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Nano Research 2016年第6期9卷 1630-1638页

作者： gaofei hu Juan Tang Xilin Bai Suying Xu Leyu Wang State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029 China

Copper sulfide （Cu7S4） nanoparticles coated with an ultra-high payload （N5.0 ~ 107 fluorine atoms per particle） of fluorinated ligands （oleylamine functionalized 3,5-bis（trifluoromethyl）benzaldehyde, 19FOAm） exhibited a single intense 19F magnetic resonance （MR） signal and efficient near infrared photothermal performance in water medium. In vivo assessment revealed strong 19F MR signals at cancerous lesions and effective inhibition of tumor growth after photothermal treatment, indicating the great potential of these fabricated nanoprobes for simultaneous 19F MR imaging and photothermal therapy.

关键词： 19F magnetic resonance imaging photothermal therapy

Organic Nanoprobes for Fluorescence and ^19F Magnetic Resonance DuaI-Modality Imaging

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Chinese Journal of Chemistry 2018年第1期36卷 25-30页

作者： Minmin Xu Chang Guo gaofei hu Suying Xu Leyu Wang State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029 China

Multimodal imaging techniques have been demonstrated to be greatly advantageous in achieving accurate diagnosis and gained increasing attention in recent decades. Herein, we present a new strategy to integrate the complementary modalities of I9F magnetic resonance imaging （19F MRI） and fluorescence imaging （FI） into a polymer nanoprobe composed of hydrophobic fluorescent organic core and hydrophilic fluorinated polymer shell. The alkyne-terminated fluorinated copolymer （Pn） of 2,2,2-trifluoroethyl acrylate （TFEA） and poly（ethylene glycol） methyl ether acrylate （PEGA） was first prepared vie atom transfer radical polymerization （ATRP）. The PEGA plays an important role in both improving ^19F signal and modulating the hydrophilicity of Pn. The alkynyl tail in Pn is readily conjugated with azide modified tetra-phenylethylene （TPE） through click chemistry to form azo polymer （TPE-azo-Pn）. The core-shell nanoprobes （TPE-P3N） with an average particle size of 57.2±8.8 nm are obtained via self-assembly with ultrasonication in aqueous solution. These nanoprobes demonstrate high water stability, good biocompatibility, strong fluorescence and good ^19F MRI performance, which present great potentials for simultaneous fluorescence imaging and ^19F-MR imaging.

关键词： organic nanoprobes, ^19F magnetic resonance imaging fluorescence imaging dual-modality imaging

Monodisperse Upconversion NaYF4 Nanocrystals： Syntheses and Bioapplications

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Nano Research 2011年第7期4卷 685-694页

作者： Mingliang Deng Yingxin Ma Sheng huang gaofei hu Leyu Wang State Key Laboratory of Chemical Resource Engineering Chemistry Department School of Science Beijing University of ChemicalTechnology Beijing 100029 China

A facile strategy using cheap and readily available precursors has been successfully developed for the synthesis of rare-earth doped hexagonal phase NaYF4 nanocrystals with uniform shape and small particle size as well as strong photoluminescence. Due to their optical properties and good biocornpatibility, these multicolor nanocrystals were successfully used as a bio-tag for cancer cell imaging. This novel synthetic method should also be capable of extension to the synthesis of other fluoride nanocrystals such as YF3 and LaF3.

关键词： Upconversion luminescence NaYF4 nanocrystals cell imaging

The mechanism and therapy of aortic aneurysms

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Signal Transduction and Targeted Therapy 2023年第3期8卷 963-982页

作者： Jianing Gao huanhuan Cao gaofei hu Yufei Wu Yangkai Xu Hongtu Cui Hong S.Lu Lemin Zheng The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine School of Basic Medical SciencesKey Laboratory of Molecular Cardiovascular Science of Ministry of EducationNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesBeijing Key Laboratory of Cardiovascular Receptors ResearchHealth Science CenterPeking University100191 BeijingChina Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesKey Laboratory of Molecular Cardiovascular ScienceMinistry of EducationBeijing Key Laboratory of Cardiovascular Receptors ResearchResearch Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular DiseasesChinese Academy of Medical Sciences100191 BeijingChina Department of Physiology Saha Cardiovascular Research CenterUniversity of KentuckySouth LimestoneLexingtonKY 40536-0298USA

Aortic aneurysm is a chronic aortic disease affected by many *** it is generally asymptomatic,it poses a significant threat to human life due to a high risk of *** of its strong concealment,it is difficult to diagnose the disease in the early *** present,there are no effective drugs for the treatment of *** intervention and endovascular treatment are the only *** current studies have discovered that inflammatory responses as well as the production and activation of various proteases promote aortic aneurysm,the specific mechanisms remain *** are further exploring the pathogenesis of aneurysms to find new targets for diagnosis and *** better understand aortic aneurysm,this review elaborates on the discovery history of aortic aneurysm,main classification and clinical manifestations,related molecular mechanisms,clinical cohort studies and animal models,with the ultimate goal of providing insights into the treatment of this devastating *** underlying problem with aneurysm disease is weakening of the aortic wall,leading to progressive *** not treated in time,the aortic aneurysm eventually *** aortic aneurysm is a local enlargement of an artery caused by a weakening of the aortic *** disease is usually asymptomatic but leads to high mortality due to the risk of artery rupture.

关键词： aortic diagnosis drugs treatment

Peak compression technique in high-performance liquid chromatography

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Chinese Science Bulletin 2009年第16期54卷 2805-2809页

作者： WEI YuXia WANG Lin XIAO ShengYuan QING Hong Zhu Yong hu gaofei DENG YuLin School of Life Science and Technology Beijing Institute of Technology Beijing 100081 China

Peak compression technique based on the difference of the solute migration velocity in two different mobile phases was described theoretically and confirmed using benzaldehyde and 4-hydroxyquinoline (4-HQ) as model compounds. After peak compression, the peak compression factors (the ratio of peak width at half-height under non-compression and that under compression condition) of benzaldehyde and 4-HQ were 0.19 and 0.13, respectively. By this application of the peak compression technique to the mixture, both enhanced peak height and good separation were obtained in one run cycle. This peak compression technique was introduced to determine benzaldehyde from semicarbazide-sensitive amine oxidase-catalyzed enzymetic reaction in order to illustrate the applicability of this technique to the real sample. As a result, the peak was compressed effectively, and 4.94-fold, 19.3-fold and 5.74-fold enhancement in peak height, plate number and signal to noise ratio were also achieved, respectively.

关键词：压缩技术高效液相色谱模型化合物脲甲醛迁移速度羟基喹啉压缩条件运行周期

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Al(Ⅲ)-槲皮素配合物的光谱分析

分析化学 2006年第8期34卷 1125-1128页

作者：林天乐严宝珍胡高飞北京化工大学理学院北京化工大学理学院北京100029

采用UV和IR分析手段,研究在甲醇溶剂酸性和中性条件下,槲皮素(3,3,′4,′5,7-五羟基黄酮)与A l(Ⅲ)形成配合物的构型、反应配比及在配位反应过程中配体分子中各个配位点的配位能力大小及优先配位的顺序。实验结果表明:在酸性介质中,槲... 详细信息

采用UV和IR分析手段,研究在甲醇溶剂酸性和中性条件下,槲皮素(3,3,′4,′5,7-五羟基黄酮)与A l(Ⅲ)形成配合物的构型、反应配比及在配位反应过程中配体分子中各个配位点的配位能力大小及优先配位的顺序。实验结果表明:在酸性介质中,槲皮素与A l(Ⅲ)所形成配合物的反应配比为A l(Ⅲ)∶Q=1∶1,其配位点为3-羟基-4-酮,配位构型中心为A l(Ⅲ)与一个槲皮素分子形成五元环四配位的配合物。在中性介质中发生两步配位反应,第一步配位反应发生在3-羟基-4-酮配位点其反应配比为1∶2,配位构型为中心A l(Ⅲ)与两个槲皮素分子形成两个五元环之间四配位的配合物;第二步配位反应发生在3,′4′-二羟基配位点其反应配比为2∶1,两个A l(Ⅲ)离子分别在上述两个配位点与一个槲皮素分子形成五元环四配位构型的配合物。

关键词：槲皮素(3,3′,4′,5,7-五羟基黄酮) Al(Ⅲ)配合物配位构型光谱表征

美国专利的反等同性原则——PC Connector Solutions LLC 案评析

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电子知识产权 2006年第1期 53-56页

作者：胡高飞蒋显荣长沙理工大学法学院

等同性原则（the Doctrine of Equivalents）是美国专利制度中的一项重要制度，是指在专利侵权诉讼中虽然被控侵权产品或方法没有被涉案专利的权利要求书的技术要素所完全覆盖，即被控产品或方法不构成字面侵权。但被控产品或方法与权... 详细信息

等同性原则（the Doctrine of Equivalents）是美国专利制度中的一项重要制度，是指在专利侵权诉讼中虽然被控侵权产品或方法没有被涉案专利的权利要求书的技术要素所完全覆盖，即被控产品或方法不构成字面侵权。但被控产品或方法与权利要求书的技术要素的区别是非实质性的，那么被控产品或方法电构成专利侵权。这一理论来源于约一个世纪前的Winans ***一案，最高法院及下级巡回法院一直采用这一原则，并且在适当的情况下继续适用，美国现代等同理论是1950年Graver Tank＆Mf *** Air Products Co．案确立的。

关键词： Solutions 美国专利等同 Products 专利侵权诉讼侵权产品权利要求书 PC 技术要素最高法院

蒺藜果实中C_(21)甾体类化合物结构解析

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北京化工大学学报（自然科学版） 2010年第4期37卷 103-107页

作者：刘颖陈光胡高飞喻长远北京化工大学生命科学与技术学院北京100029 北京化工大学理学院北京100029

采用柱层析等分离方法,从蒺藜(TribulusterrestrisL.)果实乙醇提取液的正丁醇萃取层中,分离到两种化合物。通过核磁共振、酸水解、薄层检测等方法鉴定了它们的结构。这两种化合物都是C21甾体类化合物,分别为3-O-β-lycotetraosyl3β-hyd... 详细信息

采用柱层析等分离方法,从蒺藜(TribulusterrestrisL.)果实乙醇提取液的正丁醇萃取层中,分离到两种化合物。通过核磁共振、酸水解、薄层检测等方法鉴定了它们的结构。这两种化合物都是C21甾体类化合物,分别为3-O-β-lycotetraosyl3β-hydroxy-5α-pregn-16-en-20-one(Ⅰ)和3β-hydroxy-5α-pregn-16(17)en-20-one-3-O-β-D-xylopyr-anosyl(1→2)-[β-D-xylopyranosyl-(1→3)]-β-D-glucopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-galacto-pyranoside(Ⅱ)。其中化合物Ⅰ在蒺藜科首次发现,化合物Ⅱ在蒺藜中首次发现。

关键词：蒺藜 C21甾体类核磁共振酸水解

模拟微重力效应引起大鼠脑氧化应激与Na^+,K^+-ATP酶表达下调

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化学通报 2010年第10期73卷 943-948页

作者：胡高飞朱圣华马莹周筠邓玉林北京理工大学生命学院北京100081 北京化工大学理学院北京100029

采用地基模拟微重力效应的大鼠吊尾模型重现了微重力环境导致的氧化应激现象。对脑组织中OH自由基及丙二醛含量测定结果表明,吊尾组大鼠脑纹状体及海马均较其对照组显著性升高,反映了脑中发生了明显的氧化应激。通过比较蛋白质组学方法... 详细信息

采用地基模拟微重力效应的大鼠吊尾模型重现了微重力环境导致的氧化应激现象。对脑组织中OH自由基及丙二醛含量测定结果表明,吊尾组大鼠脑纹状体及海马均较其对照组显著性升高,反映了脑中发生了明显的氧化应激。通过比较蛋白质组学方法测定了纹状体突触蛋白的差异表达情况,发现鉴定到的所有ATP酶的表达均发生下调。这些结果表明,微重力效应的影响与氧化应激增强、Na+,K+-ATP酶表达或活性下降密切相关,为进一步探究微重力环境的作用机制及其对于生理系统造成的其它损伤研究提供了依据。

关键词：氧化应激比较蛋白质组学Na+ K+-ATP酶模拟微重力效应

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习近平法治思想融入地方工科院校思政课路径

湖南工程学院学报（社会科学版） 2024年第2期34卷 21-26页

作者：胡高飞田娟秀湖南工程学院马克思主义学院湖南湘潭411104 湖南工程学院信息科学与工程学院湖南湘潭411104

习近平法治思想融入地方工科院校思政课,对丰富思政课内容体系、增强大学生政治认同、提升大学生道路自信和文化自信、培养德法兼备的现代化高素质人才有重要意义。近年来,将习近平法治思想融入地方工科院校思政课取得了一定成绩,但也... 详细信息

习近平法治思想融入地方工科院校思政课,对丰富思政课内容体系、增强大学生政治认同、提升大学生道路自信和文化自信、培养德法兼备的现代化高素质人才有重要意义。近年来,将习近平法治思想融入地方工科院校思政课取得了一定成绩,但也存在诸多亟待解决的问题。在解决融入路径上,重点从改革教学管理、构建融入课程体系、优化教学方法、完善保障体系四个维度构建起“大思政”格局。

关键词：习近平法治思想地方工科院校思政课