检索结果-南通市图书馆

Elevated peripheral levels of receptor-interacting protein kinase 1(RIPK1)and IL-8 as biomarkers of human amyotrophic lateral sclerosis

引用

Signal Transduction and Targeted Therapy 2024年第1期9卷 271-278页

作者： Jun Wei Min Li Zhi Ye Xinqian Hu Xiaoyan He Jia Wang gaofeng chen chengyu Zou Daichao Xu Hongbing Zhang Junying Yuan Yunhong Zha Institute of Neural Regeneration and Repair and Department of Neurology The First College of Clinical Medical ScienceYichang Central HospitalCollege of Basic Medical ScienceChina Three Gorges UniversityHubei Province Clinical Medical Research Center for Rare Diseases of Nervous SystemYichang 443000China Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai Key Laboratory of Aging StudiesShanghai 201210China State Key Laboratory of Common Mechanism Research for Major Diseases Haihe Laboratory of Cell EcosystemDepartment of PhysiologyInstitute of Basic Medical Sciences and School of Basic MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Amyotrophic lateral sclerosis(ALS)is a devastating fatal neurodegenerative disease with no ***-interacting protein kinase 1(RIPK1)has been proposed to mediate pathogenesis of *** has been identified as an old drug that can also inhibit RIPK1 *** conducted a drug-repurposing biomarker study of primidone as a RIPK1 inhibitor using SOD1G93A mice and ALS ***1G93A mice treated with primidone showed significant delay of symptomatic onset and improved motor ***-hundred-sixty-two ALS participants dosed daily with primidone(62.5 mg)completed 24-week follow-up.A significant reduction was showed in serum levels of RIPK1 and IL-8,which were significantly higher in ALS patients than that of healthy controls(P<0.0001).Serum RIPK1 levels were correlated positively with the severity of bulbar symptoms(P<0.05).Our study suggests that serum levels of RIPK1 and IL-8 in peripheral can be used as clinical biomarkers for the activation of RIPK1 in central nervous system in human ALS *** primidone may provide a promising therapeutic strategy for *** effect of primidone for the treatment of other inflammatory diseases may also be considered,since the activation of RIPK1 has been implicated in mediating a variety of inflammatory diseases including COVID-19-associated cytokine release syndrome(CRS).(ChiCTR2200060149).

关键词： RIPK1 diseases Serum

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

球腔内低雷诺数流体中颗粒输运研究进展

引用

力学学报 2024年第5期56卷 1284-1296页

作者：孙壮陈高峰胡安˙德˙巴勃罗蒋玺恺中国科学院力学研究所非线性力学国家重点实验室北京100190 中国科学院大学工程科学学院北京100049 芝加哥大学普利兹克分子工程学院美国芝加哥60637 阿贡国家实验室材料科学部美国莱蒙特60439

受限环境下低雷诺数流体中的颗粒输运与生物、医药、化工和能源等应用密切相关.近年来,球腔内低雷诺数流体中的颗粒输运引起了广泛关注,它在细胞内生命活动和微流控封装技术中发挥着关键作用.为了掌握颗粒输运规律、揭示微观力学机理,... 详细信息

受限环境下低雷诺数流体中的颗粒输运与生物、医药、化工和能源等应用密切相关.近年来,球腔内低雷诺数流体中的颗粒输运引起了广泛关注,它在细胞内生命活动和微流控封装技术中发挥着关键作用.为了掌握颗粒输运规律、揭示微观力学机理,各国学者进行了广泛的理论、数值和实验研究,取得了一系列成果.本文将梳理当前的研究进展,分别从理论模型、数值模拟和实验研究三方面,介绍关于球腔内低雷诺数流体中颗粒输运的重要工作.理论模型方面,主要工作包括刚性无滑移壁面、边界滑移和可变形壁面等情况下单个及多个颗粒输运的研究;数值模拟方面,重要工作包括模拟不同形状颗粒在静止与旋转球腔内的输运,研究颗粒的水动力迁移率与运动轨迹;实验研究方面,相关工作包含水液滴内颗粒三维轨迹、扩散系数的观测,以及利用球腔内颗粒布朗运动来计算受限环境性质的相关研究.通过总结相关成果,旨在为微纳尺度流动与颗粒输运领域的专家学者提供参考.

关键词：低雷诺数流体颗粒输运限域效应

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

商用车的多功能电气实训台架分析

引用

电子技术（上海） 2024年第1期53卷 180-181页

作者：陈高峰湖北工业职业技术学院湖北442000

阐述商用车多功能电气实训台架的特点,通过整车测试、系统级测试、换挡评估、油耗测试、NVH测试和特殊测试的技术实践,让学生全面了解商用车的电气系统,从而提升解决问题的能力。

关键词：多功能电气实训台架整车测试系统级测试

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Motion of a sphere and the suspending low-Reynolds-number fluid confined in a cubic cavity

引用

Theoretical & Applied Mechanics Letters 2022年第4期12卷 251-256页

作者： gaofeng chen Xikai Jiang State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China

Dynamics of a spherical particle and the suspending low-Reynolds-number fluid confined by a cubic cavity were studied *** calculated the particle’s hydrodynamic mobilities along x-,y-,and zdirections at various locations in the *** mobility is largest in the cavity center and decays as the particle becomes closer to no-slip *** was found that mobilities in the entire cubic cavity can be determined by a minimal set in a unit tetrahedron *** vortices in the cavity induced by the particle motion were observed and *** also found that the particle can exhibit a drift motion perpendicular to the external *** of the drift velocity normalized by the velocity along the direction of the external force depends on particle location and particle-to-cavity sizes *** work forms the basis to understand more complex dynamics in microfluidic applications such as intracellular transport and encapsulation technologies.

关键词： Particle dynamics Low-Reynolds-number fluid Confinement Mobility Drift

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Water pumping analysis and experimental validation of beach well infiltration intake system in a seawater source heat pump system

引用

Frontiers in Energy 2015年第3期9卷 335-342页

作者： Huan ZHANG Shu LIU Xuejing ZHENG gaofeng chen School of Environmental Science and Engineering Tianjin University Tianjin 300072 China China Architecture Design and Research Group Beijing 100044 China

Based on energy conservation equation and Darcy＇s law, a model of beach well infiltration intake system applied in a seawater source heat pump system was established. The model consists of the seawater seepage and the heat transfer process. A porous medium model in a software named FLUENT was applied to simulate the seepage and the heat transfer process. This model was also validated by field experiment conducted on the seashore in Tianjin, China. The maximum relative error between simulation results and experimental results was 2.1% （less than 5%）, which was acceptable in engineering applica- tion. The porosity and coefficient of thermal conductivity of the aquifer soil were determined to be 0.49 W/（m. K） and 1.46W/（m.K）, respectively in the simulation. In addition, the influencing factors of pumping water of beach well were also analyzed. The pumping water was found to increase when the distance between the beach well and the impervious boundary becomes longer, when the distance between the beach well and the supplying water source shortens, when the diameter of the beach well enlarges, and the drawdown enlarges.

关键词： water pumping analysis experimental valida-tion infiltration intake system seawater source heat pump

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Carbon emission analysis of a residential building in China through life cycle assessment

引用

Frontiers of Environmental Science & Engineering 2016年第1期10卷 150-158页

作者： Yin ZHANG Xuejing ZHENG Huan ZHANG gaofeng chen Xia WANG School of Environmental Science and Engineering Tianjin University Tianjin 300072 China China Architecture Design & Research Group Beijing 100044 China

In this paper, a quantitative life cycle model for carbon emission accounting was developed based on the life cycle assessment （LCA） theory. A residential building in Sino-Singapore Tianjin Eco-city （Tianjin, China） was selected as a sample, which had been constructed according to the concept of green environmental protection and sustainable development. In the scenario of this research, material production, construction, use and maintenance, and demolition phases were assessed by building carbon emission models. Results show that use and maintenance phase and material production phase are the most significant contributors to the life cycle carbon emissions of a building. We also analyzed some factor influences in LCA, including the thickness of the insulating layer and the length of building service life. The analysis suggest that thicker insulating layer does not necessarily produce less carbon emissions in the light of LCA, and if service life of a building increases, its carbon emissions during the whole life cycle will rise as well but its unit carbon emission will decrease inversely. Some advices on controlling carbon emissions from buildings are also provided.

关键词： life cycle assessment carbon emission factorinfluence analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Energy efficiency and carbon dioxide emissions reduction opportunities in district heating source in Tianjin

引用

Frontiers in Energy 2012年第3期6卷 285-295页

作者： gaofeng chen Xuejing ZHENG Lin CONG School of Environmental Science and Engineering Tianjin UniversityTianjin 300072China

Building a trading market can promote energy conservation provided that the trading method is deter- mined. Energy consumption for heat supply is huge. Tianjin Municipal Government is planning to establish an energy efficiency trading platform for district heating taking into consideration the experience in carbon trading market and specific situation in Tianjin. This paper presented an in-depth analysis of the district heating industry in Tianjin municipality, and identified the potentials of energy saving and carbon dioxide emissions reduction. Since energy efficiency was closely related to different heating source technologies, baselines were determined for boiler plants and thermal power plants respectively. Three scenarios were discussed for baseline determination. 472 boiler plants were surveyed and operational data relating to energy consumption were collected. Through data analysis, 27 boiler plants which have reasonable recorded energy consumption values were chosen as samples. By analyzing the dataset and referring to the related standards, method of determining the baseline for district heating carbon market was established. Finxally, the baseline for boiler plant was determined to be 52.0 kgce/GJ, and that for thermal power plant was 43.0 kgce/GJ in 2011. Carbon abatement against the baselines above was calculated and considerable carbon dioxide emissions reduction could be achieved.

关键词： district heating energy efficiency baseline,carbon abatement

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

MASK:An efficient mechanism to extend inter-domain IP spoofing preventions

引用

Science in China(Series F) 2008年第11期51卷 1745-1760页

作者： LU Xicheng LV gaofeng ZHU PeiDong chen YiJiao School of Computer National University of Defense Technology Changsha 410073 China

IP spoofing hinders the efficiency of DDoS defenses. While recent proposals of IP spoofing prevention mechanisms are weak at filtering spoofing packets due to the complexity in maintaining source IP spaces and the low incentive of deployments. To address this problem, we propose an efficient mechanism to extend the range of inter-domain IP spoofing prevention called MASK. Source MASK nodes inform destination MASK nodes about the source IP spaces and labels of their neighbor Stub-ASes in order to implement the marking and verification of packets towards the Stub-ASes, and limit the number of MASK peers through the propagation of BGP updates so as to reduce the overheads of computing and storing of labels. By utilizing the method of extending the spoofing prevention to Stub-ASes, MASK can not only enlarge the domain of the spoofing prevention service, but also filter spoofing packets in advance. Through analysis and simulations, we demonstrate MASK＇s accuracy and effectiveness.

关键词： DDoS IP spoofing prevention BGP

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

慢性肝病不同肝纤维化阶段的肝脏体积及其病理变化特点

引用

中华肝脏病杂志 2024年第6期32卷 517-524页

作者：朱亭亭李正鑫袁杰黄恺陈高峰国荣芳赵志敏刘成海上海中医药大学附属曙光医院肝病研究所上海201203 上海市中医临床重点实验室上海201203 肝肾疾病病证教育部重点实验室上海201203 上海市浦东新区公利医院上海200130 上海中医药大学附属曙光医院影像医学科上海201203

目的:测量不同肝纤维化程度慢性肝病患者的肝脏整体与分叶体积,并观察患者肝脏微血管、肝细胞消亡与再生等病理改变,以期了解肝纤维化时肝脏宏观体积变化及其与肝组织微观病理的联系。方法:收集同时进行肝活检组织和腹部磁共振成像检查... 详细信息

目的:测量不同肝纤维化程度慢性肝病患者的肝脏整体与分叶体积,并观察患者肝脏微血管、肝细胞消亡与再生等病理改变,以期了解肝纤维化时肝脏宏观体积变化及其与肝组织微观病理的联系。方法:收集同时进行肝活检组织和腹部磁共振成像检查的慢性乙型肝炎、酒精性脂肪肝、自身免疫性肝病、非酒精性脂肪性肝病、药物性肝病的慢性肝病患者53例。采用Masson染色并根据Ishak肝纤维化分期,将患者分为肝纤维化早期(F1~2)、中期(F3~4)和晚期(F5~6)。应用ITK-SNAP软件测量肝脏和脾脏体积。通过CD31免疫组织化学染色反映肝内血管生成,Ki67与肝细胞核因子4α多重荧光免疫组织化学染色反映肝细胞再生,谷氨酰胺合成酶(GS)染色判断肝实质细胞消亡,原位末端标记法观察肝细胞凋亡。Spearman相关性分析肝体积变化与肝组织病理变化之间的关系。结果:随着肝纤维化进展,总肝体积和右肝叶体积逐渐降低(P<0.05),脾脏体积逐渐升高(P<0.05),CD31、GS的表达逐渐增加(P<0.05),Ki67的表达先升高后下降(P<0.05)。CD31阳性率与右肝叶体积(r=-0.609,P<0.001)和总肝体积(r=﹣0.363,P=0.017)呈负相关。Ki67阳性率与右肝叶体积呈正相关(r=0.423,P=0.018),凋亡细胞的阳性率与总肝体积呈显著负相关(r=-0.860,P<0.001)。GS阳性率与右肝叶体积呈负相关(r=﹣0.440,P=0.002),肝细胞消亡数量与右肝叶体积呈负相关(r=﹣0.476,P=0.013)。CD31阳性染色面积与Ki67阳性染色面积呈负相关(r=﹣0.511,P=0.009)。结论:随肝纤维化进展,患者总肝体积与右肝叶体积缩小,主要与肝组织中肝细胞减少与微血管紊乱有关。

关键词：肝纤维化肝体积肝细胞消亡肝再生肝细胞血管生成诊断

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

一贯煎对M1型骨髓巨噬细胞治疗肝硬化大鼠模型效果的影响及其机制分析

引用

临床肝胆病杂志 2024年第8期40卷 1612-1619页

作者：宗梦瑶简迅王丹阳许燕楠郑欣瑞邢飞飞陈高峰陈佳美刘平慕永平上海中医药大学附属曙光医院上海市中医药研究院肝病研究所肝肾疾病病证教育部重点实验室上海市中医临床重点实验室上海201203

目的观察一贯煎对M1型骨髓巨噬细胞(M1-BMDM)治疗2-AAF/CCl4诱导的大鼠肝硬化作用的影响与机制。方法分离BMDM,脂多糖诱导分化为M1-BMDM。雄性Wistar大鼠随机分为正常组(n=5)和造模组(n=45)。造模组大鼠予以50%CCl4每周2次皮下注射。第... 详细信息

目的观察一贯煎对M1型骨髓巨噬细胞(M1-BMDM)治疗2-AAF/CCl4诱导的大鼠肝硬化作用的影响与机制。方法分离BMDM,脂多糖诱导分化为M1-BMDM。雄性Wistar大鼠随机分为正常组(n=5)和造模组(n=45)。造模组大鼠予以50%CCl4每周2次皮下注射。第7周开始,将造模大鼠随机分为模型组(M组)、一贯煎组(YGJD组)、M1-BMDM组、M1-BMDM+YGJD组、索拉非尼组(SORA组),改用30%CCl4皮下注射以维持肝硬化进展,同时以2-AAF灌胃,且饮水中加入CCR2抑制剂,分组干预,9周末取材。观察血清肝功能、肝组织病理、肝组织羟脯氨酸(Hyp)含量、肝星状细胞活化、肝纤维化及炎症相关因子、Wnt信号通路相关分子表达水平等。计量资料多组间比较采用单因素方差分析,进一步两两比较采用LSD-t检验。结果与M组比较,M1-BMDM+YGJD组大鼠血清ALT、AST、TBil水平均明显降低(P值均<0.05),Alb含量显著增加(P<0.05);与M1-BMDM组比较,M1-BMDM+YGJD组血清TBil含量显著降低(P<0.05)、Alb含量显著升高(P<0.05)。与M1-BMDM组比较,M1-BMDM+YGJD组CD68、TNF-α表达显著降低(P<0.05)。与M1-BMDM组比较,M1-BMDM+YGJD组Hyp含量及天狼星红胶原阳性染色面积均显著降低(P值均<0.05)。M1-BMDM+YGJD组非经典Wnt信号通路分子Wnt5a mRNA和蛋白表达均显著低于M1-BMDM组(P值均<0.05),Fzd2 mRNA表达水平显著低于M1-BMDM组(P<0.05),且Wnt4、Wnt5b和Fzd3 mRNA表达水平亦显著降低(P值均<0.05),而经典Wnt信号通路分子β-catenin、LRP5、LRP6、Fzd5和TCF mRNA表达水平均无明显改变。结论一贯煎可提高M1-BMDM对2-AAF/CCl4诱导的大鼠肝硬化的治疗效应,其机制可能与抑制非经典Wnt5a/Fzd2信号通路有关,为中医药协同M1-BMDM治疗肝硬化提供了新思路。

关键词：肝硬化巨噬细胞一贯煎 Wnt信号通路大鼠,Wistar

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：