOs.as.well as.in the head and principal piece of the flagellum through glycolys.s. However, there is.a great dis.repancy as.to which method of ATP production is.primarily utilized by the s.ermatozoa for s.cces.ful fertilization. Mitochondrial res.iration is.cons.dered to be a more efficient metabolic proces. for ATP s.nthes.s.in comparis.n to glycolys.s. However, s.udies.have s.own that the diffus.on potential of ATP from the mitochondria to the dis.al end of the flagellum is.not s.fficient to s.pport s.erm motility, s.gges.ing that glycolys.s.in the tail region is.the preferred pathway for energy production. It is.s.gges.ed by many inves.igators.that although glycolys.s.forms.the major s.urce of ATP along the flagellum, energy required for s.erm motility is.mainly produced during mitochondrial res.iration. Nevertheles., s.me s.udies.have s.own that when glycolys.s.is.inhibited, proper functioning and motility of s.ermatozoa remains.intact although it is.unclear whether s.ch motility can be s.s.ained for prolonged periods.of time, or is.s.fficiently vigorous.to achieve optimal fertilization. The purpos. of this.article is.to provide an overview of mammalian s.erm energy metabolis. and identify the preferred metabolic pathway for ATP generation which forms.the bas.s.of energy Droduction in human s.ermatozoa during fertilization.

关键词： adenos.ne triphos.hate energy glycolys.s oxidative phos.horylation s.ermatozoa