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Journal of Forestry Research 2015年第2期26卷 405-415页

作者： Biao Zhang Ji-xi gao gao-di xie Chun-xia Lu Institute of Geographical Sciences and Natural Resources Research Chinese Academy of Science Nanjing Institute of Environmental Sciences Ministry of Environmental Protection

We propose an eco-service provision unit method for estimating the benefit and spatial differences of forests in controlling soil erosion.A total of 197 eco-service provision units were grouped on 1424.43 km2 of forest according to differences in vegetation,slope,soil,and *** amount of soil conservation and its economic value were *** forests in Anji County prevent4.08 9 105 tons of soil from eroding annually,thereby avoiding 1.36 9 104 tons of nutrient loss（on-site cost） and preventing 149 tons of nutritive elements from entering water systems（off-site cost）.From an economic perspective,the soil nutrient conservation in the forests of Anji County generated an annual benefit of 43.37 million RMB（Chinese Currency,6.20 RMB = US$1）.On average,each hectare of ecological forest contributed up to 436 RMB annually because of soil *** complexes with higher rainfall intensity,such as broadleaf forest and red soil on slope gradients [25°,contributed the highest soil conservation *** study identified and quantified the dominant contributors and magnitudes of soil conservation provided by *** information can benefit decision making regarding differentiated ecological compensation policies.

关键词： Soil erosion and conservation Eco-service provision unit(ESPU) Rainfall erosivity Soil erodibility Universal Soil Loss Equation(USLE)

PDR合并玻璃体积血的玻璃体手术时机对术后远期疗效的影响

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国际眼科杂志 2017年第9期17卷 1738-1740页

作者：高宁邸瑢谢安明樊小娟西安交通大学第一附属医院眼科中国陕西省西安市710061

目的:探讨增生性糖尿病视网膜病变(proliferative diabetic retinopathy,PDR)合并玻璃体积血患者的玻璃体切除手术时机与疗效。方法:回顾性分析我院2012-02/2014-05收治的PDR合并玻璃体积血行玻璃体切除手术患者。依据玻璃体积血病程分... 详细信息

目的:探讨增生性糖尿病视网膜病变(proliferative diabetic retinopathy,PDR)合并玻璃体积血患者的玻璃体切除手术时机与疗效。方法:回顾性分析我院2012-02/2014-05收治的PDR合并玻璃体积血行玻璃体切除手术患者。依据玻璃体积血病程分为三组,病程3mo为C组(25眼)。所有患者玻璃体腔注射雷珠单抗后1~2wk行23G玻璃体切除手术,术中或术后补充或完成全视网膜激光光凝术。术前存在晶状体混浊的患者联合超声乳化+人工晶状体植入术,如术中填充硅油者待Ⅱ期硅油取出术中植入人工晶状体。术后随访时间24~42(平均28.7)mo,观察术中并发症(术中出血、医源性裂孔),术后并发症(玻璃体再次出血、新生血管性青光眼),黄斑水肿情况以及最佳矫正视力。结果:术前患者的基线资料组间比较,DR分期在三组之间存在统计学差异(P=0.033),其余各项基线资料三组间均无统计学差异(P>0.05)。末次随访时三组间视力比较存在统计学差异(P0.05)。末次随访视力达到0.5及以上者在A、B、C组中分别为41%、23%、0;视力0.05)。术后再次玻璃体积血、再次手术、黄斑水肿、视神经萎缩,新生血管性青光眼发生率三组患者间比较差异无统计学意义(P>0.05)。结论:PDR合并玻璃体积血早期行玻璃体切除术视力预后优于延迟手术的患者。

关键词：增生性糖尿病视网膜病变玻璃体出血手术时机

活性炭负载铁钴电催化氧化焦化废水生化尾水的研究

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环境污染与防治 2017年第4期39卷 356-361页

作者：李飞贞高康乐解迪李雪王海东梁文艳北京林业大学环境科学与工程学院北京市水体污染源控制技术重点实验室北京100083 中冶集团建筑研究总院有限公司北京100088

采用浸渍-焙烧法制备了负载铁钴复合催化元素的活性炭(Fe-Co/GAC)粒子电极。X射线衍射、场发射扫描电子显微镜及能谱仪、N_2吸附脱附曲线等分析表明:负载的催化组分是Fe_3O_4和钴铁氧体(CoFe_2O_4)的混合晶型;Fe和Co元素在颗粒活性炭(G... 详细信息

采用浸渍-焙烧法制备了负载铁钴复合催化元素的活性炭(Fe-Co/GAC)粒子电极。X射线衍射、场发射扫描电子显微镜及能谱仪、N_2吸附脱附曲线等分析表明:负载的催化组分是Fe_3O_4和钴铁氧体(CoFe_2O_4)的混合晶型;Fe和Co元素在颗粒活性炭(GAC)表面元素的质量分数分别为7.4%和3.2%;GAC负载前后吸附行为没发生明显变化。以Fe-Co/GAC作为粒子电极,使用两级串联电催化反应装置处理焦化废水生化尾水,结果表明,在两级反应装置水力停留时间都为20min、电流都为0.2A时,第一、二级反应装置出水COD分别在75.8~79.1、42.6~44.8mg/L,平均去除率分别达到54.4%和74.2%,处理效果相对于GAC提高了10.5百分点。同时,不同电流组合条件表明,两级反应装置的电流条件存在最佳匹配关系,适当降低第一级反应装置电流至0.2A,并适当增加第二级反应装置电流至0.6A,可获得较佳的COD去除效果,以及较低的能耗。

关键词：电催化氧化铁钴复合粒子电极活性炭焦化废水

FHL2 deficiency aggravates Candida albicans infection through decreased myelopoiesis

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Science China Life Sciences 2025年

作者： Rongmei gao Kanchao Chen Yimin Wang Rongxia Guo Xiaoyu Zhang Peng Wu Weili Wang Qingxiang Huang Xuemei xie Shangda Yang Yanling Lü Qian Ren Fei Liu Song Chen Fengxia Ma Tao Cheng Hui Cheng State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College CAMS Center for Stem Cell Medicine PUMC Department of Stem Cell and Regenerative Medicine

Hematopoiesis is a finely tuned process that generates all blood cell types through self-renewal and differentiation, which is crucial for maintaining homeostasis. Acute infections can prompt a hematopoietic response known as emergency myelopoiesis. In this study, using a Candida albicans (C. albicans) infection model, we demonstrated for the first time that disruption of Fhl2 led to increased fungal burden,heightened inflammatory response and reduced survival rates. Impaired myeloid hematopoiesis and immune cell production were evident, as proved by the decreased numbers of hematopoietic stem and progenitor cells (HSPCs) and granulocytes in the bone marrow of Fhl2-deficient mice. In conclusion, FHL2 regulated emergency myelopoiesis in response to C. albicans, affecting the host’s defense against pathogens.

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Characteristics of alcoholic liver disease and predictive factors for mortality of patients with alcoholic cirrhosis

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Hepatobiliary & Pancreatic diseases International 2013年第6期12卷 594-601页

作者： Yan-di xie Bo Feng Yan gao Lai Wei Peking University People's Hospital Peking University Hepatology Institute Beijing Key Laboratory of Hepatitis C and Immuno-therapy for Liver Disease

BACKGROUND:Alcoholic liver disease is one of the major chronic liver diseases *** aim of the study was to describe the clinical characteristics of alcoholic liver disease and to compare the predictive values of biochemical parameters,complications,Child-Turcotte-Pugh score,model for end-stage liver disease(MELD)score and discriminant function score for the mortality of in-hospital or 3-month after discharge of patients with alcoholic cirrhosis(AC).METHODS:A retrospective record review and statistical analysis were performed on 205 consecutive patients with the discharge diagnosis of alcoholic liver *** models were used to predict the mortality of patients with *** number of variceal hemorrhage,infection,hepatic encephalopathy and hepatocellular carcinoma was analyzed as"numbers of complications".Model 1 consisted of creatinine,white blood cell count,international normalized ratio and"numbers of complications".Model 2 consisted of MELD *** 3included"numbers of complications"and MELD ***:The risk of developing AC was significant for patients with alcohol consumption of higher than 80 g/d(OR=2.807,Pdicting inhospital mortality of models 1,2 and 3 was 0.950,0.886 and 0.911(all Pdicting the 3-month mortality of models 1,2 and 3 was 0.867,0.878 and0.893(all Pdictive value than Child-TurcottePugh or discriminant function score for patients with AC,and model 1 or 3 is better than model 2.

关键词： alcoholic liver disease model for end-stage liver disease mortality prognostic factors risk factors

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我国药品强制许可制度存在的问题及对策

中华医学图书情报杂志 2017年第6期26卷 36-40页

作者：高迪谢靖凡韩娟娟柴慧婷顾金辉中国医学科学院病原生物学研究所北京100730 厦门大学科技处福建厦门361005 国家卫生和计划生育委员会北京100044

面对全球公共健康的严峻形式,《多哈宣言》赋予WHO成员国处理公共健康危机时,具有使用药品专利强制许可的权利。虽然我国已基本建立药品专利强制许可制度,但是在实际工作中存在实施效力较低、行政主管部门职责不清、制药企业对有关规定... 详细信息

面对全球公共健康的严峻形式,《多哈宣言》赋予WHO成员国处理公共健康危机时,具有使用药品专利强制许可的权利。虽然我国已基本建立药品专利强制许可制度,但是在实际工作中存在实施效力较低、行政主管部门职责不清、制药企业对有关规定了解不足等诸多问题,需要改进、完善有关法律规定和相关制度,切实提高药物可及性。

关键词：专利法强制许可公共卫生健康

Identification of Reference Genes for Normalizing Quantitative Real-Time PCR in Urechis unicinctus

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Journal of Ocean University of China 2018年第3期17卷 614-622页

作者： BAI Yajiao ZHOU di WEI Maokai xie Yueyang gao Beibei QIN Zhenkui ZHANG Zhifeng Key Laboratory of Marine Genetics and Breeding of Ministry of Education College of Marine Life SciencesOcean University of China

The reverse transcription quantitative real-time PCR(RT-qPCR) has become one of the most important techniques of studying gene expression. A set of valid reference genes are essential for the accurate normalization of data. In this study, five candidate genes were analyzed with ge Norm, Norm Finder, Best Keeper and ?Ct methods to identify the genes stably expressed in echiuran Urechis unicinctus, an important commercial marine benthic worm, under abiotic(sulfide stress) and normal(adult tissues, embryos and larvae at different development stages) conditions. The comprehensive results indicated that the expression of TBP was the most stable at sulfide stress and in developmental process, while the expression of EF-1-α was the most stable at sulfide stress and in various tissues. TBP and EF-1-α were recommended as a suitable reference gene combination to accurately normalize the expression of target genes at sulfide stress; and EF-1-α, TBP and TUB were considered as a potential reference gene combination for normalizing the expression of target genes in different tissues. No suitable gene combination was obtained among these five candidate genes for normalizing the expression of target genes for developmental process of U. unicinctus. Our results provided a valuable support for quantifying gene expression using RT-qPCR in U. unicinctus.

关键词： reference gene RT-qPCR sulfide stress tissue developmental process Urechis unicinctus

Least Squares Model Averaging for Two Non-Nested Linear Models

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Journal of Systems Science & Complexity 2023年第1期36卷 412-432页

作者： gao Yan xie Tianfa ZOU Guohua Department of Statistics College of ScienceMinzu University of ChinaBeijing 100081China Faculty of Science Beijing University of TechnologyBeijing 100124China School of Mathematical Sciences Capital Normal UniversityBeijing 100048China

This paper studies the least squares model averaging methods for two non-nested linear *** is proved that the Mallows model averaging weight of the true model is root-n *** the authors develop a penalized Mallows criterion which ensures that the weight of the true model equals 1 with probability tending to 1 and thus the averaging estimator is asymptotically *** neither candidate model is true,the penalized Mallows averaging estimator is asymptotically *** results show the selection consistency of the penalized Mallows method and the superiority of the model averaging approach compared with the model selection estimation.

关键词： Asymptotic optimality consistency least squares model averaging non-nested models

A discrete Multi‑Objective Artificial Bee Colony Algorithm for a Real‑World Electronic Device Testing Machine Allocation Problem

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Chinese Journal of Mechanical Engineering 2022年第6期35卷 136-150页

作者： Jin xie Xinyu Li Liang gao State Key Laboratory of digital Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China

With the continuous development of science and technology,electronic devices have begun to enter all aspects of human life,becoming increasingly closely related to human *** have higher quality requirements for electronic *** device testing has gradually become an irreplaceable engineering process in modern manufacturing enterprises to guarantee the quality of products while preventing inferior products from entering the *** the large output of electronic devices,improving the testing efficiency while reducing the testing cost has become an urgent problem to be *** study investigates the electronic device testing machine allocation problem(EDTMAP),aiming to improve the production of electronic devices and reduce the scheduling distance among testing machines through reasonable machine ***,a mathematical model was formulated for the EDTMAP to maximize both production and the scheduling distance among testing ***,we developed a discrete multi-objective artificial bee colony(DMOABC)algorithm to solve EDTMAP.A crossover operator and local search operator were designed to improve the exploration and exploitation of the algorithm,*** experiments were conducted to evaluate the performance of the proposed *** experimental results demonstrate the superiority of the proposed algorithm compared with the non-dominated sorting genetic algorithm II(NSGA-II)and strength Pareto evolutionary algorithm 2(SPEA2).Finally,the mathematical model and DMOABC algorithm were applied to a real-world factory that tests radio-frequency *** results verify that our method can significantly improve production and reduce the scheduling distance among testing machines.

关键词： Electronic device Machine allocation Multi-objective optimization Artificial bee colony algorithm

Modeling high-speed cutting of SiC_(p)/Al composites using a semi-phenomenologically based damage model

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Chinese Journal of Aeronautics 2021年第8期34卷 218-229页

作者： Junfeng XIANG Lijing xie Feinong gao School of Civil Aviation Northwestern Polytechnical UniversityXi'an 710072China Key Laboratory of Fundamental Science for Advanced Machining Beijing Institute of TechnologyBeijing 100081China

In this paper,we attempts to investigate cutting mechanisms in high-speed cutting of Al6061/Si C_(p)/15p composites using a semi-phenomenologically based damage model in the equivalent homogeneous material(EHM)*** combining macroscale EHM modeling and underlying microscale physical mechanisms,a feasible semi-phenomenological plastic model is proposed for prediction of cutting forces and chip morphology during high-speed turning Al6061/Si C_(p)/15p *** model incorporates the modified Weibull weakest-link effect to represent the strain-based damage evolution in large *** proposed semi-phenomenological constitutive model is implemented by compiling material subroutines into cutting finite element(FE)*** effects of the critical shear stresses on chip formation that depend on the toolchip frictional coefficient are accounted for in the cutting FE *** chip formation mechanism affecting material removal behaviors during high-speed turning is further *** capabilities of the proposed constitutive model are evaluated by comparing cutting forces and chip morphologies between experiments and simulations at different cutting speeds associated with strain *** EHM-based and microstructure-based models are further compared in both computational efficiency and *** simulation results show that the developed semiphenomenological constitutive formalism and cutting model are promising and efficient tools for further investigation of dynamic mechanical and cutting behaviors of particle-reinforced composites with different volume fraction and particle size.

关键词： Chip morphology Damage evolution High-speed cutting Semi-phenomenological plasticity SiC_(p)/Al composites