Growth and survival characteristics of spa mice

作     者：Joline E.Brandenburg Matthew J.Fogarty Gary C.Sieck Joline E.Brandenburg;Matthew J.Fogarty;Gary C.Sieck

作者机构：Department of Physical Medicine and RehabilitationMayo Clinic College of MedicineRochesterMNUSA Department of Pediatric and Adolescent MedicineMayo Clinic College of MedicineRochesterMNUSA Department of Physiology and Biomedical EngineeringMayo Clinic College of MedicineRochesterMNUSA School of Biomedical SciencesThe University of QueenslandBrisbaneAustralia Department of AnesthesiologyMayo Clinic College of MedicineRochesterMNUSA 

出 版 物：《Animal Models and Experimental Medicine》 (动物模型与实验医学（英文）)

年 卷 期：2020年第3卷第4期

页      面：319-324页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：National Institute on Aging,Grant/Award Number:R01-AG044615 National Heart,Lung,and Blood Institute,Grant/Award Number:R01-HL96750 Mayo Clinic Center for Clinical and Translational Science,Mayo Clinic,Grant/Award Number:UL1TR000135 National Health and Medical Research Council,Grant/Award Number:CJ Martin Fellowship 

主　　题：animal models cerebral palsy mice reproduction survival rate 

摘      要：Characterization of growth and survival of mice displaying early onset hypertonic symptoms is critical as these animals are important for research investigating mechanisms and treatments of pediatric conditions associated with hypertonia,such as cerebral ***,most animal models of cerebral palsy reproduce risk factors for developing this condition,with most failing to develop the physical symptoms or failing to survive in the postnatal *** ***-Glrb spa/J(Gly receptor mutation)transgenic mouse(spa mouse),displays symptoms of early onset hypertonia,though little has been reported on growth and survival,with no reports of growth and survival since genotyping became *** found that the majority of spa mice display symptoms by *** mice surviving to weaning,only^9%were spa *** weaning age,spa mice had significantly lower weights than their heterozygote and wild-type *** mice that died after weaning and prior to use in experiments or being culled,48%were spa *** poor growth and decreased survival of spa mice across multiple developmental and adult ages resembled the varied survival rates observed in humans with mild or severe cerebral *** understanding of the expected survival of these mice is helpful for planning breeding and animal numbers for *** to the symptoms and timing of symptom onset,spa mice will be valuable in uncovering mechanisms and long-term effects of early onset hypertonia in order to move toward interventions for these conditions.