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World Journal of Gastroenterology 2007年第1期13卷 1-7页

作者： gary e Wild Laurie Drozdowski Carmela Tartaglia M Tom Clandinin Alan Br Thomson Department of Medicine Division of Gastroen- terology McGill University Montreal Quebec Department of Anatomy and Cell Biology McGill University Montreal Quebec Canada Division of Gastro- enterology University of Alberta Edmonton Alberta Canada Department of Physiology McGill Univer- sity Montreal Quebec Canada Department of Agriculture Foods and Nutri- tion University of Alberta Edmonton Alberta Canada

Nutrient deficiencies are common in patients with inflammatory bowel disease （IBD）. Both total parenteral and enteral nutrition provide important supportive therapy for IBD patients, but in adults these are not useful for primary therapy. Dietary intervention with omega-3 polyunsaturated fatty acids contained in fish oil may be useful for the care of IBD patients, and recent studies have slyessed the role of PPAr on NFKB activity on the potential beneficial effect of dietary lipids on intestinal function.

关键词： Crohn's disease Ulcerative colitis enteral nutrition Parenteral nutrition Glutamine Fiber Long chain fatty acids

Weak Gravity Conjecture and extremal black holes

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Science China(Physics,Mechanics & Astronomy) 2019年第11期62卷 69-86页

作者： William Cottrell gary Shiu Pablo Soler Department of Physics University of WisconsinMadison WI53706USA Institut fur Theoretische Physik Universitat HeidelbergPhilosophenweg19Heidelberg D-69120Germany

Motivated by the desire to improve our understanding of the Weak Gravity Conjecture, we compute the one-loop correction of charged particles to the geometry and entropy of extremal black holes in 4D. We use the entropy function formalism to extend previous analysis that dealt with neutral particles, and obtain the corrections to the horizon entropy for different regimes of black hole masses. These corrections are small in general. They are furthermore reduced when supersymmetry is present, and disappear in N = 4 supergravity. We provide some speculative arguments that in a theory with only sub-extremal particles, classical reissner-Nordstrom black holes actually possess an infinite microcanonical entropy, though only a finite amount is visible to an external observer, as shown by the horizon entropy computation.

关键词： black holes string theory entropy

Growth and survival characteristics of spa mice

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Animal Models and experimental Medicine 2020年第4期3卷 319-324页

作者： Joline e.Brandenburg Matthew J.Fogarty gary C.Sieck Department of Physical Medicine and rehabilitation Mayo Clinic College of MedicineRochesterMNUSA Department of Pediatric and Adolescent Medicine Mayo Clinic College of MedicineRochesterMNUSA Department of Physiology and Biomedical engineering Mayo Clinic College of MedicineRochesterMNUSA School of Biomedical Sciences The University of QueenslandBrisbaneAustralia Department of Anesthesiology Mayo Clinic College of MedicineRochesterMNUSA

Characterization of growth and survival of mice displaying early onset hypertonic symptoms is critical as these animals are important for research investigating mechanisms and treatments of pediatric conditions associated with hypertonia,such as cerebral ***,most animal models of cerebral palsy reproduce risk factors for developing this condition,with most failing to develop the physical symptoms or failing to survive in the postnatal *** ***-Glrb spa/J(Gly receptor mutation)transgenic mouse(spa mouse),displays symptoms of early onset hypertonia,though little has been reported on growth and survival,with no reports of growth and survival since genotyping became *** found that the majority of spa mice display symptoms by *** mice surviving to weaning,only^9%were spa *** weaning age,spa mice had significantly lower weights than their heterozygote and wild-type *** mice that died after weaning and prior to use in experiments or being culled,48%were spa *** poor growth and decreased survival of spa mice across multiple developmental and adult ages resembled the varied survival rates observed in humans with mild or severe cerebral *** understanding of the expected survival of these mice is helpful for planning breeding and animal numbers for *** to the symptoms and timing of symptom onset,spa mice will be valuable in uncovering mechanisms and long-term effects of early onset hypertonia in order to move toward interventions for these conditions.

关键词： animal models cerebral palsy mice reproduction survival rate

Fresnel incoherent correlation hologram-a review(Invited Paper)

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Chinese Optics Letters 2009年第12期7卷 1134-1141页

作者： Joseph rosen Barak Katz gary Brooker Department of electrical and Computer engineering Ben-Gurion University of the NegevP.O. Box 653 Beer-Sheva 84105 Israel Johns Hopkins University Microscopy Center Montgomery County Campus Advanced Technology Laboratory Whiting School of Engineering 9605 Medical Center Drive Suite 240Rockville MD 20850 USA

Holographic imaging offers a reliable and fast method to capture the complete three-dimensional （3D） information of the scene from a single perspective. We review our recently proposed single-channel optical system for generating digital Fresnel holograms of 3D real-existing objects illuminated by incoherent light. In this motionless holographic technique, light is reflected, or emitted from a 3D object, propagates through a spatial light modulator （SLM）, and is recorded by a digital camera. The SLM is used as a beamsplitter of the single-channel incoherent interferometer, such that each spherical beam originated from each object point is split into two spherical beams with two different curve radii. Incoherent sum of the entire interferences between all the couples of spherical beams creates the Fresnel hologram of the observed 3D object. When this hologram is reconstructed in the computer, the 3D properties of the object are revealed.

关键词： Color holography Digital holographic imaging Holographic techniques Spatial light modulators Three dimensional imaging Zone plates

An overview of the role of neutrophils in innate immunity,inflammation and host-biomaterial integration

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regenerative Biomaterials 2017年第1期4卷 55-68页

作者： Gretchen S.Selders Allison e.Fetz Marko Z.radic gary L.Bowlin Department of Biomedical engineering University of MemphisMemphisTNUSA Department of Microbiology Immunology and BiochemistryUniversity of Tennessee Health Science Center(UTHSC)MemphisTN 38163USA

Despite considerable recent progress in defining neutrophil functions and behaviors in tissue repair,much remains to be determined with regards to its overall role in the tissue integration of *** article provides an overview of the neutrophil’s numerous,important roles in both inflammation and resolution,and subsequently,their role in biomaterial *** function in three primary capacities:generation of oxidative bursts,release of granules and formation of neutrophil extracellular traps(NeTs);these combined functions enable neutrophil involvement in inflammation,macrophage recruitment,M2 macrophage differentiation,resolution of inflammation,angiogenesis,tumor formation and immune system *** exhibit great flexibility to adjust to the prevalent microenvironmental conditions in the tissue;thus,the biomaterial composition and fabrication will potentially influence neutrophil behavior following *** review serves to highlight the neutrophil’s plasticity,reiterating that neutrophils are not just simple suicidal killers,but the true maestros of resolution and regeneration.

关键词： neutrophil tissue engineering NeTosis tissue regeneration host response inflammation

Oxidative desulfurization of fuels using ionic liquids： A review

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Frontiers of Chemical Science and engineering 2015年第3期9卷 262-279页

作者： Hua Zhao gary A. Baker Department of Chemistry and Forensic Science Savannah State University Savannah GA 31404 USA Department of Chemistry University of Missouri-Columbia Columbia MO 65211 USA

extractive oxidation, wherein aromatic sulfur- containing compounds are extracted and subsequently oxidized to their corresponding sulfones, has proven to be one of the most effective desulfurization methods for producing ultra-low sulfur content fuels. As non-volatile and highly designable solvents, ionic liquids （ILs） have attracted considerable attention for the oxidative desulfur- ization of fuels. In this review, we systematically discuss the utility of ILs in catalytic and extractive oxidation, including their role as extractant, catalyst, or both. We also discuss the challenges facing the use of ILs in this regard, including their relatively high cost and excessive viscosity, as well as their efficiency and stability as catalyst.

关键词： oxidative desulfurization ionic liquids extraction fuels petroleum polyoxometalates

Development of Data Sheets for Statistical evaluation of Fatigue Data

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Journal of Iron and Steel research International 2011年第5期18卷 70-78页

作者： gary Marquis Timo Bjrk Lappeenranta University of technology

Instructions were developed for statistical analysis of the laboratory fatigue data step-by-step. Practical cases for solving several questions raised in the treatment of test data,which involved estimation of necessary sample size,verification of the statistical equivalence of the collated sets of data,and determination of characteristic curves in different cases,were given by using the methods and formulae in the document IIW-XIII-2138-06 （best practice guide on the statistical analysis of fatigue data） as a demonstration of various statistical methods of developing a sound procedure for creating reliable calculation rules for the fatigue analysis.

关键词： fatigue verification statistical equivalence

Utility of magnetic resonance imaging in anorectal disease

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World Journal of Gastroenterology 2007年第23期13卷 3153-3158页

作者： Loren Berman gary M Israel Shirley M McCarthy Jeffrey C Weinreb Walter e Longo Department of Surgery Yale University School of Medicine New Haven Connecticut United States Department of radiology Yale University School of Medicine New Haven Connecticut United States

Imaging of both benign and malignant anorectal diseases has traditionally posed a challenge to clinicians, and as a result history and physical exam have been relied on heavily. CT scanning and endorectal ultrasound have become popular in assessment of anatomy and staging of tumors, but have limitations. Magnetic resonance imaging (MrI) has the capability to fill in the gaps left open by more conventional imaging modalities and continues to be promising as the definitive imaging technique in the pelvis, especially with advancement of emerging technologies in this field. A comprehensive review of this topic has been undertaken. Anorectal disease is divided into three broad categories: cancer, fistula/abscess, and pelvic floor disorders. A review of the literature is performed to evaluate the use of MrI and other imaging modalities in these three areas. Preoperative imaging is useful in the evaluation of all three areas of anorectal disease. MrI is an effective tool in delineating anatomy and, when correlating with the specific clinical scenario, is an effective adjunct in clinical decision-making in order to optimize outcome. MrI continues to be a promising and novel approach to imaging various afflictions of the anorectum and the pelvic floor. Its role is more well-established in some areas than in others, and there are still signif icant limitations. As technology advances, MrI will shed more light on a complex anatomical area.

关键词： Magnetic resonance imaging, rectal cancer, Pelvic floor disorders Anal fistula and abscess

The current status of galaxy formation

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research in Astronomy and Astrophysics 2012年第8期12卷 917-946页

作者： Joseph Silk gary A.Mamon Institut d'Astrophysique de Paris (UMr 7095:CNrS&UPMC) 98 bis Boulevard AragoParis 75014France Department of Physics and Astronomy 3701 San Martin DriveThe Johns Hopkins UniversityBaltimore MD 21218USA Beecroft Institute of Particle Astrophysics and Cosmology 1 Keble RoadUniversity of OxfordOxford OX1 3RHUK

Understanding galaxy formation is one of the most pressing issues in cos- mology. We review the current status of galaxy formation from both an observational and a theoretical perspective, and summarize the prospects ... 详细信息

关键词： galaxy: formation -- galaxies: evolution -- galaxies: star formation --galaxies: active

Type Ⅰ interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential

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Zoological research 2018年第1期39卷 3-14页

作者： gary Wong Xiang-Guo Qiu Shenzhen Key Laboratory of Pathogen and Immunity State Key Discipline of Infectious DiseaseShenzhen Third People's HospitalShenzhen Guangzhou 518020China Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Special Pathogens Program National Microbiology LaboratoryPublic Health Agency of CanadaWinnipegManitoba R3E 3R2Canada Department of Medical Microbiology and Infectious Diseases University of ManitobaWinnipegManitoba R3E 0J9Canada

Due to their inability to generate a complete immune response, mice knockout for type I interferon （IFN） receptors （Ifnar-/-） are more susceptible to viral infections, and are thus commonly used for pathogenesis studies. This mouse model has been used to study many diseases caused by highly pathogenic viruses from many families, including the Flaviviridae, Filoviridae, Arenaviridae, Bunyaviridae, Henipaviridae, and Togaviridae. In this review, we summarize the findings from these animal studies, and discuss the pros and cons of using this model versus other known methods for studying pathogenesis in animals.

关键词： Ifnar Mice Animal model Flavivirus Filovirus Arenavirus Bunyavirus Henipavirus Togavirus