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Levels of synthetic musk fragrances in human milk from three cities in the Yangtze River Delta in Eastern China

Journal of Environmental Sciences 2011年第6期23卷 983-990页

作者： Xiaolan Zhang gaofeng Liang Xiangying Zeng Jing Zhou Guoying Sheng Jiamo fu Institute of Environmental Pollution and Health School of Environmental and Chemical Engineering Shanghai University Shanghai 200444 China State Key Laboratory of Organic Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China

Synthetic musks are used as additives in many household *** absorption into the human body,they accumulate and their concentrations in human milk reflect both the mother and her infant＇s exposure *** of four synthetic musks,musk xylene（1-tert-butyl-2,6-dimethyl-2,4,6-trinitrobenzene,MX）,musk ketone（4-tert-butyl-2,6-dimethyl-3,5-dinitroacetophenone,MK）,1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[γ]-2-benzopyran（HHCB） and 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4tetrahydronaphthalene（AHTN）,were determined in human milk samples collected from Shanghai,Wuxi,and Shaoxing in Eastern *** four synthetic musks were found in most samples analyzed,with HHCB the dominant component followed by *** median（mean） values for HHCB,AHTN,MX and MK concentrations were 63（82）,5（12）,17（24） and 4（9） ng/g lipid weight,*** data suggested the total synthetic musk contamination was low,and the distribution percentage was HHCB 〉 MX 〉 AHTN ≈ *** relative high ratio of nitro to polycylic musk indicated that nitro musks were still widely *** musk concentrations in these cities were not significantly different from each other（p 〉 0.05）.Principal components score plots were obtained,which showed similar exposure *** amount of total synthetic musks in human milk were not associated with mother＇s age,although HHCB was significantly correlated with AHTN（p 〈 0.05）.Daily ingestion of HHCB,AHTN,MX and MK for infants from human milk were estimated as（2526 ± 2926）,（370 ± 524）,（7391 ± 832）,and（277 ± 462） ng/day,*** doses were 1-2 orders of magnitude below the provisional tolerable daily intakes.

关键词： synthetic musks human milk exposure of infant

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用后含碳耐火材料的再利用研究现状

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耐火与石灰 2020年第6期45卷 26-29,34页

作者：曹雨桐马北越付高峰唐艳东任鑫明东北大学冶金学院沈阳110819

对用后含碳耐火材料再利用的现状进行了总结,并介绍了研究成果以及未来的发展前景。含碳耐火材料的再利用不仅能够有效降低生产成本,还能保护环境,带来一定的经济效益。

关键词：用后含碳耐火材料再利用研究现状

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比较Star-VIBE与T1-VIBE MRI显示周围型肺癌

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中国医学影像技术 2024年第6期40卷 858-862页

作者：江建芹李真真洪琴肖勇周笑徐高峰符益纲胡春洪盐城市第一人民医院影像科江苏盐城224000 苏州大学附属第一医院影像科江苏苏州215006 盐城市第三人民医院核医学科江苏盐城224000

目的比较星形堆叠容积内插屏气(Star-VIBE)与T1-容积内插屏气(T1-VIBE)MRI显示周围型肺癌的价值。方法前瞻性对52例周围型肺癌患者共56个病灶行胸部Star-VIBE和T1-VIBE MR检查。基于2种序列图像观察形态学征象并进行主观评分;测量病灶... 详细信息

目的比较星形堆叠容积内插屏气(Star-VIBE)与T1-容积内插屏气(T1-VIBE)MRI显示周围型肺癌的价值。方法前瞻性对52例周围型肺癌患者共56个病灶行胸部Star-VIBE和T1-VIBE MR检查。基于2种序列图像观察形态学征象并进行主观评分;测量病灶最大径、信噪比(SNR)及对比度噪声比(CNR);以CT为参考,比较Star-VIBE and T1-VIBE MRI显示周围型肺癌的价值。结果Star-VIBE MRI显示毛刺征、分叶征、胸膜凹陷征和晕征优于T1-VIBE(P均0.05)。结论Star-VIBE MRI显示周围型肺癌优于T1-VIBE。

关键词：肺肿瘤磁共振成像前瞻性研究

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Simes制造执行系统的应用

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仪器仪表用户 2020年第7期27卷 93-96页

作者：倪敏付高峰上海自动化仪表有限公司上海200072

主要介绍了采用计算机技术研发SIMES制造执行系统,根据生产需求将整个执行系统分为不同的模块以满足生产排产、生产质量追溯、生产进度监控,库存的管理、维护、查询。此外,还基于TCP协议的Socket网络编程实现AGV物料小车的控制,实现自... 详细信息

主要介绍了采用计算机技术研发SIMES制造执行系统,根据生产需求将整个执行系统分为不同的模块以满足生产排产、生产质量追溯、生产进度监控,库存的管理、维护、查询。此外,还基于TCP协议的Socket网络编程实现AGV物料小车的控制,实现自动化物料运输工作;同时,探讨了采用计算机技术开发工业控制软件的相关技术。

关键词：工业互联网计算机技术工业控制工业生产系统

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Schisandrin B protects PC12 cells by decreasing the expression of amyloid precursor protein and vacuolar protein sorting 35

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Neural Regeneration Research 2012年第9期7卷 652-658页

作者： Mingmin Yan Shanping Mao Huimin Dong Baohui Liu Qian Zhang gaofeng Pan Zhiping fu Department of Neurology Renmin Hospital Wuhan University Wuhan 430060 Hubei Province China Department of Neurosurgery Renmin Hospital Wuhan University Wuhan 430060 Hubei Province China

PC12 cell injury was induced using 20 μM amyloid β-protein 25-35 to establish a model of Alzheimer＇s disease. The cells were then treated with 5, 10, and 25 μM Schisandrin B. Methylthiazolyldiphenyl-tetrazolium bromide assays and Hoechst 33342 staining results showed that with increasing Schisandrin B concentration, the survival rate of PC12 cells injured by amyloid β-protein 25-35 gradually increased and the rate of apoptosis gradually decreased. Reverse transcription-PCR, immunocytochemical staining and western blot results showed that with increasing Schisandrin B concentration, the mRNA and protein expression of vacuolar protein sorting 35 and amyloid precursor protein were gradually decreased. Vacuolar protein sorting 35 and amyloid precursor protein showed a consistent trend for change. These findings suggest that 5, 10, and 25 μM Schisandrin B antagonizes the cellular injury induced by amyloid β-protein 25-35 in a dose-dependent manner. This may be caused by decreasing the expression of vacuolar protein sorting 35 and amyloid precursor protein.

关键词： Schisandrin B PC12 cells amyloid β-protein 25-35 amyloid precursor protein vacuolar protein sorting 35 neural protection

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百菌清在猕猴桃和土壤中残留动态

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湖北林业科技 2015年第5期44卷 27-29页

作者：黄成名程军勇郑莉张海玲苏彩晴付高峰三峡植物园管理处宜昌443111 湖北省林业科学研究院武汉430075

建立气相色谱法测定猕猴桃和土壤中百菌清残留的方法,方法的检出限为0.005 mg·kg-1,通过对百菌清在猕猴桃和土壤中降解动态研究,表明百菌清在猕猴桃和土壤中的降解半衰期为5.74 d和7.76 d,施药后第35 d,猕猴桃中百菌清未检出,土壤中百... 详细信息

建立气相色谱法测定猕猴桃和土壤中百菌清残留的方法,方法的检出限为0.005 mg·kg-1,通过对百菌清在猕猴桃和土壤中降解动态研究,表明百菌清在猕猴桃和土壤中的降解半衰期为5.74 d和7.76 d,施药后第35 d,猕猴桃中百菌清未检出,土壤中百菌清残留量为0.012 mg·kg-1,推荐百菌清在猕猴桃上使用的安全间隔期为35 d。

关键词：百菌清猕猴桃土壤安全间隔期

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High-performance computing of 3D blasting wave propagation in underground rock cavern by using 4D-LSM on TianHe-3 prototype E class supercomputer

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Deep Underground Science and Engineering 2022年第1期1卷 87-100页

作者： Meng fu gaofeng Zhao State Key Laboratory of Hydraulic Engineering Simulation and Safety School of Civil EngineeringTianjin UniversityTianjinChina

Parallel computing assigns the computing model to different processors on different devices and implements it ***,it has broad applications in the numerical simulation of geotechnical engineering and underground engineering,of which models are always *** parallel computing,the computing time or the memory requirements will be reduced by splitting the original domain of the numerical model into many subdomains,which is thus named as the domain decomposition *** this study,a cubic and equal volume domain decomposition strategy was utilized to realize the parallel computing on the distributed memory system of four-dimensional lattice spring model(4D-LSM)based on the message passing *** a more efficient communication strategy introduced,this study aimed at operating an one-billion-particle model on a supercomputer *** preprocessing procedure of the parallelized 4D-LSM was restructured and the particle generation strategy suitable for the supercomputer platform was employed to minimize the time consumption in preprocessing and *** this basis,numerical calculations were performed on TianHe-3 prototype E class supercomputer at the National Supercomputer Center in *** fieldscale three-dimensional blasting wave propagation models were carried out,of which the numerical results verify the computing power and the advantage of the parallelized 4D-LSM in the simulation of large-scale three-dimension ***,the time complexity and spatial complexity of 4D-LSM and other particle discrete element methods were analyzed.

关键词： domain decomposition method lattice spring model parallel computing wave propagation

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Anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab for first-line treatment in advanced natural killer T cell lymphoma

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1665-1674页

作者： Jie Xiong Shu Cheng Xiao Gao Shan-He Yu Yu-Ting Dai Xin-Yun Huang Hui-Juan Zhong Chao-fu Wang Hong-Mei Yi Hao Zhang Wei-Guo Cao Rong Li Wei Tang Yan Zhao Peng-Peng Xu Li Wang Wei-Li Zhao Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Nuclear Medicine Shanghai Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Pathology Shanghai Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Otolaryngology Shanghai Rujin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Radiation Shanghai Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Hematology Navy Medical Center of PLAShanghaiChina Pole de Recherches Sino-Francais en Science du Vivant et Genomique Laboratory of Molecular PathologyShanghaiChina

Natural killer T cell lymphoma(NKTCL)is highly aggressive,with advanced stage patients poorly responding to intensive *** explore effective and safe treatment for newly diagnosed advanced stage NKTCL,we conducted a phase ll study of anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab(NCT04096690).Twenty-two patients with a median age of 51 years(range,24-74)were enrolled and treated with induction treatment of pegaspargase 2500 IU/m2 intramuscularly on day 1 and sintilimab 200 mg intravenously on day 2 for 6 cycles of 21 days,followed by maintenance treatment of sintilimab 200 mg for 28 cycles of 21 *** complete response and overall response rate after induction treatment were 59%(95%Cl,43-79%)and 68%(95%Cl,47-84%),*** a median follow-up of 30 months,the 2 year progression-free and overall survival rates were 68%(95%Cl,45-83%)and 86%(95%Cl,63-95%),*** most frequently grade 3/4 adverse events were neutropenia(32%,n=7)and hypofibrinogenemia(18%,n=4),which were manageable and led to no discontinuation of *** proportion score of PD-L1,peripheral blood high-density lipoprotein cholesterol,and apolipoprotein A-l correlated with good response,while PD-1 on tumor infiltrating lymphocytes and peripheral Treg cells with poor response to pegaspargase plus sintilimab *** conclusion,the chemo-free regimen pegaspargase plus sintilimab was effective and safe in newly diagnosed,advanced stage *** lipid profle and immunosuppressive signature contributed to treatment resistance,providing an alternative therapeutic approach dual targeting fatty acid metabolism and CTLA-4 in NKTCL.

关键词： killer metabolism lymphoma

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核桃新品种‘清香’

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湖北林业科技 2019年第4期48卷 83-84页

作者：付高峰杨尚来张双英高本旺宜昌市林业科学研究所宜昌443001 宜昌三峡大老岭自然保护区管理局宜昌443000

‘清香’核桃是通过引种选育措施选择适宜鄂西地区海拔600~1200m栽培的优良无性系品种,雄先型开花类型,中晚结实类型,坚果品质和丰产性综合评价达到国家丰产标准优级或Ⅰ级标准,抗晚霜、核桃褐斑病、核桃细菌型黑斑病能力强。

关键词：核桃新品种 '清香’

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B1场校正T1 mapping用于鉴别肺癌病理分型及分化程度

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中国医学影像技术 2024年第2期40卷 231-234页

作者：李真真徐高峰符益纲肖勇朱明明周笑史讯江建芹南通大学第六附属医院盐城市第三人民医院核医学科江苏盐城224000 盐城市第一人民医院影像科江苏盐城224000 盐城市第一人民医院核医学科江苏盐城224000

目的观察B1场校正T1 mapping用于鉴别肺癌病理分型及分化程度的价值。方法前瞻性纳入65例肺癌患者共74处病灶,包括低分化49处、中高分化25处,其中腺癌42处、鳞癌14处、小细胞肺癌(均为低分化)18处。采集B1场校正T1 mapping图像;以2种... 详细信息

目的观察B1场校正T1 mapping用于鉴别肺癌病理分型及分化程度的价值。方法前瞻性纳入65例肺癌患者共74处病灶,包括低分化49处、中高分化25处,其中腺癌42处、鳞癌14处、小细胞肺癌(均为低分化)18处。采集B1场校正T1 mapping图像;以2种方法勾画ROI(ROI1、ROI2),观察不同病理分型及不同分化程度肺癌T1值的差异;绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC),评估B1场校正T1 mapping鉴别肺癌病理分型及分化程度的价值。结果不同病理分型肺癌T1值差异均有统计学意义(P均<0.05);小细胞肺癌与其他2种类型肺癌T1值差异均有统计学意义(P均<0.05)。低与中高分化肺癌(鳞癌+腺癌)T1值差异有统计学意义(P均<0.05)。以ROI1 T1值=1 524.21 ms为截断值,其鉴别低与中高分化肺癌(鳞癌+腺癌)的AUC为0.698,敏感度为64.50%,特异度为76.00%;而以ROI2 T1值=1 630.68 ms为截断值,其AUC为0.676,敏感度为54.80%,特异度为80.00%。结论 B1场校正T1 mapping有助于鉴别肺癌病理分型及分化程度。

关键词：肺肿瘤病理学磁共振成像 T1 mapping 前瞻性研究

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