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A Patient with Atezolizumab-Induced Autoimmune Diabetes Mellitus Presenting with Diabetic Ketoacidosis

Cardiovascular Innovations and Applications 2021年第3期6卷 45-50页

作者： Sharen Lee gary Tse Cardiovascular Analytics Group Laboratory of Cardiovascular PhysiologyHong KongHKGChina Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of CardiologyTianjin Institute of CardiologySecond Hospital of Tianjin Medical UniversityTianjin300211China Xiamen Cardiovascular Hospital Xiamen UniversityXiamen361015China

Background:Atezolizumab,an immune checkpoint inhibitor,is a humanized monoclonal,anti-programmed death ligand 1(PD-L1)antibody used for the treatment of metastatic urothelial carcinoma that has progressed after *** Presentation:We describe a patient with a known history of urothelial carcinoma who presented with dia-betic ketoacidosis 6 weeks following his second cycle of *** serum lactate level was slightly elevated(2 mM)and hisβ-hydroxybutyrate level was elevated(3.9 mM).High anion gap metabolic acidosis secondary to dia-betic ketoacidosis was *** testing demonstrated hemoglobin A 1c level of 9.9%,positivity for anti-glutamic acid decarboxylase antibody(0.03 nM,reference range<0.02 nM),and suppressed C-peptide level(0.1μg/L,reference range 0.9-7.1μg/L)in the absence of detectable anti-islet antigen 2(IA-2)or anti-insulin *** initial management included cessation of atezolizumab treatment,intravenous sodium chloride administration,and insulin pump infusion,after which metabolic acidosis gradually *** insulin pump was subsequently switched to Protaphane at 18 units before breakfast and 8 units before dinner,together with metformin at 1000 mg twice *** weeks later his medication was changed to human isophane insulin plus neutral insulin(70%/30%;Mixtard 30 HM;26 units/4 units).Linagliptin at 5 mg was added 1 month *** hemoglobin A 1c level declined to 8.1%1 year ***:PD-L1 inhibitors can induce type 1 diabetes,and patients can present with diabetic *** glucose levels should be regularly monitored in patients who are prescribed these medications.

关键词： Atezolizumab diabetic ketoacidosis PD-L1 inhibitors Type 1 diabetes

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SUBSURFACE TEMPERATURE AND ITS RELATION TO DYNAMIC HEIGHT AT 130°E ACROSS THENORTH EQUATORIAL CURRENT

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Chinese Journal of Oceanology and Limnology 1993年第2期11卷 143-148页

作者：曲堂栋 gary Meyers 胡敦欣 Institute of Oceanology Academia Sinica Qingdao 266071 Division of Oceanography CSIRO Hobart Australia

Temperature profiles down to 1500m(CTD) collected by Academia Sinica from 1986 to 1990 are used and discussed in relation to the dynamic heights at130 E across the North Equatorial Current (NEC). An extremely high correlation between subsurface (say at 400 m depth) temperature and dynamic height relative to 1500 db is found, and the corresponding regression relationships suggest a method to estimate gpostrophic circulation from subsurface temperature alone. These suggest that the conclusions from extensive studies on this topic in Australian waters also apply to the NEC region, at least at130 E , thus making the subsurface thermal structure an excellent indicator of the variation of the NEC.

关键词： subsurface temperature dynamic height relation

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Construction and Analysis of an Adapted Spectral Finite Element Method to Convective Acoustic Equations

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Communications in Computational Physics 2016年第6期20卷 1-22页

作者： Andreas Huppe gary Cohen Sebastien Imperiale Manfred Kaltenbacher TU Wien Institute of Mechanics and MechatronicsGetreidemarkt 9/E3251060WienAustria Inria-CNRS-ENSTA Saclay Ile-de-France91120 PalaiseauFrance Inria Saclay Ile-de-France91120 PalaiseauFrance

The paper addresses the construction of a non spuriousmixed spectral finiteelement(FE)method to problems in the field of computational *** a computational scheme for the conservation equations of linear acoustics,the extensiontowards convected wave propagation is *** aeroacoustic applications,the mean flow effects can have a significant impact on the generated soundfield even for smaller Mach *** those convective terms,the initial spectralFE discretization leads to non-physical,spurious ***,a regularizationprocedure is proposed and qualitatively investigated bymeans of discrete eigenvaluesanalysis of the discrete operator in space.A study of convergence and an applicationof the proposed scheme to simulate the flow induced sound generation in the processof human phonation underlines stability and validity.

关键词： Spectral finite elements aeroacoustics perturbation equations

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Nitric oxide: promoter or suppressor of programmed cell death?

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Protein & Cell 2010年第2期1卷 133-142页

作者： Yiqin Wang Chen Chen gary J.Loake Chengcai Chu National Key Laboratory of Plant Genomics and National Centre for Plant Gene Research Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Beijing Forestry University Beijing 100083China Institute of Molecular Plant Sciences School of Biological SciencesUniversity of EdinburghKing’s BuildingsEdinburgh EH93JRUnited Kingdom

Nitric oxide(NO)is a short-lived gaseous free radical that predominantly functions as a messenger and effector *** affects a variety of physiological processes,including programmed cell death(PCD)through cyclic guanosine monophosphate(cGMP)-dependent and-independent *** this field,dominant discoveries are the diverse apoptosis networks in mammalian cells,which involve signals primarily via death receptors(extrinsic pathway)or the mitochondria(intrinsic pathway)that recruit caspases as effector *** plants,PCD shares some similarities with animal cells,but NO is involved in PCD induction via interacting with pathways of *** has both promoting and suppressing effects on cell death,depending on a variety of factors,such as cell type,cellular redox status,and the flux and dose of local *** this article,we focus on how NO regulates the apoptotic signal cascade through protein S-nitrosylation and review the recent progress on mechanisms of PCD in both mammalian and plant cells.

关键词： nitric oxide S-nitrosylation programmed cell death

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Journal of Integrative Plant Biology 2005年第8期47卷 988-997页

作者： Jie CHEN gary E HARMAN Afio COMIS Gen-Wu CHENG School of Agriculture and Biology Shanghai Jiaotong University Shanghai 201101 China Department of Horticultural Science Cornell University New York State Agricultural Experiment Station Geneva NY 14456 USA College of Plant Protection Shenyang Agricultural University Shenyang 110161 China

Induced resistance has been evidenced as one of mechanisms of Trichoderma to control plant diseases, however, no study showed the change of host proteomics in Trichoderma-induced resistance of maize against damping-off caused by Pythium ultimum Trow. The mechanism of Trichoderma harzianum Rifai for controlling maize seedling disease caused by Pythium ultimum Trow was investigated firstly by proteome technique and the result suggested that T. harzianum strain T22 was not only able to promote seedling growth but also protein accumulation. One-dimensional electrophoresis assay showed that more bands appeared on the gel with T22 or T22 combined with P. ultimum （T22 ＋ P. ultimum） treatment than with other treatments. Enzyme assay showed that two chitinases of the root sample were more activated in the treatments with T22 than in the other treatments without T22. Proteins in the seedling roots from the various treatments were separated through protein extraction and 2-D electrophoresis technique. In the seedlings produced from the T22-treated seeds, there were 104 up-regulated proteins and 164 down-regulated proteins relative to the control, and 97 and 150, respectively, aftel treatment with T22 ＋ P. ultimum; however, with P. ultimum alone the values were much lower than with the other two treatments. The correlation coefficient values were 0.72, 0.51 and 0.49 for the comparison of protein spot distribution on gel among control with T22, P. ultimum and T22 ＋ P. ultimum, respectively. So it seemed that P. ultimum infection was more effective than T22 in interfering with the host proteome profile. Furthermore, analysis with MALDITOF-MAS showed that some important proteins associated with defensive reactions were identified in T22 or T22 ＋ P. ultimum treatments, including endochitinase, pathogenesis-related protein PRMS （pathogenesis-related maize seed）, GTP-binding protein, isoflavone reductase and other proteins related to respiration. All those proteins are probably part

关键词： maize inbred proteome Pythium ultimum Trow Trichoderma harzianum

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Current understanding of the molecular mechanisms in Parkinson's disease:Targets for potential treatments

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Translational Neurodegeneration 2017年第1期6卷 256-290页

作者： Panchanan Maiti Jayeeta Manna gary L.Dunbar Field Neurosciences Institute Laboratory for Restorative Neurology Mt.PleasantMI 48859USA Program in Neuroscience Mt.PleasantMI 48859USA Department of Psychology Central Michigan UniversityMt.PleasantMI 48859USA Field Neurosciences Institute St.Mary’s of MichiganSaginawMI 48604USA Department of Biology Saginaw Valley State UniversitySaginawMI 48604USA Department of Physiology University of Tennessee Health Science CenterMemphisTN 38105USA

Gradual degeneration and loss of dopaminergic neurons in the substantia nigra,pars compacta and subsequent reduction of dopamine levels in striatum are associated with motor deficits that characterize Parkinson’s disease(PD).In addition,half of the PD patients also exhibit frontostriatal-mediated executive dysfunction,including deficits in attention,short-term working memory,speed of mental processing,and *** most commonly used treatments for PD are only partially or transiently effective and are available or applicable to a minority of ***,these therapies neither restore the lost or degenerated dopaminergic neurons,nor prevent or delay the disease progression,the need for more effective therapeutics is *** this review,we provide a comprehensive overview of the current understanding of the molecular signaling pathways involved in PD,particularly within the context of how genetic and environmental factors contribute to the initiation and progression of this *** involvement of molecular chaperones,autophagy-lysosomal pathways,and proteasome systems in PD are also *** addition,emerging therapies,including pharmacological manipulations,surgical procedures,stem cell transplantation,gene therapy,as well as complementary,supportive and rehabilitation therapies to prevent or delay the progression of this complex disease are reviewed.

关键词： Parkinson’s disease Neurodegeneration Protein misfolding Molecular chaperones Cell therapy

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A photothermal reservoir for highly efficient solar steam generation without bulk water

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Science Bulletin 2019年第21期64卷 1625-1633页

作者： Xuan Wu Ting Gao Chenhui Han Jingsan Xu gary Owens Haolan Xu Future Industries Institute University of South AustraliaMawson Lakes CampusSA 5095Australia School of Chemistry Physics and Mechanical EngineeringQueensland University of TechnologyBrisbaneQLD 4001Australia

A solid photothermal reservoir is designed to implement solar-steam generation in the absence of bulk *** photothermal reservoir is composed of a water absorbing core encapsulated by a photothermal reduced graphene oxide based aerogel sheet which absorbs light and converts it into heat thus evaporating the stored *** photothermal reservoir is able to store 6.5 times its own weight in water,which is sufficient for one day solar evaporation,thus no external water supplement is *** solar-steam generation,since no bulk water is involved,the photothermal reservoir minimizes heat conduction loss,and maximizes both of the exposed evaporation surface area and net energy gain from the environment,leading to an energy efficiency beyond the theoretical *** extremely high water evaporation rate of 4.0 kg m-2 h-1(normalized to projection area)is achieved in laboratory studies over a cylinder photothermal reservoir with a diameter of 5.2 cm and a height of 15 cm under 1.0 sun *** evaluation of the photothermal reservoir outdoors as part of a desalination device demonstrates a similar evaporation rate where the salinity of the clean water produced is lower than 24 *** the photothermal reservoir shows great potential for real world applications in portable solarthermal desalination.

关键词： Solar-steam generation Photothermal Aerogel Solar-thermal energy

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Intrinsically photosensitive retinal ganglion cells

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Science China(Life Sciences) 2010年第1期53卷 58-67页

作者： gary E.PICKARD Patricia J.SOLLARS School of Veterinary Medicine and Biomedical Sciences University of Nebraska

A new mammalian photoreceptor was recently discovered to reside in the ganglion cell layer of the inner *** intrinsically photosensitive retinal ganglion cells(ipRGCs) express a photopigment,melanopsin,that confers upon them the ability to respond to light in the absence of all rod and cone photoreceptor *** relatively few in number,ipRGCs extend their dendrites across large expanses of the retina making them ideally suited to function as irradiance detectors to assess changes in ambient light *** in ipRGCs appears to be mediated by transient receptor potential channels more closely resembling the phototransduction cascade of invertebrate rather than vertebrate *** convey irradiance information centrally via the optic nerve to influence several *** are the primary retinal input to the hypothalamic suprachiasmatic nucleus(SCN),a circadian oscillator and biological clock,and this input entrains the SCN to the day/night *** contribute irradiance signals that regulate pupil size and they also provide signals that interface with the autonomic nervous system to regulate rhythmic gene activity in major organs of the *** also provide excitatory drive to dopaminergic amacrine cells in the retina,providing a novel basis for the restructuring of retinal circuits by *** we review the ground-breaking discoveries,current progress and directions for future investigation.

关键词： melanopsin circadian rhythms suprachiasmatic nucleus retina pupillary light reflex

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P波随时间衰减:以两条加利福尼亚地震破裂带为例(英文)

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地球物理学报 2005年第4期48卷 851-860页

作者： gary A Henderson Seismological Laboratory Department of Physics University of Toronto Canada

地震预测是地震学研究一个基本目标,而理解地震周期是地震预测的重要环节.遗憾的是,由于地震断层带不但结构复杂,大地震前后短时间内的震源过程更是随时间迅速变化,这些复杂因素使得常规研究方法不再适用.一类特殊的微震成群地发生在主... 详细信息

地震预测是地震学研究一个基本目标,而理解地震周期是地震预测的重要环节.遗憾的是,由于地震断层带不但结构复杂,大地震前后短时间内的震源过程更是随时间迅速变化,这些复杂因素使得常规研究方法不再适用.一类特殊的微震成群地发生在主震断层几乎同一地点上,震源系数几乎相同,近年来地震学界通称其为震群(earthquakemultiplet).本文论证如何将这类特殊的微震作为一组人工震源来阐述美国西部两次大地震(LomaPrieta和MorganHill)的震后弛豫过程.在加利福尼亚LomaPrieta(1989年9月18日,M7.0)及MorganHill(1984年4月24日,M6.2)附近的主震破裂带中就发生了此类震群.其中有两组各包含11个重复地震的震群,分别位于这两个破裂带中,其波形资料质量高,波形及震级变化极小,因而可与实验室条件下的人工震源相比.这些震群地震资料可直接用于计算P波沿波程衰减(即t)的时间性变化,其方法的简单性及结果的精确性都与实验室水平相当.我们的结果显示,每个震群周围分别存在一个异常体,在其各自主震之后的10个月中,该异常体中的P波衰减迅速上升并降落.衰减峰值发生在LomaPrieta地震后2～3周,其震群深度为10.2km.此峰值在MorganHill地震后5～6个月发生,其震群中心深度为2.6km.这两个事例中,t波动峰值都超过此前获得的加利福尼亚大致同一地区t绝对值的100%[1].此结果显示了因同震裂隙张开和震后弛豫过程(如流体移动、裂隙复原及岩石压缩),以及孔隙度和流体饱和度在主震源体部分区域发生的变化.衰减达峰值的时间之显著差异则提示我们,裂隙闭合及伴随的流体移动是负载敏感的,深度越大达峰值越快,反之亦然.如将此方法应用于主震前多重地震的资料,将有望更好地理解最终导致主震断层带大破裂的震前微破裂的物理过程.

关键词：加利福尼亚地震破裂带 P波 Morgan 地震预测人工震源弛豫过程流体移动 1989年 1984年实验室条件实验室水平流体饱和度重要环节地震周期震源过程研究方法美国西部资料质量地震资料中心深度负载敏感方法应用

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Communication,Computation,and Governance:A Multiscalar Vantage on the Prehispanic Mesoamerican World

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Journal of Social Computing 2022年第1期3卷 91-118页

作者： gary M.Feinman David M.Carballo the Negaunee Integrative Research Center Field Museum of Natural HistoryChicagoIL 60605USA Anthropology Archaeologyand Latin American StudiesBoston UniversityBostonMA 02215USA

Writing has often been put forth as one indicator of *** correspondence dovetails with the even broader cross-species expectation that the degrees of social complexity and levels of computational communication should closely *** in a general sense across human cooperative arrangements,a basic relationship between these variables undoubtedly exists,more detailed and fine-grained analyses indicate important axes of ***,our focus is on prehispanic Mesoamerica and the means of computation and communication employed over more than three millennia(ca.1500 BCE-1520 CE).We take a multiscalar and diachronic analytical frame,in which we look at 30 central places,six macroregions,and Mesoamerica as *** unraveling elements of“social complexity”,and decoupling computation from communication,we illustrate that institutional differences in governance had a marked effect on the specific modes and technologies through which prehispanic Mesoamerican peoples communicated across time and *** and spatial scale,though relevant,do not alone determine time/space diversity in media of computational *** article is part of the theme issue“Evolution of Collective Computational Abilities of(Pre)Historic Societies”.

关键词： Mesoamerica archaeology communication computation writing polity scale calendrics Maya Aztec

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