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Neuroscience Bulletin 2021年第5期37卷 720-724页

作者： Ying Luan Richard Salvi Lijie Liu Chunqiang Lu Yun Jiao Tianyu Tang Haiqing Liu gao-jun teng Jiangsu Key Laboratory of Molecular and Functional Imaging Department of RadiologyZhongda HospitalMedical School of Southeast UniversityNanjing 210009China Center for Hearing and Deafness University at BuffaloState University of New YorkBuffalo 14214USA Department of Physiology Medical College of Southeast UniversityNanjing 210009China

Dear Editor,Approximately 500 million individuals suffer from hearing loss worldwide. The number of hearing-impaired individuals is estimated to increase to 900 million by 2050. The etiology of hearing loss is complex.

关键词： impaired auditory complex.

New First-line Immunotherapy-based Therapies for Unresectable Hepatocellular Carcinoma: A Living Network Meta-analysis

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Journal of Clinical and Translational Hepatology 2024年第1期12卷 15-24页

作者： Jian-Jian Chen Zhi-Cheng Jin Biao Luo Yu-Qing Wang Rui Li Hai-Dong Zhu gao-jun teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjingJiangsuChina

Background and Aims:Several first-line immune checkpoint inhibitor(ICI)-based combination therapies have been identified for unresectable hepatocellular carcinoma(uHCC).This network meta-analysis(NMA)aimed to provide the most updated evidence about the preferred first-line ICI-based regimens for ***:A comprehensive literature search was performed in various databases from database inception to May *** phase 3 trials evaluating first-line single-agent ICIs,molecular-target agents(MTAs),or their combinations in uHCC were *** main endpoints were overall survival(OS)and progression-free survival(PFS).Pooled effect estimates were calculated using a random effects model within the frequentist *** analyses based on etiology were also ***:Twelve trials at low risk of bias with 8,275 patients comparing 13 treatments were *** with atezolizumab plus bevacizumab was comparable to sintilimab plus IBI305[hazard ratio(HR):1.16;95%confidence interval(CI):0.80–1.68]and camrelizumab plus apatinib(HR:1.06;95%CI:0.75–1.51).The combination therapies,apart from atezolizumab plus cabozantinib in OS and durvalumab plus tremelimumab in PFS,had higher P-score than single-agent MTAs or *** survival benefits were associated with a high risk of adverse events leading to treatment *** proportion of patients with hepatitis B virus-related HCC receiving ICIs combinations might positively correlate with survival advantages(R2=0.8039,p=0.0155).Conclusion:This NMA demonstrated that atezolizumab plus bevacizumab remains the stand of care and confers comparable survival benefits to sintilimab plus IBI305 and camrelizumab plus apatinib in first-line therapy for *** optimal treatment algorithms should consider efficacy,safety,and etiology.

关键词： Hepatocellular carcinoma Systemic therapy Immunotherapy Molecular targeted therapy Tyrosine protein kinase inhibitors Overall survival

Gd-EOB-DTPA-enhanced magnetic resonance imaging for focal liver lesions in Chinese patients:a multicenter,open-label,phase Ⅲ study

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Hepatobiliary & Pancreatic Diseases International 2013年第6期12卷 607-616页

作者： Meng-Su Zeng Hui-Yi Ye Liang Guo Wei-jun Peng Jian-Ping Lu gao-jun teng Josy Breuer Yi Huan Ping Li Jian-Rong Xu Chang-Hong Liang Department of Radiology Zhongshan HospitalFudan UniversityNo.180 Fenglin Road Departmentof Radiology General Hospital of PLA Department of Radiology First Affiliated HospitalSoochowUniversity Department of Radiology Cancer HospitalFudan University Department of Radiology Changhai HospitalSecond Military MedicalUniversity Department of Radiology Zhongda HospitalSoutheast University Bayer HealthCare Bayer Schering Pharma AG Department of Radiology Xijing HospitalFourth Military MedicalUniversity Bayer HealthCare CompanyLtd Department of Radiology RenjiHospitalShanghai Jiaotong University Department of Radiology Guangdong General Hospital

BACKGROUND:Contrast agents help to improve visibility in magnetic resonance(MR)***,owing to the large interstitial spaces of the liver,there is a reduction in the natural contrast gradient between lesions and healthy *** study was undertaken to evaluate the efficacy and safety of the liverspecific MR imaging contrast agent gadoxetate disodium(GdEOB-DTPA)in Chinese ***:This was a single-arm,open-label,multicenter study in patients with known or suspected focal liver lesions referred for contrast-enhanced MR *** imaging was performed in 234 patients before and after a single intravenous bolus of Gd-EOB-DTPA(0.025 mmol/kg body weight).Images were evaluated by clinical study investigators and three independent,blinded *** primary efficacy endpoint was sensitivity in lesion ***:Gd-EOB-DTPA improved sensitivity in lesion detection by 9.46%compared with pre-contrast imaging for the average of the three blinded readers(94.78%vs 85.32%for Gd-EOB-DTPA vs pre-contrast,respectively).Improvements in detection were more pronounced in lesions less than ***-EOB-DTPA improved diagnostic accuracy in lesion ***:This open-label study demonstrated that Gd-EOB-DTPA improves diagnostic sensitivity in liver lesions,particularly in those smaller than 1 ***-EOB-DTPA also significantly improves the diagnostic accuracy in lesion classification,and furthermore,Gd-EOB-DTPA is safe in Chinese patients with liver lesions.

关键词： gadoxetate disodium magnetic resonance imaging liver focal liver lesions

Re-evaluating Transarterial Chemoembolization Failure/Refractoriness:A Survey by Chinese College of Interventionalists

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Journal of Clinical and Translational Hepatology 2021年第4期9卷 521-527页

作者： Bin-Yan Zhong Wan-Sheng Wang Shen Zhang Hai-Dong Zhu Lei Zhang Jian Shen Xiao-Li Zhu gao-jun teng Cai-Fang Ni Department of Interventional Radiology the First Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjingJiangsuChina

Background and Aims:The recognition of transarterial chemoembolization(TACE)failure/refractoriness among Chinese clinicians remains *** an online survey conducted by the Chinese College of Interventionalists(CCI),the aim of this study was to explore the recognition of TACE failure/refractoriness and review TACE application for hepatocellular carcinoma(HCC)treatment in clinical ***:From 27 August 2020 to 30 August 2020 during the CCI 2020 annual meeting,a survey with 34 questions was sent by email to 264 CCI clinicians in China with more than 10 years of experience using TACE for HCC ***:A total of 257 clinicians participated and responded to the *** participants agreed that the concept of“TACE failure/refractoriness”has scientific and clinical significance(n=191,74.3%).Nearly half of these participants chose TACE-based combination treatment as subsequent therapy after so-called TACE failure/refractoriness(n=88,46.1%).None of the existing TACE failure/refractoriness definitions were widely accepted by the participants;thus,it is necessary to re-define this concept for the treatment of HCC in China(n=235,91.4%).Most participants agreed that continuing TACE should be performed for patients with preserved liver function,presenting portal vein tumor thrombosis(n=242,94.2%)or extrahepatic spread(n=253,98.4%),after the previous TACE treatment to control intrahepatic lesion(s).Conclusions:There is an obvious difference in the recognition of TACE failure/refractoriness among Chinese clinicians based on existing *** work should be carried out to re-define TACE failure/refractoriness.

关键词： Hepatocellular carcinoma TACE Failure Refractoriness Survey

Biological effects of low-dose-rate irradiation of pancreatic carcinoma cells in vitro using ^(125)I seeds

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World Journal of Gastroenterology 2015年第8期21卷 2336-2342页

作者： Zhong-Min Wang Jian Lu Li-Yun Zhang Xiao-Zhu Lin Ke-Min Chen Zhi-Jin Chen Fen-Ju Liu Fu-Hua Yan gao-jun teng Ai-Wu Mao Department of Radiology Ruijin Hospital Luwan Branch Shanghai Jiao Tong University School of Medicine Institution of Molecular Imaging Southeast University Nanjing 210009 China Department of Radiology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Soochow University School of Medicine Department of Radiobiology School of Radiological Medicine and Protection Soochow University Institution of Molecular Imaging Southeast University Department of Interventional Radiology Shanghai St. Luke’s Hospital

AIM:To determine the mechanism of the radiationinduced biological effects of 125I seeds on pancreatic carcinoma cells in ***:SW1990 and PANC-1 pancreatic cancer cell lines were cultured in DMEM in a suitable ***’s model of iodine-125(125I)seed irradiation was *** vitro,exponential phase SW1990,and PANC-1cells were exposed to 0,2,4,6,and 8 Gy using 125I radioactive seeds,with an initial dose rate of 12.13c Gy/h.A clonogenic survival experiment was performed to observe the ability of the cells to maintain their clonogenic capacity and to form ***-cycle and apoptosis analyses were conducted to detect the apoptosis percentage in the SW1990 and PANC-1 *** synthesis was measured via a tritiated thymidine(3H-Td R)incorporation *** continuous low-dose-rate irradiation with 125I radioactive seeds,the survival fractions at 2 Gy(SF2),percentage apoptosis,and cell cycle phases of the SW1990 and PANC-1 pancreatic cancer cell lines were calculated and ***:The survival fractions of the PANC-1 andSW1990 cells irradiated with 125I seeds decreased exponentially as the dose *** significant difference in SF2 was observed between SW1990 and PANC-1 cells(0.766±0.063 vs 0.729±0.045,P<0.05).The 125I seeds induced a higher percentage of apoptosis than that observed in the control in both the SW1990and PANC-1 *** rate of apoptosis increased with increasing radiation *** percentage of apoptosis was slightly higher in the SW1990 cells than in the PANC-1 ***-dependent G2/M cellcycle arrest was observed after 125I seed irradiation,with a peak value at 6 *** the dose increased,the percentage of G2/M cell cycle arrest increased in both cell lines,whereas the rate of DNA incorporation *** the 3H-Td R incorporation experiment,the dosimetry results of both the SW1990 and PANC-1cells decreased as the radiation dose increased,with a minimum at 6 *** were no significant differences in the do

关键词： 125I radioactive seeds Biological effects Pancreat

Percutaneous vertebroplasty: technical considerations

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中国介入影像与治疗学 2005年第3期2卷 219-223页

作者： gao-junteng Shi-chengHE DepartmentofRadiology Zhong-DaHospitalSoutheastUniversityNanjing210009China

Percutaneous vertebroplasty (PVP) is a relative new interventional technique, which is widely used in treatment of vertebral collapse caused by vertebral neoplasms and osteoporotic compression fractures. The general technical considerations of PVP techniques are discussed based on authors’ experience obtained over 400 patients in the past years in this article, including preparation of PMMA, instrument of PVP, guidance and puncture approaches, and technique of the procedure, etc. The conclusion is that PVP is a safe procedure if the physicians handle it properly.

关键词：经皮手术 PVP 手术方法 PMMA

Prognostic nomogram on admission predicting progression for patients with nonsevere COVID-19

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Fundamental Research 2021年第2期1卷 111-116页

作者： Zhi Wang Bin-Yan Zhong Hui Dai Qiu-Zhen Xu Wei-Bin Yang Xin Zhang Chuan-jun Xu Jin-Er Shu Biao Shi Chu-Hui Zeng Cheng Li Jian-Song Ji Yong-Gang Li gao-jun teng Jiangsu Key Laboratory of Molecular and Funetional Imaging Deparment of RadiologyZhongda HospitalSoutheast UntversityNanjing Jiangsu Province 210009China Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu Province 215006China Department of Radiology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu Province 215006China Institute of Medical Imaging Soochow UniversitySuzhouJiangsu Province 215006China Department of Radiology Lishui Central Hospital Wenzhou Medical CollegeLishuiZhejiang Province 323000China Department of Medical Imaging The Fourth People's Hospital of HuaianHuaianJiangsu Province 223002China Department of Radiology the Second Hospital of NanjingNanjing University of Chinese MedicineNanjingJiansu Province 210003China Deprtment of Radiology Jinhua Hospial of Zhejiang UntversityJinhuaZhejiang Province 321001China CT Depertment Bengbu First People's HospitalBengbu Medical CollegeBengbuArhui Province 233000China

The present study aimed to establish a prognostic nomogram to stratify high-risk patients with Coronavirus Disease 2019(COVID-19)who progressed from the nonsevere condition on admission to severe during *** multicenter retrospective study included patients with nonsevere COVID-19 on admission from Jan 10,2020 to Feb 7,*** the training cohort,independent risk factors associated with disease progression were identified by univariate and multivariate *** prognostic nomogram was established and then validated externally using *** study included 351 patients(293 and 58 in the training and validation cohorts,respectively),with 27(9.2%)and 5(8.6%)patients progressed,*** the training cohort,older age(OR 1.036,95%Cl 1.000-1.073),more lobes involved on chest CT(OR 1.841,95%Cl 1.117-3.035),comorbidity present(OR 2.478,95%Cl 1.020-6.018),and lower lymphocyte count(OR 0.081,95%Cl 0.019-0.349)were identified as independent risk *** prognostic nomogram was established in the training cohort with satisfied external prognostic performance(C-index 0.906,95%Cl 0.806-1.000).In conclusion,older age,comorbidity present,more lobes involved on chest CT,and lower lymphocyte count are independent risk factors associated with disease progression during hospitalization for patients with nonsevere COVID-19.

关键词： COVID-19 Severe disease Progression Nomogram Risk factor

Clinical practice of transarterial chemoembolization for hepatocellular carcinoma:consensus statement from an international expert panel of International Society of Multidisciplinary Interventional Oncology(ISMIO)

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Hepatobiliary Surgery and Nutrition 2021年第5期10卷 661-671页

作者： Jian Lu Ming Zhao Yasuaki Arai Bin-Yan Zhong Hai-Dong Zhu Xiao-Long Qi Thierry de Baere Uei Pua Hyun Ki Yoon David C.Madoff gao-jun teng International Society of Multidisciplinary Interventional Oncology(ISMIO) Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjingChina State Key Laboratory of Oncology in Southern China GuangzhouChina Minimally Invasive&Interventional Department Cancer CenterSun Yat-sen UniversityGuangzhouChina Department of Diagnostic Radiology National Cancer CenterTokyoJapan Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySuzhouChina CHESS Frontier Center First Hospital of Lanzhou UniversityLanzhouChina Gustave Roussy-Cancer Campus VillejuifFrance Department of Radiology Tan Tock Seng HospitalNational University of SingaporeSingaporeSingapore Department of Radiology and Research Institute of Radiology University of Ulsan College of MedicineAsan Medical CenterSeoulKorea Department of Radiology and Biomedical Imaging Section of Interventional Radiology and Department of Internal MedicineSection of Medical OncologyYale School of MedicineNew HavenCTUSA 不详

Importance:Transarterial chemoembolization(TACE)has been associated with a wide range of practice variations for hepatocellular carcinoma(HCC)between the East and the *** considerable ambiguity may lead to the heterogeneous quality in treatment and have a negative impact on the role of TACE in the overall multidisciplinary HCC treatment ***:It may be a good start to establish a guideline worldwide to have this consensus from experts who represent east and west,although it does not cover all aspects of *** Review:An international expert panel on TACE is convened to cluster the expert’s opinions and summary a standard *** panel committee consist of leading physicians in TACE on HCC from USA,France,Japan,Singapore,Korea,China,and so *** first-round face-to-face consensus meeting was held during in Nanjing,China in October *** second-round conference for revision of the consensus was held during the Annual Meeting of Chinese College of Interventionalists in August 2020 by a hybrid format of a Webinar and roundtable *** several on-line revisions,the final manuscript was approved by all members of the panel in june ***:The consensus statements were organized into the following categories:patients’selection,performing the procedure,TACE outcomes,repeat TACE,TACE failure/refractory,and TACE-based combination *** and Relevance for Reviews:More and more evidences have showed the better outcomes with strategy of combined TACE with other local therapies such as *** most-recently developing strategy of combined TACE with PD-1/PD-L1 plus tyrosine kinase inhibitor(TKI)agents has shined a light to the HCC patients,especially to those with high risk of tumor recurrence after treatment or TACE failure/refractory.

关键词： Transarterial chemoembolization(TACE) hepatocellular carcinoma(HCC) consensus

EngMedicine:A community of engineering and medicine

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EngMedicine

EngMedicine 2024年第1期1卷 1-2页

作者： gao-jun teng Interventional Radiology and Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNurturing Center of Jiangsu Province for State Laboratory of AI Imaging&Interventional Radiology(Southeast University)NanjingChina Basic Medicine Research and Innovation Center of Ministry of EducationZhongda HospitalSoutheast UniversityState Key Laboratory of Digital Medical EngineeringNanjingChina

It is generally acknowledged that in the future,medicine will be shaped by scientific and technical advances made through a wide range of related *** is because,in most cases,complex problems in healthcare cannot be addressed successfully by a single *** exaggeration,engineering has played the most important role among these related disciplines over the past century.

关键词： shaped engineering medicine

Revolutionizing breast cancer detection:Advances in fluorescent probe technology

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Nano Research 2025年第1期18卷 653-674页

作者： Qian gao Lin Tang jun Zhan Yiyuan Xue Feng Luo State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China Emergency Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Prosthodontics West China School of StomatologySichuan UniversityChengdu 610041China

With the increasing incidence of breast cancer globally,there is an urgent demand for enhanced diagnostic and therapeutic *** comprehensive review explores advancements in fluorescent probe technology for breast cancer imaging and early *** probes offer unparalleled sensitivity and specificity in detecting cancer biomarkers,enabling early diagnosis and delineation of tumor margins during *** categorize these probes into molecular,nano,ratiometric,the second near-infrared window(NIR-II),and multifunctional varieties,each with unique capabilities for targeting specific cancer *** review highlights recent innovations in probe design,emphasizing their applications in pathogenesis studies,drug development,precision medicine,and fluorescence-guided *** their promising clinical potential,challenges such as safety,biomarker targeting accuracy,system compatibility,and clinical translation *** these hurdles is crucial for the integration of fluorescent probes into standard cancer care,aiming to improve treatment outcomes and patient quality of life.

关键词： breast cancer fluorescent probes imaging early diagnosis biomarker