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99例纯感觉性卒中患者的临床研究

世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 41-42页

作者： Arboix A. garca-Plata C. garca-Eroles l. 赵睿 Dept. of Neurology Hospital Universitari del SagratCor Universitat de Barcelona Viladomat 288 08029 Dr.BarcelonaSpain

Objective: We report a clinical description of pure sensory stroke based on da ta collected from a prospective acute stroke registry. Methods: From 2500 acute stroke patients includedin a hospital-based prospective stroke registry over a 12-year period, 99 were identified as having pure sensory stroke. Results:Pure sensory stroke accounted for 4.7%of all acute stroke patients, 5.4%of acute is chemic stroke, and 17.4%of lacunar syndromes. Complete hemisensory syndrome was present in 80 patients and incomplete hemisensory syndrome in 19 (cheirooral sy ndrome 12, cheiro-oral-pedal 6, isolated oral syndrome1). The lacunar hypothes is was fulfilled in 88%of *** infarction occurred in 8 pa tients, intracerebral hemorrhage in 3, and stroke of undetermined cause in *** orrhagic pure sensory stroke was diagnosed in 1%of all cases of hemorrhagic str oke (n=270) in the database. Outcome was good (in-hospital mortality 0%, sympt om-free at discharge 41.5 %). After multivariate analysis, absence of disabili ty at discharge, hypertension, diabetes, hyperlipidemia, and thalamic(56.5 %) a nd corona radiata (4 %) locations were clinical and topographic variables signi ficantly associated with pure sensory stroke. Conclusions: Pure sensory stroke i s an infrequent cerebrovascular syndrome, in which the lacunar hypothesis is sup ported. Most patients had thalamic lacunar infarction. Incomplete hemisensory sy ndromes were also caused by a lacunar infarct in 84%of patients. Hemorrhagic pu re sensory stroke accounted only for 3%of the cases. The prognosis is good with striking similarity to other lacunar strokes. There are important differences b etween pure sensory stroke and nonlacunar strokes.

关键词：感觉性腔隙假说急性卒中感觉障碍腔隙性梗死腔隙性卒中辐射冠出血性卒中完全性动脉阻塞

腔隙性卒中患者头痛的临床意义:与梗死部位的关系

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世界核心医学期刊文摘(神经病学分册) 2006年第12期 54-55页

作者： Arboix A. Grau-Olivares M. garca-Eroles l. 朱振中 Dr.Cerebrovascular Division Department of NeurologyHospital Universitari del Sagrat CorViladomat 288E-08029 BarcelonaSpain

Objective.-To assess whether the infarction topography influenced upon the incidence of headache and the likelihood of neurological recovery in lacunar ***.-The relationship between topography of infarction and the incidence of headache as well as the influence of headache on neurological outcome in patients with lacunar stroke are still ***.-In a cohort of 387 patients with neuroimaging proven acute lacunar infarction collected from a prospective hospital-based stroke registry over a 12-year period,43 patients(11.1%)presented with headache within a 72-hour interval of stroke ***.-Headache was more common in deep brain gray matter or brainstem lacunar infarction than in supratentorial white matter lacunar infarction(14.9%vs 8%,P lacunar infarctions in the supratentorial white matter had less frequently absence of limitation at discharge(15.1%vs 25.1%,P lacunar infarction,early neurological recovery decreased from 26.2%to 19.2%when headache was present at stroke *** the multivariate analysis,dysarthria-clumsy hand and absence of headache in deep brain gray matter or brainstem lacunar infarction were independent predictors of favorable ***.-In patients with lacunar infarction,headache at stroke onset was more common in deep brain gray matter or brainstem topographies than in supratentorial white matter *** deep brain gray matter or brainstem lacunar infarctions,early neurological recovery was less likely when headache was present.

关键词：腔隙性梗死脑干脑深部头痛头疼疼痛患者

原发性胆汁性肝硬化中血管生成的证据:一项免疫组织化学的描述性研究

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世界核心医学期刊文摘（胃肠病学分册） 2005年第5期1卷 55-56页

作者： Medina J. Sanz-Cameno P. garca-Buey l. 赵天智

The intrahepatic inflammatory process occurring during primary biliary cirrhosis contributes to bile duct destruction, but the cellular and molecular pathways involved are largely unknown. Furthermore, additional pathogenetic mechanisms may exist. We aimed at evaluating the cellular infiltrate phenotype; the expression of lymphocyte acti vation, antigen recognition and cell-adhesion molecules; the occurrence of hepatic angiogenesis and the molecules involved. Immunohistochemical investigations were performed in frozen liver biopsy sections from primary biliary cirrhosis patients. CD8+and CD69+T cells were predominant in inflammatory infiltrates around damaged cholangiocytes; β2-microglobulin conformational epitope and intercellular adhesion molecule-1 expression were enhanced in bile ducts and hepatocytes. Inflamed portal areas showed vascular cell adhesion molecule-1 up-regulation; formation of tubule-like structures (neovessels) by endothelial cells expressing vascular endothelial-cadherin and CD-31; vascular endothelial growth factor expression in surrounding sinusoidal endothelial cells; and enhanced expression of angiopoietins 1 and 2, their receptor Tie-2 and endoglin, suggesting their involvement in new vascular structure formation. The inflammatory infiltrate in primary biliary cirrhosis shows an increased reactivity for lymphocyte activation, antigen recognition and cell-and vascular-adhesion molecules. Additionally, intrahepatic angiogenesis occurs, involving vascular endothelial growth factor, angiopoietins 1 and 2, Tie-2 and endoglin in neovessel formation.

关键词：描述性研究血管生成免疫组织化学门管区淋巴细胞活化肝窦内皮细胞钙黏蛋白细胞间黏附分子胆管细胞炎性浸润

内镜下胃窦部注射肉毒杆菌毒素治疗肥胖症:一项先导研究结果

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世界核心医学期刊文摘（胃肠病学分册） 2006年第2期2卷 31-32页

作者： garca-Compean D. mendoza-Fuerte E. Martnez J.A. 王志宇 Department of Gastroenterology Facultad de Medicina Hospital Universitario UANL Ave. Madero y Gonzalitos Monterrey N.L. México Mexico

Objectives-The aim of this study was to observe the effects of endoscopic injections of botulinum toxin (BT) in the gastric antrum on body weight and gastric emptying in obese patients. Patients and methods - Obese patients were selected for the study. By endoscopy, 100 U of BT type A was injected into the prepyloric antral gastric wall. Before and after treatment body weight and solid gastric emptying were evaluated. Results - Twelve patients were included into this study. Four and twelve weeks after the treatment median values of body weight and gastric emptying did not show significant changes compared to baseline values: body weight: (- 0.5 kg and - 1.0 kg respectively, P > 0.05) and gastric retention for solids at 90 min (+ 4.5% and + 10.5% respectively, P > 0.05). Abnormal gastric emptying (solid gastric retention at 90 min > 50% ) was observed in 22% of patients after 4 weeks and in 25% after 12 weeks. Conclusions - BT injected into the gastric antrum does not seem to significantly reduce body weight or delay gastric emptying in obese patients.

关键词：肉毒杆菌毒素肥胖症患者胃排空时间胃排空延迟基线值有显著性差异本项

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继发于瘢痕性脑回的枕叶癫痫

世界核心医学期刊文摘(神经病学分册) 2006年第2期 30-31页

作者： Gil-Nagel A. garca Morales I. Jiménez Huete A. 高中宝 Dept. of Neurology Hospital Ruber Internacional La Masó38 Mirasierra 28034 Madrid Spain.Dr

Objective: To analyse clinical and therapeutic aspects of epilepsy secondary to ulegyria in adults. Patients: Out of 1,020 consecutive patients studied at a tertiary care epilepsy centre, eight cases of ulegyria were identified. All patients had comprehensive clinical evaluation, neuropsychological testing, interictal EEG, and brain magnetic resonance imaging (MRI). In addition, five patients had video-EEG monitoring. Ulegyria was confirmed by histological analysis in two patients who had successful epilepsy surgery. Results: All patients had a histor y of perinatal asphyxia. In four of them there was psychomotor developmental del ay. Mean age at onset of seizures was 5.8 years (range first week to 21 years). Brain MRI demonstrated predominant involvement of occipito-parietal cortical an d subcortical areas. This posterior distribution of lesions was also supported b y the presence of auras with occipital and parietal semiology in six patients, a nd signs of visuospatial dysfunction in five. Four patients had medically refrac tory epilepsy and two of them had significant improvement with surgical treatmen t. Conclusions: In this group of adult epileptic patients with ulegyria brain MR I, ictal semiology, and neurological examination are consistent with occipital l obe epilepsy. Most patients have severe epilepsy, but in some of them epilepsy c an be controlled with antiepileptic drugs, while in others surgical treatment ca n be effective. Brain MRI criteria of ulegyria are well established, and in two cases it was possible to confirm their diagnosis with histological analysis.

关键词：枕叶癫痫脑回瘢痕性

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急性胰腺炎患者的心电图异常

世界核心医学期刊文摘（胃肠病学分册） 2006年第2期2卷 53-54页

作者： Rubio-Tapia A. garca-leiva J. Asensio-lafuente E. 赵菊辉 Department of Gastroenterology Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubir n Vasco de Quiroga 15 Tlalpan 14000 Distrito Federal Mexico Dr.

Background: Electrocardiographic abnormalities may be associated with acute pancreatitis (AP). Goals: To describe the electrocardiographic disturbances present in patients with AP and to assess differences in electrolyte and pancreatic enzyme levels among patients with and without these abnormalities. Study: Fifty-one consecutive patients with AP and without pre-existing heart disease underwent a standard 12-lead electrocardiogram (EKG) and a serum electrolyte profile. EKG abnormalities were summarized in terms of frequencies,means, and standard deviations. Electrolyte and enzyme levels were summarized as medians. Differences were analyzed using the Mann-Whitney U test. Results: Twenty-eight patients (55% ) had an abnormal EKG. Non specific changes of repolarization (20% ), sinus tachycardia (12% ), and left anterior hemiblock (10% ) were the most frequent disturbances. Patients with sinus tachycardia had lower levels of phosphorus (2.3 vs. 3.4 mEq/l, P lcium (8.4 vs. 9.1 mg/dl, P levels of potassium and lower levels of phosphorus was found in patients with sinus tachycardia and nonspecific changes of repolarization, respectively. No differences were found in amylase, pancreatic amylase, or lipase among patients with normal and abnormal EKG. Conclusions: More than 50% of the patients with AP had EKG abnormalities, and these changes could be related to electrolyte alterations.

关键词：心电图异常窦性心动过速复极化高血钾心脏病史血电解质酶水平血磷统计分析特异性

重症巴德-基亚里综合征患者的体循环血流动力学、血管作用系统与血容量研究

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世界核心医学期刊文摘（胃肠病学分册） 2006年第10期2卷 45-45页

作者： Hernández-Guerra M. lópez E. Bellot P. J.C.garca-Pagán 陈云茹 Hepatic Hemodynamic laboratory Liver UnitHospital ClinicC/Villarroel 170Barcelona 08036SpainDr

Budd-Chiari syndrome (BCS) causes postsinusoidal portal hypertension, which leads to complications similar to those observed in cirrhosis. However, no studies have investigated whether patients with BCS develop the hyperdynamic circulatory syndrome present in patients with cirrhosis who have portal hypertension. We evaluated systemic and cardiopulmonary hemodynamics, plasma renin activity, aldosterone and norepinephrine levels, and plasma volume in patients with BCS admitted for complications of portal hypertension. BCS patients had mean systemic and cardiopulmonary pressures and cardiac indices that were within the normal range but were significantly different from those of a group of patients with cirrhosis matched by sex, body surface, and liver function (cardiac index 3.1 ±0.7 vs. 4.9 ±1.2 l·min-1·m-2; P lar resistance [SVR] index, 2,189 ±736 vs. 1,377 ±422 dyne·s·cm-5·m-2, P l systemic vascular resistance, BCS patients had activation of the neurohumoral vasoactive systems, as evidenced by increased plasma renin activity, aldosterone and norepinephrine levels (15.0 ±21.5 ng/ml·h, 76.7 ±106.8 ng/dl, 586 ±868 pg/ml; respectively) and plasma volume expansion. The analysis of individual BCS patients identified that 7 of the 21 patients actually had reduced SVR index. These patients had the greatest plasma volume expansion. A significant inverse correlation between plasma volume and SVR index was observed. In conclusion, patients with BCS had activation of vasoactive neurohumoral systems and expanded plasma volume. This outcome was observed even though most of these patients did not exhibit systemic vasodilation and cardiac output was not increased, in marked contrast with what is observed in patients with cirrhosis.

关键词：血流动力学作用系统门脉高压体表面积心脏指数血浆肾素活性循环平均阻力去甲肾上腺素神经体

良性黑色素细胞痣成熟过程中膜型基质金属蛋白酶-1(MT1-MMP)的作用

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世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 58-58页

作者： Pérez l.J. Peas P.F. AtienzarM. garca-Dez A. 任建文 Av Espaa 25 Albacete 02002 Spain

Background: Metalloproteinases (MMPs) are proteins involved in extracellular matrix breakdown and have been implicated in stages of migration and metastasis. MT1-MMP is an MMP anchored to the cell membrane. During maturation, melanocytic nevi penetrate the extracellular matrix and express MMPs. Methods: We studied 10 junctional, 10 compound, and 10 intradermal nevi diagnosed by clinical and histological studies and by performing immunohistochemical study to assess MT1-MMP activity. Results: We found evidence of MT1-MMP expression in melanocytic nevus cells, particularly around the entire border of cell nests. Expression was more intense in junctional nevi and gradually decreased with acquisition of intradermal component and became nonexistent in nevi in the deep dermis. Conclusions: MT1-MMP is expressed in the membrane of nevus cells, with expression greater in nest cells in contact with the extracellular matrix. The intensity of expression correlated inversely with the maturation phase of the nevus, being very high in junctional nevi and low in intradermal nevi.

关键词：黑色素细胞 MT1-MMP 混合痣皮内痣交界痣细胞外基质真皮深层免疫组化法金属蛋白酶低

坎地沙坦对系统性高血压患者冠状动脉血流储备的影响

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世界核心医学期刊文摘（心脏病学分册） 2007年第2期3卷 59-59页

作者： Tomás J.-P. Moya J.-l. Barrios V. A. garca-lledó 罗亮 Department of Cardiology Guadalajara Hospital Donantes de sangre s/n Guadalajara 19002 Spain

背景:高血压患者的输送血管及阻力血管存在结构和功能的改变。在无冠状动脉狭窄时,可通过检测冠状动脉血流储备对冠状动脉微血管功能进行分析。本研究旨在无创性评价坎地沙坦对高血压患者冠状动脉微血管功能的影响。

关键词：冠状动脉血流坎地沙坦阻力血管左室质量指数无创性评价内膜中层厚度超声心动图