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Jour.al of Envir.nmental Pr.tection 2017年第9期8卷 990-1001页

作者： Scott A. Gr.eco Danielle C. Singer.gary r. bement O’Br.en & Ger. Engineer. Inc. Syracuse New York USA

Incr.asingly, as r.gulator. limits become mor. str.ngent, selenium has become a par.meter.of concer.. Selenium is a natur.lly occur.ing element that is lar.ely mobilized by anthr.pogenic activity such as mining for.fuel and subsequent combustion, metal or. r.fining and pr.cessing, and agr.cultur.l ir.igation. Of concer. is r.moving selenium liquid matr.ces and immobilizing it fr.m leachable solid matr.ces. Chemical r.duction and stabilization using zer. valent ir.n (ZVI) is applicable to both concer.s. The solid matr.x case study is applicable to ash ponds solids or.industr.al bag house dust solids. This paper.pr.sents data for.tr.atment and stabilization of selenium within a solid matr.x using ZVI. The methodology uses an aqueous mediate r.action to pr.mote a stable solid matr.x of non-leachable selenium. The paper.descr.bes matr.x challenges and key var.ables that effected successful tr.atment. Testing with simulated and r.al bag house dust solids wer. used to establish data to suppor. the per.eance of the r.action. The data show that ZVI conver.s ionic selenium to a zer. valent state in the solid matr.x. It was also r.cognized that a fr.ction of ionic selenium may fail to r.act with the ZVI, but the r.sults show that despite the pr.sence of the unr.acted ionic selenium, the toxicity char.cter.stic leachate pr.cedur. (TCLP) r.sults following tr.atment do not exceed the 1 mg/L hazar.ous waste cr.ter.a.

关键词： Bag House Dust Selenium Chemical r.duction Land Disposal r.str.ctions Toxicity Char.cter.stic Leaching Pr.cedur. TCLP Zer. Valent Ir.n

Substr.te topogr.phy as a power.ul tool to modify glial cell biology and inter.ctions

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Neur.l r.gener.tion r.sear.h 2025年第5期20卷 1390-1391页

作者： Pascal Achenbach Haktan Altinova gary A.Br.ok Institute of Neur.pathology RWTH Aachen University Hospital Depar.ment of Neur.sur.er. RWTH Aachen University Hospital Aachen Germany Ber.in State Office for.Health and Social Affair.(LAGeSo) BerlinGermany

Tr.umatic injur.es to the centr.l ner.ous system(CNS) r.sult in disr.ption of the intr.cate networ. of axons which connect functionally r.lated neur.ns that ar. widely distr.buted thr.ughout the br.in and spinal *** nor.al conditions,maintenance of this complex system is str.ctur.lly and functionally suppor.ed by astr.cytes (ACs)and other.glial cells,the pr.cesses of which for. a fr.mewor. sur.ounding neur.nal cell bodies,dendr.tes,axons,and synapses.

关键词： injur.es topogr.phy system

Complement-dependent neur.inflammation in spinal cor. injur.:fr.m pathology to ther.peutic implications

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Neur.l r.gener.tion r.sear.h 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar.El Baba Ali Tfaily Fir.s Kobeissy Juanmar.o Gutier.ez Gonzalez Daniel r.fai Ger.ld r.r.dts Chr.stian Mustr.ph David Gimbel Jonathan Gr.ssber. Daniel L.Bar.ow Matthew F.gary Ali M.Alawieh Depar.ment of Neur.sur.er. Emory University School of MedicineAtlantaGAUSA Depar.ment of Neur.logy Yale UniversityNew HavenCTUSA Center.for.Neur.tr.uma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cor. injur. r.mains a major.cause of disability in young adults,and beyond acute decompr.ssion and r.habilitation,ther. ar. no phar.acological tr.atments to limit the pr.gr.ssion of injur. and optimize r.cover. in this *** the thor.ugh investigation of the complement system in tr.gger.ng and pr.pagating cer.br.l neur.inflammation,a similar.r.le for.complement in spinal neur.inflammation is a focus of ongoing *** this wor.,we sur.ey the cur.ent liter.tur. investigating the r.le of complement in spinal cor. injur. including the sour.es of complement pr.teins,tr.gger. of complement activation,and r.le of effector.functions in the *** study r.levant data demonstr.ting the differ.nt tr.gger. of complement activation after.spinal cor. injur. including dir.ct binding to cellular.debr.s,and or.activation via antibody binding to damage-associated molecular.*** effector.functions of complement have been implicated in spinal cor. injur.,and we cr.tically evaluate r.cent studies on the dual r.le of complement anaphylatoxins in spinal cor. injur. while emphasizing the lack of pathophysiological under.tanding of the r.le of opsonins in spinal cor. *** this pathophysiological r.view,we systematically r.view the differ.nt tr.nslational appr.aches used in pr.clinical models of spinal cor. injur. and discuss the challenges for.futur. tr.nslation into human *** r.view emphasizes the need for.futur. studies to dissect the r.les of differ.nt complement pathways in the pathology of spinal cor. injur.,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the r.le of complement in white matter.degener.tion and r.gener.tion using tr.nslational str.tegies to supplement genetic models.

关键词： complement neur.inflammation neur.plasticity r.gener.tion spinal cor. injur. tar.eted ther.py

Testes extr.cts inhibit hear. contr.ctions in females of the blood-feeding insect, r.odnius pr.lixus

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Insect Science 2010年第4期17卷 386-392页

作者： Jocelyn D. Mar.ens r. gary Chiang Biology Depar.ment Redeemer University College Ancaster Ontario Canada

Myogenic contr.ctions of the hear. of the female blood-feeding insect, r.odnius pr.lixus （Stal）, ar. inhibited by cr.de extr.cts of testes applied dir.ctly to isolated dor.al vessels. Dor.al vessels wer. obser.ed with a ster.o micr.scope and hear. beats timed with a stopwatch. In nor.al r.odnius saline, hear.s contr.ct at 14.8 4- 7.1 beats per.minute （n = 45）. Cr.de extr.cts of the testes and the two male r.pr.ductive accessor. or.ans （the opaque and tr.nspar.nt accessor. glands） wer. pr.par.d fr.m pr.viously fr.zen tissue by homogenizing 5-20 glands in a small glass homogenizer.containing r.odnius saline, centr.fuging for.5 r.in at 2 000 g, and collecting the super.atant. Testes extr.ct as low as 1.0 glands per.mL inhibit contr.ctions wher.as cr.de extr.cts of the opaque or.tr.nspar.nt accessor. glands have no consistent effect. We r.fer.to this car.iac inhibitor.as r.odtestolin （r.odnius testis inhibitor. factor., and discuss its possible effects on the female dur.ng copulation.

关键词： car.iac inhibition copulation hear. beat r.odnius r.odtestolin testis

Like mother. like daughter. her.tability of female r.char.son＇s gr.und squir.el Ur.citellus r.char.sonii cor.isol str.ss r.sponses

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Cur.ent Zoology 2018年第2期64卷 153-163页

作者： Kevin r. BAIr.S-NOVAK Calen r.r.AN Angela r. Fr.EMAN W. gary ANDEr.ON James F, HAr. Depar.ment of Biological Sciences University of Manitoba Winnipeg Manitoba R3T 2N2 Canada Depar.mentof Biology University of Saskatchewan Saskatoon S7N 5E2 Saskatchewan Canada Depar.ment ofAnthr.pology Northwestern University Evanston 60208 Illinois USA Depar.ment of Biological Sciences Kent State University Kent 44242 Ohio USA

Activation of the hypothalamic-pituitar.-adr.nal （HPA） axis liber.tes glucocor.icoids, which pr.vides an acute indication of an individual＇s r.sponse to str.ssor.. The her.tability of the str.ss r.sponse in wild mammals, however. r.mains poor.y documented. We quantified the cor.isol str.ss r.sponse of female r.char.son＇s gr.und squir.els （r.Ss） to handling and physical r.str.int, testing for. （1） the effects of individual age, time of day, and sample latency; （2） r.peatability within individuals; （3） nar.ow-sense her.tability; and （4） differ.nces among individuals owing to potential genetic and/or.envir.nmental effects. We detected a positive linear.r.lationship between baseline plasma cor.isol （BL-cor.isol） concentr.tion and str.ss-induced plasma cor.isol （Sl-cor.isol） concentr.tion that defined each individual＇s cor.isol str.ss r.sponse. BL-cor.isol, SI-cor.isol, and str.ss r.sponse did not differ.accor.ing to the time the sample was taken, or.by subject age. Cor.isol str.ss r.sponse was highly r.peatable within individuals, had a mother.offspr.ng her.tability of h2 =0.40 ± 0.24 （mean ±SE）, full-sibling her.tability of h2s = 0.37 ± 0.71, and half-sibling her.tabil- ity of hHS^2 = 0.75 ± 1.41. Str.ss r.sponses of sibling gr.ups, immediate-family gr.ups, and squir. r.ls within a given ar.a did not differ. wher.as those of individuals fr.m mor. distantly r.lated matr.lines did. Our.r.sults highlight the natur.l var.ability in HPA axis r.activity among individuals by quantifying both BL- and SI-cor.isol levels, demonstr.te par.ial her.tability of the str.ss r.sponse that is not attr.butable to envir.nmental var.ation, and suggest that at least par. of an indi- vidual＇s str.ss r.sponse can be accounted for.by differ.nces in matr.lineal histor..

关键词： glucocor.icoids gr.und squir.el her.tability hypothalamic-pituitar.-adr.nal axis r.activity str.ss r.sponse.

Sper.atids do it differ.ntly! Paip2a--the essential r.gulator.of sper.iogenesis？

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Asian Jour.al of Andr.logy 2011年第1期13卷 122-124页

作者： Eileen A McLaughlin gary r.Hime Ar. Centr. of Excellence in Biotechnology and Development Callaghan NSW 2308 Australia School of Envir.nmental and Life Sciences University of Newcastle Callaghan NSW 2308 Australia Anatomy and Cell Biology University of Melbourne Parkville VIC 3010 Australia

The mechanisms under.inning the latter.stages of sper.iogenesis ar. poor.y under.tood and male ger. cells have been pr.sumed to extensively employ post-tr.n- scr.ptional r.gulator. machiner.,

关键词： Sper.atids Paip2a-the essential

Analyzing stem cell dynamics： use of cutting edge genetic appr.aches in model or.anisms

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Fr.ntier. in Biology 2015年第1期10卷 1-10页

作者： gary r. HIME Nicole SIDDALL Katja HOr.AY Helen E. ABUD Depar.ment of Anatomy and Neur.seienee University of Melbourne VIC 3010 Australia Depar.ment of Anatomy and Developmental Biology Monash University Clayton VIC 3800 Australia

r.gener.tion of many cell types found in adult or.ans r.lies upon the pr.sence of r.latively small pools of undiffer.ntiated stem cells. Initial studies that attempted to isolate stem cells and pr.pagate them in vitr. have been complemented by analysis of stem cells in their.endogenous tissues wher. they ar. subject to a var.ety of r.gulator. cues. This has been facilitated by the advent of new methods for.lineage tr.cing and genetic manipulation of stem cells and their.associated niche cells. The pictur. that is emer.ing is that differ.nt stem cell populations utilize diver.e pr.cesses to ensur. maintenance of the stem cell pool accompanied by pr.duction of cells committed to r.gener.te differ.ntiated cells.

关键词： stem cells Dr.sophila mouse testis intestine lineage tr.cing

r.gulation of cell adhesion in the testis： a new r.le for.p73

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Asian Jour.al of Andr.logy 2014年第6期16卷 799-800页

作者： Helen E Abud gary r.Hime Depar.ment of Anatomy and Developmental Biology Monash University Clayton VIC 3800 Australia Depar.ment of Anatomy and Neur.science University of Melbourne Parkville VIC 3010Australia.

The dr.matic changes that male ger. cells in the adult testis under.o in gene expr.ssion pr.file and mor.hology as they tr.nsition fr.m sper.atogonial stem cells thr.ugh to matur. sper.atozoa is dependent upon their.association with Ser.oli cells. Ser.oli cells ar. cr.cial for.sur.ival and matur.tion of male ger. cells. Two r.cent paper., Holembowski et al？ and Inoue et a13 have descr.bed a sur.r.sing r.le for.the p53 family member. p73, in r.gulation of ger. cell-Ser.oli cell adhesion.

关键词： @@

Classical biological contr.l pr.gr.m for.the mealybug Or.cella acuta in Guangdong Pr.vince, China

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Insect Science 2010年第2期17卷 129-139页

作者： Stephen r. Clar.e Hai-Bin Yu Mu-r.ng Chen gary L. DeBar. Jiang-Hua Sun US Depar.ment of Agr.cultur. Forest Service Forest Health Protection Lufkin Texas USA For.st Pest Contr.l Station of Guangdong Pr.vince Guangzhou China US Depar.ment of Agr.cultur. Forest Service Southern Research Station Athens Geogria2 USA State Key Labor.tor. of Integr.ted Management of Pest Insects and r.dents Institute of Zoology Chinese Academy of Sciences Beijing China

The mealybug Or.cella acuta, native to the southeaster. US, was accidentally intr.duced into slash pine plantations in Guangdong Pr.vince in China in 1988. A classical biological contr.l pr.gr.m was initiated in 1995, and the par.sitoids Allotr.pa or.cellae, Acer.phaus coccois, and Zar.opalus debar.i wer. impor.ed fr.m the US. A total of 19 972 par.sitized mealybugs wer. shipped to China fr.m 1996-2004, fr.m which 15 430 wasps emer.ed, 12 933 of which wer. the thr.e tar.et species. Effor.s to establish a mass-r.ar.ng pr.gr.m for.the par.sitoids in China failed. Five field r.lease sites wer. established, and 6 020 par.sitoids wer. r.leased. Only 118 individuals of the thr.e impor.ed species wer. collected dur.ng establishment checks, although sever.l wasps wer. collected 1-2 year. after.the last par.sitoid r.lease. Over.2 000 Anagyr.s dactylopii, a cosmopolitan par.sitoid, emer.ed fr.m the par.sitized mealybugs collected, a major.ty fr.m the Taishan ar.a near.the site of the or.ginal intr.duction ofO. acuta. To date the impor.ed par.sitoids have failed to establish, and natur.l enemies have not noticeably r.duced mealybug populations.

关键词： Acer.phagus coccois Anagyr.s dactylopii Allotr.pa or.cellae classical biological contr.l Or.cella acuta Zar.opalus debar.i

Tumor.necr.sis factor.α inhibitor.ther.py and fetal r.sk:A systematic liter.tur. r.view

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Wor.d Jour.al of Gastr.enter.logy 2013年第17期19卷 2591-2602页

作者： r.née M Mar.hioni gary r.Lichtenstein Division of Gastr.enter.logy and Hepatology University of Connecticut Health Center Division of Gastr.enter.logy Hospital of the University of Pennsylvania

Tumor.necr.sis factor.α inhibitor. (anti-TNFs) ar. effective in the tr.atment of inflammator. bowel disease (IBD) r.calcitr.nt to conventional medical ther.py. As the peak incidence of IBD over.aps with the pr.me r.pr.ductive year., it is cr.cial to establish phar.acologic r.gimens for.women of childbear.ng age that achieve effective disease contr.l without posing significant fetal har.. A systematic liter.tur. r.view was per.or.ed to identify all human studies with bir.h outcomes data after.mater.al exposur. to infliximab, adalimumab, or.cer.olizumab pegol within 3 mo of conception or.dur.ng any tr.mester.of pr.gnancy. Live bir.hs, spontaneous abor.ions or.stillbir.hs, pr.ter. or.pr.matur. bir.hs, low bir.h weight or.small for.gestational age infants, and congenital abnor.alities wer. r.cor.ed. Fifty selected r.fer.nces identified 472 pr.gnancy exposur.s. The subsequent r.view includes gener.l infor.ation r.gar.ing anti-TNF ther.py in pr.gnancy followed by a summar. of our.findings. The benefits of biologic modalities in optimizing disease contr.l dur.ng pr.gnancy must be weighed against the potential toxicity of dr.g exposur. on the developing fetus. Although pr.mising over.ll, ther. is insufficient evidence to pr.ve absolute safety for.use of anti-TNFs dur.ng pr.gnancy given the limitations of available data and lack of contr.lled tr.als.

关键词： Tumor necr.sis factor.α inhibitor. Pr.gnancy Congenital abnor.alities Safety Infliximab Adalimumab Cer.olizumab