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Complete pancreatic heterotopia of gallbladder with hypertrophic duct simulating an adenomyoma

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World Journal of Gastroenterology 2006年第11期12卷 1786-1787页

作者： Luca Pilloni Alessandro Cois Alessandro Uccheddu Rossano Ambu Pierpaolo Coni gavino faa Istituto di Anatomia Patologica Dipartimento di Citomorfologia Universita degli Studi di CagliariItaly Semeiotica Chirurgica Dipartimento Chirurgico Materno Infantile e di Scienze delle Immagini Università degli Studi di CagliariItaly Istituto di Anatomia Patologica Dipartimento di Citomorfologia Università degli Studi di CagliariItaly

The gallbladder is an unusual location of pancreatic heterotopia, defined as the presence of pancreatic tissue lacking anatomical and vascular continuity with the main body of the gland. A 28-year-old man presented with anorexia, nausea and pain in the right upper abdomen. On physical examination, the abdomen was tender to palpation and Murphy sign was positive. The patient underwent a cholecystecomy. This case, in our opinion, is very interesting since it permits to consider a controversial issue in the pathology of the gallbladder. The histological appearance of ductal structure in pancreatic heterotopia resembles the histological picture of both Aschoff-Rokitansky （AR） sinuses and adenomyomas. This finding suggests that these lesions are linked by a common histogenetic origin. We suggest that the finding of an adenomyoma in the gallbladder should prompt an extensive sampling of the organ in order to verify the coexistence of pancreatic rests.

关键词： Pancreatic heterotopia Gallbladder Hypertrophic duct Adenomyoma Aschoff-Rokitansky sinuses

Lymphoepitelioma-like hepatocellular carcinoma: A case report and a review of the literature

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World Journal of Gastroenterology 2008年第29期14卷 4694-4696页

作者： Sonia Nemolato Daniela Fanni Antonio Giuseppe Naccarato Alberto Ravarino Generso Bevilacqua gavino faa Department of Cytomorphology Section of Pathology Univeristy of Cagliari Cagliari 09124 Italy Depart-ment of Oncology Section of Pathology University of Pisa56126 Pisa Italy

Lymphoepitelioma is a particular form of undifferentiat-ed carcinoma, characterized by a prominent lymphoid stroma, originally described in the nasopharynx. Lym-phoid stroma-rich carcinomas arising in other organs have been termed lymphoepithelioma-like carcinoma (LELC). In the liver, primary LELCs are very rare, and the majority has been identified as cholangiocarcino-mas. Here a rare case of lymphoepithelioma-like hepa-tocellular carcinoma (HCC) is described. A 47-year old woman presented with abdominal pain. Ultrasonogra-phy revealed a liver nodule, 2.2 cm in diameter, local-ized in the right lobe, adjacent to the gallbladder. Viral markers for hepatic B virus (HBV), hepatic C virus (HCV) and Epstein-Barr virus (EBV) were negative. The nod-ule was hypoechogenic. The patient underwent sur-gery, with resection of the nodule. Histology showed hepatocellular carcinoma, characterized by a promi-nent lymphoid infiltrate. At immunocytochemistry, tumor cells were reactive for Hep Par1 and glypican 3. Immunophenotyping of tumor infiltrating lymphocytes evidenced the predominance of CD8+ cytotoxic sup-pressor T cells. The postoperative clinical outcome was favorable and the patient was recurrence-free 15 mo after resection. This case, to the best of our knowl-edge, is the first reported non EBV and non cirrhosis-associated lymphoepithelioma-like hepatocellular carci-noma. The association between the lack of EBV infec-tion, the absence of cirrhosis, a "cytotoxic profile" of the inflammatory infiltrate and a good prognosis could identify a variant of lymphoepithelioma-like HCC with a favorable clinical outcome.

关键词： Liver Hepatocellular carcinoma Tumorinfiltrating lymphocytes Primary liver tumors Liverlymphoepithelioma

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Correspondence

World Journal of Pediatrics 2015年第1期11卷 89-91页

作者： JoséG.Dórea Daniela Fanni gavino faa Faculty of Health Sciences Universidade de BrasiliaC.P.0432270919-970 BrasiliaDFBrazil Department of Pathology University Hospital San Giovanni di DioAOU Cagliari and University of CagliariItaly

Aluminum exposure and toxicity in neonates:sources,absorption,and retention Fanni et al^([1])proposed a"guide to halt aluminum overload in the prenatal and perinatal periods"focusing on"aluminum exposure and toxicity in neonates".Their review addressed aluminum overload and risk of systemic intoxication beyond special circumstances of patients receiving intravenous fluid therapy and parenteral *** et al^([1])are commended for bringing into perspective the immature neurologic and immunologic systems of the premature/newborn in relation to aluminum exposure during pregnancy and infancy.

关键词： bringing exposure nutrition

Aluminum exposure and toxicity in neonates:a practical guide to halt aluminum overload in the prenatal and perinatal periods

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World Journal of Pediatrics 2014年第2期10卷 101-107页

作者： Daniela Fanni Rossano Ambu Clara Gerosa Sonia Nemolato Nicoletta Iacovidou Peter Van Eyken Vassilios Fanos Marco Zaffanello gavino faa Department of Pathology University Hospital San Giovanni di DioAOU Cagliari and University of CagliariItaly National and Kapodistrian University of Athens Medical SchoolAthensGreece Department of Pathology K.U.LeuvenLeuvenBelgium Neonatal Intensive Care Unit Puericulture Institute and Neonatal SectionAOU Cagliari and University of CagliariItaly Department of Pediatrics University of VeronaItaly

Background:During the last years,human newborns have been overexposed to biologically reactive aluminum,with possible relevant consequences on their future health and on their susceptibility to a variety of ***,newborns and particularly preterm neonates are at an increased risk of aluminum toxicity because of their relative *** sources:Based on recent original publications and classical data of the literatures,we reviewed the aluminum content in mother's food during the intrauterine life as well as in breast milk and infant formula during *** also determined the possible role of aluminum in parenteral nutrition solutions,in adjuvants of vaccines and in pharmaceutical products.A special focus is placed on the relationship between aluminum overexposure and the insurgence of bone ***:Practical points of management and prevention are *** sources that infants may receive during the fi rst 6 months of life are *** the context of prevention of possible adverse effects of aluminum overload in fetal tissues during development,simple suggestions to pregnant women are ***,practical points of management and prevention are ***:Pediatricians and neonatologists must be more concerned about aluminum content in all products our newborns are exposed to,starting from monitoring aluminum concentrations in milk-and soybased formulas in which,on the basis of recent studies,there is still too much aluminum.

关键词： aluminum fetus newborn toxicity

Histopathology of renal asphyxia in newborn piglets: Individual susceptibility to tubular changes

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World Journal of Nephrology 2015年第2期4卷 313-318页

作者： Clara Gerosa Nicoletta Iacovidou Ioanna Argyri Daniela Fanni Apostolos Papalois Filippia Aroni gavino faa Theodoros Xanthos Vassilios Fanos Department of Pathology University of Cagliari National and Kapodistrian University of Athens ELPEN Research-Experimental Center Laboratory of Experimental Surgery and Surgical Research University of Athens Department of Neonatology University of Cagliari

AIM： To analyze the effects on the kidney of hypoxia-reoxygenation in an experimental model of normocapnic ***： To this end, 40 newborn Landrace/Large-White piglets aged 1-4 d were studied in this work. Hypoxia was induced by decreasing the inspired fiO2 to 0.06-0.08. Animals were resuscitated with different fO2 and subdivided into 4 groups： group 1, 2, 3 and 4 received 18%, 21%, 40% and 100% O2 respectively. Macroscopic examination was carried out to evidence possible pathological features. Tissue sample were obtained from both kidneys. Four or fve micron paraffn sections were stained with H-E and PAS stain and examined under an optical ***： Pathological changes, mainly affecting tubular cells, were observed in the vast majority of kidneys of asphyxiated piglets. The most frequent tubular changes were： tubular casts （95%）, tubulardilatation （87.5%）, tubular vacuolization （70%）, tubular eosinophilia （52.5%）, sloughing （50%）, fragmentation of the brush border （50%）, oedema （32.5%）, apoptosis （15%） and glomerular changes （meningeal cell pro-liferation, capsular adhesion between the flocculus and Bowman’s capsule, glomerulosclerosis and fbrous or cellular crescents associated with collapse of the glomerular tuft）. Statistical analysis was carried out on changes observed when the animals were allocated in the 4 groups （χ2-test 0.05）. The statistical analysis showed no evidence of differences regarding kidney lesions among the animals ***： Our data show that renal pathology in newborn piglets is characterized by interindividual variability to hypoxia and is not associated with oxygenGerosa C et al . Individual susceptibility in renal asphyxiaconcentration.

关键词： Asphyxia Kidney Tubular eosinophilia Tubular dilatation Vacuolization Sloughing Apoptosis Brush border fragmentation