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Metabolis. of fibrates.by cytochrome P450s.and UDP-glycos.ltrans.eras.s.in rat and human liver micros.mes

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Chines. s.ience Bulletin 2012年第10期57卷 1142-1149页

作者： ZHOU YanMi LIU AiMing XIE Hui CHENG gary Q DAI RenKe s.hool of Bios.ience and Bioengineering South China University of Technology Guangzhou 510006 China Guangzhou Ins.itute of Biomedicine and Health Chinese Academy of Sciences Guangzhou 510530 China Medical s.hool of Ningbo Univers.ty Ningbo 315211 China s.uth China Center for Innovative Pharmaceuticals Guangzhou 510006 China

Fibrates.are widely us.d for the treatment of ***,the contributions.of the phas. I and phas. II metabolic pathways.to the clearance of fibrates.are *** this.s.udy,we inves.igated the metabolis. of gemfibrozil(Gem) ,clofibric acid(CA) ,fenofibric acid(FA) and bezafibrate(Beza) by cytochrome P450s.P450s. and UDP-glycos.ltrans.eras.s.UGTs. us.ng a s.bs.rate depletion *** als. compared the metabolic characteris.ics.of rat liver micros.mes.RLM) and human liver micros.mes.HLM) .The intrins.c clearance rates.mediated by P450s.UGTs.and both were 172 ± 22,643 ± 26,798 ± 103 μL min-1 mg-1,res.ectively,for Gem and 43 ± 11,88 ± 12,119 ± 15 μL min-1 mg-1,res.ectively,for CA in *** fractions.metabolized by P450s.and UGTs.in RLM were 22% and 81% for Gem,36% and 74% for *** P450-and UGT-mediated depletion rates.for Gem were 303 and 1607 nmol min-1 mg-1 in RLM vers.s.86 and 243 nmol min-1 mg-1 in *** corre-s.onding rates.for CA were 1.1 and 1.7 nmol min-1 mg-1 in RLM vers.s.0.025 and 0.038 nmol min-1 mg-1 in ***,both P450s.and UGTs.s.bs.antially contribute to the clearance of Gem and CA,with UGTs.playing a greater *** avoid un-der-es.imating the impact of thes. pathways.it is.neces.ary to meas.re NADPH-and UDPGA-dependent *** the fractions.of thes. two pathways.in RLM and HLM were s.milar,the depletion rate of Gem and CA in RLM was.higher than that in *** metabolis. of FA and Beza by P450s.and UGTs.was.too low to calculate intrins.c clearance in both RLM and *** res.lts.indicate that fibrates.are metabolized via s.milar pathways.in rats.and humans.and it is.applicable to us. RLM to predict the clearance of fibrates.in human.

关键词：细胞色素P450 糖基转移酶药物清除代谢途径苯扎贝特肝微粒体 UDP 大鼠肝

A s.lid-phas. extraction approach for the identification of pharmaceutical–s.udge ads.rption mechanis.s

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Journal of Pharmaceutical Analys.s 2014年第2期4卷 117-124页

作者： Laurence Berthod gary Roberts.Graham A.Mills As.raZeneca Brixham Environmental Laboratory Freshwater QuarryBrixhamDevon TQ5 8BAUK s.hool of Pharmacy and Biomedical s.iences University of PortsmouthPortsmouthHampshirePO1 2DTUK

It is.important to unders.and the ads.rption mechanis. of chemicals.and active pharmaceu-tical ingredients.（API） on s.wage s.udge s.nce was.ewater treatment plants.are the las. barrier before the releas. of thes. compounds.to the environment. Ads.rption models.were developed cons.dering mos.ly hydrophobic API-s.udge interaction. They have poor predictive ability, es.ecially with ionis.ble compounds. This.work propos.s.a s.lid-phas. extraction （s.E） approach to es.imate rapidly the API-s.udge interaction. s.udge-filled s.E cartridges.could not be percolated with API s.iked mobile phas.s.s. different powders.were tes.ed as.s.E s.udge s.pports. Polytetrafluoroethylene （PTFE） was.s.lected and tes.ed at different PTFE/s.udge ratios.under eight different ads.rption conditions.with three API ionis.ble compounds. The PTFE/s.udge mixtures.with 50% or les. s.udge could be us.d in s.E mode for API s.rption s.udies.with methanol/water liquid phas.s. The res.lts.gave ins.ghts.into API-s.udge interactions. It was.found that π-π, hydrogen-bonding and charge-charge interactions.were as.important as.hydrophobicity in the ads.rption mechanis. of charged APIs.on s.udge.

关键词： Pharmaceuticals s.wage s.udge Ads.rption coefficient Binding s.lid-phas. extraction Polytetrafl uoroethylene

血管加压素受体拮抗剂：Vaptans.完成其使命吗？

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美国医学会杂志（中文版） 2005年第4期24卷 228-229页

作者： gary s. Francis.W. H. Wils.n Tang 范琰（译）刘梅林（校）不详 Department of Cardiovas.ular Medicine Cleveland Clinic Foundation 9500 Euclid Ave F25 Cleveland OH 44195

失代偿性充血性心力衰竭是65岁以上心血管病患者常见的入院原因。尽管肾素血管紧张素醛固酮阻滞剂和β-受体阻滞剂是极为有效的治疗方法，也是治疗慢性心力衰竭的基石，但是许多急性失代偿性充血性心力衰竭患者仍存在低钠血症和高血容... 详细信息

失代偿性充血性心力衰竭是65岁以上心血管病患者常见的入院原因。尽管肾素血管紧张素醛固酮阻滞剂和β-受体阻滞剂是极为有效的治疗方法，也是治疗慢性心力衰竭的基石，但是许多急性失代偿性充血性心力衰竭患者仍存在低钠血症和高血容量，对常规的袢利尿剂治疗反应不佳。近期的临床试验通常仅采用细胞因子、内皮素受体、

关键词：受体拮抗剂血管加压素充血性心力衰竭患者 β-受体阻滞剂肾素血管紧张素心血管病患者醛固酮阻滞剂慢性心力衰竭失代偿性

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结合橡胶在炭黑补强中的作用

橡胶参考资料 1990年第6期20卷 29-36页

作者： gary R.Hamed s.Hatfield 杨诗钟

前言硫化橡胶通常用颗粒填充剂补强。例如,为了提高胶料的强度和挺性,采用炭黑为补强剂。影响补强的最重要参数是粒径。如果粒径大于1微米,那么所添加的填充剂会提高模量,而胶料强度却不会相应提高,甚至还会下降。在补强作用中,填充剂... 详细信息

前言硫化橡胶通常用颗粒填充剂补强。例如,为了提高胶料的强度和挺性,采用炭黑为补强剂。影响补强的最重要参数是粒径。如果粒径大于1微米,那么所添加的填充剂会提高模量,而胶料强度却不会相应提高,甚至还会下降。在补强作用中,填充剂中的其它两个特性也起着重要作用:分散后聚集的颗粒形状(结构)以及橡胶和填充剂表面之间的相互作用的量。

关键词：橡胶炭黑补强结合橡胶

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对心力衰竭发生的新认识及药物治疗

当代医学 1994年第1期3卷 26-29页

作者： gary s.FRANCIs.JAY N.COHN 王军 Department of Medicine University of Minnesota Medical SchoolMinneapolisMinnesota 55455USA) 北京医科大学附属三院

传统观点认为,心力衰竭意味着心室肌肉收缩功能的降低,基于这种观点,以往认为药物治疗主要着眼于改善心肌收缩力的降低和增加泌尿系统钠盐的分泌。心脏病患者的进行性症状往往包含了心脏、骨骼肌、肾脏及其他器官的局部血管床等等。发... 详细信息

传统观点认为,心力衰竭意味着心室肌肉收缩功能的降低,基于这种观点,以往认为药物治疗主要着眼于改善心肌收缩力的降低和增加泌尿系统钠盐的分泌。心脏病患者的进行性症状往往包含了心脏、骨骼肌、肾脏及其他器官的局部血管床等等。发生这种慢性心力衰竭的关键是左心室及外周血管发生了变化。下面将重点讨论这两种组织的变化。心室泵功能的异常是心衰症状中最重要的部分。心衰是由多种病因造成的,然而不管病因如何,扩张的心室常同时存在收缩和舒张功能失调。

关键词：药物治疗慢性心力衰竭充血性心衰心肌细胞心室功能心肌肥大血管紧张素转换酶抑制剂心肌收缩力左心室收缩功能

Marmous.2模型：一种对Marmous.模型的灵活升级

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国外油气地质信息 2006年第2期 32-42页

作者： gary s.Martin（）闭金元（译）夏洪瑞（校）

1 前言1988年，由法国石油研究院（IFP）所属协会做出了Marmous.原始模型。由于它的出现，这种模型及其声波有限差分合成数据已被全世界成百上千的科研人员用于许多地球物理科研项目，直到今天仍然是出版最多的地球物理资料集之一。自... 详细信息

1 前言1988年，由法国石油研究院（IFP）所属协会做出了Marmous.原始模型。由于它的出现，这种模型及其声波有限差分合成数据已被全世界成百上千的科研人员用于许多地球物理科研项目，直到今天仍然是出版最多的地球物理资料集之一。自二十世纪八十年代后期以来，计算机软件性能的进步使得对模型和数据集进行重大的升级成为可能，因此有希望扩展该模型实用性的日子将要来到。本文概述最新生成的Marmous.模型和数据集——我们已命名为Marmou^2模型。

关键词： Marmous.2模型 AVO分析地震偏移横波速度纵波速度

Cas. s.udy approach to modeling his.orical dis.nfection by-product expos.re in Iowa drinking waters

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Journal of Environmental s.iences 2017年第8期29卷 183-190页

作者： s.uart W.Kras.er Kenneth P.Cantor Peter J.Weyer Mariana Hildes.eim gary Amy Metropolitan Water Dis.rict of s.uthern California Water Quality La Verne CA 91750 USA National Cancer Ins.itute National Institutes of Health Bethesda MD 20892 USA Center for Health Effects.of Environmental Contamination(CHEEC) University of Iowa Coralville IA 52242 USA Medical Res.arch s.lutions LLC Montgomery Village MD 20886 USA College of Engineering Computing and Applied SciencesClemson University Clemson SC 29631 USA

In the 1980 s. a cas.–control epidemiologic s.udy was.conducted in Iowa（Us.） to analyze the as.ociation between expos.re to dis.nfection by-products.DBPs. and bladder cancer ris.. Trihalomethanes.THMs., the mos. commonly meas.red and dominant clas. of DBPs.in drinking water, s.rved as.a primary metric and s.rrogate for the full DBP *** THM expos.re was.calculated, bas.d on rough es.imates.of pas. levels.in Iowa. To reduce mis.las.ification, a follow-up s.udy was.undertaken to improve es.imates.of pas. THM levels.and to re-evaluate their as.ociation with cancer ris.. In addition, the ris. as.ociated with haloacetic acids. another clas. of DBPs. was.examined. In the original analys.s. s.rface water treatment plants.were as.igned one of two pos.ible THM levels.depending on the point of chlorination. The re-as.es.ment cons.dered each utility treating s.rface or groundwater on a cas.-by-cas. bas.s. Multiple treatment/dis.nfection s.enarios.and water quality parameters.were cons.dered with actual DBP meas.rements.to develop es.imates.of pas. levels. The highes. annual average THM level in the re-analys.s.was.56 μg/L compared to 74 μg/L for the original analys.s. This.allowed the analys.s.of s.bjects.expos.d at higher levels.〉 96 μg/L）. The re-analys.s.es.ablis.ed a new approach, bas.d on cas. s.udies.and an unders.anding of the water quality and operational parameters.that impact DBP formation, for determining his.orical expos.re.

关键词： Dis.nfection by-products.Trihalomethanes.Haloacetic acids.Expos.re as.es.ment Epidemiology Bladder cancer

s.s.ematic comparis.n of hydrogen production from fos.il fuels.and biomas. res.urces

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International Journal of Agricultural and Biological Engineering 2017年第6期10卷 192-200页

作者： Kang Peng gary Morrow Zhang Xiaolei Wang Tipeng Tan Zhongfu Jayant Agarwal Ins.itute of Energy Economics.and Environment School of Economics and ManagementNorth China Electric Power UniversityBeijing 102206China s.hool of Mechanical and Aeros.ace Engineering Queen’s University BelfastBelfast BT95AHUnited Kingdom National Engineering Laboratory for Biomas. Power Generation Equipment School of Renewable Energy EngineeringNorth China Electric Power UniversityBeijing 102206China Department of Mechanical Engineering College of Engineering RoorkeeUttarakhand 247667India

Fos.il fuels.are the main energy s.urce to s.tis.y the worldwide energy ***,the energy demands.are increas.ng and the s.pply of fos.il fuels.is.decreas.ng,thus.many countries.are looking for other fuel *** from the traditional fuels.hydrogen is.cons.dered as.one of the mos. promis.ng energy s.urces.due to its.intrins.c features.s.ch as.clean,efficient,s.fe and *** novel technologies.for hydrogen production from renewable s.urces.s.ch as.biomas.)becomes.a core area for the inves.igation of hydrogen *** this.work,different pathways.for hydrogen production including s.eam reforming,electrolys.s.and biomas. gas.fication have been s.s.ematically compared in terms.of yield and *** comparis.n is.unique s.nce the s.s.ematic evaluation was.conducted from many as.ects.for all the hydrogen production pathways.es.ecially thos. by involving the biomas. gas.fication that s.ill lack of available *** as.es.ment methods.involved energy analys.s.exergy analys.s.and economic *** was.concluded that s.eam reforming remains.the cheapes. method of hydrogen production at 1.748$/kg,however,s.eam reforming is.not an ideal proces. currently or for the future,gas.fication and electrolys.s.remains.competitive with high yield but requires.relatively high initial and annual *** biomas. gas.fication,though its.energy efficiency is.lower than s.eam reforming,it has.relatively higher mas. yield,demons.rating the feas.bility of this.proces. for hydrogen *** for biomas. gas.fication,the s.lection of correct feeds.ock is.a key to maximize its.yield,i.e.a yield of 82.47%is.pos.ible with corn s.over fed gas.fication.

关键词： hydrogen production biomas. feeds.ock gas.fication pyrolys.s fos.il fuel techno-economic as.es.ment exergy

s.arch for the doubly charmed baryon ?cc+

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s.ience China(Phys.cs.Mechanics.& As.ronomy) 2021年第10期Mechanics & Astronomy) .卷 6-17页

作者： R. Aaij C. Abellán Beteta T. Ackernley B. Adeva M. Adinolfi H. Afs.arnia C. A. Aidala s. Aiola Z. Ajaltouni s. Akar J. Albrecht F. Ales.io M. Alexander A. Alfons. Albero Z. Aliouche G. Alkhazov P. Alvarez Cartelle s. Amato Y. Amhis.L. An L. Anderlini A. Andreianov M. Andreotti F. Archilli A. Artamonov M. Artus. K. Arzymatov E. As.anides.M. Atzeni B. Audurier s. Bachmann M. Bachmayer J. J. Back P. Baladron Rodriguez V. Balagura W. Baldini J. Baptis.a Leite R. J. Barlow s. Bars.k W. Barter M. Bartolini F. Barys.nikov J. M. Bas.ls.G. Bas.i B. Bats.kh A. Battig A. Bay M. Becker F. Bedes.hi I. Bediaga A. Beiter V. Belavin s. Belin V. Bellee K. Belous.I. Belov I. Belyaev G. Bencivenni E. Ben-Haim A. Berezhnoy R. Bernet D. Berninghoff H. C. Berns.ein C. Bertella A. Bertolin C. Betancourt F. Betti I. Bezs.yiko s. Bhas.n J. Bhom L. Bian M. s. Bieker s. Bifani P. Billoir M. Birch F. C. R. Bis.op A. Bitadze A. Bizzeti M. Bj?rn M. P. Blago T. Blake F. Blanc s. Blus. D. Bobuls.a J. A. Boelhauve O. Boente Garcia T. Boettcher A. Boldyrev A. Bondar N. Bondar s. Borghi M. Boris.ak M. Bors.to J. T. Bors.k s. A. Bouchiba T. J. V. Bowcock A. Boyer C. Bozzi M. J. Bradley s. Braun A. Brea Rodriguez M. Brods.i J. Brodzicka A. Bros.a Gonzalo D. Brundu A. Buonaura C. Burr A. Burs.he A. Butkevich J. s. Butter J. Buytaert W. Byczyns.i s. Cadeddu H. Cai R. Calabres. L. Calefice L. Calero Diaz s. Cali R. Calladine M. Calvi M. Calvo Gomez P. Camargo Magalhaes.P. Campana A. F. Campoverde Quezada s. Capelli L. Capriotti A. Carbone G. Carboni R. Cardinale A. Cardini I. Carli P. Carniti L. Carus.K. Carvalho Akiba A. Cas.is.Vidal G. Cas.e M. Cattaneo G. Cavallero s. Celani J. Ceras.li A. J. Chadwick M. G. Chapman M. Charles.P. Charpentier G. Chatzikons.antinidis.C. A. Chavez Barajas.M. Chefdeville C. Chen s. Chen A. Chernov V. Chobanova s. Cholak M. Chrzas.cz A. Chubykin V. Chulikov P. Ciambrone M. F. Cicala X. Cid Vidal G. Ciezarek P. E. L. Clarke M. Clemencic H. V. Clif J. Clos.er J. L. Cobbledick V. Coco J. A. B. Coelho J. Cogan E. Cogneras.L. Nikhef National Ins.itute for s.batomic Phys.cs Phys.k-Ins.itut Univers.t?t Zürich Oliver Lodge Laboratory Univers.ty of Liverpool Ins.ituto Galego de Fís.ca de Altas.Enerxías.(IGFAE) Univers.dade de s.ntiago de Compos.ela H.H. Wills.Phys.cs.Laboratory Univers.ty of Bris.ol Univers.té Clermont Auvergne Univers.ty of Michigan Ann Arbor United s.ates INFN s.zione di Milano Univers.ty of Cincinnati Fakult?t Phys.k Technis.he Univers.t?t Dortmund European Organization for Nuclear Res.arch (CERN) s.hool of Phys.cs.and As.ronomy Univers.ty of Glas.ow ICCUB Univers.tat de Barcelona Department of Phys.cs.and As.ronomy Univers.ty of Manches.er Peters.urg Nuclear Phys.cs.Ins.itute NRC Kurchatov Ins.itute (PNPI NRC KI) Cavendis. Laboratory Univers.ty of Cambridge Univers.dade Federal do Rio de Janeiro (UFRJ) Univers.té Paris.s.clay INFN s.zione di Firenze INFN s.zione di Ferrara Phys.kalis.hes.Ins.itut Ruprecht-Karls.Univers.t?t Heidelberg Ins.itute for High Energy Phys.cs.NRC Kurchatov Ins.itute (IHEP NRC KI) s.racus. Univers.ty Yandex s.hool of Data Analys.s Aix Mars.ille Univ Laboratoire Leprince-Ringuet CNRs.IN2P3 Ecole Polytechnique Ins.itut Polytechnique de Paris Ins.itute of Phys.cs Ecole Polytechnique Fédérale de Laus.nne (EPFL) Department of Phys.cs Univers.ty of Warwick Centro Bras.leiro de Pes.uis.s.Fís.cas.(CBPF) Imperial College London INFN s.zione di Genova National Univers.ty of s.ience and Technology “MIs.s. I. Phys.kalis.hes.Ins.itut RWTH Aachen Univers.ty INFN s.zione di Pis. INFN s.zione di Cagliari Ins.itute of Nuclear Phys.cs Mos.ow s.ate Univers.ty (s.NP Ms.) Ins.itute of Theoretical and Experimental Phys.cs.NRC Kurchatov Ins.itute (ITEP NRC KI) INFN Laboratori Nazionali di Fras.ati LPNHE s.rbonne Univers.té Paris.Diderot s.rbonne Paris.Cité Univers.ta degli s.udi di Padova Univers.ta e INFN Henryk Niewodniczans.i Ins.itute of Nuclear Phys.cs.Polis. Academy of s.iences s.hool of Phys.cs.and Technology Wuhan Univers.ty Univers.ty of Birmingham Univers.tà di Modena e Reggio Emilia Department of Phys.cs U

A s.arch for the doubly charmed baryon ?cc+with the decay mode ?cc+→Ξc+K-π+is.performed us.ng proton-proton collis.on data at a centre-of-mas. energy of 13 TeV collected by the LHCb experiment from 2016 to 2018, corres.onding to an integrated luminos.ty of 5.4 fb-1. No s.gnificant s.gnal is.obs.rved within the invariant mas. range of 3.6 to 4.0 GeV/c2. Upper limits.are s.t on the ratio R of the production cros.-s.ction times.the total branching fraction of the ?cc+→Ξc+K-π+decay with res.ect to the Ξcc++→Λc+K-π+π+decay. Upper limits.at 95% credibility level for R in the range 0.005 to 0.11 are obtained for diferent hypothes.s.on the ?cc+mas. and lifetime in the rapidity range from 2.0 to 4.5 and trans.ers. momentum range from 4 to 15 GeV/c.

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