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Structural studies of BaTiO_3:Er^(3+) and BaTiO_3:Yb^(3+) powders synthesized by hydrothermal method

Journal of Rare Earths 2014年第11期32卷 1016-1021页

作者： garrido-hernández a García-Murillo A Carrillo-Romo F de J Cruz-Santiago L A Chadeyron G Morales-Ramírez A de J Velumani S T.A. Post-graduate Student. Instituto Politécnico Nacional CIITEC IPN Cerrada de Cecati S/N. Col. Santa Catarina Azcapotzalco México D.F. C.P. 02250 México D.F México Instituto Politécnico Nacional CIITEC IPN Cerrada de Cecati S/N. Col. Santa Catarina Azcapotzalco México D.F. C.P. 02250 México D.F Departament of Engineering Materials Tecnológico de Estudios Superiores de Coacalco (TESCo) Av. 16 de Septiembre # 54 Cabecera Municipal C.P. 55700 Coacalco de Berriozábal Estado de México Institut de Chimie de Clermont-Ferrand UMR 6296 CNRS / UBP / ENSCCF 24 avenue des Landais BP 80026 63171 Aubière Cedex – France Department of Electrical Engineering (SEES) Centro de Investigación y de Estudios Avanzados del IPN Av. Instituto Politécnico Nacional 2508 Col. San Pedro Zacatenco C.P. 07360 Mexico D.F. Mexico

Erbium and ytterbium doped barium titanate nanopowders were prepared using the hydrothermal method. A barium titanate structure doped with rare earth ions manifested new characteristics and improved the field of application of optical devices such as trichromatic tubes, LCD displays, lamps, and infrared lasers. In this work, BaTiO3：Er3＋ and BaTiO3：Yb3＋ were prepared using barium chloride [BaCl2], titanium butoxide [C16H36O4Ti], erbium chloride [ErCl3] and ytterbium chloride [YbCl3] as precursors. Anhydrous methanol was employed as a solvent. Metallic potassium was used to promote solubility in the system and increase the pH to 13. This method yielded the formation of a predominantly cubic structure in both Er3＋ and Yb3＋ doped BaTiO3 powders. Characteristic bondings of BaTiO3 were observed with FT-IR spectroscopy. The predominantly cubic structure was confirmed by X-ray diffraction and micro-Raman analyses. The particle size（～30 nm） was estimated using the Scherrer equation and X-ray diffraction data. The results were presented and discussed.

关键词： nanopowders hydrothermal BaTiO3:Er3+ BaTiO3:Yb3+ rare earths

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Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero IrisÁlvarez-Merz Jorge hernández-Campano Sergei A.Kirov Jesús M.hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative Medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

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Dendritic spine degeneration:a primary mechanism in the aging process

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Neural Regeneration Research 2025年第6期20卷 1696-1698页

作者： Gonzalo Flores Leonardo Aguilar-hernández Fernado García-Dolores Humberto Nicolini Andrea Judith Vázquez-hernández Hiram Tendilla-Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencias Forenses(INCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto Nacional de Medicina Genómica(INMEGEN) Mexico CityMexico

Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). Consequently, this process involves a wide range of factors, spanning from genetic to environmental factors, and even includes the gut microbiome(GM)(Mayer et al., 2022). All these processes coincide at some point in the inflammatory process, oxidative stress, and apoptosis, at different degrees in various organs and systems that constitute a living organism(Mayer et al., 2022;Aguilarhernández et al., 2023).

关键词： aging process stress

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Habitat use and space preferences of Eurasian Bullfinches(Pyrrhula pyrrhula)in northwestern Iberia throughout the year

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Avian Research 2021年第1期12卷 37-51页

作者： Angel hernández Departamento de Ciencias Agroforestales Area de ZoologiaUniversidad de ValladolidCampus de PalenciaPalenciaEspana Instituto Universitario de Investigacion en Gestion Forestal Sostenible Universidad de ValladolidCampus de PalenciaPalenciaEspana

Background:For all vertebrates in general,a concerted effort to move beyond single season research is vital to improve our understanding of species *** of habitat use and selection by Eurasian Bullfinches(Pyrrhula pyrrhula)is limited with regard to the non-breeding *** date,research on the habitat of the Iberian subspecies iberiae consists of very general *** relation to space use,only broad features are available for the entire distribution range of Eurasian Bullfinches,including ***:In this study,seasonal preferences regarding habitat and space in a population of Eurasian Bullfinches are examined for the first time in the Iberian Peninsula,through direct observation during a six-year *** essential habitat components,substrate selection and perch height were ***:Hedgerows were the key essential habitat component for bullfinches during all ***,small poplar plantations became increasingly important from winter to *** perched mostly in shrubs/trees throughout the year,but there were significant seasonal changes in substrate use,ground and herbs being of considerable importance during *** the year,over half of the records corresponded to feeding,reaching almost 90%in ***,bullfinches perched noticeably lower while *** bullfinches perched markedly higher than females,notably singing males in *** perched at a height not much lower than that of *** all seasons,males tended to feed at greater heights than *** of different ages and sexes were seen bathing in all seasons except ***:Hedgerow habitat in general appeared to be valuable for bullfinches throughout the *** summer and autumn,they selected sites with an abundance of food and shade,as well as shelter,a much-needed requirement for fledglings and moulting *** was usually a close link between the most used

关键词： Habitat use Perch height Pyrrhula pyrrhula iberiae Seasonal variation Substrate selection Water bathing

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Internal dispersal of seed-inhabiting insects by vertebrate frugivores:a review and prospects

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Integrative Zoology 2011年第3期6卷 213-221页

作者： Ángel hernÁndez Department of Agroforestry University of ValladolidPalenciaSpain

The finding that some seed-inhabiting insects can survive passage through the entire digestive tract of seed-dispersing vertebrates is relatively recent,but evidence suggests that it does ***,I document this phenomenon,discuss its qualitative and quantitative dimensions,and offer suggestions for further *** few documented cases that I review include plant species belonging to different families,with varied fleshy fruit types,number of seeds per fruit and seed *** vertebrate frugivores involved include passerines that feed on relatively small fruits,and galliforms,and perissodactyls and primates that feed on larger *** seed-inhabiting insects in-volved are the larvae of seed-infesting wasps,parasitoid wasps and seed-infesting *** phenomenon has been verified in open,rural ecosystems in North America and Southern Europe,and in tropical and subtropical forests in South *** varied scenarios suggest that the qualitative dimension of the phenomenon is considerably greater than known thus far.A simple method for detecting new events is ***,re-search must also focus on the identity and biology of seed-feeding insects of wild fleshy fruits and their *** survival rates of seed-inhabiting insects after vertebrate gut passage are *** phenomenon generally appears to favor insect dispersal.

关键词： digestion-resistant insects endozoochory frugivory tetratrophic interactions tritrophic interactions

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Prognostic impact of inflammatory and nutritional biomarkers in pancreatic cancer

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World Journal of Clinical Oncology 2025年第1期16卷 5-9页

作者： Macarena Teja María I garrido Abrahams Ocanto Felipe Counago Department of Radiation Oncology GenesisCare-San Francisco de Asís University HospitalMadrid 28002Spain Department of Radiation Oncology GenesisCare-Vithas La Milagrosa University HospitalMadrid 28010Spain National Director GenesisCare SpainMadrid 28043Spain Department of Medicine School of MedicineHealth and SportEuropean University of MadridMadrid 28670Spain

Pancreatic cancer is usually associated with a poor *** is the main curative treatment but pancreatic operations are aggressive and new tools that help clinicians to predict surgical and prognostic outcomes are *** et al recently published a retrospective,single centre cohort study evaluating the impact of seven nutritional and inflammatory markers in pancreatic cancer surgical patients:The albumin-to-globulin ratio,prognostic nutritional index(PNI),systemic immune-inflammation index(SII),neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),nutritional risk index,and the geriatric nutritional risk index.A significant correlation was found between the PNI,SII,NLR,and PLR and a hospital discharge of less than 15 *** a univariable analysis,PNI,SII,NLR and PLR were significantly related to recurrence-free survival and,in a multivariable analysis PNI was associated with overall *** meta-analyses corroborate the results in terms of prognosis but individual studies are discordant on their ***,the cut-off values for these markers vary significantly between studies and there are no clinical trials comparing them to identify the most relevant *** are limitations when implementing nutritional and inflammatory biomarkers into clinical practice and further studies are needed in order to answer these questions.

关键词： Inflammatory biomarkers Nutritional biomarkers Pancreatic cancer Prognosis Surgical complications

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Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adriana Cortés Mercedes Lachén-Montes Elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique Santamaría Clinical Neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:Neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

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Topical ocular administration of DPP-Ⅳ inhibitors:a new approach for treating diabetes-induced retinal neurodegeneration

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Neural Regeneration Research 2024年第4期19卷 713-714页

作者： Rafael Simó Cristina hernández Diabetes and Metabolism Research Unit Vall d’Hebron Research Institute(VHIR) Department of Medicine Autonomous University of Barcelona Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas(CIBERDEM) Instituto de Salud CarlosⅢ(ICSⅢ)

Retinal neurodegeneration plays a significant role in the pathogenesis of diabetic retinopathy(DR),the leading cause of preventable *** fact,the American Diabetes Association has defined DR as a highly specific neurovascular complication(Solomon et al.,2017).Therefore,it is no longer acceptable to consider DR as merely a microvascular *** this regard,the term diabetic retinal disease(DRD)has been proposed as a broader term comprising microangiopathy and ***,there are currently no treatments available that directly target the neurodegenerative changes of *** paper will give new insights into the translational research in this field with particular emphasis on glucagon-like peptide 1/dipeptidyl peptidase IV(GLP-1/DPP-IV)inhibitors.

关键词： neurodegeneration ocular insight

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Topical Calendula officinalis *** inflammatory pain through antioxidant,anti-inflammatory and peripheral opioid mechanisms

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Journal of Integrative Medicine 2023年第1期21卷 34-46页

作者： Bárbara B.garrido-Suárez Gabino garrido Addis Bellma Menéndez Nelson Merino Odalys Valdés Nilia de la Paz Aylema Romero Livan Delgado Miguel D.Fernández Octavio Piñeros RenéDelgado-hernández Pharmacology and Toxicology Chemical Analytic and Pharmaceutical Technology LaboratoriesCenter for Pharmaceutical Research and Development(CIDEM)Havana 10600Cuba Department of Pharmacology Institute of Marine Science(ICIMAR)Havana 10300Cuba Department of Pharmaceutical Sciences Faculty of SciencesCatholic University of the NorthAntofagasta 1240000Chile Research Department University of Santiago de CaliCali 760032Colombia Center for Research and Biological Evaluations Institute of Pharmacy and FoodUniversity of HavanaHavana 17100Cuba

Objective The present study evaluated the antinociceptive activity of Calendula officinalis L.(Ca)cream on inflammatory *** Creams with different Ca concentrations were tested for their ability to ameliorate pain-related behavior and edema in rats using formalin test,carrageenan(Cg)-induced acute inflammation model,bradykinin(BK)-induced acute inflammation model,and complete Freund’s adjuvant(CFA)-induced chronic inflammation *** the formalin test,we also examined the implication of peripheral opioid receptors in the antinociceptive mechanisms of Ca cream,by means of Q-naloxone,a peripherally acting nonselective opioid ***,the effects of Ca cream compared with diclofenac on BK-induced edema were examined when the kininase II in tissue was preserved or inhibited by *** local production of redox biomarkers in formalin model,tumor necrosis factor-α(TNF-α)in Cg model and histopathological changes in CFA model were also *** A single application of Ca cream at a dose of 10%or 30%(w/w)decreased the formalin-induced licking/biting behavior during both phases of this test in a Q-naloxone-sensitive *** effect was associated with the reduction of oxidative stress in the injured paw and the edema associated with the later phase of formalin-induced pain.A single application of Ca cream(10%or 30%)reduced paw edema and thermal hypernociception in Cg-induced acute inflammation,corresponding with a local decrease in TNF-α.Ca cream also inhibited BK-induced spontaneous nociceptive behavior and paw inflammation in both paradigms *** applications of Ca cream also decreased CFA-induced chronic inflammation,mechanical hypernociception and histopathological changes in the *** These results reveal the topical antinociceptive and antiedematogenic effects of Ca cream.A modulatory action on peripheral opioid receptors associated with its antioxidant mechanism may be involved,at least in par

关键词： Calendulaofficinalis L. Formalintest Pain Hyperalgesia Inflammation

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Short-and long-term effects of an extreme case of autotomy:does“tail”loss and subsequent constipation decrease the locomotor performance of male and female scorpions?

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Integrative Zoology 2022年第5期17卷 672-688页

作者： Solimary GARCÍA-hernÁndez Glauco MACHADO Programa de Pós-graduação em Ecologia Instituto de BiociênciasUniversidade de São PauloSão PauloBrazil LAGE do Departamento de Ecologia Instituto de BiociênciasUniversidade de São PauloSão PauloBrazil

In many taxa,individuals voluntarily detach a body part as a form to increase their chances of escaping *** defense mechanism,known as autotomy,has several consequences,such as changes in locomotor performance that may affectﬁ*** of the genus Ananteris autotomize the“tail”,which in fact corresponds to the last abdominal *** autotomy,individuals lose nearly 25%of their body mass and the last portion of the digestive tract,including the anus,which prevents defecation and leads to constipation,because regeneration does not ***,we experimentally investigated the short-and long-term effects of tail loss on the locomotor performance of Ananteris *** a short-term experiment,the maximum running speed(MRS)of males and females did not change after ***,the relative mass of the lost tail did not affect the change in MRS after *** a long-term experiment,autotomy had a negative effect on the MRS of males,but not of *** over-fed individuals suffered from severe constipation but were not slower than autotomized normally fed *** conclusion,tail loss has no immediate effect on the locomotor performance of *** long-term decrease in the locomotor performance of autotomized males may impair mate ***,because death by constipation takes several months,males have a long time toﬁnd mates and ***,the prolonged period between autotomy and death by constipation is crucial for understanding the evolution of one of the most extreme cases of autotomy in nature.

关键词： ﬁtness costs maximum running speed sex differences tail loss weight loss

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